Gene MLKx_n (S.moellendorffii)

MLKx_n

Species: S.moellendorffii
Alias: MLKx_n
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKx

Sequence

Name Sequence Type Origin Length Description Download
MLKx_n.AA Protein None 568 None Fasta, JSON
MLKx_n.NA RNA None 1707 None Fasta, JSON
MLKx_n.kin_dom Protein Kinase Domain None 193 None Fasta, JSON

Protein domain

Protein domains of MLKx_n.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2 MLKx_n.AA C2 5-85 31 1.5e-22 79.41 Pfam 1-90 (90) Show / Hide 
Range on Protein: 5-85
Range on HMM: 1-90/90
Sequence Identity: 31% (29 aa)

VHIKVCSARGLMPRD--GCGSASPYCMVSFDG-----QQVKTQVRHRTLNPEWNETLDLNVEGDALQRSHVRVSVLNYTNRR---PLGKIK
....|..||.|.|.|  . |...||. |...|     |  || | ..||||.||||. ..|  . ||.  .|..| ..   .    .|...
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQH-TLRFTVWDWDRFGRDDFIGQCC
C2 MLKx_n.AA C2 4-100 19 6e-16 60.23 SMART 1-92 (92) Show / Hide 
Range on Protein: 4-100
Range on HMM: 1-92/92
Sequence Identity: 19% (23 aa)

KVHIKVCSARGLMPRDGCGSASPYCMVSFDGQQVKTQVRHRTL---NPEWNE---TLDLNVEGDALQRSHVRVSVLNYTNRRPLGKIKIE----------
...... .||.|.         ||. |.      || |  .||   ||.|||   |....|       . .|..| ..   ...|.. |           
TLTVHIIEARNLP--------DPYVKVY------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-----Q-LRFEVWDH---DFIGHCCIPPNNPHWHQWD

----GSEVPHCSSEPSD
     |...        
GCIHLSDIL-GYRH-WW
C2_PKD MLKx_n.AA C2_PKD 2-59 25 4.7e-07 21.39 In-house 1-76 (183) Show / Hide 
Range on Protein: 2-59
Range on HMM: 1-76/183
Sequence Identity: 25% (19 aa)

ARKVHIKVCSARGLMP-------------RDGCGSASPYCMVSFDGQQ-----VKTQVRHRTLNPEWNETLDLNVE
. .  ...|.| || |             ...| .  ||| |  |  .     ..| .. .|. ||||.. | .|.
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVY
S_TKc MLKx_n.AA S_TKc 316-554 23 1e-43 152.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 316-554
Range on HMM: 1-231/231
Sequence Identity: 23% (63 aa)

VHFGEMLGRGSYGVVRKGTWHQ--RLVAVKEFRESNLSSRELRAVSRIQAAPHIVQTIGYYKVDESCTHLVMEVMRM---DLKEYASKNKG------LTH
 .... .|.|..|.|.|....   |.||.|. .  .   ||..  ..    |.||. ....    .. ..||| .     ||..|  |...      .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

LQLVEMLLQITKGLNFLHGKNIVHRDLKPENVLIDFTDEDEEQLVLKLADFGTAYINFNTELSHTAPIGTRIFMAPELQSEEIKRNGETVYSR-SVDLYS
 .   .. || ..|...| ..|.||||||||.|.|         ..|..||| | .        |  .||. .||||.            |.. ..| .|
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL-------TTFCGTPWYMAPEVL----------GYGKCKCDWWS

LGMTFSQLVLSQP----------AIGTPTAELEALICRCSSEEPSERPVVDEVLK-----SLRNIL
.| ..  ..  .|           ||  . |.  .|..|   .|..|| . |.|.      .   .
CGCILYEMLCGYPPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase MLKx_n.AA Pkinase 316-516 28 3.3e-41 146.78 Pfam 1-210 (293) Show / Hide 
Range on Protein: 316-516
Range on HMM: 1-210/293
Sequence Identity: 28% (63 aa)

VHFGEMLGRGSYGVVRKGTWHQR--LVAVKEFRESNLSS---------RELRAVSRIQAAPHIVQTIGYYKVDESCTHLVMEVMRM-----DLKEYAS--
 |.|. .|.||.|.|.|....    .||||... .. .|         .|..   |..  |.||......   ..  ..||| ...     ||..| |  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTW

KNKGL--THLQLVEMLLQITKGLNFLHGKNIVHRDLKPENVLIDFTDEDEEQLVLKLADFGTAYI--NFNTELSHTAPIGTRIFMAPELQSEEIKRNGET
.....  .  ..  ...|| .||...| ..|.||||||||.||| ... ..   .|..||| |    . | .   | . ||. .||||.    |.  | .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEV----IR--GGQ

VYSRSVDLYSLGMTFSQLVLSQP
 |...|| .|.| .. .... .|
YYGPKVDMWSCGCILYEMLCGRP
Kinase MLKx_n.AA CAMK 321-505 18 1.8e-34 107.96 In-house 1-321 (425) Show / Hide 
Range on Protein: 321-505
Range on HMM: 1-321/425
Sequence Identity: 18% (58 aa)

MLGRGSYGVVRKGTWHQRL--------------VAVKEFR-------------------------------ESNLS--SRELRAVSRIQA------APHI
 |||||.|.|....  .                ||.|                                  ....    ||..  ...|.       |.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQTIGYYK------------VDES-------CTHLVM---EVMRM-----DLKEYASKNKG---------------LTHLQLVEMLLQITKGLNFLHGKN
.. . .|               .        . ..||   | .       || .|  ....               .|  .   .  ||  .....| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKPENVLID--FTDED---------EEQLVLKLADFGTAYINFNTELSHTA-----------------------PIGTRIFMA-PELQSEEIKRN
||||||||||.|.|  ..|.|         ...  .|..||| | . .  | ...                        . ||  .|| ||. . . . |
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

G-------ETVYSRSVDLYSLG
        .. |....|  |.|
MQNATDEEKPYYGPKCDMWSCG
Kinase MLKx_n.AA TKL 322-506 20 1.5e-33 117.8 In-house 1-277 (364) Show / Hide 
Range on Protein: 322-506
Range on HMM: 1-277/364
Sequence Identity: 20% (57 aa)

LGRGSYGVVRKGTWHQ----------RLVAVKEFRESNLSS----------------------------RELRAVSRIQA---APHIVQTIGYYKVDES-
.|.|..|.| ||.|..          . |||| |.. | ..                             ... . ..      |.||| .|| .  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------CTHLVMEVM-RMD-LKEYASKNKGLTHLQLVEMLLQITKGLNFLHG--------KNIVHRDLKPENVLID--FT--DEDE-----EQLV
             ..||| . . . |  .        . |.. . |.| .|.|.||         ..|.|||||..|.|.|  .|  . ..     .. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADWC

LKLADFGTAY-INFNTELSHTA------------------PIGTRIFMAPELQSEEIKRN---------GETVYSRSVDLYSLGM
.|..|||..  .. ... ..|.                  ..||  .||||.  .... .         ..  || ..| || |.
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI
Kinase MLKx_n.AA Ciliate-E2 316-516 18 2.9e-33 111.55 In-house 1-294 (365) Show / Hide 
Range on Protein: 316-516
Range on HMM: 1-294/365
Sequence Identity: 18% (56 aa)

VHFGEMLGRGSYGVVRKG-TWHQRL-------------------VAVKEFRESNLSSRELRAVSRIQA----------------------APHIVQTIGY
  | ...|.|..|.|.|.  | ..                    |..|..   ... ..........                        |.|.. . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YKV-DESCTHLVMEVMRM-DLKEYASKN-----------KGLTHLQLVEMLLQITK---------------GLNFLHGKN-IVHRDLKPENVLIDFTDED
..  |...  ||||     ||..|  .|           | .|. .  ..  ||..               .|..|| || |.|||.||||.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

EEQLVLKLADFGTAYI--NFNTELSHTAPI------------------------------GTRIFMAPELQS--EEIKRNGETVYSRSVDLYSLGMTFSQ
     .|..|||.. .  ..| . .|  ..                              ||  .||||  .  .. . .... |. ..|..|||... .
-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

LVLSQP
..  .|
MLFGKP
Kinase MLKx_n.AA CMGC 316-482 17 6.8e-33 104.73 In-house 1-296 (513) Show / Hide 
Range on Protein: 316-482
Range on HMM: 1-296/513
Sequence Identity: 17% (53 aa)

VHFGEMLGRGSYGVVRKGTWHQ----------------RLVAVKEFR---ESNLSS-------------RELRAVSRIQ----------------AAPHI
 .  . .|.|.|||| |.. ..                ..||.| ..   . .                ||..   ...                  ..|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQTIGYYKVDES----------------CTHLVMEVMRMDLKEYASKNK---------GLTHLQ------------LVEML------LQITKGLN--FLH
|. . ... ..|                . .||.| | .||..|  .|.         .|.. .               ..       || .||.  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

GKN--IVHRDLKPENVLID-----FTDEDE----------EQLVLKLADFGTAY-INFNTEL--------------------SHTAPIGTRIFMAPEL
 ..  |.||||||||.||.     .|.. .          .. .||..||| |  .. . .                      .|  . ||   |||.
SHWGNIIHRDLKPENILINHNCELITRM-MWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI
Kinase MLKx_n.AA STE 316-507 20 3.8e-32 110.87 In-house 1-257 (359) Show / Hide 
Range on Protein: 316-507
Range on HMM: 1-257/359
Sequence Identity: 20% (56 aa)

VHFGEMLGRGSYGVVRKGTWH-----------------QRLVAVKEFR----------------------ESNLSSRELRAVSRIQA-APHIVQTIGYYK
  . |..|.|..|.| |.  |                 ....|.|. .                      | .   .|..  .. .   |.||. .|.| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VD------ESCTHLVMEVMRM----DLKEYA-SKNKGLT----------HLQLVEMLLQITKG-LNFLHGKNIVHRDLKPENVLIDFTDEDEEQLVLKLA
..      ..  ...|| |      |. .   ...|.|.            |.  .. || || |..|| ..|.|||.|| |.|.            ||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------VKLC

DFGTAYINFN---------------TELSHT-APIGTRIFMAPELQSEEIKRNGETVYSRSVDLYSLGMT
|||.. .  .               |  ...   .||  .||||  . . .   .  |....| .||| |
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCT
Kinase MLKx_n.AA TKL-Unique 318-506 25 1.7e-28 97.71 In-house 1-216 (290) Show / Hide 
Range on Protein: 318-506
Range on HMM: 1-216/290
Sequence Identity: 25% (58 aa)

FGEMLGRGSYGVVRKGTWHQRLVAVKEFRE---SNLSSRE-----LRAVSRIQAAPHIVQTIGYYK---VDESCTHLVMEVMRMD-LKEYAS--------
|.. .|.|.||.| ||.|..  ||.| | .   |......     ..  .... .| ||. .|| .   |...   .||| . .  | .. .        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--KNKGLTHLQLVEMLLQITKGLNFLHGKN--IVHRDLKPENVLIDFTDED--EEQLVLKLADFGTAYINFNTELSHTA---------PIGTRIFMAPEL
  .|. |. .| | | ..| .|...|| ..  | |||||. |.|.   |..  . ..  |..|||.. .| .   . .          ..|. . ||||.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLV---DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

QSEEIKRNGETVYSRSVDLYSLGM
 . .      . ||...| || |.
LRMNF-----CQYSEKSDVYSFGI
Kinase MLKx_n.AA TK 316-456 18 3.8e-27 87.42 In-house 1-296 (486) Show / Hide 
Range on Protein: 316-456
Range on HMM: 1-296/486
Sequence Identity: 18% (56 aa)

VHFGEMLGRGSYG---VVRKGTWHQR---------------------------LVAVKEFRE-SNLSSR------------------ELRAVSRIQA---
...|. ||.| .|   .|.||.|..|                            ||||  .| .. |..                  |... .  ..   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-APHIVQTIG----Y--------YKVDESCTHLVMEVMR-MD----LKEYASKNKG--------------------------------------------
  |.||. .|             . |..    .||| |   |    |..|  |...                                            
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------LTHLQLVEMLLQITKGLNFLHGK------NIVHRDLKPENVLIDFTDE-----DEEQLVLKLADFG
                                ||  ||. | .|| .|. .|| |      |.|||||   |.|..  .      |. ..| |.||||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
Kinase MLKx_n.AA MLK 316-508 27 1.6e-26 89.14 In-house 1-226 (291) Show / Hide 
Range on Protein: 316-508
Range on HMM: 1-226/291
Sequence Identity: 27% (63 aa)

VHFGEMLGRGSYGVVRKGTWHQRL-----VAVKEFR---ESNLSS------------RELRAVSRIQAAPHIVQTIGYYKVDESCTHLVMEVMRM-DLKE
  | | .| ||.|.| ||.|. ..     ||||..|   .   |.            |.|| .|.    | |.|  |  . ....  .||| ..   | .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

YASKNKG--------------LTHLQLVEMLLQITKGLNFLHGKN---IVHRDLKPENVLID-FTDEDEEQLVLKLADFGTAYINFNTELS-HTAPIGTR
.   ...               .| ...   ||. .|...|| .    |.|||||. |.|||     | ....|| .||||.    ... . ..  .|| 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

IFMAPELQSEEIKRNGETVYSRSVDLYSLGMTF
..||||     |..  .. ||...| .| |. .
AWMAPEV----IQQFRCEKYSEKCDVWSWGVVL
Kinase MLKx_n.AA Pkinase_Tyr 316-456 32 4.4e-19 65.26 Pfam 1-156 (270) Show / Hide 
Range on Protein: 316-456
Range on HMM: 1-156/270
Sequence Identity: 32% (53 aa)

VHFGEMLGRGSYGVVRKGTWH------QRLVAVKEFRESNLSSRE------LRAVSRIQAA---PHIVQTIGYYK-VDES-CTHLVMEVMRM-DLKEYAS
..||..||.|..|.|.||||.      .  ||||  .| . ....      .| ..        |.||. .|     .|.    .||| |   ||..|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----NKGLTHLQLVEMLLQITKGLNFLHGKNIVHRDLKPENVLIDFTDEDEEQLVLKLADFG
|    .. ||. .|..| .|| ||...|. ||..||||   |.|..      |..| | .|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT------ENNVVKICDFG
Kinase MLKx_n.AA LRRK 412-506 34 2.2e-18 61.6 In-house 171-270 (351) Show / Hide 
Range on Protein: 412-506
Range on HMM: 171-270/351
Sequence Identity: 34% (37 aa)

LQITKGLNFLHGKN--IVHRDLKPENVLIDFTDEDE------EQLVLKLADFGTAYINFNTELSHT---APIGTRIFMAPELQSEEIKRNGETVYSRSVD
||| ||...|| .|  |.|||||..|.|.   ...       .. . |.||||.    | . . ..      |. ..||||     .. ||| .|.  ||
LQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEI----MRYNGEEEYTEKVD

LYSLGM
 || ||
CYSFGM
Kinase MLKx_n.AA TyrKc 316-550 23 1.8e-14 11.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 316-550
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

VHFGEMLGRGSYGVVRKGTWHQRLVAVKEFRESNLSS---RELRAVSRI-QAAPHIVQTIGYYKVDE------SCTHLVMEVMRM-DLKEYASKNKG-LT
...|..||.| .|.|.||||  . ||||  .|.       ||.|  ...    |.||. .|.   ..          .||| |   |||.|  |... |.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

HLQLVEMLLQITKGLNFLHGKNIVHRDLKPENVLIDFTDEDEEQLVLKLADFGTAYINFNT--------ELSHTAPIGTR----IF-MAPE-LQSE----
. .|... .|| .| ..|| ||..||||   |.|..         . | .||| .    .           ...   |..    |  |||| ..      
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

------------EIKRNGETVYSR-----SVDLYSLGMTFSQLVLSQPAIG------TPTAELEALICRCSSEEPSERPVVDEVLKSL
            ||  .|.. |.        .   .    .   . ||. .      . ..|.  .. .|  |.|..||   |. . .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKx_n.AA TAK1 316-386 32 4.6e-14 43.81 In-house 1-79 (284) Show / Hide 
Range on Protein: 316-386
Range on HMM: 1-79/284
Sequence Identity: 32% (26 aa)

VHFGEMLGRGSYGVVRKGTWHQRLVAVKEFR---------ESNLSSRELRAVSRIQAAPHIVQTIGYYKVDESCTHLVME
  . ...|.|.||||.| .|  . .|||.|.         |     ||..  ||.   | |.. .| |.  . |. ||||
IQNEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQWSRVD-HPNIIKLYGMYACHRQCQCLVME
Kinase MLKx_n.AA TAK1 412-481 31 3.4e-12 37.39 In-house 109-173 (284) Show / Hide 
Range on Protein: 412-481
Range on HMM: 109-173/284
Sequence Identity: 31% (23 aa)

LQITKGLNFLHGKN---IVHRDLKPENVLIDFTDEDEEQLVLKLADFGTAYINFNTELSHTAPIGTRIFMAPE
.|. .|...||..    ..|||.|| | |       .  ..||. ||||.   . .  .  .  || ..||||
HQCAQGVAYLHSMQPKPQIHRDIKPQNMLL-----CNKHRTLKICDFGTF-CDMHQMMTCNR--GTCRWMAPE
Kinase MLKx_n.AA LRRK 316-350 27 5e-06 17.43 In-house 1-36 (351) Show / Hide 
Range on Protein: 316-350
Range on HMM: 1-36/351
Sequence Identity: 27% (10 aa)

VHFGEMLGRGSYG-VVRKGTWHQRLVAVKEFRESNL
. ..|..|||..| .| ...| .  |.|...  . |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKML
Kinase MLKx_n.AA TKL 524-550 33 0.0004 10.76 In-house 338-364 (364) Show / Hide 
Range on Protein: 524-550
Range on HMM: 338-364/364
Sequence Identity: 33% (9 aa)

ELEALICRCSSEEPSERPVVDEVLKSL
..  |. .| ...|..||  .|.|| |
SMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKx_n.AA TKL-Unique 528-550 43 0.000476 10.38 In-house 268-290 (290) Show / Hide 
Range on Protein: 528-550
Range on HMM: 268-290/290
Sequence Identity: 43% (10 aa)

LICRCSSEEPSERPVVDEVLKSL
|| .|   .||.|| .||....|
LIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKx_n.AA TK 513-550 17 0.002159 6.38 In-house 435-486 (486) Show / Hide 
Range on Protein: 513-550
Range on HMM: 435-486/486
Sequence Identity: 17% (9 aa)

LSQPA-IGTPT-------------AELEALICRCSSEEPSERPVVDEVLKSL
. .|.  . |              .|.. |...| ...|..||  ..... |
MRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKx_n.AA LRRK 524-552 27 0.027996 3.85 In-house 323-351 (351) Show / Hide 
Range on Protein: 524-552
Range on HMM: 323-351/351
Sequence Identity: 27% (8 aa)

ELEALICRCSSEEPSERPVVDEVLKSLRN
....||  | ...| .||   ...| |  
MYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKx_n.AA MLK 525-550 23 0.041439 3.27 In-house 266-291 (291) Show / Hide 
Range on Protein: 525-550
Range on HMM: 266-291/291
Sequence Identity: 23% (6 aa)

LEALICRCSSEEPSERPVVDEVLKSL
.. |. .| ...|..||  ..... |
WKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKx_n.AA TAK1 525-549 28 0.1507 0.88 In-house 260-284 (284) Show / Hide 
Range on Protein: 525-549
Range on HMM: 260-284/284
Sequence Identity: 28% (7 aa)

LEALICRCSSEEPSERPVVDEVLKS
.| .  .| .. |..||   |. | 
IEQFMKCCWDDNPEKRPSMQECVKY