Gene MLKx_e-2 (S.moellendorffii)

MLKx_e-2

Species: S.moellendorffii
Alias: MLKx_e-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_e-2.AA Protein None 1142 None Fasta, JSON
MLKx_e-2.NA RNA None 3429 None Fasta, JSON
MLKx_e-2.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of MLKx_e-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_e-2.AA TKL 204-456 23 2.6e-72 246.55 In-house 1-364 (364) Show / Hide 
Range on Protein: 204-456
Range on HMM: 1-364/364
Sequence Identity: 23% (88 aa)

IGAGAFGSVYKAEWVG----------APVAVKEFRSGDASV----------------------------DKEVNILKELILEPHPSVLQMIGSYQKDEK-
|| |.|| |||..| |           .|||| |.| . .                             ..|.. .. ..   || ..|..|. .  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AYLVMELM-ERD-LTSVIRKAEGSLQLLTSVDIMLQIASGMSYLHQRN--------VVHRDLKPSNVLVKT-LK-------NHACITC
             ..|||..   . |  ..        .   ....|.||.||.|||..|        ..|||||..|.||.  ..       |.. . |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

FDVRLTDFGVSKSNFISFAPD------------------LSYQRGTIQYMAPEMLKGQ----------------KYSREVDVYSFGITCFQILTGTLPFQ
  . ..||| |.... |.                     .. |.||...||||.|.||                .||  .|||||||  . |||. .|..
--CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

DDGKQLVA------DKLVETIEDGNRPDLP------------TGCPLELVALLNRCWNRNPKDRPTFEHISRML
|..   .       . ..  ...|.|| .|            . || ..  |. .||. .|..||.|. |   |
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc MLKx_e-2.AA S_TKc 198-458 24 2.5e-70 240.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 198-458
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

LELKTLIGAGAFGSVYKAEWVG--APVAVKEFRSGDASVDKEVNILKELILEPHPSVLQMIGSYQKDEKAYLVMELMER---DLTSVIRKAEGS-----L
 |.  .|| ||||.|||. ...    ||.|. .    .. .|..|||.     || . ......|  .. |.|||...    || ..|.|  .      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACITCFDVRLTDFGVSKSNFISFAPDLSYQRGTIQYMAPEMLKGQKYSR-EVDVYSFG
   .   .| ||.... |.|.....||||||.|.|. .           . ..|||...          . . ||  |||||.|   .|.. ..|..|.|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

ITCFQILTGTLPFQDDGKQLVADKLVETIEDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISR-------MLWS
.. .  |.|  ||.    |.. .|..               . |.  ....|....|..|||   . .       . | 
CILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase MLKx_e-2.AA Pkinase 198-456 25 8.6e-69 239.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

LELKTLIGAGAFGSVYKAEWVGAP--VAVKEFRSGDASVDK--------EVNILKELILEPHPSVLQMIGSYQKDEKAYLVMELMER-----DLTSVIR-
....  ||.|.||.|||. ..| .  ||||...  ... .|        |. |.|.|    || ......... . . |.|||..|      || ..|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KAEGSL--QLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVK-TLKNHACITCFDVRLTDFGVSK--SNFISFAPDLSYQRGTIQYMAPEMLK-GQK
...|..  .  .  ..|.||..|. |.|.....||||||.|.|.. .  . |     .|...|||..|  .  .   . ..   ||. ||||| .. ||.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQY

YSREVDVYSFGITCFQILTGTLPFQDD----GKQLVADKLVETIEDGNRPDLPTGCP-------------------LELVALLNRCWNRNPKDRPTFEHI
|...||..|.|..... |.| .||...    .      ..... .  .. | |. |.                    |.  ....|....||.|||.|.|
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

SRM--L
     .
LQHPWF
Kinase MLKx_e-2.AA MLK 198-456 26 2.7e-60 206.62 In-house 1-291 (291) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-291/291
Sequence Identity: 26% (79 aa)

LELKTLIGAGAFGSVYKAEWVGAP-----VAVKEFR--------SG--DASVDKEVNILKELILEP-HPSVLQMIGSYQKDEK-AYLVMELMER-DLTSV
..... ||.|.||.|.|..| .       ||||..|        ..  .  ...|...|. |  .  ||.. |  |  .....  ..||| .|   | .|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IRKAEG---------------SLQLLTSVDIMLQIASGMSYLHQRN---VVHRDLKPSNVLVKTLKNHACITCFDVRLTDFGVSKSNFISFAPD-LSYQR
.. |..               .....  ....||.|.||.|||.     ..|||||..|.|.     |  .   ... .|||.|.. . .   .    ..
LHGARSKWMDANHNQKNDRVYDHDHA--MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRD-WHQMC-TNMMSNA

GTIQYMAPEML---KGQKYSREVDVYSFGITCFQILTGTLPFQDDGKQLVADKLVETIEDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRML
||  .||||..   ...|||. .||.|.|.   ..||. .|.... ... .  . . .. |.|| .| .||  .  |...||| .|..||.| .|   |
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAI--AWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKx_e-2.AA TK 198-456 18 1.7e-58 194.34 In-house 1-486 (486) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-486/486
Sequence Identity: 18% (92 aa)

LELKTLIGAGAFG---SVYKAEWVGA---------------------------PVAVKEFRSG-DASVDK-----------------EVNILKELI--LE
..|   .|.|.||    |||.|| |                            |||||  ..| ..| .                  |....| .   | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPSVLQMIG-SYQKDEK-----------AYLVMELME-RD----LTSVIRKAEG---------------------------------------------
 || .....| . |...|            ..|||.|.  |    | .  ||  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------SLQLLTSVD-------------------IMLQIASGMSYLHQR------NVVHRDLKPSNVLVKTLKNHACI---TCFDVRLTDFGVSKS
          .|..   ..                   ...|||.||.|||..      |.|||||   |.||   .. . .   ... ....||| |. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

NF----ISFAPDLSYQRGT-----------------------------IQYMAPEMLKGQK---------YSREVDVYSFGITCFQILT-G-TLPFQDDG
.         .|  | | .                             | .|||| |....         .. . ||.|||.... |.| | . .  .  
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

KQLVAD-----KLVETIEDG--------------NRPDLPTGCP--------------LELVALLNRCWNRNPKDRPTFEHISRML
 | |.       ..| ...|              .|.  | .||               |.  |. .||...|.|||||. . ..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_e-2.AA STE 198-458 20 4.3e-53 182.71 In-house 1-359 (359) Show / Hide 
Range on Protein: 198-458
Range on HMM: 1-359/359
Sequence Identity: 20% (78 aa)

LELKTLIGAGAFGSVYKAEWV-----------------GAPVAVKEFRSGDASV---------------DKEVNILKEL----ILEP-HPSVLQMIGSYQ
.|.   || ||||.||||  .                 |  .|.|. .  . .                ... .||||.     . . || . . .|.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------EKAYLVMELME-RDLTSVIR---KAEGSLQ----------LLTSVDIMLQIASG-MSYLHQRNVVHRDLKPSNVLVKTLKNHACITCFDVR
|.       .. ...||.|.   |...|.   .  ..|.                |  ||  | ..|||. ...|||.||.|.|.             | 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------------VK

LTDFGVSKSNFISFA---------------PDLSYQRGTIQYMAPEMLKG------QKYSREVDVYSFGITCFQILTGTLPFQD-DGK---QLVADK---
|.||||...   | |                      ||  .||||....      ..|.. .|..|.|.|.   .||  |. |        . ...   
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

-----LVETIEDGNRPDLPT-------------------GCPLELVALLNRCWNRNPKDRPTFEHISR--MLWS
     ..  | .|. | ||.                    .  |.   .|.| ...|..||| .   .    . 
QQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MLKx_e-2.AA TKL-Unique 200-456 30 1.3e-52 181.16 In-house 1-290 (290) Show / Hide 
Range on Protein: 200-456
Range on HMM: 1-290/290
Sequence Identity: 30% (89 aa)

LKTLIGAGAFGSVYKAEWVGAPVAVKEFR----SGDASVD---KEVNILKELILEPHPSVLQMIGSYQ----KDEKAYLVMELMERD-LTSVIR------
   .||.|..|.|||..| | |||.| |     |   ...   .|||..|   |..|| ... .|       .  . ..||| ...  | .|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMK--KLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KAEGSLQLLTSVDIMLQIASGMSYLHQRN--VVHRDLKPSNVLVKTLKNHACITCFDVRLTDFGVSKSNFISFAPDLS--------YQRGTIQYMAP
   . .  | ..  |.. ..||.|| ||| ..  . |||||.||.||    | |    . ... ||| ||.|  . .  ..           |....|||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIA---EWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAP

EMLKG--QKYSREVDVYSFGITCFQILTGTL------PFQDDGKQLVADKLVETIEDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRML
|.|..   .||. .|||||||    |.|...      |.|.   . .. .. .. |.. || .|. || |.  |...||...| .||.|. |   |
EVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_e-2.AA Ciliate-E2 198-458 19 1.1e-50 172.14 In-house 1-365 (365) Show / Hide 
Range on Protein: 198-458
Range on HMM: 1-365/365
Sequence Identity: 19% (76 aa)

LELKTLIGAGAFGSVYKAEWVGAP-------------------------VAVKEFR-SGDASVDKEVNILKELILEP--------------HPSVLQMIG
 ..  .|| |.||||||..    .                         .|.| .. ..  .. .| .|..|.                  || ...|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

SYQ--KDEKAYLVMELMER-DLTSVIR-----------KAEGSLQLLTSVDIMLQIAS---------------GMSYLHQRN-VVHRDLKPSNVLVKTLK
..|  .|.. |||||. .  || . |.           |. ... .    .|| ||..               .. |||..| ..|||.||.|.|.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NHACITCFDVRLTDFGVSKSNFIS-----------FAPDLSY--------------------QRGTIQYMAPEMLKGQK---------YSREVDVYSFGI
         . ..||| || . ..             .. ..                    . ||  |||||.|.|.|         |. ..|..|.|.
---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

TCFQILTGTLPFQDDGKQLVADKLVETIEDGNRPDLP------------------TGCPLELVALLNR----CWNRNPKDRPT-FEHISRMLWS
. .. |.| .||             . .   .  |.|                    ...|   |...    . ...|. |.| .| |    | 
ILYEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MLKx_e-2.AA TyrKc 198-456 27 4.5e-50 173.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-280/280
Sequence Identity: 27% (80 aa)

LELKTLIGAGAFGSVYKAEWVGAPVAVKEFRSGDASVDKEVNILKELIL---E--PHPSVLQMIGSYQKD-------EKAYLVMELMER-DLTSVIRKAE
..|.  .| |||| |||..|   .||||  ...      .  ...|. .       || .....|   ..       |  ..|||.|.  || . .|| .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

GSLQLLTSVDIMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACITCFDVRLTDFGVSKSNFIS----FAPDLSY------QR--GTIQYMAPEMLK
. |.. . .....|||.||.|||..|..||||   |.||.  .         |. .||| |.          . |          .    |  |||| ..
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GQKYSREVDVYSFGITCFQILTGTLPFQDDGKQ--LVADKLVETIEDGNRPDLPTG--------CPLELVALLNRCWNRNPKDRPTFEHISRML
  |.. . ||.|||.... |.|   .   .  |  . .. ..| ...|.|.. |          || |.  .  .||...|.|||||. | . .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_e-2.AA UTK 198-456 26 8.3e-43 144.28 In-house 1-296 (296) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-296/296
Sequence Identity: 26% (81 aa)

LELKTLIGAGAFGSVYKAEWVG-------APVAVKEFRSGDASVDKEV---------N---ILKELILEPHPSVLQMIGSYQKDEKAYLVMELME-RDLT
..|  ..|.|||| |.||...        . ||||. ...... ...          .   ..| .    ||.||...|   ..|  ..|.|.||  || 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH--WHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

SVIRKAEGSLQ----LLTSVD---IMLQIASGMSYLHQRNVVHRDLKPSNVLVKTLKNHACITCF-DVRLTDFG---VSKSNFISF--------APDLSY
|. |..  ..     .||. .    ...||.||.|||....|||||   |.||          |. .... |||    |.   ...          ....
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRM-MWH-CMMVCKIADFGRGGMSR--RVNTFHFSNRYWESYYYM

QRG----TIQYMAPEMLKGQ-KYSREVDVYSFGITCFQILT-GTLPFQDDGKQLVADKLVETIEDG--NRPDLPTGCPLELVALLNRCWNRNPKDRPTFE
...    .|. |||| |  . ....  ||.|||..|. |.| | ||. .    . ...... ...|   |.  | .||...  |..|||. .| .||.||
AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPG----MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFE

HISRML
 .   .
DLVQQM
Kinase MLKx_e-2.AA TK-Unique 198-456 27 3.8e-42 143.15 In-house 1-294 (294) Show / Hide 
Range on Protein: 198-456
Range on HMM: 1-294/294
Sequence Identity: 27% (85 aa)

LELKTLIGAGAFGSVYKAEWVG--------APVAVKEFRSGDASVD-----KEVNILKELILEPHPSVLQMIGSYQKD-EKAYLVMELMERD-LTSVIRK
||.. .|| |||| |...| .|          ||||  . .   .|     || ...||  | .|| ..|..|  .|. |  ...|| ...  | . .|.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKE--LGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

AEGS-------------------------LQLLTSVDIMLQIASGMSYLHQ--RNVVHRDLKPSNVLVKTLKNHACITCFDVRLTDFGVSK--SNFISFA
  .                          ... . . .. |||.||.||..  ...|||||  .|||.           . . ..||| ..  ..    .
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE--------DKVCKICDFGMARDVYTNGVYS

PDLSYQRGTIQYMAPEMLK--GQKY-SREVDVYSFGITCFQILT-GTLPFQDDGKQLVADKLVETIEDGNRPDLPTGC-PLELVALLNRCWNRNPKDRPT
   |..|  | .|||| ||  .. | . . ||.|||.. . |.| |  |.     .. .....| |.|| |...| .| . |.  |. .||...|..||.
MMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYP----GMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPS

FEHISRML
|. |  .|
FRQIKHRL
Kinase MLKx_e-2.AA LRRK 267-458 28 6.1e-41 142.34 In-house 132-351 (351) Show / Hide 
Range on Protein: 267-458
Range on HMM: 132-351/351
Sequence Identity: 28% (63 aa)

LVMELMER-DLTSVIRKAEGS--------LQLLTSVDIMLQIASGMSYLHQRN--VVHRDLKPSNVLVKTLKNH----ACITCFDVRLTDFGVSKSNFIS
.|||..   || ..... . .        .   .   |.||||.|| ||| .|  ..|||||. |.|.......    .  .   . . ||| |   | .
MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQC

FAPD-LSYQRGTIQYMAPEMLKGQ---KYSREVDVYSFGITCFQILTGT-LPFQD-DGKQLV--ADKLVETIEDGNRPDLPTG-CPL-----ELVALLNR
| .  ..   |....|||| ...     |. .||.||||.  . .||.. .||.. |..       .. . | .| || .|   ||      .. .|.. 
FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQH

CWNRNPKDRPTFEHISRMLWS
||. .||.||.|. |   | .
CWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_e-2.AA Pkinase_Tyr 198-316 32 6.8e-29 98.49 Pfam 1-137 (270) Show / Hide 
Range on Protein: 198-316
Range on HMM: 1-137/270
Sequence Identity: 32% (45 aa)

LELKTLIGAGAFGSVYKAEWV------GAPVAVKEFRSGDASVD-------KEVNILKEL-ILEPHPSVLQMIGSYQ-KDEK--AYLVMELMER-DLTSV
...   .|.||||.|||..|       . |||||  . |  . .       .|..|.|.|     || .....|    ..|    |.|||.|.  || . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGH---HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IRKA---EGSLQLLTSVDIMLQIASGMSYLHQRNVVHRDL
 ||    ...| . . ... .|||.||.||...| .||||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase MLKx_e-2.AA Dicty4 361-458 35 3.7e-26 84.39 In-house 179-277 (277) Show / Hide 
Range on Protein: 361-458
Range on HMM: 179-277/277
Sequence Identity: 35% (36 aa)

GTIQYMAPEMLKGQKYSREVDVYSFGITCFQILTGTLPFQDDGKQLVADKLVETIED-GNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRM--LW
||  .||||.. .| |   .|||||||  ..|||.  |.|  .. ..  ..|. . . ..|| .|  ||  . .|...||. .|. ||.|| |.    | 
GTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYM--QFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILE

S
.
H
Kinase MLKx_e-2.AA Dicty4 198-323 28 1.6e-24 78.8 In-house 1-147 (277) Show / Hide 
Range on Protein: 198-323
Range on HMM: 1-147/277
Sequence Identity: 28% (43 aa)

LELKTLIGAGAFGSVYKAEWVGAPVAVKEF--RSGD------ASVDKEVNILKELILEPHPSVLQMIGSYQ----KDEKAYLVMELM-ERDLTSVIRK--
.    .|| |.||.|||. | |  |||| .  .  .       .  |||.|.. .    || ...  |.      . .|   |.|.|   .| |....  
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIR---HPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

----AEGSLQ--LLTS-VDIMLQIASGMSYLHQRN--VVHRDLKPSNVLV
     . .|.  | ..   ... .| || .|| .|  ..|||||..| ||
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV
Kinase MLKx_e-2.AA Pkinase_Tyr 366-456 37 5.9e-23 78.37 Pfam 181-270 (270) Show / Hide 
Range on Protein: 366-456
Range on HMM: 181-270/270
Sequence Identity: 37% (35 aa)

MAPEMLKGQKYSREVDVYSFGITCFQILT-GTLP-FQDDGKQLVADKLVETI-EDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRML
|||| ..  |.. . ||.|||.... |.| |  | ...    .    ..| | |||.| . | .|| |.  |. .||. .|.|||||. | ..|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG----MSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_e-2.AA LRRK 198-227 45 2.1e-09 29.41 In-house 1-31 (351) Show / Hide 
Range on Protein: 198-227
Range on HMM: 1-31/351
Sequence Identity: 45% (14 aa)

LELKTLIGAGAFG-SVYKAEWVGAPVAVKEF
|.   .|| |.|| .||.|.| |.||.|...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRM
Kinase MLKx_e-2.AA TKL 665-769 18 4.4e-12 39.82 In-house 1-152 (364) Show / Hide 
Range on Protein: 665-769
Range on HMM: 1-152/364
Sequence Identity: 18% (28 aa)

VGMSNHGTMFRGRWLD----------VPVMVKALGTGN-------------------------EAEKLLKELDKGHAELRNRPHPNVTQVIGYTRHGED-
.|    |. ..|.|             .| || . . |                         ||... ... .    .... |||. | .||   ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LFVVTEQVSGGH-FRVTKFPLVLTIEILLQVAQGVAYLHQHN
            |. |.| ..||  . .    . ... . |..|.|..|||..|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--WHQRCRWALDIARGMNYLHSMN
Kinase MLKx_e-2.AA TK 659-770 11 3.9e-08 22.58 In-house 1-255 (486) Show / Hide 
Range on Protein: 659-770
Range on HMM: 1-255/486
Sequence Identity: 11% (30 aa)

IVLLDLVGMSNHG---TMFRGRWLD---------------------------VPVMVKALGTGNEAEKLLKELD--------------KGHAELRN---R
|.|..  |  . |   . ..|.| .                           .|| || |  |.....  ....                 ... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPNVTQVIGYTRHGED------------LFVVTEQVSGG-----------HFRVTKFPLVLTIE-----------------------------------
 |||. . .|.  .||             . .|.| ...|             | ....   ...                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------ILLQVAQGVAYLHQHNC
                                      . .|.|.| .|||..||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNC
Kinase MLKx_e-2.AA UTK 659-770 20 2.7e-07 21.03 In-house 1-139 (296) Show / Hide 
Range on Protein: 659-770
Range on HMM: 1-139/296
Sequence Identity: 20% (28 aa)

IVLLDLVGMSNHGTMFRGRWLD----VPVMVKALGTGNEAEKLLKELDKG-----HAE---LRNRPH--PNVTQVIGYTRHGEDLFVVTEQVSGGHFRV-
. |... |  . |. ...|. .    ...|..|. . .. ..  .| . .     .|    .. ..|  ||| ...|.   .| . .|||  ..|. |  
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

------TKF--PLVLT----IEILLQVAQGVAYLHQHNC
      | .  |. ||    ..  ...| |..|||....
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF
Kinase MLKx_e-2.AA TK-Unique 659-770 18 6.2e-07 20.08 In-house 1-154 (294) Show / Hide 
Range on Protein: 659-770
Range on HMM: 1-154/294
Sequence Identity: 18% (29 aa)

IVLLDLVGMSNHGTMFRGRWL--------DVPVMVKALG---TGNEAEKLLKELDKGHAELRNRPHPNVTQVIGYTRHG-EDLFVVTEQVSGG-------
....|..|. . |. .||           .. | ||.|    |. .  ..|||. . . ||   .|||. | .|..    |. . . |....|       
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEI-QMMKELG--DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

-----HFRV-------------TKFPL--VLT----IEILLQVAQGVAYLHQ--HNC
     ....             ...|.   ..    . .. |.|.| .||..  ...
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI
Kinase MLKx_e-2.AA TKL-Unique 661-782 18 1.2e-05 16.08 In-house 1-148 (290) Show / Hide 
Range on Protein: 661-782
Range on HMM: 1-148/290
Sequence Identity: 18% (28 aa)

LLDLVGMSNHGTMFRGRWLDVPVMVKALGTGNEAEKLLKELDKGHAEL----RNRPHPNVTQVIGYTR----HGEDLFVVTEQVSGG------H------
 . ..| .  |. ..| |   || .| .    .... ...... . |.    . ..|||... .||.     .  ... |.| ..||      |      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---FRVTKFPLVLTIEILLQVAQGVAYLHQHN-----CELSDLNTLLVEF
    . .|... . . . ...|||  |||  .     . |  .|.|....
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN
Kinase MLKx_e-2.AA Pkinase 708-770 15 2.1e-05 20.22 Pfam 54-129 (293) Show / Hide 
Range on Protein: 708-770
Range on HMM: 54-129/293
Sequence Identity: 15% (12 aa)

LRNRPHPNVTQVIGYTRHGEDLFVVTEQVSGG----HFR-------VTKF--PLVLTIEILLQVAQGVAYLHQHNC
...  |||. . ... . . .. .|.| . ||               ..|  .    . ...|...|..|.|....
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGI
Kinase MLKx_e-2.AA STE 712-769 19 6e-05 13.56 In-house 87-172 (359) Show / Hide 
Range on Protein: 712-769
Range on HMM: 87-172/359
Sequence Identity: 19% (17 aa)

P-HPNVTQVIGYTRHG-------EDLFVVTEQVSGGHFR---V----------------TKFPLVLTIEILLQVAQG-VAYLHQHN
. |||. . .|.  ..       ..|... | ..|| ..                    ..||  . . |. |. .|  .|||.|.
HMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH
Kinase MLKx_e-2.AA Pkinase_Tyr 659-770 22 0.00103 13.2 Pfam 1-132 (270) Show / Hide 
Range on Protein: 659-770
Range on HMM: 1-132/270
Sequence Identity: 22% (30 aa)

IVLLDLVGMSNHGTMFRGRWL------DVPVMVKAL--GTGNEA---EKLLKELDKGHAELRNR-PHPNVTQVIGYTR-HGED--LFVVTEQVSGG----
|...   |  . |. ..|.|       ..|| || |  |.  |.   |....|.      ...   |||. . .|    .||   ...|.| . .|    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKI----MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

--HFR---VTKFPLVLTIEILLQVAQGVAYLHQHNC
  . .     ....   ... .|.|.| .||...||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNC
Kinase MLKx_e-2.AA LRRK 740-769 43 0.002814 7.43 In-house 155-184 (351) Show / Hide 
Range on Protein: 740-769
Range on HMM: 155-184/351
Sequence Identity: 43% (13 aa)

HFRVTKFPLVLTIEILLQVAQGVAYLHQHN
||  ....  |...| ||.| |..||| ||
HFMKAHISWMLKLKIALQIAKGMEYLHSHN
Kinase MLKx_e-2.AA MLK 659-739 23 0.004241 6.75 In-house 1-95 (291) Show / Hide 
Range on Protein: 659-739
Range on HMM: 1-95/291
Sequence Identity: 23% (23 aa)

IVLLDLVGMSNHGTMFRGRWLDVP-----VMVKALG--------TGNEAEKLLKELDKGHAELRNRPHPN----VTQVIGY-TRHGEDLFVVTEQVSGG
| ..  .| .  | ...|||         | ||.          |. |.... .|      .||   |||    . |. |  .... ....|.| ..||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMEC----RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGG
Kinase MLKx_e-2.AA MLK 756-768 53 0.013345 5.0 In-house 131-143 (291) Show / Hide 
Range on Protein: 756-768
Range on HMM: 131-143/291
Sequence Identity: 53% (7 aa)

LQVAQGVAYLHQH
||.|.|..|||..
LQCARGMHYLHSM
Kinase MLKx_e-2.AA Dicty4 746-770 26 0.228432 0.52 In-house 108-133 (277) Show / Hide 
Range on Protein: 746-770
Range on HMM: 108-133/277
Sequence Identity: 26% (7 aa)

FPLVLT-IEILLQVAQGVAYLHQHNC
.||..  . . . .|.|...||  |.
WPLIKRAMRMAFDAARGMNWLHCCNP
Kinase MLKx_e-2.AA LRRK 857-899 24 0.000736 9.52 In-house 299-351 (351) Show / Hide 
Range on Protein: 857-899
Range on HMM: 299-351/351
Sequence Identity: 24% (13 aa)

EEILLSGNLPQVSHD-CTG------IKAVIEKCLSSQP---PDFHQIVELLQS
|.. ..|  | .. . |..       .. |..| . .|   | | |||. | .
EDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_e-2.AA TKL 842-897 17 0.19489 0.95 In-house 275-364 (364) Show / Hide 
Range on Protein: 842-897
Range on HMM: 275-364/364
Sequence Identity: 17% (16 aa)

FGIACAEMITGQTIGEEILLS------------------GNLPQVS------------HDC-TGIKAVIEKCLSSQP---PDFHQIVELL
|||   |..|...  ...  .                  |. | .             .|| ...|  ...| .. |   | | .|.. |
FGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKx_e-2.AA MLK 888-897 60 0.287934 0.31 In-house 282-291 (291) Show / Hide 
Range on Protein: 888-897
Range on HMM: 282-291/291
Sequence Identity: 60% (6 aa)

PDFHQIVELL
|.| |||. |
PSFRQIVQHL