Gene MLK-Un_y (S.moellendorffii)

MLK-Un_y

Species: S.moellendorffii
Alias: MLK-Un_y
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MLK-Un_y.AA Protein None 395 None Fasta, JSON
MLK-Un_y.NA RNA None 1188 None Fasta, JSON
MLK-Un_y.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of MLK-Un_y.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank MLK-Un_y.AA Ank 32-64 45 1.5e-09 38.71 Pfam 1-33 (33) Show / Hide 
Range on Protein: 32-64
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

DKRTALHLAASEGHADCVLLLIQHGVDLSPRDR
| .|.||||.. ||...| .|.||| |.  .|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank MLK-Un_y.AA Ank 65-85 47 0.170403 9.65 Pfam 1-21 (33) Show / Hide 
Range on Protein: 65-85
Range on HMM: 1-21/33
Sequence Identity: 47% (10 aa)

WGRTPLADARRYGHMRICKLL
 |.|||  | |.||....|.|
DGFTPLHLACRCGHTEVVKML
Kinase MLK-Un_y.AA TKL 125-381 26 4.9e-81 275.52 In-house 1-364 (364) Show / Hide 
Range on Protein: 125-381
Range on HMM: 1-364/364
Sequence Identity: 26% (99 aa)

IGRGAFGEIRVVKWRG----------TKVAAKTILT--SLLQDK----------------------QVVREFVRELVLLQKLHHPNIVQFLGAVTKQEN-
||.|.|||.   ||||          . || |.. .  . . .|                      .   ....|.... .|.|||||||.|...  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LIIITEYLPKGDLQALLRRKSKGSLGGKQVLHFALDIARGMNFLHEHKP-----EPVIHRDLKPTNILLDDAGH--------------
            | |..|| |.|.|  .|           | ...|||||||||.|| ..|      |.||||||. |||.|. ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

LKVGDFGLSRLVKASGATVDE------------VYKMTGETGSSDRYMAPEVFKHQ----------------SYDKSVDVYSFALIVYEMFEGHVGNRYE
.|..|||||| .. ||   |               |.|.  . . |.|||||.. |                .|....|||||... .|.. . .  . .
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

NPIHAV---------EDRARHGYKPAFT------------AKYPTNMKQLLTRCLDFDAKKRPSFREIIAEL
...  .         . .. .|..|                  |. ||.|...| | |..||||| ||. .|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase MLK-Un_y.AA Pkinase 119-381 24 1.8e-66 231.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 119-381
Range on HMM: 1-293/293
Sequence Identity: 24% (74 aa)

IGNNDPIGRGAFGEIRVVKWRGTK--VAAKTILTSLLQDKQVVREFV-RELVLLQKLHHPNIVQFLGAVTKQENLIIITEYLPKG----DLQALLRRKSK
.    .||.|.||. .  ...||   || |.|  .   ... .. .  .|. ....|.|||||.......   .. ...||...|    || ........
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSL--GGKQVLHFALDIARGMNFLHEHKPEPVIHRDLKPTNILLDDAGHL----KVGDFGLSRLVKASGATVDEVYKMTGETGSSDRYMAPEVFK-HQSY
|..    ... .... |.||....|..    .||||||| |||.|. ||.    |..||||.....           ||. .|.. .|||||| . .| |
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTP-WYMAPEVIRGGQYY

DKSVDVYSFALIVYEMFEGHVGNRYE------NPIHAVEDRARHGYKPAFTAKYP-------------------TNMKQLLTRCLDFDAKKRPSFREIIA
...||..|. .|.|||. |.   . .      .... .. . .  ..  .  ...                    ..|.....||..| ||||....|  
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

E--L
   .
HPWF
Kinase MLK-Un_y.AA MLK 119-381 30 1.5e-65 224.13 In-house 1-291 (291) Show / Hide 
Range on Protein: 119-381
Range on HMM: 1-291/291
Sequence Identity: 30% (91 aa)

