Gene MLK-p1_f-1 (S.moellendorffii)

MLK-p1_f-1

Species: S.moellendorffii
Alias: MLK-p1_f-1
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-plant1

Sequence

Name Sequence Type Origin Length Description Download
MLK-p1_f-1.AA Protein None 467 None Fasta, JSON
MLK-p1_f-1.NA RNA None 1404 None Fasta, JSON
MLK-p1_f-1.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of MLK-p1_f-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-p1_f-1.AA Dicty4 191-443 46 5.3e-123 411.96 In-house 1-277 (277) Show / Hide 
Range on Protein: 191-443
Range on HMM: 1-277/277
Sequence Identity: 46% (130 aa)

LTIRELIGQGSCGSVYRGMWCGSDVAVKVF--SERGFSPALLDDFRKEVAIMRKVRHPNVLLFMGAVA----TPDNLCIVTEFLPRGSLFRLLHR-----
..| ..||.||.|.||.| | |..||||..     .|. ..| .|||||.|| | ||||..|||||      .|  .|||||..|.|.|..|||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-KTPGLD--LRRR-LRMALDIARGMNYLHHCKPPIVHRDLKSSNLLVDKDWTV--GDFGLSR-LKHATLLTT--KSGRGTPQWMAPEVLRNEPSDERADV
 .   ||  |..| .|||.|.|||||.|| | | |.||||||.||||||.|.|  .|||||.  |  . ...  ..  ||| ||||||....| .| |||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSFGVIVWELATEQVPWD--GMNPMQVVGAVGFMNQRLTIPPNTDPGLTALMEQCWQSDPKARPSFEEIIAK--IRE
|||| . ||..| | |    .|..||.| ||.    |. ||....| ...|.. ||  ||. |||||||| .    .
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK-p1_f-1.AA DRK 191-443 43 2e-107 363.21 In-house 1-258 (258) Show / Hide 
Range on Protein: 191-443
Range on HMM: 1-258/258
Sequence Identity: 43% (111 aa)

LTIRELIGQGSCGSVYRGMWCGSDVAVKVFSERGFS-PALLDDFRKEVAIMRKVRHPNVLLFMGAVATPDNLCIVTEFLPRGSLFRLLHRKTPGLDLRRR
  |   || |..| |.|| | |. ||||           .| .|..|. .| . ||||. .|||.   |   ||..|..||||| . ||     .|  ..
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

LRMALDIARGMNYLHHCKPPIVHRDLKSSNLLVDKDWTV--GDFGLSR--LKHATLLTTKSGRGTPQWMAPEVLRNEPSDERADVYSFGVIVWELATEQV
..|..|.|.||.||| | | |.|||||| |||||  | |   |||||    ||    ...   ||| | |||||||..  | ||||||... ||..| | 
KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQD

PWDGMNPMQVVGAVGFMNQRLTIPPNTDPGLTALMEQCWQSDPKARPSFEEIIAKIRE
|  ||...||| .||    |. .|..  |  ..||  ||  ||  |||..|..  .  
PYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase MLK-p1_f-1.AA TKL 197-441 30 6.5e-106 358.17 In-house 1-364 (364) Show / Hide 
Range on Protein: 197-441
Range on HMM: 1-364/364
Sequence Identity: 30% (114 aa)

IGQGSCGSVYRGMWCG----------SDVAVKVFSERGFSPALL-------------------------DDFRKEVAIMRKVRHPNVLLFMGAVATPDN-
||.|. | ||.| | |           |||||.|...  .   .                         . ...|. .|.. ||||...|||..  |.. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCIVTEFLPRGSLFRLLHRKTPGLDLRRRLRMALDIARGMNYLHHCK------PPIVHRDLKSSNLLVDKDWT---------------
            ||||.|. |.|||. .||       . .|.|.|||||||||||| ..      |||.||||||.|.|||..||               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

-VGDFGLSRLKHATLL-------------------TTKSGRGTPQWMAPEVLRNE----------------PSDERADVYSFGVIVWELATEQVPWDGMN
 ..|||||| .. .                     || . .|||.||||||||..                . .|..||||||.. ||..| ..|.....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

PMQVV---------GAVGFMNQRLTIP------------PNTDPGLTALMEQCWQSDPKARPSFEEIIAKI
.|...           |.  ..|..||            |...|..  ||..||..||..||||.||. ..
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-p1_f-1.AA TKL-Unique 193-441 38 8.4e-104 351.16 In-house 1-290 (290) Show / Hide 
Range on Protein: 193-441
Range on HMM: 1-290/290
Sequence Identity: 38% (113 aa)

IRELIGQGSCGSVYRGMWCGSDVAVKVFS-ERGFSPALLDDFRKEVAIMRKVR-HPNVLLFMGAVA----TPDNLCIVTEFLPRGSLFRLLH--------
. ..||.|..|.||.|.| |..||.|.|. . ..|. ....|..|| .| | . |||....||. .    .| |.|||.|..|.|||  .||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-RKTPGLDLRRRLRMALDIARGMNYLHHCKPPIVHRDLKSSNLLVDKD-----WTV--GDFGLSRLKHATLLTTKSGR---------GTPQWMAPEVLRN
 ..   |.. .|..||.|||.||.|||||.||| ||||||||.||| .     | .   |||||...   . .|...          |...||||||||.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--EPSDERADVYSFGVIVWELATEQV------PWDGMNPMQVVGAVGF--MNQRLTIPPNTDPGLTALMEQCWQSDPKARPSFEEIIAKI
  .  .| .||||||...||.|| ..      | .||.. |.  .| .   |.|..||..  . .. |..||| .||  ||||.||| ..
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK-p1_f-1.AA MLK 191-441 35 4.6e-90 305.51 In-house 1-291 (291) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-291/291
Sequence Identity: 35% (103 aa)

LTIRELIGQGSCGSVYRGMWCGSD-----VAVKVFSERGFSPAL----LDDFRKEVAIMRKVRHPN----VLLFMGAVATPDN-LCIVTEFLPRGSLFRL
... | || || |.|..| | . |     |||| .  | |. .      .||..|. . |...|||    .  |.|. . | . .|||.|... |||...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHRKTP-------------GLDLRRRLRMALDIARGMNYLHHCKP-PIVHRDLKSSNLLVD--------KDWTVGDFGLSRLKHATLLTTKSG-RGTPQW
|| ...               |.   .. ||..||||.|||  .| ||.||||||.|.|.|        ..  . |||.|| .| .  |.. . .||. |
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

MAPEVL---RNEPSDERADVYSFGVIVWELATEQVPWD-GMNPMQVVGAVGFMNQRLTIPPNTDPGLTALMEQCWQSDPKARPSFEEIIAKI
|||||.   |.|. .| .||.|.||. ||. | .|| . ...||..   |.  ..|..||.. ....  ||.|||..||. |||| .|. . 
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK-p1_f-1.AA Shk 191-446 42 7.7e-86 291.49 In-house 1-269 (269) Show / Hide 
Range on Protein: 191-446
Range on HMM: 1-269/269
Sequence Identity: 42% (115 aa)

LTIRELIGQGSCGSVYRGMWCGSDVAVKVFSERGFSPALLDDFRKEVAIMRKVRHPNVLLFMGAVA-TPDNLCIVTEFLPRGSLFRLLHRKTPGLD--LR
 .  ...|||| |.|| |   | .|||||     |. . . .|||||.|| |..|||..|||||   .|  . ||||  |.|.|  ||| .   ..  | 
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY

RR-LRMALDIARGMNYLHHCKPPIVHRDLKSSNLLVDKDWTV--GDFGLSR-LKHATLLTT--KSGRGTPQWMAPEVLRNEPSDERADVYSFGVIVWELA
.| .||..| | ||| ||   . |.|||||..|||||..|.|  .|||.|   |  . |    |.  ||| ||||||. | | .| ||||||| | ||..
KRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEIL

TEQVPWD--GMNPMQVVGAVGFMNQRLTIPPNTDPGLTALMEQCWQSDPKARPSFEEIIAK--IRELLA
| | |      .  . . |.     |  ||  . . |  | . ||  .|. ||||.||| .    . | 
TCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase MLK-p1_f-1.AA LRRK 191-443 28 7.1e-74 251.74 In-house 1-351 (351) Show / Hide 
Range on Protein: 191-443
Range on HMM: 1-351/351
Sequence Identity: 28% (102 aa)

LTIRELIGQGSCG-SVYRGMWCG----------------------------SDVAVKVFSERG--------------------------------FSPAL
| | |.||.|. | .|||. | |                            ..||.|..   .                                ...  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LDDFRKEVAIMRKVRHPNVLLFMGAVATPDNLCIVTEFLPRGSLFRLLH--RKTP------GLDLRRRLRMALDIARGMNYLHHCKPPIVHRDLKSSNLL
.  ||.||.||.. .|||..  .|    |  ||.|.|..| |.| ..||  ....       ..   .|. ||.||.||.||| ..|||.|||||| | |
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

