Gene WAKc-23_b (S.moellendorffii)

WAKc-23_b

Species: S.moellendorffii
Alias: WAKc-23_b
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: WAKc23

Sequence

Name Sequence Type Origin Length Description Download
WAKc-23_b.AA Protein None 169 None Fasta, JSON
WAKc-23_b.NA RNA None 510 None Fasta, JSON
WAKc-23_b.kin_dom Protein Kinase Domain None 142 None Fasta, JSON

Protein domain

Protein domains of WAKc-23_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase WAKc-23_b.AA TKL 1-149 23 1.3e-36 127.96 In-house 12-239 (364) Show / Hide 
Range on Protein: 1-149
Range on HMM: 12-239/364
Sequence Identity: 23% (55 aa)

GSLQG---------GTTVAIKKANNGN-----------------------APRIQ---QFLNEVT-ILSKVKHRNLVKVMGCCVESEV------------
| ..|         |..||.|| .  |                       .| ..   .|..|.. ..|. .| |.|. ||.| ...             
GKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWG

-PLVVYEFVPRGTLYEHLHKRGDTLSWKNRLRIATETAVALTYLHFAAS-----PLIYHRDVKSSNILLDEKLT--------------AKVADFGISKLV
 .  |.|..|.|.|...||       |  |.|.| ..| .. |||         | | ||| ||.|||.||..|              .|..|||.|. .
QLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

P--IDSTHISTT----------------LHGTLGY
    ......||                  ||...
SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRW
Kinase WAKc-23_b.AA Dicty4 6-130 33 1.8e-35 115.87 In-house 22-162 (277) Show / Hide 
Range on Protein: 6-130
Range on HMM: 22-162/277
Sequence Identity: 33% (48 aa)

GTTVAIKKA--NNGN--APRIQQFLNEVTILSKVKHRNLVKVMGCCV----ESEVPLVVYEFVPRGTLYEHLHK------RGDTLSWKNRLR---IATET
|. ||.||.  .| |  . ... |..||.|..|  | |... || |     ... .. | |..|.|.||. ||.        ..|.|  ..|   .|  .
GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDA

AVALTYLHFAASPLIYHRDVKSSNILLDEKLTAKVADFGISK
|  ...|| .  | | ||| ||.|.| |. ...||.|||.|.
ARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQ
Kinase WAKc-23_b.AA TKL-Unique 6-131 33 6.2e-32 109.97 In-house 20-166 (290) Show / Hide 
Range on Protein: 6-131
Range on HMM: 20-166/290
Sequence Identity: 33% (50 aa)

GTTVAIKKANN---GNAPRIQQFLNEVTILSKVK-HRNLVKVMGCCVESEVPLV----VYEFVPRGTLYEHLH---------KRGDTLSWKNRLRIATET
|. ||||. ..    .   .| | |||....| . | |.|. || |.   |.      | |..|.|.||..||         ..  .|....|...|   
GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDI

AVALTYLHFAASPLIYHRDVKSSNILLDEK-----LTAKVADFGISKL
| .. |||.   | |.||| ||||.|.|..     . .|..|||.||.
AQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKF
Kinase WAKc-23_b.AA DRK 6-129 35 1.4e-29 97.41 In-house 22-147 (258) Show / Hide 
Range on Protein: 6-129
Range on HMM: 22-147/258
Sequence Identity: 35% (45 aa)

GTTVAIKKANNGNAP---RIQQFLNEVTILSKVKHRNLVKVMGCCVESEVPLVVYEFVPRGTLYEHLHKRGDTLSWKNRLRIATETAVALTYLHFAASPL
|| ||.|.. | |      .. |  |......  | | .  || | ..  .... |. ||| ||  ||     ..|  .....   |  ..|||    | 
GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLH-CCNPI

IYHRDVKSSNILLDEKLTAKVADFGIS
| ||| || | | ||    |||||| |
IIHRDLKSHNLLVDEHWQVKVADFGLS
Kinase WAKc-23_b.AA IRAK 1-127 31 6.2e-28 96.16 In-house 18-158 (317) Show / Hide 
Range on Protein: 1-127
Range on HMM: 18-158/317
Sequence Identity: 31% (45 aa)

GSLQGGT-TVAIKKANNGNAPRI----QQFLN---EVTILSKVKHRNLVKVMGCCVESEVPLVVYEFVPRGTLYEHLHKRGD--T---LSWKNRLRIATE
| ... | ..|.||  ... . .    |.|.    |. ....  | |.| . | | |.. .  ||.. | |.|   |. ..   .   |||  |. |.  
GQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWG

TAVALTYLHFAAS--PLIYHRDVKSSNILLDEKLTAKVADFG
|| .. .|| . .  |.| |.|.||.|||||. .|.| .|||
TACGIQFLHQNHPCTPII-HGDIKSANILLDQHFTPKICDFG
Kinase WAKc-23_b.AA Pkinase_Tyr 4-132 25 1.5e-26 90.53 Pfam 26-161 (270) Show / Hide 
Range on Protein: 4-132
Range on HMM: 26-161/270
Sequence Identity: 25% (36 aa)

QGGTTVAIKKANNGNAPR---IQQFLNEVTILSKV-KHRNLVKVMGCCV-ESEV--PLVVYEFVPRGTLYEHLHKR---GDTLSWKNRLRIATETAVALT
.....||.|. ..|  ..   .. |..|. |...  .| |.|. .|.|. ..|   ...| |..| | |...|.|.   .. |. |  | .... | .. 
NTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGME

YLHFAASPLIYHRDVKSSNILLDEKLTAKVADFGISKLV
||.      . |||.   |.|..|....|..||| ....
YLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase WAKc-23_b.AA Dicty4-Unclassified 6-146 35 1.4e-24 81.05 In-house 22-171 (263) Show / Hide 
Range on Protein: 6-146
Range on HMM: 22-171/263
Sequence Identity: 35% (55 aa)

GTTVAIKKANNGN-APR---IQQFLNEVTILSKVKHRNLVKVMGCCVES----EVPLVVYEFVPRGTLYEHLH----KRGDTLSWKN--RLRIATETAVA
|  ||.|| | .    |   || |. || ||  . | ||||. | |.          .| || ..|.| |  |     .   ..      ...| . |  
GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQG

LTYLHFAASPLIYHRDVKSSNILLDEKLTAKVADFGISKLVPIDSTHISTTLHGT
. .||   .  . |||.||||||.|    .|.||||||    || .   ||  ||
MQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRV--IDFNFNMTTIAGT
Kinase WAKc-23_b.AA MLK 6-130 24 4.1e-24 80.62 In-house 22-181 (291) Show / Hide 
Range on Protein: 6-130
Range on HMM: 22-181/291
Sequence Identity: 24% (40 aa)

GTT-----VAIKKAN---NGNAPR----IQQFLNEVTILSKVKHRN----LVKVMGCCVESEV-PLVVYEFVPRGTLYEHLHKRGD-------------T
...     ||.|...      . .    ...|  |. .|....|.|     ....|.| ...   ..| |... | ||. || . .             .
NKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRV

LSWKNRLRIATETAVALTYLHFAASPLIYHRDVKSSNILLDE------KLTAKVADFGISK
 .    ...|.  | .. |||  | ..| ||| ||.|||.||      ..|.|..|||.|.
YDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase WAKc-23_b.AA Pkinase 6-150 23 5.6e-23 82.34 Pfam 24-178 (293) Show / Hide 
Range on Protein: 6-150
Range on HMM: 24-178/293
Sequence Identity: 23% (37 aa)

GTTVAIKKANNGNAPRIQQ--FLN--EVTILSKVKHRNLVKVMGCCVESEVPLVVYEFVPRG----TLYEHLH-KRGDTL--SWKNRLRIATETAVALTY
| .||.|. .  ..   ..   ..  |. |. ...| | |.  ... ..  . .| |... |     |..... .|. ..  |..   ....... .| |
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEY

LHFAASPLIYHRDVKSSNILLDEKLTA----KVADFGISKLVPIDSTHISTTLHGTLGYI
.|      | |||.|..|||.|.. .     |..|||..|.. . . .  ||. ||..|.
CHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYM
Kinase WAKc-23_b.AA TK-Unique 7-130 25 4.4e-21 69.54 In-house 31-181 (294) Show / Hide 
Range on Protein: 7-130
Range on HMM: 31-181/294
Sequence Identity: 25% (40 aa)

TTVAIKKANNGNAPR-IQQFLNEVTILSKVK-HRNLVKVMGCCVES-EVPLVVYEFVPRGTLYEHLHKRGDT-------------------------LSW
. ||.|. . .. .   |.||.|  ...... | |.|. .|||..| | .. ..|..|.|.|  .|......                         .| 
KCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISP

KNRLRIATETAVALTYLHFAAS--PLIYHRDVKSSNILLDEKLTAKVADFGISK
|  ...| . | .. ||   ||    | |||. ..|.|| |....|..|||...
KDLYHFAWQIACGMEYL---ASQRKKIVHRDLCARNVLLTEDKVCKICDFGMAR
Kinase WAKc-23_b.AA TK 1-146 16 4.8e-21 66.6 In-house 47-323 (486) Show / Hide 
Range on Protein: 1-146
Range on HMM: 47-323/486
Sequence Identity: 16% (45 aa)

GSLQGGTTVAIKKANNGNAPRIQQ--------------FLNEVTILSKVK-----HRNLVKVMGCCVES------------EVPLVVYEFVPRGT----L
|. .| |.||.|    |.|   ..              ||.|. .... .     | |.|.  |.|...            | ...| |..| |     |
GKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSL

YEHLHKRGDT---------------------------------------------------------------------------LSWKNRLRIATETAV
 ..|.|. ..                                                                           |. . .| ..   | 
RDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIAC

ALTYLHFA----ASPLIYHRDVKSSNILLDEKLT-----------AKVADFGIS--------KLVPIDSTHISTTLHGT
.. |||        . . |||.   |.|..|...           .|.|||| |        . .. |.   ... .||
GMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGT
Kinase WAKc-23_b.AA LISK 3-127 32 2.5e-20 62.56 In-house 16-150 (296) Show / Hide 
Range on Protein: 3-127
Range on HMM: 16-150/296
Sequence Identity: 32% (45 aa)

LQGGTTVAIKKANN----GNAPRIQQFLN-EVTILSKVKHRNLVKVMGCCVE-SEVPLVVYEFVPRGTLYEHLHKRGD---TLSWKNRLRIATETAVALT
.| |. .|||.  .     | |  | |.. || .. .  |.| |. || |.. .     | |..  |.| . |....     |.|. |..||.  | ...
RQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMS

YLHFAASPLIYHRDVKSSNILLDEK----LTAKVADFG
|||.     | ||| || |.|..|.     ..||.|||
YLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase WAKc-23_b.AA TyrKc 1-165 17 8e-11 -47.63 SMART 18-280 (280) Show / Hide 
Range on Protein: 1-165
Range on HMM: 18-280/280
Sequence Identity: 17% (47 aa)

GSLQGGTTVAIKKANNGNAPRIQQFLNEVTILSKV--KHRNLVKVMGCCVES-------EVPLVVYEFVPRGTLYEHLHKRGDTLSWKNRLRIATETAVA
| .   ..||.|. ...    .. |..|  |..|.  .| |.|.  |.|...       | ...| |..| | | ..|.|....|..|  | ...  |  
GTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACG

LTYLHFAASPLIYHRDVKSSNILLDEKLTAKVADFGISKLVPID--------STHI----STT-------------LHG-------------------TL
  |||    ..| |||    |.|..|..|.|..||| |. .  |          .     ..               .|                   |.
MEYLHSK--NCI-HRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTY

GYIDSTS---------------------KAISL--------------------------------QIRATF
|                           .                                    .|.  |
GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase WAKc-23_b.AA S_TKc 1-169 21 3.4e-09 -42.01 SMART 18-220 (231) Show / Hide 
Range on Protein: 1-169
Range on HMM: 18-220/231
Sequence Identity: 21% (49 aa)

GSLQG-GTTVAIKKANNGNAPRIQQFLNEVTILSKVKHRNLVKVMGCCVESEVPLVVYEFVPR--GTLYEHLHKRGD-----TLSWKNRLRIATETAVAL
.   . |  ||||. .       .....|. ||.| .| |.||  ..... .   .| |...   |.|.....|||       ..     ... ... ||
CRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCAL

TYLHFAASPLIYHRDVKSSNILLDEKLTAKVADFGISKLVPIDSTHISTTLHGTLGYI-------DS---------------------------------
 |.|      | |||.| .||||||  . |..|||.....        ||. ||. |.       .                                  
EYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG

TSKAISLQIRATFT----------ALE
.. |..  ||  ..          ||.
SPEAKD-FIRKCLQKDPEKRPTAEALQ