IGNNDPIGRGAFGEIRVVKWRGTK-----VAAKTILTSLLQDKQV----VREFVRELVLLQKLHHPN----IVQFLGAVTKQEN-LIIITEYLPKGDLQA
| .   || |.||.    .||..      || | . ..   ||..     ..| .|  .| .| |||    |.||.|. ..... . |..||...| |  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLRR-KSKGS-----------LGGKQVLHFALDIARGMNFLHEHKPEPVIHRDLKPTNILLDD------AGHLKVGDFGLSRLVKASGATVDEVYKMTGE
.|.  .||..               ... .||..||||..||...| |.||||||. |||.|.       |.||. |||.|| .. ....      |.. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN------MMSN

TGSSDRYMAPEVF---KHQSYDKSVDVYSFALIVYEMFEGHVGNR-YENPIHAVEDRARHGYKPAFTAKYPTNMKQLLTRCLDFDAKKRPSFREIIAEL
 |.  ..|||||.   ... |....||.|.... .||. . |  . . .|. .    | .|  |.     |  .|.|...| . |..||||||.|. .|
AGTY-AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK-Un_y.AA TyrKc 119-381 29 4.8e-64 220.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 119-381
Range on HMM: 1-280/280
Sequence Identity: 29% (87 aa)

IGNNDPIGRGAFGEIRVVKWRGTKVAAKTILTSLLQDKQVVREFVRELVLLQKL--HHPNIVQFLGAVTKQ-------ENLIIITEYLPKGDLQALLRRK
|  .. .|.|||||..  .|. ..|| |..  .       ...| ||. .. ||  ||||||...|..|.|       | | |..|| |.|||.  ||..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

SKGSLGGKQVLHFALDIARGMNFLHEHKPEPVIHRDLKPTNILLDDAGHLKVGDFGLSRLVKAS---GATVDEVYKMTGETGSSD-----RYMAPEVFKH
 .  |  |. |.|...||.||..||..   ..|||||   |.|... .. |..|||||| ..     |  . . |... |.....     | ||||....
RPK-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPECINY

QSYDKSVDVYSFALIVYEMFEGHVGNRYE-----NPIHAVEDRARHGYKPAFTAK--------YPTNMKQLLTRCLDFDAKKRPSFREIIAEL
  .    ||.||    .|.|       ..      .   |  . ..|| .   .          |. | |. ..| ..|...||.|.||. ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-Un_y.AA TKL-Unique 119-381 31 2.7e-63 216.62 In-house 1-290 (290) Show / Hide 
Range on Protein: 119-381
Range on HMM: 1-290/290
Sequence Identity: 31% (91 aa)

IGNNDPIGRGAFGEIRVVKWRGTKVAAKTILTSLLQDKQVVREFVRELVLLQKLH-HPNIVQFLGAVT----KQENLIIITEYLPKGDLQALLRR-----
..|   ||.|..|..  .||||..|| |..    .. .....|| .|. .. ||| |||||.. |. .    .. |..|..||.| | |  .| .     
FWNK--IGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KSKGSLGGKQVLHFALDIARGMNFLHEHKPEPVIHRDLKPTNILLDDA-----GHLKVGDFGLSRLVKAS-GATVDEVYKMTGETGS-SDRYMAPEV
   ...  |  .|....|.|||.||..||  .|  .||||||..|.|.| .        |. |||||.. . .   |. |     ..|   | |.|||||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

FKH--QSYDKSVDVYSFALIVYEMFEGHVGNRYENPIHAVEDR------AR--HGYKPAFTAKYPTNMKQLLTRCLDFDAKKRPSFREIIAEL
..     |....|||||. ...|......   |  | .....       .    .| |      | . . |...| . |  .|||| ||| .|
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK-Un_y.AA Dicty4 119-383 34 3e-62 206.44 In-house 1-277 (277) Show / Hide 
Range on Protein: 119-383
Range on HMM: 1-277/277
Sequence Identity: 34% (97 aa)

IGNNDPIGRGAFGEIRVVKWRGTKVAAKTILTSLLQD--KQVVREFVRELVLLQKLHHPNIVQFLGAVT----KQENLIIITEYLPKGDLQALLRR----
|   . ||.|.|||    .|||..|| | .| .. |.       || .|  .. |. ||||..|.|| |    . . . | |||.|||.|  ||.     
INIEQRIGKGSFGEVYKGTWRGKEVAVK-KLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-KSKGSLGGKQVLH---FALDIARGMNFLHEHKPEPVIHRDLKPTNILLDDAGHLKVGDFGLSRLVKASGATVDEVYK-MTGETGSSDRYMAPEVFKHQS
 ... .|    ..     |.|.||||| ||.  |  .||||||. |.| |.    ||.|||||.. |    .. .    ...  |.   .|||||  ||.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMK----KHEDHKDNQMTACGTP-CWMAPEVMMHQP

YDKSVDVYSFALIVYEMFEGHVGNR--YENPIHAVEDRARHGYKPAFTAKYPTNMKQLLTRCLDFDAKKRPSFREIIAE--LED
|. ..|||||... .|.. .       . ..  .|.  .... .|   .  |.. |.|...|.| | ..|||| ||| .  || 
YNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK-Un_y.AA HH498 119-381 30 2.1e-55 173.93 In-house 1-284 (284) Show / Hide 
Range on Protein: 119-381
Range on HMM: 1-284/284
Sequence Identity: 30% (88 aa)

IGNNDPIGRGAFGEIRVVKWRGTKVAAKTILTSLLQDKQV-----VREFVRELVLLQKLHHPNIVQFLGAVTKQE-NLIIITEYLPKGDLQALL------
|     || |.||..  ..||.  || |    .    |       |  |.|| ... .| ||. |||..|    .  . |.|.|   | |  .|      
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIG

----------RRKSKGSLGGKQVLHFALDIARGMNFLHEHKPEPVIHRDLKPTNILLDDAGHLKVGDFGLSRLVKASGATVDEVYKMTGETGSSDRYMAP
           ..    .     .  ..|.|.|||.||.  . |.|||||   |||..  || .| ||| || |.  .   |.   ||   |   |.|||
GAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMH---DD--NMTKQPGNL-RWMAP

EVFK-HQSYDKSVDVYSFALIVYEMFEGHVGNRYENPIHAVEDRARHGYKPAFTAK----YPTNMKQLLTRCLDFDAKKRPSFREIIAEL
|||.  | |.. |||.|.|....||. . |      |. |  . | |   |          |     |. .| .     ||.| .|.. |
EVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase MLK-Un_y.AA Pkinase_Tyr 119-321 31 8.7e-54 182.78 Pfam 1-208 (270) Show / Hide 
Range on Protein: 119-321
Range on HMM: 1-208/270
Sequence Identity: 31% (69 aa)

IGNNDPIGRGAFGEIRVVKWR------GTKVAAKTILTSLLQDKQ-VVREFVRELVLLQKL-HHPNIVQFLGAVT-KQEN--LIIITEYLPKGDLQALLR
|  .  .|.|||||..  .|.      ...|| |..      ..|   ..| ||. .. .| ||||||...|..| ..|   ..|..|| |.|||   ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RK--SKGSLGGKQVLHFALDIARGMNFLHEHKPEPVIHRDLKPTNILLDDAGHLKVGDFGLSRLVKASGATVDEVY-KMTGETGSSDRYMAPEVFKHQSY
..  .|..|  |. |.....||.||..|....    |||||   |.|... .. |..||||.|..     . |. | ...|..    . ||||....  .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI-----YNDDYYYRKRGGGKLPIKWMAPECINYGKF

DKSVDVYSFALIVYEMF
    ||.||    .|.|
TTKSDVWSFGVLMWEIF
Kinase MLK-Un_y.AA S_TKc 119-389 26 1.9e-53 184.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 119-389
Range on HMM: 1-231/231
Sequence Identity: 26% (74 aa)

IGNNDPIGRGAFGEIRVVKWRG--TKVAAKTILTSLLQDKQVVREFVRELVLLQKLHHPNIVQFLGAVTKQENLIIITEYLPK--GDLQALLRRKSKGS-
    ..||.||||. . .....   .|| | |           . . ||. .|.| ||||||.....    ..| ...||..   |||  ..... ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LGGKQVLHFALDIARGMNFLHEHKPEPVIHRDLKPTNILLDDAGHLKVGDFGLSRLVKASGATVDEVYKMTGETGSSDRYMAPEVFKHQSYDK-SVD
   .   .. ...  |.......|.|.   .||||||| |||||.  |.|..||||.|..             |   |. . ||||||.   .|.| ..|
RFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPW-YMAPEVL---GYGKCKCD

VYSFALIVYEMFEGHVGNRYENPIHAVEDRARHGYKPAFTAKYPTNMKQLLTRCLDFDAKKRPSFREIIA-ELEDMERSQK
..|.  |.|||. |    .    .... .. .           .  .|... .||..| .|||.  |. . |.. .     
WWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK-Un_y.AA TK 119-381 16 4.4e-53 175.89 In-house 1-486 (486) Show / Hide 
Range on Protein: 119-381
Range on HMM: 1-486/486
Sequence Identity: 16% (79 aa)

IGNNDPIGRGAFG---EIRVVKWRG---------------------------TKVAAKTILTSLLQDKQVVRE--------------FVRELVLLQ--KL
|   . .|.|.||   |..  .|||                           |.|| |..     ....  ..              ...|. ...  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHPNIVQFLGAVTKQEN------------LIIITEYLPKGD----LQALLRRKSKG--------------------------------------------
||||||...|..|..|.            ..|..|| |.||    |.  ||.....                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------SLGGKQVLH-------------------FALDIARGMNFLHEHKPEPV----IHRDLKPTNILLDDAGH-----------LKVGDFGLSR
          .|. |. |.                   ....||.|| .||... |      .||||   |.|... ..            |..||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LVKASGAT----------------------VDEVYKMTGETGSSDRYMAPEVFKHQS---------YDKSVDVYSFALIVYEMFE-GHVGNRYEN
     | .. .                         .. |...  .    |.||||.....          .    ||.||   ..|.|  | .    . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PI---------HAVEDRARHG--------------YKPAF-TAKYP-------------TNMKQLLTRCLDFDAKKRPSFREIIAEL
.          . | .. | |              . ..      .             . . .|...| ..|...||.|...  .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-Un_y.AA LISK 124-313 31 1.4e-48 155.86 In-house 1-225 (296) Show / Hide 
Range on Protein: 124-313
Range on HMM: 1-225/296
Sequence Identity: 31% (72 aa)

PIGRGAFGEIRVVKWR--GTKVAAKTILT--SLLQDKQVVREFVRELVLLQKLHHPNIVQFLGAVTK-QENLIIITEYLPKGDLQALLRRKS--KGSLGG
 ||.|.||..  . .|  |. .| | | .    . |.   . . ||. ....| ||||||| |.  . .  | |.|||   |||. .|....  |  |  
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

KQVLHFALDIARGMNFLHEHKPEPVIHRDLKPTNILLDDA----GHLKVGDFGLSRLVKASG---------------ATVDEVYKMTGETG-----S---
.| ...|||||.|| .||. .   .|||||| .|.|...        ||.|||. |..  .                .  | ..| ..            
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

----SDRYMAPEVFKHQSYDKSVDVYSF
    ..  ||||. . |||| |.||.||
TICGTPYWMAPEMLLGQSYDESCDVFSF
Kinase MLK-Un_y.AA STE 120-376 19 5.2e-48 165.82 In-house 1-350 (359) Show / Hide 
Range on Protein: 120-376
Range on HMM: 1-350/359
Sequence Identity: 19% (72 aa)

GNN-DPIGRGAFGEIRVVKWR-----------------GTKVAAKTILTSL------------LQDK--QVVREFVRELVLLQKLH--HPNIVQFLGAVT
  . . ||.||||.    . .                 |. .| | .  .             |..|  . . .. .|. ...|..  |||||...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KQ-------ENLIIITEYLPKGDLQALLRRKSKGSLG------------GKQVLHFALDIARG-MNFLHEHKPEPVIHRDLKPTNILLDDAGHLKVGDFG
|        ..| |. ||.. | |  ....| .   .             .|. ... .| .| ...||.|.   .||||.|| ||||      |  |||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LSRLVKASGA------------TVD-EVYKMTGETGSSDRYMAPEVFKH------QSYDKSVDVYSFALIVYEMFEGHVGNRYENPI---------HAVE
..  .  |.|            | . . . ..|       .||||| .       . || ..|..|. . . || .|..    ..|          ....
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-----WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

D---------RARHGYKPAFT---------------AKYPTNMKQLLTRCLDFDAKKRPSFRE
.               .. .                 |.  ..|. . .||. | .|||.  .
QQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase MLK-Un_y.AA CZAK 125-320 36 1.3e-44 154.49 In-house 7-215 (279) Show / Hide 
Range on Protein: 125-320
Range on HMM: 7-215/279
Sequence Identity: 36% (79 aa)

IGRGAFGEIRVVKWRGTKVAAKTILTSLLQDKQV---VREFVRELVLLQKLHHPNIVQFLGAVTKQE--NLIIITEYLPKGDLQALLRRKSKGSLG-GKQ
||.| |||..   |||. || | |      .|        | .|   . || |||.|||||| .        |..|.   | |  ||  ..   .     
IGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHL

VLHFALDIARGMNFLHE-HKPEPVIHRDLKPTNILLDDAGH-------------LKVGDFGLSRLVKASGATVDEVYKMTGETGSSDRYMAPEVFKHQSY
 .  |.|||||||.||   || |..||||   |||||.                 |. ||||||. .  .        ||   |.   .||||.||  .|
QWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPF------EMTQTMGCL-CWMAPECFKGENY

DKSVDVYSFALIVYEM
   ||||||..|....
TEKVDVYSFGMILWCI
Kinase MLK-Un_y.AA TK-Unique 119-321 30 6.8e-44 149.26 In-house 1-233 (294) Show / Hide 
Range on Protein: 119-321
Range on HMM: 1-233/294
Sequence Identity: 30% (74 aa)

IGNNDPIGRGAFGEIRVVKWRGTK---VAAKTILTSLLQ---DKQVVREFVRELVLLQKLH-HPNIVQFLGAVTKQ-ENLIIITEYLPKGDLQALLRRKS
. ..| ||.||||..   . .|..    . | ... .|.   ... ...| .|. ....|  ||||||.||. ||  |.  || ||.|.|.|| .||.. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

KG------------------------SLGGKQVLHFALDIARGMNFLHE--HKPEPVIHRDLKPTNILLDDAGHLKVGDFGLSRLVKASGATVDEVYKMT
..                        ..  |...||| .||.||..|..  .|   ..||||   |.|| . . .|..|||..| | .     ..|| |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK---IVHRDLCARNVLLTEDKVCKICDFGMARDVYT-----NGVYSMM

-GETGSSDRYMAPEVFK--HQSY-DKSVDVYSFALIVYEMF
 ..   . |.||||..|  |. |     ||.||. . .|.|
CSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIF
Kinase MLK-Un_y.AA Pkinase_Tyr 353-381 34 4.4e-07 24.6 Pfam 242-270 (270) Show / Hide 
Range on Protein: 353-381
Range on HMM: 242-270/270
Sequence Identity: 34% (10 aa)

PTNMKQLLTRCLDFDAKKRPSFREIIAEL
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PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK-Un_y.AA TK-Unique 341-381 30 1e-05 15.88 In-house 253-294 (294) Show / Hide 
Range on Protein: 341-381
Range on HMM: 253-294/294
Sequence Identity: 30% (13 aa)

RHGYKPAFTAKY-PTNMKQLLTRCLDFDAKKRPSFREIIAEL
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RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MLK-Un_y.AA LISK 358-381 45 0.000258 9.7 In-house 273-296 (296) Show / Hide 
Range on Protein: 358-381
Range on HMM: 273-296/296
Sequence Identity: 45% (11 aa)

QLLTRCLDFDAKKRPSFREIIAEL
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DLCFDCCKYDPKNRPSFKEIVQWL
Kinase MLK-Un_y.AA CZAK 355-381 33 0.000834 9.88 In-house 253-279 (279) Show / Hide 
Range on Protein: 355-381
Range on HMM: 253-279/279
Sequence Identity: 33% (9 aa)

NMKQLLTRCLDFDAKKRPSFREIIAEL
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NLGELIEMCWNKNPDERPSFKQILQHL