Gene MLKx_h (S.moellendorffii)

MLKx_h

Species: S.moellendorffii
Alias: MLKx_h
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_h.AA Protein None 1141 None Fasta, JSON
MLKx_h.NA RNA None 3426 None Fasta, JSON
MLKx_h.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of MLKx_h.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_h.AA TKL 204-455 23 7.9e-77 261.56 In-house 1-364 (364) Show / Hide 
Range on Protein: 204-455
Range on HMM: 1-364/364
Sequence Identity: 23% (88 aa)

IGAGAFGSVYKAEWLG----------APVAVKEFRSGDASF----------------------------DKEVNILKELISEPHPSVLQMIGYYQKDEK-
|| |.|| |||..| |           .|||| |.| . ..                            ..|.. .. ...  || ..|..|| .  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AYLVMELM-ERDLANVIRKTQGSLQLLTSIDIMLQIASGMSYLHQ--------KNVVHRDLKPSNILVKTPNH-------ACATCSNV
             ..|||..   .| ...        .   ....|.||.||.|||.        ....|||||..||||.  ..       . .   ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

RLTDFGVSKSNFISFAPD------------------LSYQRGTIQYMAPEMLRGQ----------------KYSREVDVYSFGITCFQILTGTLPFQDDG
 ..||| |.... |.                     .. |.||...||||.||||                .||  .|||||||  . |||. .|..|..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

KQLVA------DKLVETIEDGNRPDLP------------TGCPLELVALLNRCWNRNPKDRPTFEHISRML
   .       . ..  ...|.|| .|            . || ..  |. .||. .|..||.|. |   |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase MLKx_h.AA Pkinase 198-455 26 1.6e-72 252.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 198-455
Range on HMM: 1-293/293
Sequence Identity: 26% (82 aa)

LELKTLIGAGAFGSVYKAEWLGAP--VAVKEFRSGDASFDK--------EVNILKELISEPHPSVLQMIGYYQKDEKAYLVMELMER-----DLANVIR-
....  ||.|.||.|||. . | .  ||||...  ... .|        |. |.|.| .  || ......... . . |.|||..|      ||. .|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N--HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KTQGSL--QLLTSIDIMLQIASGMSYLHQKNVVHRDLKPSNILVKTPNHACATCSNVRLTDFGVSK--SNFISFAPDLSYQRGTIQYMAPEMLR-GQKYS
. .|..  .  . ...|.||..|. |.|.....||||||.|||..  .| .|    |...|||..|  .  .   . ..   ||. ||||| .| ||.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

REVDVYSFGITCFQILTGTLPFQDD----GKQLVADKLVETIEDGNRPDLPTGCP-------------------LELVALLNRCWNRNPKDRPTFEHISR
..||..|.|..... |.| .||...    .      ..... .  .. | |. |.                    |.  ....|....||.|||.|.|  
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

M--L
   .
HPWF
S_TKc MLKx_h.AA S_TKc 198-457 25 2.3e-72 247.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 198-457
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

LELKTLIGAGAFGSVYKAEWLG--APVAVKEFRSGDASFDKEVNILKELISEPHPSVLQMIGYYQKDEKAYLVMELMER---DLANVIRKTQGS-----L
 |.  .|| ||||.|||. . .    ||.|. .    .. .|..|||.     || . ......|  .. |.|||...    ||  .|.| ..      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QLLTSIDIMLQIASGMSYLHQKNVVHRDLKPSNILVKTPNHACATCSNVRLTDFGVSKSNFISFAPDLSYQRGTIQYMAPEMLRGQKYSR-EVDVYSFGI
   .   .| ||.... |.|.....||||||.|||. .         .. ..|||...          . . ||  |||||.|   .|.. ..|..|.|.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

