Gene SD2b2_n (S.moellendorffii)

SD2b2_n

Species: S.moellendorffii
Alias: SD2b2_n
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: SD2b2

Sequence

Name Sequence Type Origin Length Description Download
SD2b2_n.AA Protein None 235 None Fasta, JSON
SD2b2_n.NA RNA None 708 None Fasta, JSON
SD2b2_n.kin_dom Protein Kinase Domain None 100 None Fasta, JSON

Protein domain

Protein domains of SD2b2_n.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SD2b2_n.AA TKL 100-227 21 9.4e-24 82.41 In-house 9-200 (364) Show / Hide 
Range on Protein: 100-227
Range on HMM: 9-200/364
Sequence Identity: 21% (45 aa)

VFKGCYIQ---------GEAVAVERLIK-----------------------------------FEPELSTIGTLQHVNLVRLRG---------YCGK---
|.|| . .         |. ||| .. .                                   .| |.  .  |.| |.|.. |         .|..   
VYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVG

---ERLLVYEFVEGGSQDRSLFNRDLNGAENSVVLSWSQRFGIALGTAKGLPYLHE----ECRDR--IIHYAIKPENILLDAKMK--------------P
   .  .|.|...|||    |               |.||. .||..|.|. |||      |.    |||  .|..|||.| ...              .
PWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVADFGL
|..||||
KICDFGL
Kinase SD2b2_n.AA IRAK 122-227 40 3.2e-23 79.27 In-house 53-159 (317) Show / Hide 
Range on Protein: 122-227
Range on HMM: 53-159/317
Sequence Identity: 40% (45 aa)

ELSTIGTLQHVNLVRLRGYCGKERL--LVYEFVEGGSQDRSLFNRDLNGAENSVV---LSWSQRFGIALGTAKGLPYLHEEC-RDRIIHYAIKPENILLD
|| .  ...| |.| | ||| ..    |||..  .|    ||. | | .  ...    ||| ||. |..|||.|. .||.      |||  ||. |||||
ELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNG----SLEDR-LWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLD

AKMKPKVADFGL
. . || .||||
QHFTPKICDFGL
Kinase SD2b2_n.AA TKL-Unique 118-227 30 1e-20 69.88 In-house 41-163 (290) Show / Hide 
Range on Protein: 118-227
Range on HMM: 41-163/290
Sequence Identity: 30% (38 aa)

KFEPELSTIGTLQ-HVNLVRLRGYCG------KERLLVYEFVEGGSQDRSLFNRDLNGA---ENSVVLSWSQRFGIALGTAKGLPYLHEECRDRIIHYAI
.|| |.... .|. | |.|.. |||       ... .| |...|||  ... .. .|     .|.  |...||  .|.  |.|. ||| .    ||| ..
EFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSL-YDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDL

KPENILLDAK-----MKPKVADFGL
|. |.|.| .     .. |..||||
KSSNFLVDNNSNIAEWNIKICDFGL
Kinase SD2b2_n.AA MLK 99-227 27 5.6e-17 55.53 In-house 14-179 (291) Show / Hide 
Range on Protein: 99-227
Range on HMM: 14-179/291
Sequence Identity: 27% (47 aa)

AVFKGCYIQGEA-----VAVERLI--------------KFEPELSTIGTLQHVN----LVRLRGYCGKE---RLLVYEFVEGGSQDRSLFNRDLNGAE--
.|.|| . ...      ||| |                .|| |      |.| |     ....| | ..    ..| |..|||    ||.|  |.||.  
KVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGG----SLYNV-LHGARSK

---------NSVVLSWSQRFGIALGTAKGLPYLHEECRDRIIHYAIKPENILLDA------KMKPKVADFGL
         |..| . .. . .||  |.|. |||.. .. |||. .|. |||.|.      ... |..|||.
WMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGT
Kinase SD2b2_n.AA Pkinase 122-227 26 1.6e-13 48.9 Pfam 50-158 (293) Show / Hide 
Range on Protein: 122-227
Range on HMM: 50-158/293
Sequence Identity: 26% (32 aa)

ELSTIGTLQHVNLVRLRGYC--GKERLLVYEFVEGG----SQD----RSLFNRDLNGAENSVVL--SWSQRFGIALGTAKGLPYLHEECRDRIIHYAIKP
|..    |.| | |||....  ...  .| |..|||    .      .          ... ..  |. .   ... ...|| |.|..   .|||  .||
EIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKP

ENILLDAKMKP----KVADFGL
||||.| .. .    |..||||
ENILIDNNGHIDACVKICDFGL
Kinase SD2b2_n.AA HH498 143-226 24 6.7e-13 36.83 In-house 76-169 (284) Show / Hide 
Range on Protein: 143-226
Range on HMM: 76-169/284
Sequence Identity: 24% (23 aa)

KERLLVYEFVEGGSQDRSL---------FNRDLNGAE-NSVVLSWSQRFGIALGTAKGLPYLHEECRDRIIHYAIKPENILLDAKMKPKVADFG
.. ..| .....||  . |          | . ..   |  ...   .  |..  |.|  |||.     |||      |||...  . .|||||
SQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFG
Kinase SD2b2_n.AA MARK 201-230 43 4.1e-10 29.45 In-house 124-155 (262) Show / Hide 
Range on Protein: 201-230
Range on HMM: 124-155/262
Sequence Identity: 43% (14 aa)

RIIHYAIKPENILLDAKM--KPKVADFGLGNE
.|.|  |||||||.|...  . | .|||....
NIVHRDIKPENILIDENGNHNIKIIDFGFSIC
Kinase SD2b2_n.AA LISK 150-227 34 4.7e-10 28.64 In-house 77-151 (296) Show / Hide 
Range on Protein: 150-227
Range on HMM: 77-151/296
Sequence Identity: 34% (28 aa)

EFVEGGSQDRSLFNRDLNGAENSVVLSWSQRFGIALGTAKGLPYLHEECRDRIIHYAIKPENILLDAK----MKPKVADFGL
|...||   . |...|.     ...|.|.||  |||. |.|. |||. .   |||   |  |.|.. .     . ||.|||.
EYINGGDLHQYLKDMDK----HKIPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGF
Kinase SD2b2_n.AA Dicty4 172-227 36 9.6e-10 28.86 In-house 103-160 (277) Show / Hide 
Range on Protein: 172-227
Range on HMM: 103-160/277
Sequence Identity: 36% (22 aa)

SVVLSWSQRFG---IALGTAKGLPYLHEECRD-RIIHYAIKPENILLDAKMKPKVADFGL
|. |.|. .     .|. .|.|. .||  |.. .|||  .|. |.| |. .. ||.||||
SIKLDWPLIKRAMRMAFDAARGMNWLH--CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGL
Kinase SD2b2_n.AA NuaK 199-229 54 1.3e-09 20.91 In-house 117-147 (252) Show / Hide 
Range on Protein: 199-229
Range on HMM: 117-147/252
Sequence Identity: 54% (17 aa)

RDRIIHYAIKPENILLDAKMKPKVADFGLGN
..||.|   | ||||||..   |.||||| |
KHRICHRDLKLENILLDQNCNAKIADFGLSN
Kinase SD2b2_n.AA Dicty4-Unclassified 183-227 42 1e-07 22.43 In-house 114-155 (263) Show / Hide 
Range on Protein: 183-227
Range on HMM: 114-155/263
Sequence Identity: 42% (19 aa)

IALGTAKGLPYLHEECRDRIIHYAIKPENILLDAKMKPKVADFGL
.|.  |.|. .||   |. .||  ||  |||.|     |.||||.
YAFDIAQGMQHLH--TRN-FIHRDIKSSNILMDKHFNIKIADFGI
TyrKc SD2b2_n.AA TyrKc 85-235 13 0.000131 -148.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 85-235
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)

SSGKSPCSHGWFQAAVFKGCYIQGEAVAV-----ERLIKFEPELSTIGTL--QHVNLVRLRGYCG---------KERLLVYEFVEGGSQDRSL-FNRDLN
 . .    .| |   |.|| ..  . |||     . .  |  |..    |  .| |.||| |.|          .  ..| |....|. .  |  .|.  
ITLGKKLGEGAF-GEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

GAENSVVLSWSQRFGIALGTAKGLPYLHEECRDRIIHYAIKPENILLDAKMKPKVADFGL------------------------GN----------ESL-
       |....   ...  |.|  |||.    ..||  .   |.|....   |..||||                        |.          |.. 
-------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

------------------------------------------------------AE-------------------------------------L
                                                      ..                                     .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SD2b2_n.AA Pkinase_Tyr 122-196 25 0.002192 12.09 Pfam 53-129 (270) Show / Hide 
Range on Protein: 122-196
Range on HMM: 53-129/270
Sequence Identity: 25% (21 aa)

ELSTIGTL-QHVNLVRLRGYCG--KER---LLVYEFVEGGSQDRSLFNRDLNGAENSVVLSWSQRFGIALGTAKGLPYLHE
|...  .| .| |.||| | |   .|    ..| |....|. .  | ..     |.   |. ..  ....  |||. ||..
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR----EDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase SD2b2_n.AA Dicty4-Unclassified 114-141 42 0.003401 6.75 In-house 40-67 (263) Show / Hide 
Range on Protein: 114-141
Range on HMM: 40-67/263
Sequence Identity: 42% (12 aa)

ERLIKFEPELSTIGTLQHVNLVRLRGYC
| .  |  |    | .|| |||...|||
EMIQDFKKEVEILGSIQHPNLVKCYGYC
Kinase SD2b2_n.AA Pkinase_Tyr 211-227 41 3.47862 1.25 Pfam 141-157 (270) Show / Hide 
Range on Protein: 211-227
Range on HMM: 141-157/270
Sequence Identity: 41% (7 aa)

NILLDAKMKPKVADFGL
|.|.. ... |..||||
NCLVTENNVVKICDFGL