Gene MLKx_g-2 (S.moellendorffii)

MLKx_g-2

Species: S.moellendorffii
Alias: MLKx_g-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_g-2.AA Protein None 697 None Fasta, JSON
MLKx_g-2.NA RNA None 2094 None Fasta, JSON
MLKx_g-2.kin_dom Protein Kinase Domain None 271 None Fasta, JSON

Protein domain

Protein domains of MLKx_g-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKx_g-2.AA TKL 209-475 24 1.7e-68 233.86 In-house 1-364 (364) Show / Hide 
Range on Protein: 209-475
Range on HMM: 1-364/364
Sequence Identity: 24% (93 aa)

LGQGSFGLVFQTTWAGHT----------VAVKKFSK---ELWSQ------------DPWELVMVFCSLVSFQ--GEIMVKLRPCHPSVLQILG-------
.|.|.|| |.. .| |..          ||||||..    ...             |.  | . . |   |.   |||...| .|| ..|..|       
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDM-QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

--WSEK----DNKAYLVMELM-QGS-LARLIPSLVTAPIILIVEIMLQIAQGMDFVHK--------KKIIHRDLKPGNVLVNFDGK------FEDGSAHN
  ....    ... ..|||..  || | .|.       . ... ..|.||.||.. |         ..|||||||. |.||. ...      .    . .
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY--NPNAD

IVAKVADFGLSKMNFSSNH-------------------YHSHLKGTVLYMAPEMLEGD-----WE------MKSQYDLSVDVYSYGMMFAEILTGTPPY-
...|..|||||.... |..                    ...  ||  .||||.|.|.     .       ....|. ..||||.|... ||||. .|| 
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-PLGLTKKAL-------LDEIRRGLRPRLP------------QRCPQALKDTIAYCWDSQPRRRPTFEHICTRL
 .   . ..           . .|||| .|              ||. .|. .  |||. |. ||.|. |  ||
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
S_TKc MLKx_g-2.AA S_TKc 203-477 22 3.1e-53 184.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 203-477
Range on HMM: 1-231/231
Sequence Identity: 22% (67 aa)

LDDTKPLGQGSFGLVFQTTWAG--HTVAVKKFSKELWSQDPWELVMVFCSLVSFQGEIMVKLRPCHPSVLQILGWSEKDNKAYLVMELMQG---SLARLI
 .  ...|.|.|| |.. .. .  . ||.|. .                   ... || .  .  || . ..... .  .. |.|||.. |   .| ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

PSLVT------APIILIVEIMLQIAQGMDFVHKKKIIHRDLKPGNVLVNFDGKFEDGSAHNIVAKVADFGLSKMNFSSNHYHSHLKGTVLYMAPEMLEGD
 .  .       |   .  .| ||...... |...|||||||| |.|..             . |..||||..         ... ||  |||||.|   
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---

WEMKSQYDL-SVDVYSYGMMFAEILTGTPPYPLGLTKKALLDEIRRGLRPRLPQRCPQALKDTIAYCWDSQPRRRPTFEHICT-------RLWR
     .|.  ..|..| | ...| |.| ||.|   . ..... |.           .. .|| |  |..  |..|||   . .         | 
-----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase MLKx_g-2.AA Pkinase 203-475 26 3.6e-53 187.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 203-475
Range on HMM: 1-293/293
Sequence Identity: 26% (84 aa)

LDDTKPLGQGSFGLVFQTTWAGHT--VAVKKFSKELWSQDPWELVMVFCSLVSFQGEIMVKLRPCHPSVLQILGWSEKDNKAYLVMELMQG-----SLAR
.   ...|.|||| |.. .. |    ||||...|.  ....|...  .        || . .| .|| ......| | ... |.|||...|     .|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

LIP--SLVTA--PIILIVEIMLQIAQGMDFVHKKKIIHRDLKPGNVLVNFDGKFEDGSAHNIVAKVADFGLSKMN-FSSNHYHSHLKGTVLYMAPEMLEG
.|   .  .   .   .  .|.||..|... |...|||||||| |.|.. .|  ..        |..||||.|     .|.  ... ||  ||||| .  
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-

DWEMKSQYDLSVDVYSYGMMFAEILTGTPPYPLGL----TKKALLDEIRRGLRPRLPQRCP-----------------------QALKDTIAYCWDSQPR
     . |. .||..|.| ...| |.| ||.| |     .    .  |.| ..|.|.  .|                       ...|| | .|..  | 
---GGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