TCFQILTGTLPFQDDGKQLVADKLVETIEDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISR-------MLWS
. .  |.|  ||.    |.. .|..               . |.  ....|....|..|||   . .       . | 
ILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKx_h.AA MLK 198-455 27 8.2e-61 208.34 In-house 1-291 (291) Show / Hide 
Range on Protein: 198-455
Range on HMM: 1-291/291
Sequence Identity: 27% (82 aa)

LELKTLIGAGAFGSVYKAEWLGAP-----VAVKEFR--------SG--DASFDKEVNILKELISEP-HPSVLQMIGYYQKDEK-AYLVMELMER-DLANV
..... ||.|.||.|.|..| .       ||||..|        ..  .  |..|...|. |  .  ||.. |  |  .....  ..||| .|   |.||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

I--RKTQGS-----------LQLLTSIDIMLQIASGMSYLHQKN---VVHRDLKPSNILVKTPNHACATCSNVRLTDFGVSKSNFISFAPD-LSYQRGTI
.  ......             .   ....||.|.||.|||..    ..|||||..|||.    |      ... .|||.|.. . .   .    ..|| 
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRD-WHQMC-TNMMSNAGTY

QYMAPEML---RGQKYSREVDVYSFGITCFQILTGTLPFQDDGKQLVADKLVETIEDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRML
 .||||..   |..|||. .||.|.|.   ..||. .|.... ... .  . . .. |.|| .| .||  .  |...||| .|..||.| .|   |
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAI--AWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKx_h.AA TK 198-455 19 9e-58 191.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 198-455
Range on HMM: 1-486/486
Sequence Identity: 19% (93 aa)

LELKTLIGAGAFG---SVYKAEWLGA---------------------------PVAVKEFRSGDASFDK------------------EVNILKELIS--E
..|   .|.|.||    |||.|| |                            |||||  ..|||. ..                  |....| . .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPSVLQMIGYYQKD------------EKAYLVMELME-RD----LANVIRKTQG---------------------------------------------
 || .....|.  ..            |  ..|||.|.  |    | .  ||  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------SLQLLTSID-------------------IMLQIASGMSYLHQK------NVVHRDLKPSNILVKTPNHA----CATCSNVRLTDFGVSKS
          .|..   ..                   ...|||.||.|||.|      |.|||||   |.||   |.       ..  ....||| |. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

NF----ISFAPDLSYQRGT-----------------------------IQYMAPEMLRGQK---------YSREVDVYSFGITCFQILT-G-TLPFQDDG
.         .|  | | .                             | .|||| |....         .. . ||.|||.... |.| | . .  .  
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

KQLVAD-----KLVETIEDG--------------NRPDLPTGCP--------------LELVALLNRCWNRNPKDRPTFEHISRML
 | |.       ..| ...|              .|.  | .||               |.  |. .||...|.|||||. . ..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_h.AA TKL-Unique 200-455 30 1.8e-55 190.59 In-house 1-290 (290) Show / Hide 
Range on Protein: 200-455
Range on HMM: 1-290/290
Sequence Identity: 30% (90 aa)

LKTLIGAGAFGSVYKAEWLGAPVAVKEFRS---GDAS----FDKEVNILKELISEPHPSVLQMIGYYQ----KDEKAYLVMELMERD-LANVIR------
   .||.|..|.|||..| | |||.| |        .    | .|||..| |  ..|| ... .||      .  . ..||| ...  | .|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKL--HYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KTQGSLQLLTSIDIMLQIASGMSYLHQKN--VVHRDLKPSNILVKTPNHACATCSNVRLTDFGVSKSNFISFAPDLS--------YQRGTIQYMAPE
   .    | ..  ... ..||.|| ||| ..  . |||||.||.||   |.      |... ||| ||.|  . .  ..           |....||||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVD--NNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

MLRG--QKYSREVDVYSFGITCFQILTGTL------PFQDDGKQLVADKLVETIEDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRML
.||.   .||. .|||||||    |.|...      |.|.   . .. .. .. |.. || .|. || |.  |...||...| .||.|. |   |
VLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_h.AA TyrKc 198-455 28 1.4e-54 188.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 198-455
Range on HMM: 1-280/280
Sequence Identity: 28% (84 aa)

LELKTLIGAGAFGSVYKAEWLGAPVAVKEFR--SGDASFDKEVNILKEL-ISEPHPSVLQMIGYYQKD-------EKAYLVMELMER-DLANVIRKTQGS
..|.  .| |||| |||..|   .||||  .  .  . | .| .|...|     || .....|.  ..       |  ..|||.|.  || . .||... 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGG--HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LQLLTSIDIMLQIASGMSYLHQKNVVHRDLKPSNILVKTPNHACATCSNVRLTDFGVSKSNFIS----FAPDLSY------QR--GTIQYMAPEMLRGQK
|.. . .....|||.||.|||.||..||||   |.||. ..        |. .||| |.          . |          .    |  |||| ..  |
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YSREVDVYSFGITCFQILTGTLPFQDDGKQ--LVADKLVETIEDGNRPDLPTG--------CPLELVALLNRCWNRNPKDRPTFEHISRML
.. . ||.|||.... |.|   .   .  |  . .. ..| ...|.|.. |          || |.  .  .||...|.|||||. | . .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_h.AA STE 198-457 21 1.7e-54 187.36 In-house 1-359 (359) Show / Hide 
Range on Protein: 198-457
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

LELKTLIGAGAFGSVYKAEWL-----------------GAPVAVKEFRSGDASF---------------DKEVNILKEL--ISEP---HPSVLQMIGYYQ
.|.   || ||||.||||                    |  .|.|. .  . .                ... .||||.   ..    || . . .|.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------EKAYLVMELME-RDLANVIR---KTQGSLQ----------LLTSIDIMLQIASG-MSYLHQKNVVHRDLKPSNILVKTPNHACATCSNVRL
|.       .. ...||.|.   |  .|.   .....|.              . |  ||  | ..|||.....|||.||.|||.            | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------------VKL

TDFGVSKSNFISFA---------------PDLSYQRGTIQYMAPEMLRG------QKYSREVDVYSFGITCFQILTGTLPFQD-DGK---QLVADK----
.||||...   | |                      ||  .||||....      ..|.. .|..|.|.|.   .||  |. |        . ...    
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

----LVETIEDGNRPDLPT-------------------GCPLELVALLNRCWNRNPKDRPTFEHISR--MLWS
    ..  | .|. | ||.                    .  |.   .|.| ...|..||| .   .    . 
QQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MLKx_h.AA Dicty4 198-457 29 1.4e-53 177.15 In-house 1-277 (277) Show / Hide 
Range on Protein: 198-457
Range on HMM: 1-277/277
Sequence Identity: 29% (84 aa)

LELKTLIGAGAFGSVYKAEWLGAPVAVKEF--RSGD------ASFDKEVNILKELISEPHPSVLQMIGYYQ----KDEKAYLVMELM-ERDLANVIRK--
.    .|| |.||.|||. | |  |||| .  .  .       .| |||.|.. .    || ...  |.      . .|   |.|.|   .|......  
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIR---HPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

----TQGSLQ--LLTS-IDIMLQIASGMSYLHQKN--VVHRDLKPSNILVKTPNHACATCSNVRLTDFGVSK--SNFISFAPDLSYQRGTIQYMAPEMLR
       .|.  | .. . ... .| || .||  |  ..|||||..|.||   .       .|  .||| |.     ...   .. . ||  .||||...
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNW-------RVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMM

GQKYSREVDVYSFGITCFQILTGTLPFQDDGKQLVADKLVETIED-GNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRM--LWS
.| |   .|||||||  ..|||.  |.|  .. ..  ..|. . . ..|| .|  ||  . .|...||. .|. ||.|| |.    | .
HQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYM--QFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKx_h.AA Ciliate-E2 198-457 19 7e-53 179.85 In-house 1-365 (365) Show / Hide 
Range on Protein: 198-457
Range on HMM: 1-365/365
Sequence Identity: 19% (78 aa)