VDKDW--------------TVGDFGLSRLKHATLLT--TKSGRGTPQWMAPEVLR---NEPSDERADVYSFGVIVWELATEQ-VPWDGMN-P-----MQV
. .                ...|||.||.  .....  .|   |.|.|||||..|   .|  .| .|.||||.| ||| | |  | |... .     |  
LWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQ

VGAVGFMNQRLTIPPN-TDP-----GLTALMEQCWQSDPKARPSFEEIIAKIRE
.       .| |||..   |      . .|...||| ||| ||.|..|. .. .
IEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-p1_f-1.AA Dicty4-Unclassified 191-441 35 1.1e-72 247.73 In-house 1-263 (263) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-263/263
Sequence Identity: 35% (94 aa)

LTIRELIGQGSCGSVYRGMWCGSDVAVKVFSERGFSPA--LLDDFRKEVAIMRKVRHPNVLLFMGAVATP----DNLCIVTEFLPRGSLFRLLH----RK
. |   ||.|    |..| | | ||||| | |  |.    ...||.|||.|.  . ||| .   |.   |      .|||.||...| || . |     .
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

TPGLDLRR--RLRMALDIARGMNYLHHCKPPIVHRDLKSSNLLVDKDWT--VGDFGLSRLKHATLLTTKSGRGTPQWMAPEVLRNEPSDERADVYSFGVI
   . |     ...|.|||.|| .||     ..|||.||||.|.||.    ..|||.||    .   |  . ||| | .||.|. |    ..||||....
QQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIA-GTPKWESPECLMHESYNQKSDVYSYAMM

VWELATEQVPWDGMN-PMQVVGAVGFMNQRLTIPPNTDPGLTALMEQCWQSDPKARPSFEEIIAKI
 .||||   |. .   .| .   |     |  || | |. .  |   ||  ||. ||....|| . 
LYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLK-p1_f-1.AA Pkinase_Tyr 191-441 31 4.3e-69 234.61 Pfam 1-270 (270) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-270/270
Sequence Identity: 31% (85 aa)

LTIRELIGQGSCGSVYRGMWC------GSDVAVKVFSERGFSPAL--LDDFRKEVAIMRKV-RHPNVLLFMGAVA-TPDN--LCIVTEFLPRGSLFRLLH
.|. . .|.|. |.||.| |       . .||||.    | ..    ..|| .|..||..  .|||.. ..|..    .   ..||.|. | |.|   |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RK---TPGLDLRRRLRMALDIARGMNYLHHCKPPIVHRDLKSSNLLVDKDWTV--GDFGLSRLK--HATL-LTTKSGRGTPQWMAPEVLRNEPSDERADV
..    . |.. . | |...||.||.||.  .  ..||||   | ||... .|  .||||.|.     .   ....|.    |||||....    .  ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVIVWELAT-EQVP-WDGMNPMQVVGAVGFMNQRLTIPPNTDPGLTALMEQCWQSDPKARPSFEEIIAKI
.||||  ||. |  . | . || . .|. ...  ..|. .|.|. . .  || |||. ||. ||.|.||. ..
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK-p1_f-1.AA CZAK 191-441 37 5.8e-68 232.11 In-house 1-279 (279) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-279/279
Sequence Identity: 37% (106 aa)

LTIRELIGQGSCGSVYRGMWCGSDVAVKVFSERGFSPALL----DDFRKEVAIMRKVRHPNVLLFMGA--VATPDNLCIVTEFLPRGSLFRLLHRKTPGL
|..   ||||  | ||.. | | |||.|      |           | |||.|| | .|||.. |.||     |.  |||.|.   ||| |||  .   .
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

DL--RRRLRMALDIARGMNYLHH-CKP-PIVHRDLKSSNLLVDKDWT---------------VGDFGLSRLKHATLLTTKSGRGTPQWMAPEVLRNEPSD
      .. ||.||||||||||   || ||.|||| |.| | |   |               . ||||||..        .  |   |||||.   |   
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYT

ERADVYSFGVIVWELATEQVPWDGMNPMQVVGAVGFMNQRLTIPPNTDPGLT---ALMEQCWQSDPKARPSFEEIIAKI
| .|||||| |.|.. |   |  .| ||       . | |. .|  .||       |.|.|| . |  |||| .|.   
EKVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase MLK-p1_f-1.AA Pkinase 191-441 24 5.2e-67 233.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

LTIRELIGQGSCGSVYRGMWCGSD--VAVKVFSERGFSPALLDDFRK--EVAIMRKVRHPNVLLFMGAVATPDNLCIVTEFLPRG----SLFRLLH-RKT
..| . ||.|| |.||.... |.   ||||... |. ..  .   |.  |..||....|||.. . ... ..|....|.|... |    .||.... .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PGL--DLRRRLRMALDIARGMNYLHHCKPPIVHRDLKSSNLLVDKDWTV------GDFGLSRLK-HATLLTTKSGRGTPQWMAPEVLR-NEPSDERADVY
 ..  . .   .... |.||..|.| .   |.|||||..|.|.|.. ..      .||||.... .     ...  ||| .|||||.| ... . ..|..
GCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVIVWELATEQVPWDGM------NPMQVVGAVGFMNQRLTIP-------------------PNTDPGLTALMEQCWQSDPKARPSFEEIIAK--I
|.|.|..|... . |..|       ..||..  ..    .  .|                   .|... .  ... |.. ||| ||..|.|     .
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLK-p1_f-1.AA TK 191-441 18 1.1e-63 212.08 In-house 1-486 (486) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-486/486
Sequence Identity: 18% (90 aa)

LTIRELIGQGSCG---SVYRGMWCG---------------------------SDVAVKVFSER-GFSPALLDD--------------FRKEVAIMR--KV
.|. . .|.|  |    ||.|.| |                            .||||.  |  . |..   |              .  | ..|.  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNVLLFMGAVATPDN------------LCIVTEFLPRGS----LFRLLHRKTPG--------------------------------------------
.|||.. . |..  ...            ..||.|. | |.    |   |... |.                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDLRRRLRMALDIARGMNYLHHCKP----PIVHRDLKSSNLLVDKDWT-------------VGDFGLSR
                               |.....| |...||.|| ||| ..      .|||||   | ||... .             ..||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

LK---HATLL------TTKSGRGTPQ-------------------------WMAPEVLR---------NEPSDERADVYSFGVIVWELAT--EQVPWDGM
 .   .|  .      ..||..||.                          |||||.|.         .    .  ||.|||| .||. |  .. .  ||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NP---------MQVVGAVGFM-----------NQRLTIP--PNTD--------------PGLTALMEQCWQSDPKARPSFEEIIAKI
.           .|.  .               .|.  |  |.                . .  || |||. ||. ||.|...  ..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-p1_f-1.AA TyrKc 191-441 31 9.4e-61 209.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 191-441
Range on HMM: 1-280/280
Sequence Identity: 31% (91 aa)

LTIRELIGQGSCGSVYRGMWCGSDVAVKVFSERGFSPALLDDFRKEVAIMRKV--RHPNVLLFMGAVATP-------DNLCIVTEFLPRGSLFRLLHRKT
.|  . .| |  | ||.|.|   .||||.  |       . ||..|  ||.|.  .|||.. . |.. ..       . |.||.|. | |.|   |... 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

PGLDLRRRLRMALDIARGMNYLHHCKPPIVHRDLKSSNLLVDKD--WTVGDFGLSRLKHAT-------LLTTK----SGR--GTPQWMAPEVLRNEPSDE
| | ..  | ....||.||.|||.   ...||||   | ||...    ..||||||  .            .|    .|.      |||||...     .
PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

RADVYSFGVIVWELATE-QVPWDG-----MNPMQVVGAVGFMNQRLTIPPN--------TDPGLTALMEQCWQSDPKARPSFEEIIAKI
  ||.||||  ||. |  | |. |     |.. .|.  |     |. .|||          . .  .|.|||. ||. ||.|.||. ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-p1_f-1.AA S_TKc 191-445 24 1.1e-59 205.57 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-445
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

LTIRELIGQGSCGSVYRGMWCG--SDVAVKVFSERGFSPALLDDFRKEVAIMRKVRHPNVLLFMGAVATPDNLCIVTEFLPR--GSLFRLLHRKTPG---
 .| ..||.|. |.||.. . .    ||.|. .         ...|.|..|..| .|||.  . ..  . |.|..|.|...   |.||...... ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDLRRRLRMALDIARGMNYLHHCKPPIVHRDLKSSNLLVDKDWTV--GDFGLSRLKHATLLTTKSGRGTPQWMAPEVLRNEPSDE-RADVYSFGVIVW
  ..  .  ...  |.....|.|     |.||||| .|.|.|.  ..  .||||.|.        ..  ||| .||||||   . .  ..|..|.|.|..
FPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELATEQVPWDGMNPMQVVGAVGFMNQRLTIPPNTDPGLTALMEQCWQSDPKARPSFEEIIA-----KIRELL
|... . |..  .....   .|            .| .  ....|.| ||. ||.  |. .     |. . .
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF