Gene MLK-Un_u-2 (S.moellendorffii)

MLK-Un_u-2

Species: S.moellendorffii
Alias: MLK-Un_u-2
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_u-2.AA Protein None 364 None Fasta, JSON
MLK-Un_u-2.NA RNA None 1095 None Fasta, JSON
MLK-Un_u-2.kin_dom Protein Kinase Domain None 275 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_u-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-Un_u-2.AA TKL 72-340 25 6.8e-81 275.05 In-house 1-364 (364) Show / Hide 
Range on Protein: 72-340
Range on HMM: 1-364/364
Sequence Identity: 25% (98 aa)

IAHGTYGVVHRGVYNG----------QDVAVKLLDWGEEQAMSQALVN---------------TLRSSFQQEVAVWQK---LDHPNVTKFVGACVGSPD-
|  |..|.|..|...|          .||||| .   ...  .  . .               ...  ...|. ..     |.|||. .|.|.|  .|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------LQVASTGGFVRISSNICCVVVEYLAGGT-LKQFLIQHCRKKLRLKVVIQLALDLSRGLDYLHS--------KKIVHRDVKSENMLLDNKRR---
      .           ... .| | ||  ||. | ...         . . ...||| .||..||||        ..|.||| ||.| |.|.. .   
CVCMHPV----------GPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS

-----------VKIADFGVAR-VEAQNPKDMTG------------------ETGTVGYMAPEVLDGK----------------PYNRKCDVYSFGICLWE
           .||.||| .| ..  . . .|.                  . || ..||||||.|.                .|. |||||||||.|||
NYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWE

IYCCDMPFADYSFADMT---------YAVVHQDLRPNIP----------GC--CPPPLANIMRKCWDANPDRRPNMSEVVQLL
|...  |..|| . .|          . |..  ||| ||           |  |||.....| .|||..|. ||...|... |
ILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-Un_u-2.AA TKL-Unique 68-340 30 9.1e-70 238.1 In-house 1-290 (290) Show / Hide 
Range on Protein: 68-340
Range on HMM: 1-290/290
Sequence Identity: 30% (95 aa)

LNDIIAHGTYGVVHRGVYNGQDVAVKLLDWGEEQAMSQALVNTLRSSFQQEVAVWQKLD-HPNVTKFVGACVGSPDLQVASTGGFVRISSNICCVVVEYL
    |  |.||.| .|...| .||.| .   .|      . |...  |  || .. ||. |||.....|.|.   | ||         . . .| |.||.
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NED-----SSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCM---DHQV---------YPPNMCIVMEYC

AGGTLKQFLIQ--------HCRKKLRLKVVIQLALDLSRGLDYLHSKK--IVHRDVKSENMLLDNK-----RRVKIADFGVARVEAQNPKDMTGET----
 ||.|   | |           .|| .......|.| ..|..|||...  | ||| || | |.||.      ..||.||| ... ... |  ..|     
PGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR

-----GTVGYMAPEVLDG--KPYNRKCDVYSFGICLWEIYCCDM------PFADYSFADMTYAVVHQ---DLRPNIPGCCPPPLANIMRKCWDANPDRRP
     |.  .|||||| .  . |..|.|||||||.||||.  .       |. .... .  ...||.    .|| ||  ||. . .....||. .|. ||
NQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQ-EQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRP

NMSEVVQLL
. .|..  |
SFDEIIHRL
Pkinase_Tyr MLK-Un_u-2.AA Pkinase_Tyr 66-340 26 9.8e-68 230.03 Pfam 1-270 (270) Show / Hide 
Range on Protein: 66-340
Range on HMM: 1-270/270
Sequence Identity: 26% (78 aa)

LQLNDIIAHGTYGVVHRGVYN------GQDVAVKLLDWGEEQAMSQALVNTLRSSFQQEVAVWQKL-DHPNVTKFVGACVGSPDLQVASTGGFVRISSN-
....  . .| .|.|..|...      ...|||| |    |.||....   .| .| .|...  .| .|||. ...|.|.              . .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML---KEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCT--------------DQGEPN

ICCVVVEYLAGGTLKQFLIQH--CRKKLRLKVVIQLALDLSRGLDYLHSKKIVHRDVKSENMLLDNKRRVKIADFGVARVE----AQNPKDMTGETGTVG
  ..|.|| ..| |. .| .|   ...| .|  .| ... ..|..||.||...|||.   | |..... |||.||| ||          .  .|    . 
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIK

YMAPEVLDGKPYNRKCDVYSFGICLWEIYC-CDMP-FADYSFADMTYAVVHQDLRPNIPGCCPPPLANIMRKCWDANPDRRPNMSEVVQLL
 ||||..  . .. | ||.|||...|||.  ...| ... | ...  ..  .  |  .|  ||... ..|..||...|..|| .||... |
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
S_TKc MLK-Un_u-2.AA S_TKc 66-343 24 4.6e-67 230.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 66-343
Range on HMM: 1-231/231
Sequence Identity: 24% (72 aa)

LQLNDIIAHGTYGVVHRGVYNG--QDVAVKLLDWGEEQAMSQALVNTLRSSFQQEVAVWQKLDHPNVTKFVGACVGSPDLQVASTGGFVRISSNICCVVV
 .. ..| .|..|.|.... ..  . ||.| ..                 ....|... .| .|||. |. ....                  .  ..| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD-----------------DHLYMVM

EYLAG--GTLKQFLIQHCRKK----LRLKVVIQLALDLSRGLDYLHSKKIVHRDVKSENMLLDNKRRVKIADFGVARVEAQNPKDMTGETGTVGYMAPEV
||. |  |.|.... .. |..    .   ..  ..  . ..|.|.||..|.|||.| || |||.  ..||.|||.||.        |   ||  ||||||
EYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEV

LDGKPYNR-KCDVYSFGICLWEIYCCDMPFADYSFADMTYAVVHQDLRPNIPGCCPPPLANIMRKCWDANPDRRPNMSEVVQ------LLEAI
|   .|.. |||..|.|..|.| .|   ||      .|.. ..            .|.. ...|||.. .|..||   |. |      . . .
L---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK-Un_u-2.AA MLK 160-340 33 1.5e-64 220.74 In-house 86-291 (291) Show / Hide 
Range on Protein: 160-340
Range on HMM: 86-291/291
Sequence Identity: 33% (70 aa)

CVVVEYLAGGTLKQFL--IQ-------HCRK---KLRLKVVIQLALDLSRGLDYLHSKK---IVHRDVKSENMLLDN------KRRVKIADFGVARVEAQ
|.| ||..|| |  .|  ..       |  |      . .... ||. .||..||||..   |.||| || |.|.|.      .. .||.|||..| . .
CIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR-DWH

NPKD-MTGETGTVGYMAPEVL---DGKPYNRKCDVYSFGICLWEIYCCDMPFA-DYSFADMTYAVVHQDLRPNIPGCCPPPLANIMRKCWDANPDRRPNM
. .. |..  ||. .|||||.    . .|..||||.|.|..|||.  . .|.. .|. .   . |..  ||| ||  ||..... | .||...| .||..
QMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSF

SEVVQLL
...|| |
RQIVQHL
TyrKc MLK-Un_u-2.AA TyrKc 66-340 27 1.2e-58 202.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 66-340
Range on HMM: 1-280/280
Sequence Identity: 27% (82 aa)

LQLNDIIAHGTYGVVHRGVYNGQDVAVKLLDWGEEQAMSQALVNTLRSSFQQEVAVWQKL--DHPNVTKFVGACVGSPDLQVASTGGFVRISSNICCVVV
..|.... .| .|.|..|... ..|||| |  .             |  | .|  .  ||  .|||. ...|.|. .          |  ...   ..|.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------F--MYIEPLMIVM

EYLAGGTLKQFLIQHCRKKLRLKVVIQLALDLSRGLDYLHSKKIVHRDVKSENMLLDNKRRVKIADFGVARVEAQN------PKDMT-----GET--GTV
|| ..| ||..|  | .| | .|  .. ... ..| .|||||...|||    | |......|||.||| .|            .  .     |.     .
EYMPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

GYMAPEVLDGKPYNRKCDVYSFGICLWEIY-CCDMPFAD-----YSFADMTYAVVHQDLRPNIPG-------CCPPPLANIMRKCWDANPDRRPNMSEVV
  ||||... . .. | ||.|||.|.|||.  ...|  .      | ...   | . . .|  |        |||. . .||..||...|. ||..||..
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

QLL
...
ECF
Kinase MLK-Un_u-2.AA TK 66-340 15 1.1e-56 188.25 In-house 1-486 (486) Show / Hide 
Range on Protein: 66-340
Range on HMM: 1-486/486
Sequence Identity: 15% (77 aa)

