Gene MLK-p1_i (S.moellendorffii)

MLK-p1_i

Species: S.moellendorffii
Alias: MLK-p1_i
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK-plant1

Sequence

Name Sequence Type Origin Length Description Download
MLK-p1_i.AA Protein None 776 None Fasta, JSON
MLK-p1_i.NA RNA None 2331 None Fasta, JSON
MLK-p1_i.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of MLK-p1_i.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLK-p1_i.AA Dicty4 510-766 45 4e-116 388.7 In-house 1-277 (277) Show / Hide 
Range on Protein: 510-766
Range on HMM: 1-277/277
Sequence Identity: 45% (125 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKIL--LDQDATQELLSELTREIVILRRLRHPNIVLFMGAVT----KSPHLSIVTEYLPRGALFRLLHT----P
..  .|.|.||||.|... | |..||||.|  . |.. ...|.|. .|. |.  .|||||.||||| |    ... ..|||||.|.| |..|||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

KAREILDEKRRLR---MALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSR-FKSKTFLSS--QTGAGTPEWMAPEVLRDEPSKEKSDV
. .  ||  ...|   ||.|.|||.|.|| . | |.|||||| |||||| ..|||||||||. .|  . ..    | .||| ||||||.. .|  ||.||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSFGVVLWELVTLQKPWT--GLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDA--LKK
|||| ||||..| | |    .   ||.|.||.  . |. ||... |. ..||. || .||. ||||. || .  |  
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK-p1_i.AA DRK 510-766 43 1.3e-103 350.51 In-house 1-258 (258) Show / Hide 
Range on Protein: 510-766
Range on HMM: 1-258/258
Sequence Identity: 43% (113 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKILLDQDAT-QELLSELTREIVILRRLRHPNIVLFMGAVTKSPHLSIVTEYLPRGALFRLLHTPKAREILDEK
 .   | | |..| | .  | || |||| |        ..|.|. ||| .. .||||||..|||. . .|   |..||.||| | . || ..    .|  
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIE--MDWP

RRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSR----FKSKTFLSSQTGAGTPEWMAPEVLRDEPSKEKSDVYSFGVVLWELV
....|..|.|.|..||| . | |.|||||| |||||    ||| |||||      |...|    |  ||| | ||||||...  || |||||..||||.|
LMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKF--AMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV

TLQKPWTGLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDALKK
| | |  |   .||| .|   | |. .| .. ||  .|.  ||  ||  |||.  ..  |  
TRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase MLK-p1_i.AA TKL 516-764 31 2.4e-102 346.29 In-house 1-364 (364) Show / Hide 
Range on Protein: 516-764
Range on HMM: 1-364/364
Sequence Identity: 31% (117 aa)

LGGGSFGTVHLADWQG----------TDVAVKILLDQD-------------------------ATQELLSELTREIVILRRLRHPNIVLFMGAVTKSPH-
.| |.||.|. . |.|          .|||||..  ..                          .. .  .. .||....||||||||.|||... .|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LSIVTEYLPRGALFRLLHTPKAREILDEKRRLRMALDVARGVNYLHRSK------PAIVHRDLKSPNLLVDKYLT-------------
            | ||.|| |.| |. .||           .|.|.|||.|||.|||| ..      |.|.||||||.|.|||. .|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VKVCDFGLSRFKSKTFLSSQTG-------------------AGTPEWMAPEVLRDE----------------PSKEKSDVYSFGVVLWELVTLQKPWTG
 .|.||||||||.|... .. |.                    ||| ||||||||..                .  ||.||||||.||||..| ..|. .
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

LTAMQVV---------AAVAFNGRRLQIP------------SNVNPKMRALIESCWANDPELRPSFASIIDAL
.  |...         . |. .|.|. ||            ... | |. |.. ||. ||| ||||  |.. |
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK-p1_i.AA MLK 510-764 36 3.7e-96 325.77 In-house 1-291 (291) Show / Hide 
Range on Protein: 510-764
Range on HMM: 1-291/291
Sequence Identity: 36% (106 aa)

LVLKERLGGGSFGTVHLADWQGTD-----VAVKILL----DQDATQELLSELTREIVILRRLRHPN----IVLFMGAVTKSPH-LSIVTEYLPRGALFRL
. ..| .| |||| |... |...|     ||||.      |   | .   .. .|. .||.|.|||    |. |.|. ...|. . ||.||.. | |...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHT-PKARE----------ILDEKRRLRMALDVARGVNYLHRSKP-AIVHRDLKSPNLLVD------KYLTVKVCDFGLSRFKSKTFLSSQTG-AGTPEW
||. ..  .          . |    .. ||..|||..|||  .| .|.||||||.|.|.|      ...|.|.||||.||.....  .  .. |||. |
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

MAPEVL---RDEPSKEKSDVYSFGVVLWELVTLQKPWT-GLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDAL
|||||.   | |.  ||.||.|.||||||..| . |   .. .|.. . || || |. |||. .. .  |.. ||  ||. ||||..|.  |
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK-p1_i.AA TKL-Unique 512-764 37 1e-88 301.04 In-house 1-290 (290) Show / Hide 
Range on Protein: 512-764
Range on HMM: 1-290/290
Sequence Identity: 37% (109 aa)

LKERLGGGSFGTVHLADWQGTDVAVKILL-DQDATQELLSELTREIVILRRLR-HPNIVLFMGAVT----KSPHLSIVTEYLPRGALFRLLHT-------
  . .|.|..|.|  . | |..||.|..    |   |.. |. .|. .. .|. |||||..||. .    . |...||.||.|.| |  .||.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-PKAREILDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKY-----LTVKVCDFGLSRFKSKT---FLS------SQTGAGTPEWMAPEVLR
 ..  . |. ..|..||.|.|.| .|||...| | ||||||.|.|||       . .|.||||||.|.||    ...       ||  |.. ||||||||
NNNNCK-LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

D--EPSKEKSDVYSFGVVLWELVTLQK------PWTGLTAMQVVAAVAF--NGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDAL
.  .   |||||||||.||||..| .       |  |..  |. ..|..   . |. ||.. ..  | ||. ||. ||. |||| .||  |
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK-p1_i.AA LRRK 510-766 27 5.5e-79 268.73 In-house 1-351 (351) Show / Hide 
Range on Protein: 510-766
Range on HMM: 1-351/351
Sequence Identity: 27% (99 aa)

LVLKERLGGGSFG-TVHLADWQG----------------------------TDVAVKILLDQ---------DATQ-----------------------EL
|.  | .| |.|| .|. |.|.|                            ..||.|...           . .                        . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LSELTREIVILRRLRHPNIVLFMGAVTKSPHLSIVTEYLPRGALFRLLHTPKAREI------LDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLL
..|. .|..|...|.|||||  .|   .  .| .|.||.| |.| ..|| .|  ..      ..   .|. ||..|.|..|||...| |.|||||||| |
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

V---D---------KYLTVKVCDFGLSR-FKSKTFLS--SQTGAGTPEWMAPEVLRDE---PSKEKSDVYSFGVVLWELVTLQ-KPWTGLT-A-----MQ
.   .            ..|..|||.|| |  ..|..    .  |.| |||||..|..      ||.|.||||..||||.|.|  |  ...       | 
LWSSPQNHSPNYPNAHVCAKIADFGISRMF--QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME

VVAAVAFNGRRLQIPSN-VNP-----KMRALIESCWANDPELRPSFASIIDALKK
 .     .|.|  ||..  .|      . .||..||..||. ||.| .|.. |. 
QIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK-p1_i.AA Pkinase_Tyr 510-764 33 1.2e-74 253.43 Pfam 1-270 (270) Show / Hide 
Range on Protein: 510-764
Range on HMM: 1-270/270
Sequence Identity: 33% (92 aa)

LVLKERLGGGSFGTVHLADWQ------GTDVAVKILLDQDATQEL--LSELTREIVILRRL-RHPNIVLFMGAVT-KSPH--LSIVTEYLPRGALFRLLH
... . || |.||.|... |       ...||||.|  ..|..|   . .. ||. |.. | .||||| ..|..| .. .  . ||.|| | | |   |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

