Gene MLKx_m (S.moellendorffii)

MLKx_m

Species: S.moellendorffii
Alias: MLKx_m
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_m.AA Protein None 163 None Fasta, JSON
MLKx_m.NA RNA None 492 None Fasta, JSON
MLKx_m.kin_dom Protein Kinase Domain None 158 None Fasta, JSON

Protein domain

Protein domains of MLKx_m.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_m.AA Pkinase 4-161 26 1.2e-29 105.94 Pfam 9-180 (293) Show / Hide 
Range on Protein: 4-161
Range on HMM: 9-180/293
Sequence Identity: 26% (47 aa)

RGSYGVVRKGTWHQR--LVAVKEFKESQDLPSQ--------ELPAVSSIQAAPHIVQTIGYYKVDESCTHLVMEVMRM-----NLKEYAS--KNKEL--T
.||.|.|.|....    .||||..| . . ...        |.    ...  |.||......   ..  ..||| ...      |..| |  ... .  .
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS

LLQLVEILLQITKGLDFLHGKNIVHRDLKPENVLIDFTDEDEEQLVLKLTDFGTAYI--NFNIEQSHTAPVGTRFFRPP
  ..  ...|| .||...| ..|.||||||||.||| ... ..   .|..||| |    . | .   | ..||.....|
EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAP
Kinase MLKx_m.AA CMGC 2-161 17 3e-27 85.81 In-house 7-294 (513) Show / Hide 
Range on Protein: 2-161
Range on HMM: 7-294/513
Sequence Identity: 17% (51 aa)

LHRGSYGVVRKGTWHQ----------------RLVAVKEFKESQDLPSQEL-------------PAVSSIQAA------------------PH-IVQTIG
. .|.|||| |.. ..                ..||.| .|. .  . |..               ..  .                    .. ||. . 
IGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYD

YYKVDES----------------CTHLVMEVMRMNLKEYASKNK---------ELTLLQ------------LVEIL------LQITKGLD--FLHGKN--
... ..|                . .||.| | ..|..|  .|.         .|.  .               ..       || .||.  ..| ..  
IFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGN

IVHRDLKPENVLID-----FTDEDE----------EQLVLKLTDFGTAY-INFN--------------------IEQSHTAPVGTRFFRPP
|.||||||||.||.     .|.. .          .. .||. ||| |  .. .                    . . .|  | ||. |.|
IIHRDLKPENILINHNCELITRM-MWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAP
Kinase MLKx_m.AA TKL 2-161 19 9.6e-25 86.03 In-house 1-242 (364) Show / Hide 
Range on Protein: 2-161
Range on HMM: 1-242/364
Sequence Identity: 19% (48 aa)

LHRGSYGVVRKGTWHQ----------RLVAVKEFKE-----------------------------SQDLPSQELPAVSSIQA-APHIVQTIGYYKVDES-
. .|..|.| ||.|..          . |||| ||.                             |.     |  ... ..   |.||| .|| .  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------CTHLVMEVM-RMN-LKEYASKNKELTLLQLVEILLQITKGLDFLHG--------KNIVHRDLKPENVLID--FT--DEDE-----EQLV
             ..||| . . . |  .        . |.. . |.| .|...||         ..|.|||||..|.|.|  .|  . ..     .. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADWC

LKLTDFGTAYINFNI-EQSHTA------------------PVGTRFFRPP
.|..|||..  ...  ....|.                  ..||  . .|
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAP
Kinase MLKx_m.AA CAMK 1-139 17 1.3e-23 72.28 In-house 1-243 (425) Show / Hide 
Range on Protein: 1-139
Range on HMM: 1-243/425
Sequence Identity: 17% (43 aa)

LLHRGSYGVVRKGTWHQRL--------------VAVKEFK--------------------------------ESQDLPSQELPAVSSIQA------APHI
 | |||.|.|....  .                ||.|  .                                ....   .|.   ...|.       |.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQTIGYYK------------VDES-------CTHLVM---EVMRMN-----LKEYASKNKE---------------LTLLQLVEILLQITKGLDFLHGKN
.. . .|               .        . ..||   | .        | .|  ...                .|  .   .  ||  .....| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKPENVLID--FTDED---------EEQLVLKLTDFGTA
||||||||||.|.|  ..|.|         ...  .|..||| |
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA
Kinase MLKx_m.AA STE 4-139 21 1.8e-22 76.23 In-house 9-194 (359) Show / Hide 
Range on Protein: 4-139
Range on HMM: 9-194/359
Sequence Identity: 21% (42 aa)

RGSYGVVRKGTWH-----------------QRLVAVKEFK---------------------ESQDLPSQELPAVSSIQA-APHIVQTIGYYKVD------
.|..|.| |.  |                 ....|.|. .                     | ..   .|.   .  .   |.||. .|.| ..      
KGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKN

ESCTHLVMEVMR-MNLKEYASKN----KELT----------LLQLVEILLQITKG-LDFLHGKNIVHRDLKPENVLIDFTDEDEEQLVLKLTDFGTA
..  ...|| |    | .   ..    |.|.            |.  |. || || |..|| ..|.|||.|| |.|.            ||.|||..
DDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------VKLCDFGVC
Kinase MLKx_m.AA TK 2-137 17 2.4e-20 64.24 In-house 7-296 (486) Show / Hide 
Range on Protein: 2-137
Range on HMM: 7-296/486
Sequence Identity: 17% (50 aa)

LHRGSYG---VVRKGTWHQR---------------------------LVAVKEFKE--SQDLPSQEL---------------PAVSSIQA-----APHIV
| .| .|   .|.||.|..|                            ||||  ||  ...   ...                .. ..        |.||
LGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIV

QTIG----Y--------YKVDESCTHLVMEVMR-MN----LKEYASKNKE--------------------------------------------------
. .|             . |..    .||| |   .    |..|  |...                                                  
RLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLI

--------------------------LTLLQLVEILLQITKGLDFLHGK------NIVHRDLKPENVLIDFTDE-----DEEQLVLKLTDFG
                          ||. ||. . .|| .|. .|| |      |.|||||   |.|..  .      |. ..| |..|||
KDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
Kinase MLKx_m.AA Ciliate-E2 46-149 25 4.3e-20 65.66 In-house 92-215 (365) Show / Hide 
Range on Protein: 46-149
Range on HMM: 92-215/365
Sequence Identity: 25% (35 aa)

PHIVQTIGYYKV-DESCTHLVMEVMRM-NLKEYASKN-----------KELTLLQLVEILLQITK---------------GLDFLHGKN-IVHRDLKPEN
|.|.. . ...  |...  ||||     .|..|  .|           | .|. .  .|  ||..               .| .|| || |.|||.||||
PNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPEN

VLIDFTDEDEEQLVLKLTDFGTAYI--NFNIEQSH
.|.           .|..|||.. .  ..|....|
ILF-----------IKIIDFGLSKKYDDDNQNRTH
Kinase MLKx_m.AA MLK 5-139 24 4.3e-19 62.98 In-house 10-180 (291) Show / Hide 
Range on Protein: 5-139
Range on HMM: 10-180/291
Sequence Identity: 24% (42 aa)

GSYGVVRKGTWHQRL-----VAVKEFK----------ESQDLPSQELPAVSSIQ---AAPHIVQTIGYYKVDESCTHLVMEVMR---MNLKEYA-SKNKE
||.|.| ||.|. ..     ||||...          ..|.   .| . .. ..     | |.|  |  . ....  .||| ..   ..   .. ... .
GSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWM

-----------LTLLQLVEILLQITKGLDFLHGKN---IVHRDLKPENVLID-FTDEDEEQLVLKLTDFGTA
            .. ... . ||. .|...|| .    |.|||||. |.|||     | ....|| .||||.
DANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTS
Kinase MLKx_m.AA Ciliate-B1 81-148 33 7.5e-19 62.73 In-house 113-187 (290) Show / Hide 
Range on Protein: 81-148
Range on HMM: 113-187/290
Sequence Identity: 33% (25 aa)

KELTLLQLVEILLQITKGLDFLHGKNIVHRDLKPENVLID------FTDEDEEQLVLKLTDFGTAYINFN-IEQS
...|.  ......||.||. .||  .|.|||||||| ||       .     .....| ||||   . .. ..||
QNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEYMMQS
Kinase MLKx_m.AA Ciliate-E2-Unclassified 54-161 24 1.6e-18 60.87 In-house 88-235 (352) Show / Hide 
Range on Protein: 54-161
Range on HMM: 88-235/352
Sequence Identity: 24% (37 aa)