LQLNDIIAHGTYG---VVHRGVYNG---------------------------QDVAVKLLDWGEEQAMSQALVNTLRS--------SFQQEVAVWQ--KL
..| . . .| .|   .|..| ..|                           ..|||| |  | .... . .   ..         .. .| .. .  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPNVTKFVGACVGSPD---LQVASTGGFVRISSNICCVVVEYLAGGT----LKQFLIQHCRK-------------------------------------
.|||. ...|.|. .     .       .| . .  ...|.|| ..|     |...| .. .|                                     
HHPNIVRLYGVCTQGEPKPCFE------VV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSP

-----------------KLRLKVVIQ-------------------LALDLSRGLDYLHSK------KIVHRDVKSENMLLDNKRR-----------VKIA
                  |..|  .|                    ......|. |||||      ..||||.   | |.... .           .|||
CPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA

DFG--------VARVEAQNPKDMTGETGTVGY--------------------------MAPEVLDGKP---------YNRKCDVYSFGICLWEIYC-CDM
|||         ||   ..    . .....|                           ||||.|...          .  | ||.|||...|||.  ...
DFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQE

PFADYSFA---------DMTYAVVHQD--------------LR-PNIPGCCP-------------PPLANIMRKCWDANPDRRPNMSEVVQLL
|.. .            .  .  . .               .| |  |.|..             . .. .|..||...|..||..|.... |
PYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-Un_u-2.AA Dicty4 159-342 37 3.1e-56 186.11 In-house 77-277 (277) Show / Hide 
Range on Protein: 159-342
Range on HMM: 77-277/277
Sequence Identity: 37% (76 aa)

CCVVVEYLAGGTLKQFLIQ-----HCRKKLRLKVVIQ---LALDLSRGLDYLHS--KKIVHRDVKSENMLLDNKRRVKIADFGVAR----VEAQNPKD-M
.| | ||.  |.|   |         ..|| .  ...   .|.|  ||. .||.    |.||| || | | |   |||..||| ..    .| .  || .
MCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDH--KDNQ

TGETGTVGYMAPEVLDGKPYNRKCDVYSFGICLWEIYCCDMPFA--DYSFADMTYAVVHQDLRPNIPGCCPPPLANIMRKCWDANPDRRPNMSEVVQL--
..  ||...|||||. ..||| | ||||||| ||||  .. |..    ..     ||.   ||| ||  |||...  . .||| .| .|| ..|..|   
MTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRI

LEA
||.
LEH
Kinase MLK-Un_u-2.AA Dicty4-Unclassified 66-340 30 2.7e-55 187.83 In-house 1-263 (263) Show / Hide 
Range on Protein: 66-340
Range on HMM: 1-263/263
Sequence Identity: 30% (86 aa)

LQLNDIIAHGTYGVVHRGVYNGQDVAVKLLDWGEEQAMSQALVNTLRSSFQQEVAVWQKLDHPNVTKFVGACVGSPDLQVASTGGFVRISSNICCVVVEY
.|    |  |    ||.|.  | ||||| .  .  ..    . .     |  ||..   . |||  |  |.|.  |           |      |.| | 
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQD-----FKKEVEILGSIQHPNLVKCYGYCI-NP-----------RSHKSTMCIVMEF

LAGGTLKQFLIQH-----CRKKLRLKV--VIQLALDLSRGLDYLHSKKIVHRDVKSENMLLDNKRRVKIADFGVARVEAQNPKDMTGETGTVGYMAPEVL
.  |.|  | . |       . ..|    .|  |.|  .|. .||.. ..|||.|| |.|.|    .||||||..||   .   ||   ||.   .||.|
MHKGNL--FEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRV-IDFNFNMTTIAGTPKWESPECL

DGKPYNRKCDVYSFGICLWEIYCCDMPFADYS-FADMTYAVVHQDLRPNIPGCCPPPLANIMRKCWDANPDRRPNMSEVVQLL
 .  || | ||||... |.|    | |. .     ..   |    ||| ||  |.. .      ||   | .|| | ...| |
MHESYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLK-Un_u-2.AA LISK 71-340 27 8.8e-54 173.02 In-house 1-296 (296) Show / Hide 
Range on Protein: 71-340
Range on HMM: 1-296/296
Sequence Identity: 27% (86 aa)

IIAHGTYGVVHRGVYN--GQDVAVKLLDWGEEQAMSQALVNTLRSSFQQEVAVWQKLDHPNVTKFVGACVGSPDLQVASTGGFVRISSNICCVVVEYLAG
.|  | .| | .| ..  ||..|.| .    . .   ..  .    ...||.. ..|.|||. .|.|.|.                 .     | ||  |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKF----MLREVQMMKNLRHPNIVQFMGVCYH---------------NDGQLHIVTEYING

GTLKQFLIQH--CRKKLRLKVVIQLALDLSRGLDYLHSKKIVHRDVKSENMLLDNK----RRVKIADFGVARVEAQNP----------------------
|.|.|.|       . |  .. . .||| ..|. ||||..|.||| || | |....    .|.|..||| ||.  . .                      
GDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPM

-------------KDMTGETGTVGYMAPEVLDGKPYNRKCDVYSFGICLWEIYCCDMPFADYSFADM--TYAVVHQDLRPNIPGC-CPPPLANIMRKCWD
             . ||   ||   ||||.| |. |...|||.|||| | || .   .  ||   ..   . .  . ... |..  ||||.  .. .| .
KRKIPKKCMNQRKRRMT-ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPPPFLDLCFDCCK

ANPDRRPNMSEVVQLL
 .|. ||. .|.|| |
YDPKNRPSFKEIVQWL
Kinase MLK-Un_u-2.AA Pkinase 66-340 23 2.8e-51 181.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 66-340
Range on HMM: 1-293/293
Sequence Identity: 23% (75 aa)

LQLNDIIAHGTYGVVHRGVYNGQD--VAVKLLDWGEEQAMSQALVNTLRSSFQQEVAVWQKLDHPNVTKFVGACVGSPDLQVASTGGFVRISSNICCVVV
...  .|  |..|.| ...  |    |||| ..   . . |. ... .|    .|... ..|.|||. .. ...                 ...|. .| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK--KRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFED---------------KDHIY-MVM

EYLAGG----TLKQFLIQHCRKKL--RLKVVIQLALDLSRGLDYLHSKKIVHRDVKSENMLLDNKRRV----KIADFGVARV--EAQNPKDMTGETGTVG
||. ||     |. ..  . ....    ....  .. . |||.|.||..|.|||.|.|| |.||.  .    ||.|||.|..  .  |.  ||. .|| .
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPW

YMAPEVLD-GKPYNRKCDVYSFGICLWEIYCCDMPFADY----SFADMTYAVVHQDLRPNIPGCCP-----------------------PPLANIMRKCW
||||||.  |..| .|.|..|.|. |.| .|   || .     . .|. .... ....| ..  .|                       ...  ....|.
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQ-MQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

DANPDRRPNMSEVVQL--L
. .| .||.  ...|   .
CKDPKKRPTAEQILQHPWF
Kinase MLK-Un_u-2.AA Dicty5 162-344 36 3.4e-49 167.46 In-house 77-260 (260) Show / Hide 
Range on Protein: 162-344
Range on HMM: 77-260/260
Sequence Identity: 36% (68 aa)

VVEYLAGGTLKQFLIQHCRK----KLRLKVVIQLALDLSRGLDYLHSKKIVHRDVKSENMLLDNKRRVKIADFGVAR-VEAQNPKDMTGETGTVGYMAPE
| ||   |.|   | .  ||     .     . .|.|  ... .|||. |.|||.|| | |.     .|| |||. | |...  . || . ||  .||.|
VTEYCHNGSLFNYLNDQ-RKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNR--YHMTMHVGTQCWMACE

VLDGKPYNRKCDVYSFGICLWEIYCCDMPFADYSFADMTYAVVHQDLRPNIPGCCPPPLANIMRKCWDANPDRRPNMSEVVQLLEAID
.  |.||  ||||||||| |||.   . |. .    .    |   . || ||  ||   .|.  |||   | .||   |... .| | 
LFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGE-RPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase MLK-Un_u-2.AA TAK1 160-339 31 2.1e-47 158.15 In-house 75-284 (284) Show / Hide 
Range on Protein: 160-339
Range on HMM: 75-284/284
Sequence Identity: 31% (67 aa)

CVVVEYLAGGTLKQFLIQHC-RKKLRLKV--VIQLALDLSRGLDYLHSKK---IVHRDVKSENMLLDNKRRV-KIADFGVARVEAQNPKDMTGETGTVGY
|.| ||. .| |  ||  |  ..|   ..  ..  .. .. |..||||..   ..|||.|  |||| || |. || ||| . .  ..   ||   ||  .
CLVMEYMDCGSLHNFL--HGAKPKWEYTHAHAMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTLKICDFGTF-CDMHQ--MMTCNRGTCRW

MAPEV----------------------LDGKPYNRKCDVYSFGICLWEIYCCDMPFADYSF----ADMTYAVVHQDLRPNIPG--CCPPPLANIMRKCWD
|||||                      . ...|| |||.||.|| .||.   . |. ..        . .|.    ..| .     ||... . | .|||
MAPEVRELFDFKSNRIIINQPTGFQKVFRCEKYNMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFMKCCWD

ANPDRRPNMSEVVQL
 ||. || |.|.|  
DNPEKRPSMQECVKY
Kinase MLK-Un_u-2.AA LRRK 159-342 30 8e-45 155.23 In-house 130-351 (351) Show / Hide 
Range on Protein: 159-342
Range on HMM: 130-351/351
Sequence Identity: 30% (68 aa)

CCVVVEYLAGGTLKQFLIQHCRKK-------LRLKVVIQLALDLSRGLDYLHSKK--IVHRDVKSENMLL---D---------NKRRVKIADFGVAR-VE
.| | ||.  |.| .||  . . .       .   .....||. ..|..||||..  |.||| ||.| ||   .         .   .||||||  |   
LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-

AQNPKD-MTGETGTVGYMAPEVLDG---KPYNRKCDVYSFGICLWEIYCCD-MPFADYSFAD---MTYAVVH---QDLRPNIPGC-CPP-----PLANIM
.  ..    | .|. |.||||.. .   . |. | |.||||. |||..  .  || ...| |   ... .       ||| ||   |||      . . .
QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLI

RKCWDANPDRRPNMSEVVQLLEA
 .||...|..|| .|..|. |. 
QHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-Un_u-2.AA Dicty5 66-136 31 6.5e-12 37.28 In-house 1-66 (260) Show / Hide 
Range on Protein: 66-136
Range on HMM: 1-66/260
Sequence Identity: 31% (23 aa)

LQLNDIIAHGTYGVVHRGVYNGQDVAVKLLDWGEEQAMSQALVNTLRSSFQQEVAVWQKLD--HPNVTKFVGA
  . |.|| |  | |  |.|.| |||.| .  . |  |   ..     .|. ||..    .  |||.... ||
VSFHDWIASGASGRVYNGIYKGMDVAIKVY--SQENCMCFDWN-----EFYREVTIMSIFQSDHPNFIRCYGA
Kinase MLK-Un_u-2.AA Dicty4 66-144 27 4.3e-11 33.42 In-house 1-78 (277) Show / Hide 
Range on Protein: 66-144
Range on HMM: 1-78/277
Sequence Identity: 27% (23 aa)

LQLNDIIAHGTYGVVHRGVYNGQDVAVKLLDWGEEQAMSQALVNTLRSSFQQEVAVWQKLDHPNVTKFVGACV----GSPDLQ
..  ..|  | .| |..|   |..||||.|    . . .  |     ..| .||.   |. |||. .| |||      .....
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENML-----NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMC
Kinase MLK-Un_u-2.AA MLK 66-137 25 5.3e-11 34.54 In-house 1-78 (291) Show / Hide 
Range on Protein: 66-137
Range on HMM: 1-78/291
Sequence Identity: 25% (21 aa)

LQLNDIIAHGTYGVVHRGVYNGQD-----VAVKLLDWGEEQAMSQALVNTLRSSFQQEVAVWQKLDHPN----VTKFVGAC
.|.  .| .|..|.|..|.. ..|     ||||  .   . ..|..   . .  |..|.    .|.|||    . .|.|.|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDT--YCEQWDFEMECRHLRILSHPNNHPCIIQFYGVC
Kinase MLK-Un_u-2.AA LRRK 66-137 18 7.4e-10 31.04 In-house 1-126 (351) Show / Hide 
Range on Protein: 66-137
Range on HMM: 1-126/351
Sequence Identity: 18% (24 aa)

LQLNDIIAHGTYG-VVHRGVYNG----------------------------QDVAVKLLDWG------------------------EEQAMSQALVNTLR
|  .  |  |..| .|.|. ..|                            |.||.| .. .                         |  |.| . ...|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR

--SSFQQEVAVWQKLDHPNVTKFVGAC
  ..|..||..  .|.|||. . .| |
AFREFRHEVWIMSHLNHPNIVSLKGFC
Kinase MLK-Un_u-2.AA TAK1 66-143 25 1.5e-08 24.87 In-house 1-75 (284) Show / Hide 
Range on Protein: 66-143
Range on HMM: 1-75/284
Sequence Identity: 25% (21 aa)

LQLNDIIAHGTYGVVHRGVYNGQDVAVKLLD---WGEEQAMSQALVNTLRSSFQQEVAVWQKLDHPNVTKFVG--ACVGSPDL
 |.   . .|||||| . .. ....|||  .   .  | ..  .        .  |.  | . ||||. |  |  || . ...
IQNEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKN--------IEREIMQWSRVDHPNIIKLYGMYACHRQCQC