LELKTLIGAGAFGSVYKAEWLGAP-------------------------VAVKEFR-SGDASFDKEVNILKELISEP--------------HPSVLQMIG
 ..  .|| |.||||||..    .                         .|.| .. ..  .. .| .|..|. .                || ...|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

YYQ--KDEKAYLVMELMER-DLANVIR--KTQ--------GSLQLLTSIDIMLQIAS---------------GMSYLHQKN-VVHRDLKPSNILVKTPNH
..|  .|.. |||||. .  ||   |.  |..        ... .   ..|| ||..               .. |||.|| ..|||.||.|||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

ACATCSNVRLTDFGVSKSNFIS-----------FAPDLSY--------------------QRGTIQYMAPEMLRGQK---------YSREVDVYSFGITC
       . ..||| || . ..             .. ..                    . ||  |||||.|.|.|         |. ..|..|.|.. 
-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

FQILTGTLPFQDDGKQLVADKLVETIEDGNRPDLP------------------TGCPLELVALLNR----CWNRNPKDRPT-FEHISRMLWS
.. |.| .||             . .   .  |.|                    ...|   |...    . ...|. |.| .| |    | 
YEMLFGKPPF-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MLKx_h.AA CAMK 203-457 16 1.1e-48 154.61 In-house 1-425 (425) Show / Hide 
Range on Protein: 203-457
Range on HMM: 1-425/425
Sequence Identity: 16% (72 aa)

LIGAGAFGSVYKAEWLGAP--------------VAVKE--------------------------------FRSGDASFDKEVNILKELISEP----HPSV
 .| |.|| |....    .              ||.|                                   .  ... .|..|.| | .      || .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LQMIGYYQK-------------------DEKAYLVM---ELMERD------LANVIRKTQ-------------GSLQLLTSIDIMLQIASGMSYLHQKNV
.... .|.                    |.. |.||   |...        .  ......             | ..      .. ||.|.. |.|..|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNILVKTPNH-ACATC----------SNVRLTDFGVSKSNFISF----------------------APDLSYQRGTIQYMA-PEMLRG-----
||||||| |||. . |   .              |. ..||| ..  . .                        . .. . ||  ||| ||.|.|     
VHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QKYSREVDVYSFGITCFQILTGTLPFQDD-GKQLVA--------DKLVETIEDGNRP-DLPT----------------------GCPLELV
         . |....|. | |. ..  |.|..||..| ... .          .| | |  |.   . |                        .  |  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

ALLNRCWNRNPKDRPTFEHISRMLWS
 |.... ...|..|.| | . .  | 
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MLKx_h.AA LRRK 267-457 29 7.3e-44 152.05 In-house 132-351 (351) Show / Hide 
Range on Protein: 267-457
Range on HMM: 132-351/351
Sequence Identity: 29% (66 aa)

LVMELMER-DLANVIRKTQGS--------LQLLTSIDIMLQIASGMSYLHQKN--VVHRDLKPSNILV-KTPNH----ACATCSNVRLTDFGVSKSNFIS
.|||..   ||  ...... .        .   . . |.||||.|| ||| .|  ..|||||. |||. . |..    . ..  .. . ||| |   | .
MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQC

FAPD-LSYQRGTIQYMAPEMLRGQ---KYSREVDVYSFGITCFQILTGT-LPFQD-DGKQLV--ADKLVETIEDGNRPDLPTG-CPL-----ELVALLNR
| .  ..   |....|||| .|.     |. .||.||||.  . .||.. .||.. |..       .. . | .| || .|   ||      .. .|.. 
FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQH

CWNRNPKDRPTFEHISRMLWS
||. .||.||.|. |   | .
CWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_h.AA UTK 198-455 27 1e-42 143.95 In-house 1-296 (296) Show / Hide 
Range on Protein: 198-455
Range on HMM: 1-296/296
Sequence Identity: 27% (84 aa)

LELKTLIGAGAFGSVYKAEWLG-------APVAVKEFRSGDA---------SFDKEVN---ILKELISEPHPSVLQMIGYYQKDEKAYLVMELME-RDLA
..|  ..|.|||| |.||..         . ||||. .....          | .| .   ..| .    ||.||...|.  ..|  ..|.|.||  ||.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH--WHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

NVIR---KTQG----SLQLLTSIDIMLQIASGMSYLHQKNVVHRDLKPSNILVKTPN---HACATCSNVRLTDFG---VSKSNFISF--------APDLS
.. |   .|..    .| | . .. ...||.||.|||....|||||   |.||   .   | |   . ... |||    |.   ...          ...
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWH-C--MMVCKIADFGRGGMSR--RVNTFHFSNRYWESYYY

YQRG----TIQYMAPEMLRGQ-KYSREVDVYSFGITCFQILT-GTLPFQDDGKQLVADKLVETIEDG--NRPDLPTGCPLELVALLNRCWNRNPKDRPTF
....    .|. |||| |  . ....  ||.|||..|. |.| | ||. .    . ...... ...|   |.  | .||...  |..|||. .| .||.|
MAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPG----MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDF

EHISRML
| .   .
EDLVQQM
Kinase MLKx_h.AA Pkinase_Tyr 198-316 32 1.8e-29 100.41 Pfam 1-137 (270) Show / Hide 
Range on Protein: 198-316
Range on HMM: 1-137/270
Sequence Identity: 32% (46 aa)

LELKTLIGAGAFGSVYKAEWL------GAPVAVKEF--RSGDAS-----FDKEVNILKEL-ISEPHPSVLQMIGYYQ-KDEK--AYLVMELMER-DLANV
...   .|.||||.|||..|       . |||||     . .       | .|..|.|.|     || .....|    ..|    |.|||.|.  || . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGH---HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IRKT---QGSLQLLTSIDIMLQIASGMSYLHQKNVVHRDL
 ||    ...| . . ... .|||.||.||..|| .||||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase MLKx_h.AA Pkinase_Tyr 365-455 37 9.2e-23 77.71 Pfam 181-270 (270) Show / Hide 
Range on Protein: 365-455
Range on HMM: 181-270/270
Sequence Identity: 37% (35 aa)

MAPEMLRGQKYSREVDVYSFGITCFQILT-GTLP-FQDDGKQLVADKLVETI-EDGNRPDLPTGCPLELVALLNRCWNRNPKDRPTFEHISRML
|||| ..  |.. . ||.|||.... |.| |  | ...    .    ..| | |||.| . | .|| |.  |. .||. .|.|||||. | ..|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG----MSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_h.AA LRRK 198-227 45 8.4e-09 27.26 In-house 1-31 (351) Show / Hide 
Range on Protein: 198-227
Range on HMM: 1-31/351
Sequence Identity: 45% (14 aa)

LELKTLIGAGAFG-SVYKAEWLGAPVAVKEF
|.   .|| |.|| .||.|.| |.||.|...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRM
Kinase MLKx_h.AA TKL 664-768 18 2.8e-12 40.52 In-house 1-152 (364) Show / Hide 
Range on Protein: 664-768
Range on HMM: 1-152/364
Sequence Identity: 18% (28 aa)

IGMSNHGTIFEARWLD----------VPVMVKALGTGN----------------------EAEKLLKELDKRHAEL-INRP--HPNVVQVIGYTRHGEN-
||    |... ..|             .| || . . |                      ..... .. ...  |. . .   |||.|| .||   ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LFVVSERVSGGH-FRVTKFPLVLTIEILLQVAQGVAYLHEHN
            |. | | ..||  . .    . ... . |..|.|..||| .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--WHQRCRWALDIARGMNYLHSMN
Kinase MLKx_h.AA TK 658-769 11 7.4e-11 31.85 In-house 1-255 (486) Show / Hide 
Range on Protein: 658-769
Range on HMM: 1-255/486
Sequence Identity: 11% (30 aa)

IVLLNFIGMSNHG---TIFEARWLD---------------------------VPVMVKALGTGNEAEKLLKELD--------------KRHAELIN---R
|.|.. .|  . |   ......| .                           .|| || |  |.....  ....               . ... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHPNVVQVIGYTRHGEN------------LFVVSERVSGG-----------HFRVTKFPLVLTIE-----------------------------------
 |||.|. .|.  .||.            . .| | ...|             | ....   ...                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------ILLQVAQGVAYLHEHNC
                                      . .|.|.| .|||..||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNC
Kinase MLKx_h.AA UTK 658-769 19 3.7e-09 27.5 In-house 1-139 (296) Show / Hide 
Range on Protein: 658-769
Range on HMM: 1-139/296
Sequence Identity: 19% (27 aa)

IVLLNFIGMSNHGTIFEARWLD----VPVMVKALGTGNEAEKLLKELDKR-------HAE---LINRPH--PNVVQVIGYTRHGENLFVVSERVSGGHFR
. |.. .|  . |....||. .    ...|..|. . .  ..  .. ...       .|    .  ..|  |||....|.   .| . .|.|  ..|. |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

V-------TKF--PLVLT----IEILLQVAQGVAYLHEHNC
        | .  |. ||    ..  ...| |..|||....
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF
Kinase MLKx_h.AA Pkinase 712-769 18 2e-06 24.11 Pfam 59-129 (293) Show / Hide 
Range on Protein: 712-769
Range on HMM: 59-129/293
Sequence Identity: 18% (13 aa)

HPNVVQVIGYTRHGENLFVVSERVSGG----HFR-------VTKF--PLVLTIEILLQVAQGVAYLHEHNC
|||.|. ... . . .. .| | . ||               ..|  .    . ...|...|..|.|....
HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGI
Kinase MLKx_h.AA TKL-Unique 660-765 20 5e-06 17.3 In-house 1-127 (290) Show / Hide 
Range on Protein: 660-765
Range on HMM: 1-127/290
Sequence Identity: 20% (27 aa)

LLNFIGMSNHGTIFEARWLDVPVMVKALGTGNEAEKLLKELD--KRHAELINR--PHPNVVQVIGYTR----HGENLFVVSERVSGG------H------
 .| || .  |... . |   || .| .    .... .....  ...  ....  .|||.|. .||.     .  |.. |.| ..||      |      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---FRVTKFPLVLTIEILLQVAQGVAYLH
    . .|... . . . ...|||  |||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLH
Kinase MLKx_h.AA CAMK 712-768 14 9e-06 13.83 In-house 97-199 (425) Show / Hide 
Range on Protein: 712-768
Range on HMM: 97-199/425
Sequence Identity: 14% (15 aa)

HPNVVQVIGYTRHGEN-------------------LFVVS---ERVSGG------HFRVTK------------------FPLVLTIEILLQVAQGVAYLH
|||... . .   ...                   .. |    | .|||        ....                  |.   .  .  |....|.|.|
HPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH

EHN
.||
SHN
Kinase MLKx_h.AA Pkinase_Tyr 658-769 22 1.9e-05 19.1 Pfam 1-132 (270) Show / Hide 
Range on Protein: 658-769
Range on HMM: 1-132/270
Sequence Identity: 22% (30 aa)

IVLLNFIGMSNHGTIFEARWL------DVPVMVKAL--GTGNEA---EKLLKELDKRHAELINR-PHPNVVQVIGYTR-HGEN--LFVVSERVSGG----
|...  .|  . |......|       ..|| || |  |.  |.   |....|.      . .   |||.|. .|    .||   ...| | . .|    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKI----MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

--HFR---VTKFPLVLTIEILLQVAQGVAYLHEHNC
  . .     ....   ... .|.|.| .||...||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNC
Kinase MLKx_h.AA STE 711-768 20 0.000134 12.3 In-house 87-172 (359) Show / Hide 
Range on Protein: 711-768
Range on HMM: 87-172/359
Sequence Identity: 20% (18 aa)

P-HPNVVQVIGYTRHG-------ENLFVVSERVSGGHFR---V----------------TKFPLVLTIEILLQVAQG-VAYLHEHN
. |||.|. .|.  ..       ..|... | ..|| ..                    ..||  . . |. |. .|  .|||.|.
HMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH
Kinase MLKx_h.AA LRRK 739-768 43 0.002778 7.45 In-house 155-184 (351) Show / Hide 
Range on Protein: 739-768
Range on HMM: 155-184/351
Sequence Identity: 43% (13 aa)

HFRVTKFPLVLTIEILLQVAQGVAYLHEHN
||  ....  |...| ||.| |..||| ||
HFMKAHISWMLKLKIALQIAKGMEYLHSHN
Kinase MLKx_h.AA Ciliate-E2 712-769 17 0.008393 5.43 In-house 91-182 (365) Show / Hide 
Range on Protein: 712-769
Range on HMM: 91-182/365
Sequence Identity: 17% (16 aa)

HPNVVQVIGYTR--HGENLFVVSERVSGG----------HFRVTKFP------LVLTIEILLQVAQ---------------GVAYLHEHN-C
|||... . .      .|.. | | ..||          ..|  ...      .   ..|  |..|               .. |||. | .
HPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNI
Kinase MLKx_h.AA MLK 755-767 53 0.008718 5.65 In-house 131-143 (291) Show / Hide 
Range on Protein: 755-767
Range on HMM: 131-143/291
Sequence Identity: 53% (7 aa)

LQVAQGVAYLHEH
||.|.|..|||..
LQCARGMHYLHSM
Kinase MLKx_h.AA MLK 658-738 22 0.017004 4.63 In-house 1-95 (291) Show / Hide 
Range on Protein: 658-738
Range on HMM: 1-95/291
Sequence Identity: 22% (22 aa)

IVLLNFIGMSNHGTIFEARWLDVP-----VMVKALG--------TGNEAEKLLKELDKRHAELINRPH--PNVVQVIGY-TRHGENLFVVSERVSGG
| .. .|| .  |  . .||         | ||.          |. |.... .|   ||.  ...|   |...|. |  .... ....|.| ..||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMEC--RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGG
Kinase MLKx_h.AA Dicty4 745-769 26 0.09366 1.83 In-house 108-133 (277) Show / Hide 
Range on Protein: 745-769
Range on HMM: 108-133/277
Sequence Identity: 26% (7 aa)

FPLVLT-IEILLQVAQGVAYLHEHNC
.||..  . . . .|.|...||. |.
WPLIKRAMRMAFDAARGMNWLHCCNP
Kinase MLKx_h.AA LRRK 856-898 26 0.000144 12.06 In-house 299-351 (351) Show / Hide 
Range on Protein: 856-898
Range on HMM: 299-351/351
Sequence Identity: 26% (14 aa)

EEILLSGKLPQLPHD-CTG------IKAVIEKCLSSQP---PGFHQIVELLQS
|.. ..|  | .| . |..       .. |..| . .|   | | |||. | .
EDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_h.AA TKL 835-896 20 0.009864 5.68 In-house 269-364 (364) Show / Hide 
Range on Protein: 835-896
Range on HMM: 269-364/364
Sequence Identity: 20% (20 aa)

KIDAYKFGIACVEMITGQTIGEEILLS------------------GKLPQLP------------HDC-TGIKAVIEKCLSSQP---PGFHQIVELL
|.| | |||   |..|...  ...  .                  |. | .|            .|| ...|  ...| .. |   | | .|.. |
KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL