Gene MLK-Un_b (S.moellendorffii)

MLK-Un_b

Species: S.moellendorffii
Alias: MLK-Un_b
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_b.AA Protein None 635 None Fasta, JSON
MLK-Un_b.NA RNA None 1908 None Fasta, JSON
MLK-Un_b.kin_dom Protein Kinase Domain None 211 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-Un_b.AA TKL 418-626 20 4.7e-34 119.45 In-house 84-364 (364) Show / Hide 
Range on Protein: 418-626
Range on HMM: 84-364/364
Sequence Identity: 20% (59 aa)

HANVLPIRGIWIDGRN-------------LWAVSKLVSGGSLRDLVDRREKIELRSVLRMACDIAEGMQFLHECG--------IVHRQVNLKLSNILLDD
| |.... |. .....             |. |  ...||||....       .   .|.| ||| ||..|| ..        |.||  .|| .|||.|.
HPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHR--DLKSKNILVDE

NGC--------------AVIGGLRIARAIKSPTKDERSFKDGEEED--------KTSWPV------PPEV-----DLEK----------SAITPKADVYS
|.               . |. . ..| ..  ...... ... |          .|. ..      .|||     ....          .  ..|.||||
NWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMME-SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS

FGTLLCELVSCHTTAD-----------------QNIGKEKETPRRS-----RTTRSMPAPVVPLDCFPLLKYLIHQCWASNPLDRPDFCEILEMV
|| .|.|.... .  .                   ...... | .      .    . . . . || | .| |. .||...| .|| | |||.  
FGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH---K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-Un_b.AA TKL-Unique 441-626 26 9e-19 62.96 In-house 82-290 (290) Show / Hide 
Range on Protein: 441-626
Range on HMM: 82-290/290
Sequence Identity: 26% (58 aa)

VSGGSLRDLVD----------RREKIELRSVLRMACDIAEGMQFLHECG--IVHRQVNLKLSNILLDDN-----GCAVIGGLRIARAIKSPTKDERSFK-
..||||.|. .          .  |. .  ...|| ||| || .|| |.  | ||  .|| ||.|.| |       . | .  ...  .. .|   . . 
CPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHR--DLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHK

---DGEEEDKTSWPVPPEVDLEK--SAITPKADVYSFGTLLCELVSCHT-----------TADQNIGKEKETPRRSRTTRSMPAPVVPLDCFPLLKYLIH
   . .... . | ..||| |.   . .. |.||||||. | |... .            . .| . ..... ...|       | .| .| . .. || 
GTRNQTRCGSFRW-MAPEV-LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYR-------PPIPNHCPKEYRDLIQ

QCWASNPLDRPDFCEILEMV
|||...| .|| | ||..  
QCWHHDPSQRPSFDEIIHRL
Kinase MLK-Un_b.AA UTK 416-563 25 5.4e-15 47.73 In-house 66-235 (296) Show / Hide 
Range on Protein: 416-563
Range on HMM: 66-235/296
Sequence Identity: 25% (45 aa)

FA-HANVLPIRGIWIDGRNLWAVSKLVSGGSLRDLVD--------RREKIELRSVLRMACDIAEGMQFLHECGIVHRQVNLKLSNILLDDNG-------C
|. | |||   |.  ..  .. |. . ..|.||...         ...   |.. | || |||.|||.||.||.|||  .|   |.|.....        
FHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHR--DLAARNCLVHMHRMMWHCMMV

AVIGGLR---IARAIKSPTKDERSFKDGEEEDKTS---WPV---PPEVDLEKS-AITPKADVYSFGTLLCELVS
..|...     .|.... . .  . .. ... ...   ||.    ||. | .    | | ||.||| .. |...
CKIADFGRGGMSRRVNTFH-FSNRYWESYYYMAQHQDRWPIRWMAPEA-LTHHTRFTTKSDVWSFGVVCWEIWT
S_TKc MLK-Un_b.AA S_TKc 370-628 19 3.9e-14 30.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 370-628
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

LEKEEAI--------PTARARFGGEAVALELINPPGDGDRELQEEVLWLCTRSGFAHANVLPIRGIWIDGRNLWAVSKLVSG--GSLRDLVDRREK----
 |. . |          .| .  |. ||.  |.      . .. |.  |       | |.  . ... |  .|. |  ...|  |.|.|. ..| .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IELRSVLRMACDIAEGMQFLHECGIVHRQVNLKLSNILLDDNGCAVIGGLRIARAIKSPTKDERSFKDGEEEDKTSWPVPPEVDLEKSAITP-KADVY
  .    . .... |.......|. ||.||   || .|||||.  .  |.   .|| .                  | | ..|||       .. |.|..
FPFPE-HARFYMYQICCALEYCHSHGIIHR--DLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----GYGKCKCDWW

SFGTLLCELVSCHTTADQNIGKEKETPRRSRTTRSMPAPVVPLDCFPLLKYLIHQCWASNPLDRPDFCEILE-------MVAT
|.| .| |...  .  . .. .  .  .                  | .| .| .|.  .| .||   |.|.       .   
SCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK-Un_b.AA TK 418-483 12 1.4e-12 37.69 In-house 102-264 (486) Show / Hide 
Range on Protein: 418-483
Range on HMM: 102-264/486
Sequence Identity: 12% (20 aa)

HANVLPIRGIWIDGRN------------LWAVSKLVSGGS----LRDLVDRREK----------------------------------------------
| |.. . |.  .|..            .. |  ....|.    |||   .. .                                              
HPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYD

------------------------------IELRSVLRMACDIAEGMQFLHEC------GIVHR
                              . ..  | |...||.||..||..      ..|||
DDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHR
TyrKc MLK-Un_b.AA TyrKc 370-626 20 3.1e-12 -24.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 370-626
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

LEKEEAIPT--------ARARFGGEAVALELINPPGDGDRELQEEVLWLCTRSGF--AHANVLPIRGIWIDG-------RNLWAVSKLVSGGSLRDLV-D
..... .          ....   . ||   ...     ... .|   .|    .   | |.. . |. ...         |. |  ....|.|.|   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCK---LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RREKIELRSVLRMACDIAEGMQFLHECGIVHRQVNLKLSNILLDDNGCAVIGGLRIARAIKSP----TKDERSFKDGEEEDKTSWPV---PPEVDLEKSA
.|.|. ..  | .. .||.||..||. ...||   |   |.|...|... |.    .|.|..       ..   | ...  || .|.   .||. . .. 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHR--DLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC-INYGK

ITPKADVYSFGTLLCELVSCHTTADQNIG------KEKETPRRSRTTRSMPAPVVPLD-----CFPLLKYLIHQCWASNPLDRPDFCEILEMV
 |.| ||.||| .. |. .    .    |      . .|  .. .. . || |  ..      | . .  .. |||. .| ||| | || |  
FTTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-Un_b.AA MLK 414-502 23 8e-11 33.9 In-house 60-174 (291) Show / Hide 
Range on Protein: 414-502
Range on HMM: 60-174/291
Sequence Identity: 23% (27 aa)

SGFAHAN----VLPIRGIWID-GRNLWAVSKLVSGGSLRDLV-DRREKIE-------------LRSVLRMACDIAEGMQFLHECG---IVHRQVNLKLSN
. . | |    . ...|. .. . ..  |.  ..|||| ..  ..| |..             . .... | ..|.||..||.     |.||   || .|
RILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHR--DLKSHN

ILLDD------NGCAVI
||.|.      .| ..|
ILIDEICHDMHHGTLKI
Kinase MLK-Un_b.AA Pkinase 418-498 26 5.4e-10 36.41 Pfam 59-145 (293) Show / Hide 
Range on Protein: 418-498
Range on HMM: 59-145/293
Sequence Identity: 26% (24 aa)

HANVLPIRGIWIDGRNLWAVSKLVSGG----SLRDLVD--RREKI--ELRSVLRMACDIAEGMQFLHECGIVHRQVNLKLSNILLDDNG
| |.. ..... |..... |  .. ||    .| |..   |. ..  . . . ...  |..|....|..||.||   ||..|||.|.||
HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR--DLKPENILIDNNG
Kinase MLK-Un_b.AA NZAK 536-626 26 1.2e-09 28.11 In-house 241-329 (329) Show / Hide 
Range on Protein: 536-626
Range on HMM: 241-329/329
Sequence Identity: 26% (24 aa)

PEVDLEKSAITPKADVYSFGTLLCELVSCHTTADQNIGKEKETPRRSRTTRSMPAPVVPLDCFPLLKYLIHQCWASNPLDR-PDFCEILEMV
||. .  . |. | ||.||| .  ....        |   ||        .    |..|      .| .| |||  .|. |  || .. |  
PEN-KNNHRINEKSDVWSFGCTVWQMFGYNPP--NTIYSPKEMASMVSDQKFNYIPQIPFHVPDKMKDFITQCWDIDPKKRPKDFSHMIEKL
Kinase MLK-Un_b.AA Dicty4 451-497 37 4.7e-09 26.52 In-house 99-150 (277) Show / Hide 
Range on Protein: 451-497
Range on HMM: 99-150/277
Sequence Identity: 37% (20 aa)

DRREKIELR--SVLR---MACDIAEGMQFLHE--CGIVHRQVNLKLSNILLDDN
.  ..|.|    ..|   || |.| ||. ||.  . |.||   || .|.| |.|
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHR--DLKSHNLLVDKN
Kinase MLK-Un_b.AA Pkinase_Tyr 418-483 23 9.9e-09 30.19 Pfam 63-135 (270) Show / Hide 
Range on Protein: 418-483
Range on HMM: 63-135/270
Sequence Identity: 23% (17 aa)

HANVLPIRGIWI-DGRN--LWAVSKLVSGGSLRDLVDR----REKIELRSVLRMACDIAEGMQFLHECGIVHR
| |..   |. . .|.   .. |  .. .|.|.|   .    .... .   | |. .||.||..|.. ...||
HPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHR
Kinase MLK-Un_b.AA TKL-ciliate1 443-495 35 2e-08 24.93 In-house 83-139 (279) Show / Hide 
Range on Protein: 443-495
Range on HMM: 83-139/279
Sequence Identity: 35% (21 aa)

GGSLRDLVDRREK----IELRSVLRMACDIAEGMQFLHECG--IVHRQVNLKLSNILLD
.|.. |.  |  .    |     .|.  ||| |||.||     ..||  .||  |||.|
KGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHR--DLKMQNILYD
Kinase MLK-Un_b.AA RIPK 463-497 45 8.6e-08 22.6 In-house 111-145 (290) Show / Hide 
Range on Protein: 463-497
Range on HMM: 111-145/290
Sequence Identity: 45% (17 aa)

RMACDIAEGMQFLHECG--IVHRQVNLKLSNILLDDN
||   |..||..||  .  | ||   ||..|||.| |
RMIHEISCGMCYLHSMNPPIIHR--DLKPENILVDNN
Kinase MLK-Un_b.AA RIPK 601-626 38 1.9e-07 21.43 In-house 265-290 (290) Show / Hide 
Range on Protein: 601-626
Range on HMM: 265-290/290
Sequence Identity: 38% (10 aa)

LKYLIHQCWASNPLDRPDFCEILEMV
.. |. .||...| ||| | |. | .
MIELMQRCWQQDPNDRPCFQECEEWT
Kinase MLK-Un_b.AA TKL-ciliate1 593-626 35 3.5e-07 20.63 In-house 246-279 (279) Show / Hide 
Range on Protein: 593-626
Range on HMM: 246-279/279
Sequence Identity: 35% (12 aa)

VPLDCFPLLKYLIHQCWASNPLDRPDFCEILEMV
.. || . .  |.  ||  || .||.| ||.. .
IHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL
Kinase MLK-Un_b.AA TK 594-626 25 4.1e-07 19.07 In-house 440-486 (486) Show / Hide 
Range on Protein: 594-626
Range on HMM: 440-486/486
Sequence Identity: 25% (12 aa)

PLDCF--------------PLLKYLIHQCWASNPLDRPDFCEILEMV
| .|               ...  |. |||. .| |||.| ...|. 
PPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-Un_b.AA Pkinase 534-626 16 8.4e-07 25.14 Pfam 178-293 (293) Show / Hide 
Range on Protein: 534-626
Range on HMM: 178-293/293
Sequence Identity: 16% (20 aa)

VPPEVDLEKSAITPKADVYSFGTLLCELVSCHTTADQNIGKEKETPRRSRTTRSMPAPVVPLDCF-----------------------PLLKYLIHQCWA
..||| .. . ..||.|..|.| .| |... ..  .. .  ...  .     .    | .. |..                       . .| .|  |..
MAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

SNPLDRPDFCEILEM--V
 .| .|| . .||.   .
KDPKKRPTAEQILQHPWF
Kinase MLK-Un_b.AA MLK 593-626 35 9.2e-07 19.63 In-house 258-291 (291) Show / Hide 
Range on Protein: 593-626
Range on HMM: 258-291/291
Sequence Identity: 35% (12 aa)

VPLDCFPLLKYLIHQCWASNPLDRPDFCEILEMV
.| .| . .| |..||| ..| .||.| .|..  
IPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK-Un_b.AA NZAK 430-498 27 1e-06 17.74 In-house 73-142 (329) Show / Hide 
Range on Protein: 430-498
Range on HMM: 73-142/329
Sequence Identity: 27% (20 aa)

DGRNLWAVSKLVSGGSLRDLV-DRREKIELRSVLR--MACDIAEGMQFLHECGIVHRQVNLKLSNILLDDNG
|  .   ..  ..|| | ... . .   . .  ..  |  ||||.| .||  .|.||   .| .|..|| |.
DDNYHCIYMEWMEGGNLTQFLMNDKKQLRFKEHRIIKMIADIAETMSYLHKHHIIHR--DIKSNNVILDFNK
Kinase MLK-Un_b.AA CZAK 443-497 38 1e-06 20.24 In-house 86-145 (279) Show / Hide 
Range on Protein: 443-497
Range on HMM: 86-145/279
Sequence Identity: 38% (24 aa)

GGSLRDLVDRREKIELR---SVLRMACDIAEGMQFLHE----CGIVHRQVNLKLSNILLDDN
||||| | . .    .      . || |||.|| .||       |.||   |  .|||||..
GGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHR--DLSSRNILLDHS
Kinase MLK-Un_b.AA CZAK 604-626 47 3e-06 18.75 In-house 257-279 (279) Show / Hide 
Range on Protein: 604-626
Range on HMM: 257-279/279
Sequence Identity: 47% (11 aa)

LIHQCWASNPLDRPDFCEILEMV
|| .|| .||  || | .||.  
LIEMCWNKNPDERPSFKQILQHL
Kinase MLK-Un_b.AA Pkinase_Tyr 607-626 55 1.5e-05 19.41 Pfam 251-270 (270) Show / Hide 
Range on Protein: 607-626
Range on HMM: 251-270/270
Sequence Identity: 55% (11 aa)

QCWASNPLDRPDFCEILEMV
|||. .| ||| | ||.|. 
QCWHYDPEDRPTFSEIHEQL
Kinase MLK-Un_b.AA Dicty4 591-628 37 1.6e-05 14.61 In-house 238-277 (277) Show / Hide 
Range on Protein: 591-628
Range on HMM: 238-277/277
Sequence Identity: 37% (15 aa)

PVVPLDCFPLLKYLIHQCWASNPLDRPDFCEILEM--VAT
| .| .| | .| ||  ||  .|  || | ||..     .
PPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK-Un_b.AA CZAK 546-564 52 6.8e-05 13.88 In-house 200-218 (279) Show / Hide 
Range on Protein: 546-564
Range on HMM: 200-218/279
Sequence Identity: 52% (10 aa)

TPKADVYSFGTLLCELVSC
|.|.|||||| .| ... |
TEKVDVYSFGMILWCIITC
Kinase MLK-Un_b.AA UTK 604-626 39 0.000103 12.06 In-house 274-296 (296) Show / Hide 
Range on Protein: 604-626
Range on HMM: 274-296/296
Sequence Identity: 39% (9 aa)

LIHQCWASNPLDRPDFCEILEMV
| |.||...| .|||| .... .
LMHRCWHYDPQERPDFEDLVQQM
Kinase MLK-Un_b.AA Dicty4 548-562 66 0.011354 4.93 In-house 197-211 (277) Show / Hide 
Range on Protein: 548-562
Range on HMM: 197-211/277
Sequence Identity: 66% (10 aa)

KADVYSFGTLLCELV
|||||||| .| |..
KADVYSFGIVLWEIL
Kinase MLK-Un_b.AA TK 546-563 50 0.011746 3.87 In-house 372-389 (486) Show / Hide 
Range on Protein: 546-563
Range on HMM: 372-389/486
Sequence Identity: 50% (9 aa)

TPKADVYSFGTLLCELVS
|.| ||.||| |. |...
TTKSDVWSFGVLMWEIFT
Kinase MLK-Un_b.AA RIPK 535-563 41 0.016701 4.31 In-house 190-223 (290) Show / Hide 
Range on Protein: 535-563
Range on HMM: 190-223/290
Sequence Identity: 41% (14 aa)

PPEVDL--EKSAI---TPKADVYSFGTLLCELVS
|||  .  .|..|   ||| |||||. .. |. .
PPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLT
Kinase MLK-Un_b.AA TKL-ciliate1 545-563 31 0.02238 3.94 In-house 196-214 (279) Show / Hide 
Range on Protein: 545-563
Range on HMM: 196-214/279
Sequence Identity: 31% (6 aa)

ITPKADVYSFGTLLCELVS
|. |.|.|..| .. .|..
INEKIDIYAYGIVMYILCF
Kinase MLK-Un_b.AA MLK 536-564 32 0.034047 3.57 In-house 202-232 (291) Show / Hide 
Range on Protein: 536-564
Range on HMM: 202-232/291
Sequence Identity: 32% (10 aa)

PEVD--LEKSAITPKADVYSFGTLLCELVSC
|||   .. .  . |.||.|.| .| |....
PEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase MLK-Un_b.AA Pkinase_Tyr 546-563 50 0.989027 3.1 Pfam 192-209 (270) Show / Hide 
Range on Protein: 546-563
Range on HMM: 192-209/270
Sequence Identity: 50% (9 aa)

TPKADVYSFGTLLCELVS
| | ||.||| |. |...
TTKSDVWSFGVLMWEIFT