YYKVDESCTHLVMEVMRM-NLKEYASKNKE-----------------LTLLQLV-----EILLQITKGLDFLHGKN-IVHRDLKPENVLIDFTDEDEEQL
|.. |. .  .||| ..  .|..| .|.|                  .|  | .      .. || .||..|| || |.|||.||||.|.|   .    .
YCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---NY

VLKLTDFGTAY---------------INFNIEQSHTAPVGTRFFR----PP
 .|..||| ..               ......|  .  .||  .     .|
YIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAP
Kinase MLKx_m.AA TKL-Unique 1-120 28 8.9e-18 59.41 In-house 4-146 (290) Show / Hide 
Range on Protein: 1-120
Range on HMM: 4-146/290
Sequence Identity: 28% (41 aa)

LLHRGSYGVVRKGTWHQRLVAVKEFKESQDLPS----Q----ELPAVSSIQAAPHIVQTIGYYK---VDESCTHLVMEVMRMN-LKEYAS----------
.. .|.||.| ||.|..  ||.| |.. . ..|    |    |.   . .. .| ||. .|| .   |...   .||| . .. | .. .          
KIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

KNKELTLLQLVEILLQITKGLDFLHGKN--IVHRDLKPENVLID
.|..|...| | . ..| .|...|| ..  | |||||. |.|.|
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVD
Kinase MLKx_m.AA S_TKc 4-163 18 4.7e-11 -14.82 SMART 9-220 (231) Show / Hide 
Range on Protein: 4-163
Range on HMM: 9-220/231
Sequence Identity: 18% (43 aa)

RGSYGVVRKGTWHQ--RLVAVKEFKESQDLPSQELPAVSSIQAAPHIVQTIGYYKVDESCTHLVMEVMRM---NLKEYASKNKE------LTLLQLVEIL
.|..|.|.|....   |.||.|. |   .   .|.   ..    |.||. ....    .. ..||| .     .|..|  |..       ..  .   ..
KGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYM

LQITKGLDFLHGKNIVHRDLKPENVLIDFTDEDEEQLVLKLTDFGTAYINFNIEQSHTAPVGTRFFRPP------S------------------------
 || ..|...| ..|.||||||||.|.|         ..|..||| | .        |  .||.....|                               
YQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL-------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQ

----------------------------------C
                                   
MQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase MLKx_m.AA Pkinase_Tyr 78-137 34 4.2e-09 31.44 Pfam 100-156 (270) Show / Hide 
Range on Protein: 78-137
Range on HMM: 100-156/270
Sequence Identity: 34% (22 aa)

SK---NKELTLLQLVEILLQITKGLDFLHGKNIVHRDLKPENVLIDFTDEDEEQLVLKLTDFG
..   .. ||. .|... .|| ||...|. ||..||||   |.|..      |..| | .|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT------ENNVVKICDFG
Kinase MLKx_m.AA TyrKc 1-163 17 3e-07 -105.37 SMART 6-280 (280) Show / Hide 
Range on Protein: 1-163
Range on HMM: 6-280/280
Sequence Identity: 17% (49 aa)

LLHRGSYGVVRKGTWHQRLVAVKEFKESQDLPS---QELPAVSSI-QAAPHIVQTIGYYKVDE------SCTHLVMEVMRM-NLKEYASKNKE-LTLLQL
 | .| .|.|.||||  . ||||  ||.        .|.   ...    |.||. .|.   ..          .||| |   .||.|  |... |.. .|
KLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDL

VEILLQITKGLDFLHGKNIVHRDLKPENVLIDFTD-------------EDE-------EQLV------LK------------LTDF--------------
... .|| .| ..|| ||..||||   |.|..                .|.       .  .       |            . .               
LSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVC

--------GTAYIN-----FNIEQ-SHTAPVGTRFFRPPS-------------------------------------C
        .. | .      . ..  .    | |  .||.                                      
MWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_m.AA Pkinase_Tyr 4-28 41 0.009781 9.89 Pfam 9-39 (270) Show / Hide 
Range on Protein: 4-28
Range on HMM: 9-39/270
Sequence Identity: 41% (13 aa)

RGSYGVVRKGTWH------QRLVAVKEFKES
.|..|.|.||||.      .  ||||  ||.
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG