Gene SD21_h-1 (S.moellendorffii)

SD21_h-1

Species: S.moellendorffii
Alias: SD21_h-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: SD21

Sequence

Name Sequence Type Origin Length Description Download
SD21_h-1.AA Protein None 857 None Fasta, JSON
SD21_h-1.NA RNA None 2574 None Fasta, JSON
SD21_h-1.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of SD21_h-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin SD21_h-1.AA B_lectin 127-228 30 6e-24 83.88 Pfam 1-137 (137) Show / Hide 
Range on Protein: 127-228
Range on HMM: 1-137/137
Sequence Identity: 30% (42 aa)

PDHLVWTANGN---DPVSPQS-----TIVLTA-QGNLELRDAR-R---GLVWST--NTSNLG---VRMLKLKMSGNLVLVT-AN--GTEVWRS--FDHPT
.   ||.|| .   .||.. |     | ....  ||| | |.      . ||||  |||. |      ...  |||||| . .|  .. .|.|  |||||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DTLMPEQMLHI------GKK----LEAYKSSS--GLD
||. | . |        ...    | . ||..     
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin SD21_h-1.AA B_lectin 77-202 25 1.5e-09 38.99 SMART 1-126 (126) Show / Hide 
Range on Protein: 77-202
Range on HMM: 1-126/126
Sequence Identity: 25% (35 aa)

SNQVAEGMVLLVNNATKNIGCGFSSVQCPNRPQKCLVLGVAFLGKDGGFLPDHLVWTA--NGNDPVS---PQSTIVLTAQGNLELRDARRGLVWSTNTS-
.|   .| .|  .| .  . .|| . .        . .|. . .. .   ..  || |  | . ||.   . .. ...  ||| . |     |||.||. 
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ------WCNGIWYKNISNK--QRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTR

NLGVRMLKLKMSGNLVLVTAN----GTEVWRSFDHP
| |.  ..|  .||.|..  .    |  .| |||||
NNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
Kinase SD21_h-1.AA TKL 550-818 23 7.3e-64 218.49 In-house 1-364 (364) Show / Hide 
Range on Protein: 550-818
Range on HMM: 1-364/364
Sequence Identity: 23% (89 aa)

LGRGGFGTVYHGMLED---------GTKVAIKRLESSRGGGD---------------------------DQFRAEVIAIGSVHHSNLVKLIGFCCDEHK-
.|.||||.||.| .           |. ||.|.. |     .                           .... |.  . . .| |.|...|.||.. . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------HTLLVYEYMPNGSLDMWIFARDDNNFLDWRTRSKIALDIAKGLSYLHE----GCDQS--ILHLDIKPQNILLDVEFK------------
           .  .|.||.|.|||   .          |  | ..|||||.|..|||     .|     |.| |.|..|||.|  ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKISDFGLAIFAAKGSNNLRDTA-----------------LRGTPGYMAPEWLR-----------------CEVSLKIDVYSFGIVLLEIVSGKQALE
  .||.||||. |  . .|. .                     .|||..|||| ||                  | | |.||||||||| ||.....   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

FLDAIDHHSDSDDDHRPFHAEQSDLV-ELLDPRLK-GWSY------SSSEVERFVLVALCCIQDDPSARPGMGNVVKML
   . ..... .  .  |.....  . . | | ..  |..       ..  ...   . .| . ||..|| .  ..| |
-PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase SD21_h-1.AA IRAK 545-746 36 1.8e-53 183.98 In-house 2-225 (317) Show / Hide 
Range on Protein: 545-746
Range on HMM: 2-225/317
Sequence Identity: 36% (81 aa)

NFSRKLGRGGFGTVYHGMLEDGT-KVAIKRL----ESSRGGGDDQFRA---EVIAIGSVHHSNLVKLIGFCCDEHKHTLLVYEYMPNGSLDMWIFARDDN
. ....| ||||.||.| .   |  .|.|.|    ..| .. . .|..   |. .  . .| |.| | |.| .. .|  |||.|||||||     ..|  
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHC-LVYPYMPNGSLEDRLWCQDGQ

NF---LDWRTRSKIALDIAKGLSYLHEGC-DQSILHLDIKPQNILLDVEFKAKISDFGLAIFA----AKGSNNL---RDTALRGTPGYMAPEWLR---CE
.    | | .| .|.. .|.|. .||.     .| | |||. |||||  | .||.||||. |     .| .  .   .   .|||  ||.|| .|    .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VSLKIDVYSFGIVLLEIVSGK-QAL
 . | |||||||||||...|  ...
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase SD21_h-1.AA TKL-Unique 546-744 35 2.9e-50 173.3 In-house 1-226 (290) Show / Hide 
Range on Protein: 546-744
Range on HMM: 1-226/290
Sequence Identity: 35% (82 aa)

FSRKLGRGGFGTVYHGMLEDGTKVAIKRLE-SSRGGGD--DQFRAEVIAIGSVH-HSNLVKLIGFCCD---EHKHTLLVYEYMPNGSLDMWIF-------
|. |.|.||.|.||.|.   |..||||...  .    .  . |. ||  .   | | |.|...|.| |     ..  .| ||.| |||.  .        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

ARDDNNFLDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVE-----FKAKISDFGLAIFAAKG----SNNL---RDTALRGTPGYMAPEWL
   .|. |..  | |.|.|||.|. |||  |.  |.|.|.|..|.|.| .     ...||.||||..|..|     .|..   |..   |.. .|||| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLH-HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

RC---EVSLKIDVYSFGIVLLEIVSGKQ
|      | |.||||||||| ||...|.
RMNFCQYSEKSDVYSFGIVLWEIATRKI
Pkinase SD21_h-1.AA Pkinase 544-818 23 3.3e-50 177.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 544-818
Range on HMM: 1-293/293
Sequence Identity: 23% (74 aa)

ANFSRKLGRGGFGTVYHGMLEDGTK-VAIKRLESSRGGGDDQFRA-----EVIAIGSVHHSNLVKLIGFCCDEHKHTLLVYEYMPNG----SLDMWIFAR
  . ||.|.|.||.||...  .  | ||.|... . .  ... ..     |.    ...| | |.|.... | ..|  .| ||...|    .|  .| ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTW

DDNNF-LDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVEFKA----KISDFGLAIFAAKGSNNLRDTALRGTPGYMAPEWLR--CEVSLK
....| .....  .... |..|| |.|. .  .|.| |.||.|||.| .       ||.||||| ..    ||   | . |||.|||||..|   . . |
RHGCFYFSEWECKFYMYQILRGLEYCHS-M--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDVYSFGIVLLEIVSGKQALEFLDAIDHHSDSDDDHRPFHAE-----QSDLVELLDPRLKGWSYSSSEV---------------------ERFVLVALCC
.|..|.|..| | ..|.                    ||  .      .... .   . . .......                      | .  .  .|
VDMWSCGCILYEMLCGR-------------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

IQDDPSARPGMGNVVKM--L
.. ||. ||.   ...   .
LCKDPKKRPTAEQILQHPWF
S_TKc SD21_h-1.AA S_TKc 544-818 25 9.5e-43 149.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 544-818
Range on HMM: 1-231/231
Sequence Identity: 25% (74 aa)

ANFSRKLGRGGFGTVYHGMLED-GTKVAIKRLESSRGGGDDQFRAEVIAIGSVHHSNLVKLIGFCCDEHKHTLLVYEYMPN--GSLDMWIFARDDNNF--
  . ||.|.|.||.|| .   . | .||||..        ...| |.    . || |.|||.... |  .|  .| ||...  |.|   |  |  .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVEFKAKISDFGLAIFAAKGSNNLRDTALRGTPGYMAPEWLRCEVSL-KIDVYSFGIVL
 ..  .  ...  |...| |.|.   . |.| |.||.|||||     ||.||||| .          | . ||| ||||| |    .  |.|..|.|..|
PFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL

LEIVSGKQALEFLDAIDHHSDSDDDHRPFHAEQSDLVELLDPRLKGWSYSSSEVERFVLVALCCIQDDPSARPGMGNVVK---------ML
 | ..|.   .                    ..  . ...              . .      | | ||. ||.   . .          .
YEMLCGYPPFP--------------------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SD21_h-1.AA LRRK 544-764 25 5.6e-39 135.53 In-house 1-308 (351) Show / Hide 
Range on Protein: 544-764
Range on HMM: 1-308/351
Sequence Identity: 25% (80 aa)

ANFSRKLGRGGFG-TVYHGMLED---------------------------GTKVAIKRLESSR---------------------GGGDDQ----------
  . ...|||||| .|| . ...                           ...|||| ..  .                     . ..|           
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

---FRAEVIAIGSVHHSNLVKLIGFCCDEHKHTLLVYEYMPNGSLDMWIFARDDNNF------LDWRTRSKIALDIAKGLSYLHEGCDQS--ILHLDIKP
   || ||  . . .|.|.|.|.|||   ...  .| ||.|.|.|.  ....  . |      ..| .. ||||.||||. |||   ...  |.| | |.
FREFRHEVWIMSHLNHPNIVSLKGFC---IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH---SHNPPIIHRDLKS

QNILL---D---------VEFKAKISDFGLAI-FAAKGSNNLRDTALRGTPGYMAPEWLR----CEVSLKIDVYSFGIVLLEIVSGK-QALEFLDAID--
 ||||   .          . .|||.|||.   |.. ..  ...    |.||.|||| .|     | . |.|.||||..| |..... .. . .|  |  
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV--GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHM

--HHSDSD---DDHRP
  .  ..|   . .||
QWMEQIEDKIIEGLRP
Kinase SD21_h-1.AA STE 544-743 23 2e-37 129.75 In-house 1-265 (359) Show / Hide 
Range on Protein: 544-743
Range on HMM: 1-265/359
Sequence Identity: 23% (65 aa)

ANFSRKLGRGGFGTVYHGMLED----------------GTKVAIKRLESSRGGG-----------------DDQFRAEVIAIGSVH--HSNLVKLIGFCC
  . .|.|.|.||||| .|  .                |. .|||... ..                     .|.  |.      .  | | || .| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE------HKHTLLVYEYMPNGSLD-----MWIFARDDN------NFLDWRTRSKIALDIAKG-LSYLHEGCDQSILHLDIKPQNILLDVEFKAKISDFG
.|      . .  .. |||..||||      ..  ...|       ...    ..|. .| || |.|||.     | | ||||.||||     .|..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAIFAAKG--------------SNNLRDTALRGTPGYMAPEWLRCE-------VSLKIDVYSFGIVLLEIVSGK
..   ..               ..  . . . ||| .|||| ....        . | |..|.|....| . ||
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase SD21_h-1.AA CAMK 549-736 19 5.1e-36 113.03 In-house 1-324 (425) Show / Hide 
Range on Protein: 549-736
Range on HMM: 1-324/425
Sequence Identity: 19% (64 aa)

KLGRGGFGTVYHGMLE-DG------------TKVAIKRLESS----------------------------RGGGDDQFRAEVIAIGS-------VHHSNL
.||||.||.|. ..   ..            .||||| .. .                            |.   ...| |.    .       ..| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLIGFCCDEHK------------------HTLLVY---EYMPNG----SLDMWIFARDDN------------NFLDWRTRSKIALDIAKGLSYLHEGCD
.||. .  |.|.                  |  .|    ||...|     |  .| .. ..              .. |  ...   |. .. |.|   .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH---S

QSILHLDIKPQNILLDVE-----------------FKAKISDFGLA--IFA---------AKGSNNLRDT------------ALRGTPGYMA-PEWLRCE
. | |.|.|| |||||                   .. ||.|||.|  ..           || . . ..               |||.||| ||.|. .
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGK

---------------VSLKIDVYSFGIVL
               .. |.|. | |..|
GHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase SD21_h-1.AA MLK 544-743 27 9e-36 121.61 In-house 1-233 (291) Show / Hide 
Range on Protein: 544-743
Range on HMM: 1-233/291
Sequence Identity: 27% (65 aa)

ANFSRKLGRGGFGTVYHGMLEDGTK-----VAIKRLE------SSRGGGDDQFRAEVIAIGSVHHSN----LVKLIGFCCDEHKHTLLVYEYMPNGSLDM
 .|....| |.|| |. |    ..      ||.|| .      |. .  ...|. |.     . | |     ... | | .. .| ..| ||...|||  
IQFHEWIGSGSFGKVWKGRWR-NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WIFARDDNNF-----------LDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDV------EFKAKISDFGLAIFAAKG-SNNLRDTALRGT
 . ..... .            |     ..||..|.|..|||.   . | | |.|..|||.|       . ..||.|||.. .  .  .|    .  .||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN---MMSNAGT

PGYMAPEWL---RCE-VSLKIDVYSFGIVLLEIVSGK
. .|||| .   ||| .| | ||.|.|.|| |.....
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase SD21_h-1.AA Dicty4 545-740 33 2.3e-35 115.54 In-house 2-211 (277) Show / Hide 
Range on Protein: 545-740
Range on HMM: 2-211/277
Sequence Identity: 33% (72 aa)

NFSRKLGRGGFGTVYHGMLEDGTKVAIKRLESSRGGGDDQ----FRAEVIAIGSVHHSNLVKLIGFCC--DEHK-HTLLVYEYMPNGSLDMWIFA----R
|.  ..|.|.||.|| |    |..||.| | .   . |      ||.||   ..  | |.... | |     |.   . | |||| |.|   . .     
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

DDNNFLDWRTRSK---IALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVEFKAKISDFGLAIFAAKGSNNLR-DTALRGTPGYMAPEWLRCEV-SLKID
 ..  ||| .. .   .|.|.|.|. .||. |.  |.|.|.|. |.| |  ...|..||||.    |....    ..  |||..|||| .. .    | |
QQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKAD

VYSFGIVLLEIV
|||||||| ||.
VYSFGIVLWEIL
Kinase SD21_h-1.AA TK 544-741 16 6.7e-34 110.47 In-house 1-389 (486) Show / Hide 
Range on Protein: 544-741
Range on HMM: 1-389/486
Sequence Identity: 16% (63 aa)

ANFSRKLGRGGFG---TVYHGMLEDG--------------------------TKVAIKRLESSRGGGDDQFRA--------------EVIAIGSVH----
  . .|||.| ||   .|| |.....                          |.||.| | .  .  ...|..              |. ..   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HSNLVKLIGFCCDEH-----------KHTLLVYEYMPNGS----LDMWIFARDD---------------------------------------------
 | |.|.|.| |...            .. ..| ||||.|.    |. .  ....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------NNFLDWRTRSKIALDIAKGLSYLHEG----CDQSILHLDIKPQNILLDVEFK-----------AKISDFG--
                            ...|. ...  ....||.|..|||.       | . | |.   |.|.. . .           .||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAIFAAKGSNNLRDTALRGTPG------------------------YMAPEWLRCEV----------SLKIDVYSFGIVLLEIVS
      ||    ....  |..  ... .                        .|||| |.  |          . | ||.|||... ||..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase SD21_h-1.AA Pkinase_Tyr 544-744 29 4e-33 112.8 Pfam 1-213 (270) Show / Hide 
Range on Protein: 544-744
Range on HMM: 1-213/270
Sequence Identity: 29% (64 aa)

ANFSRKLGRGGFGTVYHGMLE-----DGTKVAIKRLESSRGGGD---DQFRAEVIAIGSV-HHSNLVKLIGFCCDEHKH--TLLVYEYMPNGSLDMWIFA
  | .|||.| ||.||.| .      ....||.| |  .    .   . | .|.    .  || |.|.|.| | |. ..   ..| ||||.|.|.    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R-DDNNFLDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVEFKAKISDFGLAIFAAKGSNN-LRDTALRGTPGYMAPE-WLRCEVSLKIDV
. .|.. |.  .  .....||||..||..     . | |.   |.|.. ....||.|||||    . ..     .  .     |||| .  .. . | ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGIVLLEIVS-GKQ
.|||... ||.. |.|
WSFGVLMWEIFTYGEQ
Kinase SD21_h-1.AA RIPK 550-747 29 1.3e-32 108.49 In-house 1-229 (290) Show / Hide 
Range on Protein: 550-747
Range on HMM: 1-229/290
Sequence Identity: 29% (69 aa)

LGRGGFGTVYHGMLED-GTKVAIKRLESSR------GGGDDQFRAEVIAIGSVHHSNLVKLIGFCCDE-----HKHTLLVYEYMPNGSLDMWIFARD--D
.|.||||.|.     . |. ||.|   .             .   |. .  .  ... |.. ||| .|      |   .| |||.||||     ..    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

NNFLDWRTRSKIALDIAKGLSYLHEGCDQS--ILHLDIKPQNILLDVEFKAKISDFGLAIFAAKGSNNL----------RDTALR-GTPGYMAPEWLR--
.  . |  |  .   |. |  |||   ..   |.|.| ||.|||.| .| .||.||||| .    . .            . ..| ||  ||.|| .|  
HHPDPWPLRCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

--CE---VSLKIDVYSFGIVLLEIVSGKQALE
       |. | |||||.||. |. ..|.. |
NKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYE
Kinase SD21_h-1.AA TyrKc 544-818 22 2e-27 98.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 544-818
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

ANFSRKLGRGGFGTVYHGMLEDGTKVAIKRLESSRGGGDDQFRAEVIAIGSV--HHSNLVKLIGFCCDEH------KHTLLVYEYMPNGSLDMWIFARDD
  . .|||.| ||.||.|..   ..||.| | ..       |. |     ..  || |.|.|.| | ..       .  ..| ||||.|.|.  . .. .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NNFLDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVEFKAKISDFGLAIFAAKG------SNNLRDT---ALR--GTPGYMAPEWL-RCEV
.  | ...  .....||.| .|||.     . | |.   |.|.. .. .|||||||. .   .      .   | .     .       |||| .  .. 
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SLKIDVYSFGIVLLEIVSGKQALEF------LDAIDHHSDSDDDHRPFHAEQ----SDLVELLDPRLKGWSYSSSEVERFVLVALCCIQDDPSARPGMGN
. | ||.|||... || .  |          ..... . . .. .|.   .     |             .      | .  . ..| . ||. || . .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------F-VCCPDEMYQ-IMKQCWHEDPEDRPTFSE

VVKML
... .
IHECF
Kinase SD21_h-1.AA TK 795-818 25 0.000868 7.73 In-house 463-486 (486) Show / Hide 
Range on Protein: 795-818
Range on HMM: 463-486/486
Sequence Identity: 25% (6 aa)

LVALCCIQDDPSARPGMGNVVKML
.. ..| . ||. || .  ....|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase SD21_h-1.AA MLK 799-818 35 0.00785 5.81 In-house 272-291 (291) Show / Hide 
Range on Protein: 799-818
Range on HMM: 272-291/291
Sequence Identity: 35% (7 aa)

CCIQDDPSARPGMGNVVKML
.| ..||. || .  .|. |
QCWNQDPHKRPSFRQIVQHL