TP-KAREILDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSRFK-SKTFL-SSQTGAGTP-EWMAPEVLRDEPSKEKSDV
..   .. |. |. | |....|.| .||.. .  ..||||   | ||.. ..||.|||||.|   ..     ...|.  |  |||||....    .||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVVLWELVTL-QKP-WTGLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDAL
.||||..||..|. ..| . |..  .|..... .|.|. .| |  ...  |. .||. ||| ||.|. |.  |
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK-p1_i.AA Shk 510-764 41 7.3e-74 251.69 In-house 1-264 (269) Show / Hide 
Range on Protein: 510-764
Range on HMM: 1-264/269
Sequence Identity: 41% (110 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKILLDQDATQELLSELTREIVILRRLRHPNIVLFMGAVT-KSPHLSIVTEYLPRGALFRLLHTPKAREILDE-
 .  . ||.||||.|  .   | .||||... |   .  ...   |  |  ...||||.||||| | ..  ..||||  |.| |  |||   . ..  . 
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLH---DQMVKKPF

---KRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSR-FKSKTFLSS-QTGA-GTPEWMAPEVLRDEPSKEKSDVYSFGVVLW
   || .||..| | |.| || | . |.|||||. |||||. ..|||||||.|   |  . |.  | || ||| ||||||.   |  ||.|||||| .||
ILYKRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILW

ELVTLQKPWT--GLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDA--L
|. | | |         . ..|.     |  ||    .  . ||. ||  .|. ||||. || .  |
EILTCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRIL
Kinase MLK-p1_i.AA TK 510-764 18 2.4e-68 227.99 In-house 1-486 (486) Show / Hide 
Range on Protein: 510-764
Range on HMM: 1-486/486
Sequence Identity: 18% (92 aa)

LVLKERLGGGSFG---TVHLA------DWQG---------------------TDVAVKILL---DQDATQELLSELT------------REIVILR--RL
..| . || | ||   .|...      .|.|                     |.||||.|    ......... |..            .|. ...   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNIVLFMGAVTKS------------PHLSIVTEYLPRGA----LFRLLHTPKA---------------------------------------------
.||||| . |..|..            ... ||.|| | |     |   |.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------REILDEKRRLRMALDVARGVNYLHRSKP----AIVHRDLKSPNLLVDKYLT-----------VKVCDFGLSR
                            ...|. ...| |....|.|  |||. .      .|||||   | ||.. ..           .|..||||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

FKS---------KTFLSSQTGAGTPE-------------------------WMAPEVLRDEPSKEK---------SDVYSFGVVLWELVTLQ-KPWTG-L
 .|         ..   .... ||.                          |||||.|.|    |.         |||.||||..||..|.  .|. | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TA---------MQVVAAVAFN-----------GRRLQIP--SNVN--------------PKMRALIESCWANDPELRPSFASIIDAL
.           .|.  .              |.|.. |   .                . .  |. .||. ||| ||.|. . ..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK-p1_i.AA TyrKc 510-764 31 1.3e-67 231.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 510-764
Range on HMM: 1-280/280
Sequence Identity: 31% (93 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKILLDQDATQELLSELTREIVILRRL--RHPNIVLFMGAVTKS-------PHLSIVTEYLPRGALFRLLHTPK
..|.. || | ||.|... |  ..|||| | .       . .. ||. |...|  .||||| . |..|..       . | ||.|| | |.|   |. ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

AREILDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSRFKSKT--------FLSSQTGAGTPE-----WMAPEVLRDEPS
 .  |  |  | .....|.| .|||.    ..||||   | ||.. .|||..||||||.              ..... |.       |||||....   
PK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

KEKSDVYSFGVVLWELVTL-QKPWTG-----LTAMQVVAAVAFNGRRLQIPSN--------VNPKMRALIESCWANDPELRPSFASIIDAL
 .||||.||||..||. |. |.|. |     ... .|.. |  .|.|. .| |          ..|  ....||. ||| ||.|. |.. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK-p1_i.AA Dicty4-Unclassified 510-764 34 2.6e-67 229.56 In-house 1-263 (263) Show / Hide 
Range on Protein: 510-764
Range on HMM: 1-263/263
Sequence Identity: 34% (93 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKIL-LDQDATQ-ELLSELTREIVILRRLRHPNIVLFMGAVTKSP-----HLSIVTEYLPRGALFRLLH---TP
.     .| | |  ||   | | |||||..   ..    |.. .  .|. ||  . ||| |   |.    |      . ||.| ...| || . |     
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCI-NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

KAREI-LDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSRFKSKTFLSSQTGAGTPEWMAPEVLRDEPSKEKSDVYSFGV
. . | ||.   ...|.|.|.|  .||     ..|||.|| |.|.||   .|. |||.||  . .|    | |||| | .||.|. |    ||||||...
QQQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNF-NMTTIAGTPKWESPECLMHESYNQKSDVYSYAM

VLWELVTLQKPWTGLT-AMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDAL
.|.||.|   |. .    | .   |.  . | .||.|. . .. ||  || |||  ||..  ||. |
MLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLK-p1_i.AA Pkinase 510-764 27 1.9e-65 228.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 510-764
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

LVLKERLGGGSFGTVHLADWQGTD--VAVKILLDQDATQELLSELTR--EIVILRRLRHPNIVLFMGAVTKSPHLSIVTEYLPRG----ALFRLLHTPKA
.......| ||||.| .. ..||   |||||.  ...  . . ...|  || |..||.||||| . .... ..|. .|.||.. |     ||....| ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

REIL--DEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTV----KVCDFGLSRFK-SKTFLSSQTGAGTPEWMAPEVLR-DEPSKEKSDV
.  .  .|.   .... ..||..|.|.    |.|||||. |.|.|.  ..    |.|||||....        .| .|||..|||||.| ...   |.|.
HGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFGVVLWELVTLQKPWTGL------TAMQVVAAVAFNGRRLQIP-------------------SNVNPKMRALIESCWANDPELRPSFASIIDA--L
.|.|..|.|... . |. |       . ||... .     . ..|                    |... .. .|..|.. ||. ||... |     .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLK-p1_i.AA TKL-ciliate2 510-765 37 1e-62 208.01 In-house 1-273 (273) Show / Hide 
Range on Protein: 510-765
Range on HMM: 1-273/273
Sequence Identity: 37% (103 aa)

LVLKERLGGGSFGTVHLADWQGTDVAVKILLDQDATQELLSELTREIVILRRLRHPNIVLFMGAVTKSPHLSIVTEYLPRGALFRLLHTPKAREILDEKR
| .....  | .| .  | |  . ||||    .   |. . .   |   .  |||||||.|.|| ||.|  .|. ||  ||.|. ||     | .  | |
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVR-LTWEDR

RLRMALDVARGVNYLHRSKPAIVHRDLK--------------------SPNLLVDKYLTVKVCDFGLSRFK-SKTFLSSQTGAGTPEWMAPEVLRDEPSK
| |.|||.|||| ||| |.| |.|||||                    | |.|||  .  |. |||  | |    ..  .   ||  ||||||..     
R-RIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNK--IGTYQWMAPEVIKAFYYT

EKSDVYSFGVVLWELVTLQKPWTGLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIIDALK
|| ||.|....|||.     |. .     |   |  |  |  || |. |..  |.. || |. .|||||  ||  |.
EKADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase MLK-p1_i.AA S_TKc 510-772 28 7.3e-61 209.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 510-772
Range on HMM: 1-231/231
Sequence Identity: 28% (77 aa)

LVLKERLGGGSFGTVHLADWQG--TDVAVKILLDQDATQELLSELTREIVILRRLRHPNIVLFMGAVTKSPHLSIVTEYLPR--GALFRLLHTPKA---R
  . . .| |.||.|... . .    ||.||.            . ||| ||.. .||||| . ..     || .|.||..   | ||....  .    |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

EILDEKRRLRMALDVARGVNYLHRSKPAIVHRDLKSPNLLVDKYLTVKVCDFGLSRFKSKTFLSSQTGAGTPEWMAPEVLRDEPSKEKSDVYSFGVVLWE
  ..| .  ...  ......|.|. .  |.|||||  |.|.|.  ..|.|||||.|.         |  |||..||||||    .|.|.|..|.|..|.|
FPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYE

LVTLQKPWTGLTAMQVVAAVAFNGRRLQIPSNVNPKMRALIESCWANDPELRPSFASIID-ALKKFQEPLF
... . |.     ||..  .              | .. .|. |.  ||| ||.   .    ..  . | |
MLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF