Gene SD2b_a-2 (S.moellendorffii)

SD2b_a-2

Species: S.moellendorffii
Alias: SD2b_a-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: SD2b

Sequence

Name Sequence Type Origin Length Description Download
SD2b_a-2.AA Protein None 822 None Fasta, JSON
SD2b_a-2.NA RNA None 2469 None Fasta, JSON
SD2b_a-2.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of SD2b_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin SD2b_a-2.AA B_lectin 67-168 28 1.3e-31 110.18 Pfam 1-137 (137) Show / Hide 
Range on Protein: 67-168
Range on HMM: 1-137/137
Sequence Identity: 28% (40 aa)

PPTLVWMPNRT---QSL-----SSNSSLQVT--DSGLVIIESG---ET--VWRS-----GAAGAVVAEAELLDVGNFVLR-SAS--SNIVWQS--FDFPT
..| ||  ||    ...     ..|..|...  |  ||. ..|   ..  ||..     |...|  . |...| ||.||. ...  .|..|||  ||.||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DTLLLGQKLLPI------AGQ---ALSSWRTKA--DPK
||.| |.||          .     |.||..    || 
DTWLPGMKLG-WDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin SD2b_a-2.AA B_lectin 26-140 29 2.6e-16 61.45 SMART 1-126 (126) Show / Hide 
Range on Protein: 26-140
Range on HMM: 1-126/126
Sequence Identity: 29% (38 aa)

ILTPGSNRFWTSSNGMFG--LGFFNSSAPTTEIHVGIAFVDQM--PPTLVWMP--NRTQSLSS---NSSLQVT-DSGLVIIESGETVWRSGAA-GAVVAE
 .| .|.... |.|..|   ||||.         .|| .      . | ||    ||.  ...   .. |  . |  |||   . .||.|. . .  .  
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ---WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD-NRPVWSSNTTRNNGNYV

AELLDVGNFVLRSAS----SNIVWQSFDFP
|.|.| ||||... .    .|..|||||.|
AVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop SD2b_a-2.AA S_locus_glycop 244-322 27 3.3e-07 26.79 Pfam 55-117 (117) Show / Hide 
Range on Protein: 244-322
Range on HMM: 55-117/117
Sequence Identity: 27% (22 aa)

RLTLDPDGNFRYYVRAPNSTKWGVVWRALFDACDVYSTCGINGLCDFNSPANSKPPAGCPVADEDPHPCSCPPGYRPVD
|.|....| . ..   |||. | . | |  | ||.| .|| .|.|               .  . |  |.| .| .|  
RFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYC---------------DMNTSPM-CNCIKGFVPKN
Kinase SD2b_a-2.AA TKL 499-773 19 5e-56 192.46 In-house 1-364 (364) Show / Hide 
Range on Protein: 499-773
Range on HMM: 1-364/364
Sequence Identity: 19% (74 aa)

LGQGGYGAVYLGVLPD---------DTRVAVKLLNEGFPQEFDSGSNED--------------------KSFLAEVATLANIRHSNVVHLLGFCLEAPK-
.|.||.| || |..           .. |||| ...   .||.. |.|.                    . .  |.  . ..|| |.|...|.|.. |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------HLLVYEYLENKS-LDKVLFEPTTPLTKWKTRMQILIGAARGIEYFHSYSG----DRRVVHRDIKPANVLLTADFH-------------
            . .|.|| .. | |. ..         |  |... ...|||..| ||        . ..|||.|..|.|.  ...             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-AKVADFGLAKIMDT------------------ATHTTNFTMPGTVGYRAPEC---TIIGD------------AITVQADVFSFGVVCIEVVSGRRLVYV
 .|..||||.. |..                   ...|. |  || .. |||.   ..  .              . ..||.|||.|  |.....|    
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

EQQGRTRVLLFRRALELMLQ-----EEYMKLVDERLAEDGID------------EDEVRKVVRVAGWCLQEDPKQRPTMDAVVALL
          ..   . . .     ||....| ..     |.            .|  . . . . .| ..||..||... ..  |
---------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase SD2b_a-2.AA IRAK 494-773 27 2.6e-48 166.8 In-house 2-317 (317) Show / Hide 
Range on Protein: 494-773
Range on HMM: 2-317/317
Sequence Identity: 27% (90 aa)

DFANVLGQGGYGAVYLGVLPDDT-RVAVKLLNEGFPQEFDSGSNEDKSFLA---EVATLANIRHSNVVHLLGFCLEAPKHLLVYEYLENKSLDKVLFEPT
. .|..|.||.| || |..   |  .|||.| |.   ....    ...|..   |. ... .|| |.| |.|.|.| ..| |||.|. | ||   |   .
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNE---HWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQD

---TP--LTKWKTRMQILIGAARGIEYFHSYSGDRRVVHRDIKPANVLLTADFHAKVADFGLAK------IMDTATH---TTNFTMPGTVGYRAPECTI-
   .|  |. | .|  |..|.|.||.. |. .    . |.|||.||.|| ..| .| .||||.        .  .|     |. .  ||  | .||    
GQCPPKPLS-WHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVR-GTTWYMPPEFIRD

-IGDAITVQADVFSFGVVCIEVVSGRRLVYVE-QQGRTRVLLFRRALELMLQ-----------------------EEYMKLVDERLAEDGIDEDEVRKVV
  |  .|.. ||.|||.|  ||..|.| || .    .. ..| .   |   .                         | |..|.| .  . ..... .  
PQG-QLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMP--PCPPNMEKEMC

RVAGWCLQEDPKQRPTMDAVVALL
 .|. |. .  . |..|. |...|
QCACCCGHHRANRRCDMAWVMQQL
S_TKc SD2b_a-2.AA S_TKc 493-780 19 1.9e-39 138.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 493-780
Range on HMM: 1-231/231
Sequence Identity: 19% (59 aa)

KDFANVLGQGGYGAVYLGVLPD-DTRVAVKLLNEGFPQEFDSGSNEDKSFLAEVATLANIRHSNVVHLLGFCLEAPKHLLVYEYLEN--KSLDKVLFEPT
 .. ...|.|..| ||...  . . .||.| ..              .... |.. | . .| |.|.|.... .  .  .| ||...   .| ... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

TP-----LTKWKTRMQILIGAARGIEYFHSYSGDRRVVHRDIKPANVLLTADFHAKVADFGLAKIMDTATHTTNFTMPGTVGYRAPECTIIGDAITV-QA
..     ..   .|  ..   ....|| ||    ....|||.||.|.||.   | |..|||||...         |. ||  |.|||        .   .
RHGLRFPFPE-HAR-FYMYQICCALEYCHS----HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKC

DVFSFGVVCIEVVSGRRLVYVEQQGRTRVLLFRRALELMLQEEYMKLVDERLAEDGIDEDEVRKVVRVAGWCLQEDPKQRPTMDAVVA--LLNDDTKAV
|. |.|.. .| ..|. . .      .  ..|.. .                          . .      ||| ||..|||   . .  ..      .
DWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SD2b_a-2.AA TKL-Unique 495-698 28 1.2e-37 130.38 In-house 1-224 (290) Show / Hide 
Range on Protein: 495-698
Range on HMM: 1-224/290
Sequence Identity: 28% (66 aa)

FANVLGQGGYGAVYLGVLPDDTRVAVKLLNEGFPQEFDSGSNEDKSFLAEVATLANIR-HSNVVHLLGFCL----EAPKHLLVYEYLENKSLDKVLF---
| |..|.||||.|| |. .  . ||.| ..   | . || . . . |  || .. ... | |.||. |.|      .|.  .| ||..  ||..||    
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFH---P-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNN

------EPTTPLTKWKTRMQILIGAARGIEYFHSYSGDRRVVHRDIKPANVLLTAD-----FHAKVADFGLAKIMDTATHTTNF--------TMPGTVGY
      .. ..|. .. |... | .|.| .| |....   . |||.|. |.|.. .     . .|..||||.|. .. . .||         |  |.  .
NNNNNNNNNCKLN-MQQRVKMAIDIAQGMYYLHHCEPP--IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRW

RAPECTIIG-DAITVQADVFSFGVVCIEVVSG
.||| .    . .. ..||.|||.| .| ...
MAPEVLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase SD2b_a-2.AA Pkinase 498-773 22 1.2e-37 134.18 Pfam 6-293 (293) Show / Hide 
Range on Protein: 498-773
Range on HMM: 6-293/293
Sequence Identity: 22% (71 aa)

VLGQGGYGAVYLGVLPDDTR-VAVKLLNEGFPQEFDSGSNEDKSFLA--EVATLANIRHSNVVHLLGFCLEAPKHLLVYEYLENK----SLDKVLF-EPT
..|.|..| ||...  .. . |||| ..       .  |..|.. .   |.. .....| |.| |.... . ..  .| ||.|.     .|  ..  .  
KIGSGSFGCVYKCHHKGTGKIVAVKIIK-----KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TPL--TKWKTRMQILIGAARGIEYFHSYSGDRRVVHRDIKPANVLLTADFHA----KVADFGLAKIMDTATHTTNFTMP-GTVGYRAPECTII-GDAITV
...  . |  .. ..   .||.|| ||     ...|||.||.|.|.  . |     |..|||||| .|   . . .| . || .|.|||  |  |  .. 
GCFYFSEWECKF-YMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV-IRGGQYYGP

QADVFSFGVVCIEVVSGRRLVYVEQQGRTRVLLFRRA----LELMLQEEYMKLVDERLAEDGIDEDEV------------------RKVVRVAGWCLQED
 .|..|.|....|...||             ..|. .      .  .. . .  . .| .|   ....                  .    .  |||. |
KVDMWSCGCILYEMLCGR-------------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

PKQRPTMDAVVAL--L
||.||| . ..    .
PKKRPTAEQILQHPWF
Kinase SD2b_a-2.AA Dicty4 494-691 29 7.4e-33 107.03 In-house 2-206 (277) Show / Hide 
Range on Protein: 494-691
Range on HMM: 2-206/277
Sequence Identity: 29% (64 aa)

DFANVLGQGGYGAVYLGVLPDDTRVAVKLL---NEGFPQEFDSGSNEDKSFLAEVATLANIRHSNVVHLLGFCL----EAPKHLLVYEYLENKSLDKVLF
.. . .|.|..| ||.|     . ||||.|   |..| .      |. ..|..||. ...||| |.. ..| |.    . .| . | ||.   .| ..| 
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDE------NMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLH

E------PTTPLT-KWKTR-MQILIGAARGIEYFHSYSGDRRVVHRDIKPANVLLTADFHAKVADFGLAKIMDTAT-HTT-NFTMPGTVGYRAPECTIIG
       . ..|     .| |.. . ||||. . |.   . ...|||.|..| |  ... .||.||||...| . . |..   |. ||... |||.   .
DKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC--CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEV-MMH

DAITVQADVFSFGVV
.. .  |||.||| |
QPYNEKADVYSFGIV
Kinase SD2b_a-2.AA MLK 493-691 25 9.3e-33 111.01 In-house 1-225 (291) Show / Hide 
Range on Protein: 493-691
Range on HMM: 1-225/291
Sequence Identity: 25% (58 aa)

KDFANVLGQGGYGAVYLGVLPDDTR-----VAVKLLNEGFPQEFDSGSNEDKSFLAEVATLANIRHSN----VVHLLGFCLEAPKH-LLVYEYLENKSLD
 .|  ..| |..|.|..|.    ..     ||||  .  .  .  . . |.. |  |.  |. ..| |    .. ..| ||. |.| ..| ||.|. || 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

KVLFE-PTTPL-----------TKWKTRMQILIGAARGIEYFHSYSGDRR--VVHRDIKPANVLLTA------DFHAKVADFGLAKIMDTATHTTNFTMP
 || . .. .             .    |..    |||..|.||   . .  ..|||.|. |.|...      . ..|..|||... . . . |. . ..
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHS---MAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA

GTVGYRAPECT--IIGDAITVQADVFSFGVV
||. ..||| .  . ..  .  .||.|.|||
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVV
Pkinase_Tyr SD2b_a-2.AA Pkinase_Tyr 491-697 26 1.2e-30 104.45 Pfam 1-209 (270) Show / Hide 
Range on Protein: 491-697
Range on HMM: 1-209/270
Sequence Identity: 26% (59 aa)

VTKDFANVLGQGGYGAVYLGVLP-----DDTRVAVKLLNEGFPQEFDSGSNE--DKSFLAEVATLANI-RHSNVVHLLGFCL-EAPK--HLLVYEYLENK
.|..   .||.| .| ||.|..      ... |||| |.|      .. . .   ..|..|.... .. .| |.| |.| |. .     ...| || .. 
ITFG--KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE------GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG

SLDKVLFEP--TTPLTKWKTRMQILIGAARGIEYFHSYSGDRRVVHRDIKPANVLLTADFHAKVADFGLAKIM-DTATH-TTNFTMPGTVGYRAPECTII
.|.. | ..    .  . |.  |. .  |.| || .|    .. .|||.   |.|.| ....|..|||||. . .. .  ..    .  .   |||| | 
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES----KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC-IN

GDAITVQADVFSFGVVCIEVVS
    |.. || ||||.. |...
YGKFTTKSDVWSFGVLMWEIFT
Kinase SD2b_a-2.AA STE 493-699 19 1.1e-28 98.42 In-house 1-265 (359) Show / Hide 
Range on Protein: 493-699
Range on HMM: 1-265/359
Sequence Identity: 19% (55 aa)

KDFANVLGQGGYGAVYLGVLPD----------------DTRVAVKLLNEGFPQ------EFDSGS------NEDKSFLAEVATLANIR--HSNVVHLLGF
 ..  ..|.|..| ||...  .                 ...|.| .|    .      |  . .      .| ...| |. .. . .  | |.|. .| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

CLEA-------PKHLLVYEYLENKSLDKVLF---EPTTPLTKW---------KTRMQILIGAARG-IEYFHSYSGDRRVVHRDIKPANVLLTADFHAKVA
..          .  .. ||... |||...    ..  ||..          .    |.    .|  .| ||      ..||||||||.||     .| .
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH----IIHRDIKPANILL-----VKLC

DFGLAKIMDT---------------ATHTTNFTMPGTVGYRAPECTIIG------DAITVQADVFSFGVVCIEVVSGR
|||......                 .   . |. ||  . |||  | .      .  ....|. |.| ..|| . |.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE-VIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase SD2b_a-2.AA RIPK 499-699 25 1.8e-28 94.11 In-house 1-225 (290) Show / Hide 
Range on Protein: 499-699
Range on HMM: 1-225/290
Sequence Identity: 25% (59 aa)

LGQGGYGAVYLGVLPDDTRVAVKLLNEGFPQEFDSGSNEDKSFLAEVATLANIRHSNVVHLLGFCLEA-----PK-HLLVYEYLENKSLDKVLFEPTT--
.| || | |.. .  .   ...|.   . . .    . | .  . |.. ....|....| ..||| .      .|   .| || || || ..|   .   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

-PLTKWKTRMQILIGAARGIEYFHSYSGDRR--VVHRDIKPANVLLTADFHAKVADFGLAKIMDTATHTTNFT-----------MP-GTVGYRAPECTI-
 . . |. |  ..   ..|  | ||        . ||| ||.|.|. ..||.|.||||||. | . . ..               . ||  | .||    
HHPDPWPLRCRMIHEISCGMCYLHS----MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT

-IGDAI---TVQADVFSFGVVCIEVVSGR
   ..|   |   || ||..|  || ...
DNKKPIKVVTPKYDVYSFAIVMWEVLTQK
Kinase SD2b_a-2.AA TyrKc 493-773 22 6.5e-28 99.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 493-773
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

KDFANVLGQGGYGAVYLGVLPDDTRVAVKLLNEGFPQEFDSGSNEDKSFLAEVATLANI--RHSNVVHLLGFCLEA-------PKHLLVYEYLENKSLDK
  .  .|| | .| ||.|..   . |||| |.|.            . |. |   . ..  .| |.| |.| |..        . ...| || .. .|..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLFEPTTPLTKWKTRMQILIGAARGIEYFHSYSGDRRVVHRDIKPANVLLTADFHAKVADFGLAKIMDTA--------THTTNF--TMP--GTVGYRAPE
 | ..     ..|.  .. . .|.| || ||     ...|||.   |.|.......|..||||..  .          . ..           .   |||
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

CTIIGDAITVQADVFSFGVVCIEVVSGRRLVYVE--QQGRTRVLLFRRALELMLQEEYMKLVDERLAEDGI----DEDEVRKVVRVAGWCLQEDPKQRPT
|       | . ||.||||.. |. .     | .  ||    ..  ....|.  | ..|.  .. .    .      ||. .. .   .| .|||..|||
CI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIMK---QCWHEDPEDRPT

MDAVVALL
. ... ..
FSEIHECF
Kinase SD2b_a-2.AA LRRK 493-691 21 1.1e-27 94.97 In-house 1-271 (351) Show / Hide 
Range on Protein: 493-691
Range on HMM: 1-271/351
Sequence Identity: 21% (63 aa)

KDFANVLGQGGYG-AVYLGVLPD---------------------------DTRVAVKLLNE---------------------GFPQEFDSGSNEDKS---
  . . .|.||.|  || . . .                           .. ||.| .|                      .      |...|| .   
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNN------SEQVED-MDQN

----------FLAEVATLANIRHSNVVHLLGFCLEAPKHLLVYEYLENKSLDKVLFEPT-TPL----TK--WKTRMQILIGAARGIEYFHSYSGDRR--V
          |  ||. . . .|.|.| |.|||.. .   .| ||. . .|...|...  ...    ..  | .. .| .  |.|.|| ||    ..  .
HEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS----HNPPI

VHRDIKPANVLL---T---------ADFHAKVADFGLAKIMDTATHTT-NFTMPGTVGYRAPECTIIGD----AITVQADVFSFGVV
.||| |. |.||   .         |. .||.||||.   | ...|..   .. |. |..|||  |...      | ..|..|||..
IHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPE--IMRYNGEEEYTEKVDCYSFGMI
Kinase SD2b_a-2.AA DRK 500-691 30 3e-25 82.5 In-house 8-191 (258) Show / Hide 
Range on Protein: 500-691
Range on HMM: 8-191/258
Sequence Identity: 30% (60 aa)

GQGGYGAVYLGVLPDDTRVAVKLLNEGFPQEFDSGSNED-----KSFLAEVATLANIRHSNVVHLLGFCLEAPKHLLVYEYLENKSLDKVLFEPTTPLTK
| |.|| |..|     | |||| |            |..     . |  |.  . . || |..  .| |.. |  . . ||.   || ..| ..   .  
GRGNYGEVFRGTW-RGTQVAVKMLFN---------HNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEM-D

WKTRMQILIGAARGIEYFHSYSGDRRVVHRDIKPANVLLTADFHAKVADFGLAK-IMDTATHTTNFTMPGTVGYRAPECTIIGDAITVQADVFSFGVV
|  ..|. . .|.|. | |.   .  ..||| |  | |    .  |||||||.        |..  || || .  |||     .  |  |||.||..|
WPLMKQMMFDCAKGMIYLHCC--NPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEV-LRNQRYTEKADVYSFAIV
Kinase SD2b_a-2.AA TK 493-697 16 9.3e-25 79.27 In-house 1-389 (486) Show / Hide 
Range on Protein: 493-697
Range on HMM: 1-389/486
Sequence Identity: 16% (63 aa)

KDFANVLGQGGYG---AVYLGVLPDD--------------------------TRVAVKLLNEGFPQEFDSGSNEDKS-------FLAEVATLANIR----
  . ..||.| .|    ||.| . ..                          |.|||| | || ... .    |.         ||.|.. ..  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HSNVVHLLGFCLEA------------PKHLLVYEYLENKS----LDKVLF--EPTTPL-----------------------------------------
 | |.|.|.| |..             .  ..| || .. .    |.. |    |..                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------TKWKTRMQILIGAARGIEYFHSY--SGDRRVVHRDIKPANVLLTADFH-----------AKVADFG---
                                  .... .   .|.| || ||   ..  ..||||.   |.|.. . .           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKIMDTA---THTTNFTMP----------GTVGYRA------------PECTIIGD--------AITVQADVFSFGVVCIEVVS
     ||. ..     . ... ...          ... ||.            |||   .           | . ||.||||.. |...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase SD2b_a-2.AA DRK 755-775 38 9e-06 15.64 In-house 238-258 (258) Show / Hide 
Range on Protein: 755-775
Range on HMM: 238-258/258
Sequence Identity: 38% (8 aa)

CLQEDPKQRPTMDAVVALLND
|. ||| .||.|. ..  |  
CWNEDPQHRPSMQECLERLEA
Kinase SD2b_a-2.AA TK 755-773 36 1.7e-05 13.54 In-house 468-486 (486) Show / Hide 
Range on Protein: 755-773
Range on HMM: 468-486/486
Sequence Identity: 36% (7 aa)

CLQEDPKQRPTMDAVVALL
| ..||..|||.....  |
CWHYDPEDRPTFSQLHEQL
Kinase SD2b_a-2.AA Dicty4 754-775 29 3.4e-05 13.46 In-house 254-277 (277) Show / Hide 
Range on Protein: 754-775
Range on HMM: 254-277/277
Sequence Identity: 29% (7 aa)

WCLQEDPKQRPTMDAVVAL--LND
||. .||..||..  ..    |. 
WCWDHDPQHRPSFEEIIQRRILEH
Kinase SD2b_a-2.AA LRRK 754-775 40 5.3e-05 13.62 In-house 330-351 (351) Show / Hide 
Range on Protein: 754-775
Range on HMM: 330-351/351
Sequence Identity: 40% (9 aa)

WCLQEDPKQRPTMDAVVALLND
.| |.|||.||..  .|  | .
HCWQHDPKKRPHFSQIVKRLSQ
Kinase SD2b_a-2.AA MLK 755-773 36 0.000118 12.22 In-house 273-291 (291) Show / Hide 
Range on Protein: 755-773
Range on HMM: 273-291/291
Sequence Identity: 36% (7 aa)

CLQEDPKQRPTMDAVVALL
| ..||..||... .|  |
CWNQDPHKRPSFRQIVQHL
Kinase SD2b_a-2.AA Pkinase_Tyr 755-773 36 0.000586 14.03 Pfam 252-270 (270) Show / Hide 
Range on Protein: 755-773
Range on HMM: 252-270/270
Sequence Identity: 36% (7 aa)

CLQEDPKQRPTMDAVVALL
| ..||..|||. ...  |
CWHYDPEDRPTFSEIHEQL
Kinase SD2b_a-2.AA TKL-Unique 755-773 42 0.005241 6.66 In-house 272-290 (290) Show / Hide 
Range on Protein: 755-773
Range on HMM: 272-290/290
Sequence Identity: 42% (8 aa)

CLQEDPKQRPTMDAVVALL
|   || |||. | ..  |
CWHHDPSQRPSFDEIIHRL
Kinase SD2b_a-2.AA STE 755-767 61 0.211583 0.86 In-house 337-349 (359) Show / Hide 
Range on Protein: 755-767
Range on HMM: 337-349/359
Sequence Identity: 61% (8 aa)

CLQEDPKQRPTMD
||| ||..||| .
CLQKDPNKRPTAS