Gene MLKy_b-2 (S.moellendorffii)

MLKy_b-2

Species: S.moellendorffii
Alias: MLKy_b-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKy

Sequence

Name Sequence Type Origin Length Description Download
MLKy_b-2.AA Protein None 687 None Fasta, JSON
MLKy_b-2.NA RNA None 2064 None Fasta, JSON
MLKy_b-2.kin_dom Protein Kinase Domain None 166 None Fasta, JSON

Protein domain

Protein domains of MLKy_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKy_b-2.AA TKL 161-310 20 3.2e-16 54.91 In-house 142-364 (364) Show / Hide 
Range on Protein: 161-310
Range on HMM: 142-364/364
Sequence Identity: 20% (45 aa)

AQGVLDLHS--------RGITALNLKPFNFLLDEHDQ--------------AVLGEFGIPFLL-----MDAISSDGP------------LVWLGTPNYMA
|.|.  |||        ..|   .||. | |.||. .              . .. ||.   .     | .......                |||..||
ARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMA

PEQWEPKLR-------------GPVSYETDSWGFACSFIEMLTGVKPWNTMSPS---------EIFHAVVEKGDKPVVP------------SGLPIALTR
||  . ..              .. |  .| . |.  . |.||. .|.  . ..         |.|  |..|| .| .|            .  |  . .
PEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKK

MLTSCLASDRRDRPTFTEIMSVL
 .. | ..| ..||.|.||.. |
LMQDCWDHDPEKRPSFQEILKRL
S_TKc MLKy_b-2.AA S_TKc 47-315 19 3.4e-14 31.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 47-315
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

LTLKHRIGRGPFGDVWLATIHSHREEFDEFHEVAVKMLPAISEDHIRGFTSKLEKIFSISQGASSVTWPRGLTMKNGKACVITKFFEL---SIGDKMARL
 ..   ||.| || |.... ..        ..||.|...          . . |     . .   .    .     .. .... . .    .  | . . 
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

PGNS----IPLADALRYGVNLAQGVLDLHSRGITALNLKPFNFLLDEHDQAVLGEFGIPFLLMDAISSDGPLVWLGTPNYMAPEQWEPKLRGPVSY-ETD
...     .|  .| .|   .....  .||.||    ||| | ||||  .  .. ||.  .|             |||.|||||        . .. . |
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCD

SWGFACSFIEMLTGVKPWNTMSPSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMS----VLRSPNV
 | . | ..|||.|  |.    . ..|. ..            .  .  ..  ||  | ..|||  |..     .   | .
WWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKy_b-2.AA MLK 215-310 29 6.8e-12 37.66 In-house 195-291 (291) Show / Hide 
Range on Protein: 215-310
Range on HMM: 195-291/291
Sequence Identity: 29% (29 aa)

GTPNYMAPEQWEPKLRGPVSYETDSWGFACSFIEMLTGVKPWN-TMSPSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSVL
||. .||||  . .  ...|   | | ..  . ||||.  |    ..|..|.  |...|  | .||. |  . .... |  .| ..||.| .|.. |
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKy_b-2.AA STE 215-305 23 1.2e-10 33.88 In-house 225-350 (359) Show / Hide 
Range on Protein: 215-305
Range on HMM: 225-350/359
Sequence Identity: 23% (30 aa)

GTPNYMAPEQWEP--KL-RGPVSYETDSWGFACSFIEMLTGVKPWNTMSPS-EIFHAVVEK-------------GDKPVVPSGLP---------------
||| .||||  ..  .  ... ..  | | . |  |||.||  || .|.|   .|..  ..             |. |  |. |                
GTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYP

----IALTRMLTSCLASDRRDRPTFTE
      .   .  ||  | ..||| ..
HKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase MLKy_b-2.AA Pkinase 215-310 20 3.2e-10 37.22 Pfam 173-293 (293) Show / Hide 
Range on Protein: 215-310
Range on HMM: 173-293/293
Sequence Identity: 20% (25 aa)

GTPNYMAPEQWEPKLR--GPVSYETDSWGFACSFIEMLTGVKPWNTM------SPSEIFHAVVEKGDKPVVPSGLP-------------------IALTR
|||.|||||     .|   . ... | |.. | ..|||.|  |.         .. ...  . ..  .   |   .                    ..  
GTPWYMAPEV----IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

MLTSCLASDRRDRPTFTEIMSV--L
 ...||. |  .|||...|.    .
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLKy_b-2.AA TyrKc 47-310 21 9e-10 -64.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 47-310
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

LTLKHRIGRGPFGDVWLATIHSHREEFDEFHEVAVKMLPAISEDHIRGFTSKLEKIFSI---------SQGASSVTWPRGLTMKNGKACVITKFFELSIG
.||.. .|.| || |...|            .|||||| . .   .. | . ..   ..           |. .    .   |  .  .... . ..  |
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPH--G

DKMARLPGNS--IPLADALRYGVNLAQGVLDLHSRGITALNLKPFNFLLDEHDQAVLGEFGIPFLLMDAISSD------GPLVWL----GTP-----NYM
|   .|  .   ....| | . .  |.|   |||...    |   | |..|  ..  . ||    |. .| .|      .         |.        |
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG----LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEQWEPKLRGPVSYETDSWGFACSFIEMLT-GVKPWNT-----MSPSEIFHAVVEKGDKPVVPSG-------LPIALTRMLTSCLASDRRDRPTFTEIM
||| .     |  . ..| | |     |..| | .|.       ||..|... | . .  |  |..        | .. .. ..| . |  |||||.|| 
APECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

SVL
. .
ECF
Kinase MLKy_b-2.AA Pkinase_Tyr 248-310 32 1.5e-09 32.96 Pfam 206-270 (270) Show / Hide 
Range on Protein: 248-310
Range on HMM: 206-270/270
Sequence Identity: 32% (21 aa)

EMLT-GVKP-WNTMSPSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSVL
|..| | .| .  ||..|..... |.|     | . |  . .....| . |  |||||.|| . |
EIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKy_b-2.AA Dicty4 248-312 27 2.3e-09 27.58 In-house 209-277 (277) Show / Hide 
Range on Protein: 248-312
Range on HMM: 209-277/277
Sequence Identity: 27% (19 aa)

EMLTGVKPWN--TMSPSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSV--LRS
|.||.  | .   |.. ... ||..|. .| .|.  |  ... .. |.  |   ||.| || .   | .
EILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKy_b-2.AA RIPK 215-310 25 3.1e-09 27.6 In-house 184-290 (290) Show / Hide 
Range on Protein: 215-310
Range on HMM: 184-290/290
Sequence Identity: 25% (27 aa)

GTPNYMAPEQWEPKLRGP---VSYETDSWGFACSFIEMLTGVKPWNTMSPSEIFHAVVEKGDKPV---VPSGLPIA-----LTRMLTSCLASDRRDRPTF
||  ||.||  .. .. |   |. . |   ||    | ||. .|     ..... .....|  |    ||   |..     . . ...| ..| .|||.|
GTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCF

TEIMSVL
 |. .  
QECEEWT
Kinase MLKy_b-2.AA TK 47-84 21 4.1e-08 22.47 In-house 1-60 (486) Show / Hide 
Range on Protein: 47-84
Range on HMM: 1-60/486
Sequence Identity: 21% (13 aa)

LTLKHRIGRGPFG---DVWLATIHSHRE-------------------EFDEFHEVAVKML
.|| . .|.| ||   .|.... ....                    . .. ..||||||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKML
Kinase MLKy_b-2.AA TKL-Unique 247-310 22 5.8e-08 24.37 In-house 219-290 (290) Show / Hide 
Range on Protein: 247-310
Range on HMM: 219-290/290
Sequence Identity: 22% (16 aa)

IEMLTGVK------PWNTMSPSEIFHAVVE--KGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSVL
.|..|.        |   |.. ... .| .  ..  | .|. .|  ..  .. | ..|  .||.|.|| . |
WEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKy_b-2.AA TK 219-310 18 2.3e-07 19.91 In-house 351-486 (486) Show / Hide 
Range on Protein: 219-310
Range on HMM: 351-486/486
Sequence Identity: 18% (25 aa)

YMAPEQWEPKL------RGPVSYETDSWGFACSFIEMLT-G-VKPWNTMSP---------SEIFHAVVEK-----------GDKPVVP--SGLP------
.|||| .. .        |  . ..| | | .   |..| | . .   ||           |..  ...            |..   |   . |      
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYR

--------IALTRMLTSCLASDRRDRPTFTEIMSVL
         .. .....| . | .|||||... . |
MHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKy_b-2.AA Dicty4-Unclassified 248-310 23 5.2e-07 20.02 In-house 200-263 (263) Show / Hide 
Range on Protein: 248-310
Range on HMM: 200-263/263
Sequence Identity: 23% (15 aa)

EMLTGVKPWNTMS-PSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSVL
|..||  |.     . ..   | .|. .| .|.  .  . ..   |.  | . |||. .|   |
ELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKy_b-2.AA TK-Unique 269-310 20 5.5e-07 20.26 In-house 252-294 (294) Show / Hide 
Range on Protein: 269-310
Range on HMM: 252-294/294
Sequence Identity: 20% (9 aa)

VEKGDKPVVPSGL-PIALTRMLTSCLASDRRDRPTFTEIMSVL
...|. . .|..  . ...  . ||. ... .||.|..| ..|
IRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Pkinase_Tyr MLKy_b-2.AA Pkinase_Tyr 47-91 28 6.6e-07 24.02 Pfam 1-43 (270) Show / Hide 
Range on Protein: 47-91
Range on HMM: 1-43/270
Sequence Identity: 28% (13 aa)

LTLKHRIGRGPFGDVWLATIHSHREEFDEFHEVAVKMLPAISEDH
.|. . .|.| ||.|...| .   .. ..  .||||||.  . ..
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHE
Kinase MLKy_b-2.AA TK-Unique 47-84 39 8.7e-07 19.56 In-house 1-38 (294) Show / Hide 
Range on Protein: 47-84
Range on HMM: 1-38/294
Sequence Identity: 39% (15 aa)

LTLKHRIGRGPFGDVWLATIHSHREEFDEFHEVAVKML
|... .||.| || || ... .  ...|... ||||||
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKML
Kinase MLKy_b-2.AA SrcA 47-65 47 3e-06 15.13 In-house 1-19 (250) Show / Hide 
Range on Protein: 47-65
Range on HMM: 1-19/250
Sequence Identity: 47% (9 aa)

LTLKHRIGRGPFGDVWLAT
..|..|.|.| ||.||. |
IRLERRLGQGCFGEVWMGT
Kinase MLKy_b-2.AA SrcA 238-310 31 1.2e-05 13.36 In-house 178-250 (250) Show / Hide 
Range on Protein: 238-310
Range on HMM: 178-250/250
Sequence Identity: 31% (23 aa)

DSWGFACSFIEMLT-GVKPWNTMSPSEIFHAVVEKGDKPVVPSGLPIALTRMLTSCLASDRRDRPTFTEIMSVL
| | |     |..| |  |.  |   |.    ||.| .   | . |..|  ..  |   |  .||||  . | |
DVWSFGILLTELVTKGRVPYPGMNNREVLEQ-VERGYHMPCPQDCPESLHELMCQCWRKDPEERPTFEYLQSFL
Kinase MLKy_b-2.AA MLK 47-65 36 0.000225 11.23 In-house 1-19 (291) Show / Hide 
Range on Protein: 47-65
Range on HMM: 1-19/291
Sequence Identity: 36% (7 aa)

LTLKHRIGRGPFGDVWLAT
..... || |.||.||...
IQFHEWIGSGSFGKVWKGR
Kinase MLKy_b-2.AA Dicty4-Unclassified 147-197 33 0.000247 10.71 In-house 103-155 (263) Show / Hide 
Range on Protein: 147-197
Range on HMM: 103-155/263
Sequence Identity: 33% (18 aa)

SIPLAD--ALRYGVNLAQGVLDLHSRGITALNLKPFNFLLDEHDQAVLGEFGI
.| | |   ..|    |||   ||.| .    .|  | |.| |  .  . |||
PIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGI
Kinase MLKy_b-2.AA TKL 53-85 27 0.000542 10.28 In-house 1-35 (364) Show / Hide 
Range on Protein: 53-85
Range on HMM: 1-35/364
Sequence Identity: 27% (10 aa)

IGRGPFGDVWLATIHSHREEFD---EFHEVAVKMLP
||.| || |. .. . ...         .||||...
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFK
Kinase MLKy_b-2.AA TKL-Unique 161-223 24 0.001167 8.99 In-house 120-196 (290) Show / Hide 
Range on Protein: 161-223
Range on HMM: 120-196/290
Sequence Identity: 24% (19 aa)

AQGVLDLHSRG--ITALNLKPFNFLLDEH-----DQAVLGEFGIPFLLM--DAISSDGP-----LVWLGTPNYMAPE
|||   ||...  |. ..||. |||.|..      .. .  ||.. ..   .. .. ..      . .|....||||
AQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE
Kinase MLKy_b-2.AA Pkinase 47-85 25 0.023346 9.42 Pfam 1-33 (293) Show / Hide 
Range on Protein: 47-85
Range on HMM: 1-33/293
Sequence Identity: 25% (10 aa)

LTLKHRIGRGPFGDVWLATIHSHREEFDEFHEVAVKMLP
.... .||.| || |.... .. ..      .|||| ..
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIK
Kinase MLKy_b-2.AA Dicty4 47-65 42 0.128093 1.37 In-house 1-19 (277) Show / Hide 
Range on Protein: 47-65
Range on HMM: 1-19/277
Sequence Identity: 42% (8 aa)

LTLKHRIGRGPFGDVWLAT
..   |||.| || | ..|
INIEQRIGKGSFGEVYKGT
Kinase MLKy_b-2.AA Dicty4 215-223 77 0.308171 0.08 In-house 179-187 (277) Show / Hide 
Range on Protein: 215-223
Range on HMM: 179-187/277
Sequence Identity: 77% (7 aa)

GTPNYMAPE
||| .||||
GTPCWMAPE