RRPTFEHICTR--L
.|||.|.|.    .
KRPTAEQILQHPWF
Kinase MLKx_g-2.AA TKL-Unique 205-475 28 2.5e-50 173.51 In-house 1-290 (290) Show / Hide 
Range on Protein: 205-475
Range on HMM: 1-290/290
Sequence Identity: 28% (87 aa)

DTKPLGQGSFGLVFQTTWAGHTVAVKKFSK-ELWSQDPWELVMVFCSLVSFQGEI--MVKLRPCHPSVLQILGWSE----KDNKAYLVMELMQ-GSLARL
. . .|.|..| |....|.|  ||.|.|.. |. | .         ..  |  |.  | ||.. || .... |..     . .. ..||| .. |||  .
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNE---------MMQEFENEVNWMKKLHY-HPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDV

IP----------SLVTAPIILIVEIMLQIAQGMDFVHKKK--IIHRDLKPGNVLVNFDGKFEDGSAHNIVAKVADFGLSKMNFSSNHYHSHLK-------
.           .  . .  ..| . ..|||||.. | ..  |||||||. |.||.     ..     . .|..|||||| | ..|   .  .       
LHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVD-----NNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQT

--GTVLYMAPEMLEGDWEMKSQYDLSVDVYSYGMMFAEILTGTP------PYPLGLTKK---ALLDEIRRGLRPRLPQRCPQALKDTIAYCWDSQPRRRP
  |. ..||||.|..     .||. ..||||.|..  ||.|..       ||  |.. .   .....  ...|| .|..||. ..| |  ||...|  ||
RCGSFRWMAPEVLRMNF---CQYSEKSDVYSFGIVLWEIATRKITKTYKKPY-QGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRP

TFEHICTRL
.|. | .||
SFDEIIHRL
Kinase MLKx_g-2.AA MLK 203-475 25 7.8e-48 164.02 In-house 1-291 (291) Show / Hide 
Range on Protein: 203-475
Range on HMM: 1-291/291
Sequence Identity: 25% (78 aa)

LDDTKPLGQGSFGLVFQTTWAGHT-----VAVKKFS--KELWSQDP---WELVMVFCSLVSFQGEIMVKLRPCHPSVLQILGWSEKDNK-AYLVMELMQ-
..  . .| |||| |. ..| . .     ||||..   ..  ..|     . .  .| ...    |. ..   ||.. |..| . ....  ..||| .. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLR----ILSHPNN-HPCIIQFYGVCLQPPCHFCIVMEYCEG

GSLARLIPSL--------------VTAPIILIVEIMLQIAQGMDFVHKKK---IIHRDLKPGNVLVNFDGKFEDGSAHNIVAKVADFGLSKMNFSSNHY-
|||.... .               .. .  ... ..||.|.||.. |...   |||||||. |.|.  |   .    |. ..|..|||.|.. .....  
GSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI--DE-ICH-DMHHGTLKICDFGTSRD-WHQMCTN

HSHLKGTVLYMAPEMLEGDWEMKSQYDLSVDVYSYGMMFAEILTGTPPYP-LGLTKKALLDEIRRGLRPRLPQRCPQALKDTIAYCWDSQPRRRPTFEHI
.   .||. .||||...      ..|. ..||.|.|... |.||.  ||        ..   .  |||| .|. ||  .|  .  ||.. |..||.| .|
MMSNAGTYAWMAPEVIQQ--FRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQI

CTRL
 . |
VQHL
Kinase MLKx_g-2.AA Dicty4 257-477 31 2.2e-45 149.4 In-house 50-277 (277) Show / Hide 
Range on Protein: 257-477
Range on HMM: 50-277/277
Sequence Identity: 31% (78 aa)

EIMVKLRPCHPSVLQILGWSE----KDNKAYLVMELM-QGSLARLIPS-------LVTAPIILIVE---IMLQIAQGMDFVHK--KKIIHRDLKPGNVLV
.|| |.|  || ... .| .     .  |   |.|.| .|.|..|. .        .. . .||     ... .|.||   |     |||||||. | ||
HIMCKIR--HPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV

NFDGKFEDGSAHNIVAKVADFGLSK-MNFSSNHYH--SHLKGTVLYMAPEMLEGDWEMKSQYDLSVDVYSYGMMFAEILTGTPPYP-LGLTKKALLDEIR
            | ..||.|||||. |   ..|    .  .||...||||..     |.  |. ..||||.|..  ||||.  ||. ..     . . . 
D----------KNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM-----MHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVC

R-GLRPRLPQRCPQALKDTIAYCWDSQPRRRPTFEHICTR--LWR
. .||| .|. ||  .|. |. |||  | .||.|| |  |  |  
NKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKx_g-2.AA STE 203-469 19 2.4e-44 153.64 In-house 1-349 (359) Show / Hide 
Range on Protein: 203-469
Range on HMM: 1-349/359
Sequence Identity: 19% (71 aa)

LDDTKPLGQGSFGLVFQTTWA-----------------GHTVAVKKFSKELWSQDPWE-------LVMVFCSLVSFQGEIMVKLRPC--HPSVLQILGWS
... . .|.|.|| |..                     |  .|.|. ..|  ..   |         .    . ... || .  .    || . . .|  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EKD-------NKAYLVMELMQ-GSLARLIPSLVTAPI--------------ILIVEIMLQIAQG-MDFVHKKKIIHRDLKPGNVLVNFDGKFEDGSAHNI
.|.       .. ...||.|  |||  .| .    .                .|  |  || .| ... |...|||||.||.|.|.              
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------------

VAKVADFGLSKMNFS---------------SNHYHS-HLKGTVLYMAPEMLEGDWEM-KSQYDLSVDVYSYGMMFAEILTGTPPYPLGLTKKALLDEIRR
 .| .|||...   .               ..  .. .. ||  .||||..... .  ...|| ..|..| | .  | .|| ||.  .   .|..  .. 
-VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFN

--------------GLRPRLPQ-------------------RCPQALKDTIAYCWDSQPRRRPTFE
              |  |.||.                   .. . .|| |. | .  |. ||| .
YHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS
Kinase MLKx_g-2.AA LRRK 284-477 30 2.7e-40 140.21 In-house 132-351 (351) Show / Hide 
Range on Protein: 284-477
Range on HMM: 132-351/351
Sequence Identity: 30% (69 aa)

LVMELMQ-GSLARLIPSLVTAP-----II----LIVEIMLQIAQGMDFVHKKK--IIHRDLKPGNVLV-NFD-GKFEDGSAHNIVAKVADFGLSKMNFSS
.|||... |.| ... .    .     .     |. .|.|||| ||.. |...  |||||||. |.|.  .. .  ..  . ...||.||||.| |  ..
MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QC

NHY--HSHLKGTVLYMAPEMLEGDWEM-KSQYDLSVDVYSYGMMFAEILTGT-PPYPLGLT-------KKALLDEIRRGLRPRLPQR-CPQ-----ALKD
 |.   . . |. ..|||| . .   . ...|.  ||.||.||   |.||.. .|.  ...          . |.| .|||| .||  ||.      ..|
FHMGVAKGCVGNPGWMAPEIMRY---NGEEEYTEKVDCYSFGMILWELLTRQHHPF-DEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQD

TIAYCWDSQPRRRPTFEHICTRLWR
 |  ||. .|..||.|. |  ||  
LIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_g-2.AA RIPK 209-475 25 7.5e-39 130.01 In-house 1-290 (290) Show / Hide 
Range on Protein: 209-475
Range on HMM: 1-290/290
Sequence Identity: 25% (79 aa)

LGQGSFGLVFQTTWAGH-TVAVKKFSKELWSQDP--WELVMVFCSLVSFQGEIMVKLRPCHPSVLQILGWSEKDNK------AYLVMELM-QGSLARLIP
.| |.|| ||. . . . ....|| .. .  . .   . .|     .. ....| |||  |  ...|.|  .. ..        .||| |  |||. .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMY----QKEEAKHMHKLRCEH--IVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLH

SLVT-----APIILIVEIMLQIAQGMDFVHKKK--IIHRDLKPGNVLVNFDGKFEDGSAHNIVAKVADFGLSKMNFSS--NH----------YHSHLK-G
.         |  |   .  .|. || . | ..  ||||||||.|.||       |.  |   .|.|||||.. .  |  .           . | .. |
TKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILV-------DNNFH---VKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWG

TVLYMAPEMLEGDWEMKSQ---YDLSVDVYSYGMMFAEILTGTPPYPLGLTKKALLDEIRRGLRPRL---PQRCPQA-----LKDTIAYCWDSQPRRRPT
|  ||.||... |   |.     .   ||||...   |.||.  ||    .   ..  . .| || |   |. .|..     ... .  ||...|. ||.
TLSYMPPEHFRTD--NKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPC

FEHICTRL
|  .  . 
FQECEEWT
Kinase MLKx_g-2.AA TK 203-475 16 3.8e-38 124.94 In-house 1-486 (486) Show / Hide 
Range on Protein: 203-475
Range on HMM: 1-486/486
Sequence Identity: 16% (83 aa)

LDDTKPLGQGSFG---LVFQTTWAGH---------------------------TVAVKKFSKELWSQDPWELVMVFCSLVSFQ---------GEIMVKLR
.   | ||.| ||    |.. .| |.                           .||||   ..  ...  .. ...      .          |.| ...
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD----RDGGEDFLEEAEEMKMMC

---PCHPSVLQILG-WSEKDNK-----------AYLVMELMQ-GS----LARLIPSLVTAPII-------------------------------------
     || .....|  .....|            ..|||.|. |.    |     .     .                                      
HSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPE

---------------------------------------LIVEIMLQIAQGMDFVHKK------KIIHRDLKPGNVLVNFDGK----FEDGSAHNIVAKV
                                         . ...|||.|| . |.|      ...||||   |.||. ...    |   .    |.|.
EQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHF---DGCGPVCKI

ADFG--------LSKMNFS-SNHYHSHLKGT-------------------------VLYMAPEMLEGDWEMKS----QYDLSVDVYSYGMMFAEILT-GT
||||        |..   | .. | .. .||                         . .|||| |..  .  .     .    ||.|.| .  ||.| | 
ADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQ

PPYPLGLTK---------KALLDEIRRG--------------LRPRLPQRCP--------------QALKDTIAYCWDSQPRRRPTFEHICTRL
 ||. |..          . ... .|||              .|.  |. ||              ... | .  ||. .|..||||. .  .|
EPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_g-2.AA TyrKc 203-475 23 2.7e-36 127.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 203-475
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

LDDTKPLGQGSFGLVFQTTWAGHTVAVKKFSKELWSQDPWELVMVFCSLVSFQGEIMVKLRP--CHPSVLQILGWSEKD-------NKAYLVMELMQ-GS
.   | || | || |.. ||   .||||.  ..               .  |  |. .  .    || .....|   ..          ..|||.|  |.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LARLIPSLVT-APIILIVEIMLQIAQGMDFVHKKKIIHRDLKPGNVLVNFDGKFEDGSAHNIVAKVADFGLSKMNFSS-------NHYHS----HLK--G
|   . .     .    .....|||.||.. |.|..|||||   |.||. ..          ..|..|||||.   .          |..    . |   
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

TVLYMAPEMLEGDWEMKSQYDLSVDVYSYGMMFAEILTGTPPYPLG-----LTKKALLDEIRRGLRPRLPQR--------CPQALKDTIAYCWDSQPRRR
 .  |||| .     ... .    ||.|.| .  ||.|   . . |     .. . ..  ...| |.. |.         ||... . .  ||. .|  |
PIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

PTFEHICTRL
|||. |. ..
PTFSEIHECF
Kinase MLKx_g-2.AA ULK 257-421 31 4.7e-34 116.3 In-house 62-256 (329) Show / Hide 
Range on Protein: 257-421
Range on HMM: 62-256/329
Sequence Identity: 31% (62 aa)

EIMVKLR-----PC-HPSVLQILGWSEKD--NKAYLVMELMQG-SLARLIPSLVTAPIIL----------IVEIMLQIAQGMDFVHKKKIIHRDLKPGNV
.|| ||      .. || . . . |.| .  |  |..||. .|  |  .|    . |             ..... ||..|. . ||..|||||.|| |.
KIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNI

LVNF-DGKFEDGS---AHNIVAKVADFGLSKMNFSS----NHYHSHL-----KGTVLYMAPEMLEGDWEMKSQYDLSVDVYSYGMMFAEILTGTPPY
|..  ..|. |     . |.|.|.||||..|.  ..    . ... .     .|| |||||. |.|  | | .||  .|..| |..| |.|.| ||.
LIHNGQPKT-DSKKVHP-NGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPF
Kinase MLKx_g-2.AA Dicty4-Unclassified 307-475 33 1.2e-32 109.17 In-house 110-263 (263) Show / Hide 
Range on Protein: 307-475
Range on HMM: 110-263/263
Sequence Identity: 33% (57 aa)

LIVEIMLQIAQGMDFVHKKKIIHRDLKPGNVLVNFDGKFEDGSAHNIVAKVADFGLSKMNFSSNHYHSHLKGTVLYMAPEMLEGDWEMKSQYDLSVDVYS
||. . . ||||| . | . .||||.|  |.|.            .  .|.||||.|    . |       ||.   .|| |     |   |    ||||
LIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMD----------KHFNIKIADFGISRV-IDFNFNMTTIAGTPKWESPECL-----MHESYNQKSDVYS

YGMMFAEILTGTPPYPLGLT--KKALLDEIRRGLRPRLPQRCPQALKDTIAYCWDSQPRRRPTFEHICTRL
|.||  | .||  || ..      |      ..|||..|  |.  .|  |  ||   |..|||.. |  .|
YAMMLYELATGDEPY-QEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKx_g-2.AA Pkinase_Tyr 266-475 28 1.8e-28 97.03 Pfam 63-270 (270) Show / Hide 
Range on Protein: 266-475
Range on HMM: 63-270/270
Sequence Identity: 28% (64 aa)

HPSVLQILGWSE-KDNK--AYLVMELMQG-SLARLIPS----LVTAPIILIVEIMLQIAQGMDFVHKKKIIHRDLKPGNVLVNFDGKFEDGSAHNIVAKV
|| ... .|    ..     |.|||.|.. .|     .        ..  .... .|||.||.. . |..|||||   |.||.          .| |.|.
HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT----------ENNVVKI

ADFGLSKMNFSSNHY---HSHLKGTVLYMAPEMLEGDWEMKSQYDLSVDVYSYGMMFAEILT-GTPP-YPLGLTKKALLDEI-RRGLRPRLPQRCPQALK
.||||..  ..   |   ... |  .  |||| .         .    ||.|.|    ||.| |  | || |..   ... | ..| |   |. ||. . 
CDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQPTYP-GMSNEEVYEYIYEDGYRMPCPENCPDEIY

DTIAYCWDSQPRRRPTFEHICTRL
| .  ||. .| .||||. |  .|
DLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKx_g-2.AA Dicty4 203-235 40 6.6e-08 22.63 In-house 1-35 (277) Show / Hide 
Range on Protein: 203-235
Range on HMM: 1-35/277
Sequence Identity: 40% (14 aa)

LDDTKPLGQGSFGLVFQTTWAGHTVAVKKF--SKE
.. .. .|.|||| |.  || |  |||||.   ..
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQ
Kinase MLKx_g-2.AA LRRK 203-235 19 1e-06 19.7 In-house 1-62 (351) Show / Hide 
Range on Protein: 203-235
Range on HMM: 1-62/351
Sequence Identity: 19% (12 aa)

LDDTKPLGQGSFG-LVFQTTWAG----------------------------HTVAVKKFSKE
|   . .|.|.|| .|.. .| |                             .||.||. ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRD
Kinase MLKx_g-2.AA Dicty4-Unclassified 203-232 40 0.000615 9.33 In-house 1-30 (263) Show / Hide 
Range on Protein: 203-232
Range on HMM: 1-30/263
Sequence Identity: 40% (12 aa)

LDDTKPLGQGSFGLVFQTTWAGHTVAVKKF
.   . .|.| |  |    | |  ||||||
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKF
Pkinase_Tyr MLKx_g-2.AA Pkinase_Tyr 201-235 36 0.003341 11.47 Pfam 1-38 (270) Show / Hide 
Range on Protein: 201-235
Range on HMM: 1-38/270
Sequence Identity: 36% (15 aa)

LELDDTKPLGQGSFGLVFQTTWA------GHTVAVKKFSKE
....  | ||.|.|| |.. ||       . .||||.  ||
ITFG--KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE
Kinase MLKx_g-2.AA ULK 203-231 31 0.095456 1.98 In-house 1-35 (329) Show / Hide 
Range on Protein: 203-231
Range on HMM: 1-35/329
Sequence Identity: 31% (11 aa)

LDDTKPLGQGSFGLVFQT----TW--AGHTVAVKK
    . ||.|||| |..     |   ..  ||.|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKM