Gene SD21_k (S.moellendorffii)

SD21_k

Species: S.moellendorffii
Alias: SD21_k
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: SD21

Sequence

Name Sequence Type Origin Length Description Download
SD21_k.AA Protein None 905 None Fasta, JSON
SD21_k.NA RNA None 2718 None Fasta, JSON
SD21_k.kin_dom Protein Kinase Domain None 210 None Fasta, JSON

Protein domain

Protein domains of SD21_k.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SD21_k.AA IRAK 46-73 46 7.3e-07 20.54 In-house 190-219 (317) Show / Hide 
Range on Protein: 46-73
Range on HMM: 190-219/317
Sequence Identity: 46% (14 aa)

APQYAL--QGRLTFKVDVYSYGVLLLEIIS
.| .    ||.|| |.|||| |. |||...
PPEFIRDPQGQLTKKTDVYSFGIVLLEVLT
Kinase SD21_k.AA Src-Echino1 46-74 48 2e-06 17.81 In-house 165-193 (252) Show / Hide 
Range on Protein: 46-74
Range on HMM: 165-193/252
Sequence Identity: 48% (14 aa)

APQYALQGRLTFKVDVYSYGVLLLEIISY
||  || || | | ||.|.|.|. |.. .
APEAALYGRFTIKSDVWSFGILMTEMVTF
Kinase SD21_k.AA TKL 52-73 40 8.4e-05 13.24 In-house 263-284 (364) Show / Hide 
Range on Protein: 52-73
Range on HMM: 263-284/364
Sequence Identity: 40% (9 aa)

QGRLTFKVDVYSYGVLLLEIIS
..  . |.||||.|..| ||..
GFEYSEKCDVYSFGIVLWEILT
Kinase SD21_k.AA Pkinase_Tyr 53-74 54 0.000893 13.41 Pfam 189-210 (270) Show / Hide 
Range on Protein: 53-74
Range on HMM: 189-210/270
Sequence Identity: 54% (12 aa)

GRLTFKVDVYSYGVLLLEIISY
|. | | ||.|.|||. ||..|
GKFTTKSDVWSFGVLMWEIFTY
Kinase SD21_k.AA CZAK 58-72 66 0.001238 9.25 In-house 202-216 (279) Show / Hide 
Range on Protein: 58-72
Range on HMM: 202-216/279
Sequence Identity: 66% (10 aa)

KVDVYSYGVLLLEII
||||||.| .| .||
KVDVYSFGMILWCII
Kinase SD21_k.AA MLK 58-73 50 0.001366 8.48 In-house 216-231 (291) Show / Hide 
Range on Protein: 58-73
Range on HMM: 216-231/291
Sequence Identity: 50% (8 aa)

KVDVYSYGVLLLEIIS
|.||.|.||.| |...
KCDVWSWGVVLWEMLT
Kinase SD21_k.AA LRRK 58-73 50 0.001977 7.98 In-house 262-277 (351) Show / Hide 
Range on Protein: 58-73
Range on HMM: 262-277/351
Sequence Identity: 50% (8 aa)

KVDVYSYGVLLLEIIS
|||.||.|..| |...
KVDCYSFGMILWELLT
Kinase SD21_k.AA TK 60-74 60 0.002984 5.9 In-house 376-390 (486) Show / Hide 
Range on Protein: 60-74
Range on HMM: 376-390/486
Sequence Identity: 60% (9 aa)

DVYSYGVLLLEIISY
||.|.|||. || .|
DVWSFGVLMWEIFTY
Kinase SD21_k.AA Dicty4 58-71 64 0.020951 4.03 In-house 197-210 (277) Show / Hide 
Range on Protein: 58-71
Range on HMM: 197-210/277
Sequence Identity: 64% (9 aa)

KVDVYSYGVLLLEI
|.||||.| .| ||
KADVYSFGIVLWEI
Kinase SD21_k.AA TKL-Unique 58-73 56 0.026439 4.15 In-house 360-375 (290) Show / Hide 
Range on Protein: 58-73
Range on HMM: 360-375/290
Sequence Identity: 56% (9 aa)

KVDVYSYGVLLLEIIS
|.||||.|. | ||..
KSDVYSFGIVLWEIAT
Kinase SD21_k.AA Dicty4-Unclassified 56-72 47 0.127476 1.28 In-house 186-202 (263) Show / Hide 
Range on Protein: 56-72
Range on HMM: 186-202/263
Sequence Identity: 47% (8 aa)

TFKVDVYSYGVLLLEII
. | |||||...| | .
NQKSDVYSYAMMLYELA
Kinase SD21_k.AA Pkinase 56-73 38 2.020644 2.57 Pfam 190-207 (293) Show / Hide 
Range on Protein: 56-73
Range on HMM: 190-207/293
Sequence Identity: 38% (7 aa)

TFKVDVYSYGVLLLEIIS
. |||..|.|..| | ..
GPKVDMWSCGCILYEMLC
B_lectin SD21_k.AA B_lectin 178-258 35 9.9e-30 103.75 Pfam 1-105 (137) Show / Hide 
Range on Protein: 178-258
Range on HMM: 1-105/137
Sequence Identity: 35% (37 aa)

TSRLIWEANRE---DPV-GFN----ASLTLGA-DGNLVLRDAD-G-RS--VWST-DT-ANKG---ATHAEILPTGNFVVR--SN--NTILWQS--FDHPS
     | |||.   .|| .      ..||. . |||||| |.. | .   |||| .. ...|   ...|... .||.|..  .|  |..||||  ||||.
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DTLMV
||. .
DTWLP
B_lectin SD21_k.AA B_lectin 143-252 29 1.7e-20 75.3 SMART 1-126 (126) Show / Hide 
Range on Protein: 143-252
Range on HMM: 1-126/126
Sequence Identity: 29% (38 aa)

NNDLGRFGAPLEKQDIYD--STFYRTAFFESDRGPSYTS------RLIWEA--NREDPVGF---NASLTLGADGNLVLRDADGRSVWSTDTA-NKGATHA
.|.|.        . ...    |...       | .| .      . .| |  ||. ||     .. ||.. |||||. |  .|.|||..|. |.| . |
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ-WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNNGNYVA

EILPTGNFVVRSNN-----TILWQSFDHP
. ...||||.....      ..|||||||
VLQDDGNFVIYDPDDNDSGNFIWQSFDHP
B_lectin SD21_k.AA B_lectin 268-305 38 0.971743 4.11 Pfam 12-52 (137) Show / Hide 
Range on Protein: 268-305
Range on HMM: 12-52/137
Sequence Identity: 38% (16 aa)

LQSRTTLSNSS-LGVYSLVME--PGGLVLYSNFSG-SQQPYW
| . . ...||  | |.|.|    | |||| . .| |..| |
L-TGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVW
PAN_AP SD21_k.AA PAN_AP 408-481 23 1e-06 29.53 SMART 1-85 (85) Show / Hide 
Range on Protein: 408-481
Range on HMM: 1-85/85
Sequence Identity: 23% (21 aa)

VQSLDFLPVPGAEYFSSRY----LNSTVTSFEDCRSRCLQNCSCSAFFYWNESSSCFMTN--NVTLQIV--------SNQSHVAYIKA
 . ..|. .|.... .|.     . . |.| |.|...||.|||| .| | | ...| . .  . .  .          ||. . |.| 
CCDDCFVRMPNMKL-FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN-TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase SD21_k.AA TKL 569-833 22 6.7e-64 218.61 In-house 1-364 (364) Show / Hide 
Range on Protein: 569-833
Range on HMM: 1-364/364
Sequence Identity: 22% (85 aa)

LGTGGFGGVYEGVLPD---------GRKVAVKKLES---TGQGK-------------------------KEFYAEVAVLGTIHHWNLVKLLGFCSEGLN-
.| |||| || |..           |. |||||. |       |                         ...  |. ..  ..| |.|...|.| .. . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEHMENGSLDKWIYQDFLEQKVLNWQQRMEIMLGMARGLAYLHE----ECVEK--IIHLDIKPQNILLNEDLV-----------
              .|.| ...|||   .           |.||. ..|..|||..|||      |  |  ||| |.|..|||..|..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---AKVADFGLSRLMSRDQSYVMTT------------------MRGTPGYLAPEWLLEA----------------AITEKSDVYSFGVVLLEVISGRRNF
   .|..|||||| ||....  .|                    .|||...||| | ..                  .||.||||||.|| |.....| .
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

SRVS-EREKFYLPAYALELVTQEKEM-ELVDP-------RLKGECDEAVVRAVIRIAFQCLQENGSSRPSMGKVVQML
.    . ..|  | . ....   ..   .  |       . .  . . . . ..... .| ... ..|||. .... |
YDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHK-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase SD21_k.AA Pkinase 564-761 27 3.4e-55 194.49 Pfam 2-209 (293) Show / Hide 
Range on Protein: 564-761
Range on HMM: 2-209/293
Sequence Identity: 27% (60 aa)

NFSKVLGTGGFGGVYEGVLPDGRK-VAVKKLESTGQGKKEFYA-----EVAVLGTIHHWNLVKLLGFCSEGLNRLLVYEHMENG----SLDKWIYQDFLE
 . ...| |.|| ||...  . .| ||||...  .. ... ..     |....  ..| | |.|.... .. .  .| |..|.|    .|      |...
HIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-----DYIS

---QKVL--NWQQRMEIMLGMARGLAYLHEECVEKIIHLDIKPQNILLNEDLVA----KVADFGLSRLMSRDQSYVMTTMRGTPGYLAPEWLL-EAAITE
   ....   ...   .|. ..|||.|.|..   .||| |.||.|||.... .     |..||||.....   ...|||  |||.|.|||...    .. 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPEVIRGGQYYGP

KSDVYSFGVVLLEVISGR
|.|..|.|..| |...||
KVDMWSCGCILYEMLCGR
Kinase SD21_k.AA IRAK 564-833 31 2.6e-52 180.11 In-house 2-317 (317) Show / Hide 
Range on Protein: 564-833
Range on HMM: 2-317/317
Sequence Identity: 31% (102 aa)

NFSKVLGTGGFGGVYEGVLPDGRK--VAVKKLE-----STGQGKKEFYA---EVAVLGTIHHWNLVKLLGFCSEGLNRLLVYEHMENGSL-DKWIYQDFL
. . ..| |||| || |.. ..    .|||||      |... ...| .   |. |. ...| |.| |.|.|.|. .  |||. | |||| |    ||  
HKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

EQ-KVLNWQQRMEIMLGMARGLAYLHEEC-VEKIIHLDIKPQNILLNEDLVAKVADFGLSRLM---S--RDQSY--VMT-TMRGTPGYLAPEWLL--EAA
   | | |.|| .| .| |.|. .||.      ||| |||. |||| .....| .|||| |     |   .|.|   || . |||  |..|| .      
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

ITEKSDVYSFGVVLLEVISGRRNFSRVSE-REKFYLPAYALELVTQEKE--------------------------MELVDPRLKGECDEAVVRAVIRIAF
.| |.||||||.|||||..|.|    ... .|  ||  .  |.  ...                             ..|.| .. |..... .    | 
LTKKTDVYSFGIVLLEVLTGCRAV--YDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHR-MPPCPPNMEKEMCQCAC

QCLQENGSSRPSMGKVVQML
.|. .    |..| .|.| |
CCGHHRANRRCDMAWVMQQL
Kinase SD21_k.AA TKL-Unique 565-760 31 6.6e-47 162.16 In-house 1-224 (290) Show / Hide 
Range on Protein: 565-760
Range on HMM: 1-224/290
Sequence Identity: 31% (72 aa)

FSKVLGTGGFGGVYEGVLPDGRKVAVKKLE----STGQGKKEFYAEVAVLGTIH-HWNLVKLLGFCS----EGLNRLLVYEHMENGSLDKWIYQ------
|....|.||.| || |. . | .||.|...    |  . ..||. || .. ..| | |.|.. |.|        |. .| | .. |||.. . |      
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

DFLEQKVLNWQQRMEIMLGMARGLAYLHEECVEKIIHLDIKPQNILLNED-----LVAKVADFGLSRLMSRD--QSYVMT------TMRGTPGYLAPEWL
   . . ||.|||. . . .|.|. ||| .    |||.|.|..|.|....     . .|..|||||.. |..   .. .       |  |.. ..||| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

LE--AAITEKSDVYSFGVVLLEVISG
    . ..|||||||||.|| | ...
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase SD21_k.AA MLK 564-761 28 4.1e-43 147.43 In-house 2-233 (291) Show / Hide 
Range on Protein: 564-761
Range on HMM: 2-233/291
Sequence Identity: 28% (67 aa)

NFSKVLGTGGFGGVYEGVLPDGRK-----VAVKKLE-------STGQGKKEFYAEVAVLGTIHHWN----LVKLLGFCSE-GLNRLLVYEHMENGSLDKW
.|....| |.|| |. |.   ..      ||||. .       .|.  ...|  |.  |  . | |     ....| |.. . . ..| | .|.|||   
QFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IYQDF-------LEQK---VLNWQQRMEIMLGMARGLAYLHEECVEKIIHLDIKPQNILLNE------DLVAKVADFGLSRLMSRDQSYVMTTMRGTPGY
..           .||   |   .. | ..| .|||..|||.. . .||| |.|..|||. |      ....|..|||.|| ... .   |. ..||. .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

LAPEWL---LEAAITEKSDVYSFGVVLLEVISGR
 ||| .    .   .||.||.|.|||| |.....
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase SD21_k.AA TK 563-833 16 2.2e-42 139.42 In-house 1-486 (486) Show / Hide 
Range on Protein: 563-833
Range on HMM: 1-486/486
Sequence Identity: 16% (80 aa)

DNFSKVLGTGGFG---GVYEGVLPDGR--------------------------KVAVKKLEST-GQGKKEFYA--------------EVAVLGTIH----
  . |.|| | ||    ||.| . ...                          .|||| | .. .. ..|| .              |....   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HWNLVKLLGFCSEGLN------------RLLVYEHMENGS----LDKWIYQ------------------------------------------------
 | |.|.|.| |..| .             ..| |.|..|.    |...  .                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------DFLE---------QKVLNWQQRMEIMLGMARGLAYLHEECVE---KIIHLDIKPQNILLNEDLV-----------AKVADFG---
               |.|          .  |. .|.. ...  |.|..|||.  .|   ...| |.   |.|..|..|           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRLMSRDQSYVMTTMRGTPG-------------------------YLAPEWLLEAA---------ITEKSDVYSFGVVLLEVIS-GRRNFSRVS
     |.| . .|. |. .. .||..                         ..||| |..            |.||||.||||.. |. . |.  .    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EREKFYL---PAYALELVTQ----------EKEMELVDPRLKGECD---------EAVVRAVIRIAFQCLQENGSSRPSMGKVVQML
  ..      ..  .|....          | .  .  |. .. .|         ..   .. ..  || ... . ||..  ....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase SD21_k.AA Dicty4 564-756 33 1e-41 137.01 In-house 2-209 (277) Show / Hide 
Range on Protein: 564-756
Range on HMM: 2-209/277
Sequence Identity: 33% (71 aa)

NFSKVLGTGGFGGVYEGVLPDGRKVAVKKLESTGQGK-----KEFYAEVAVLGTIHHWNLVKLLGFCS----EGLNRLLVYEHMENGSLDKWIYQ---DF
|. . .|.|.|| || |    | .|||||| .. |.      .|| .||. .. | | |.....| |     .    . | | |  |.| . .     . 
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

LEQKVLNWQQRME---IMLGMARGLAYLHE-ECVEKIIHLDIKPQNILLNEDLVAKVADFGLSRLMSRDQ--SYVMTTMRGTPGYLAPEWLLEAAITEKS
 . . | |  .     ...  |||...||.  .|  |||.|.|. |.|  .....||.|||||..| ..   .  ..|. |||.. ||| . . . .||.
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVVLLE
|||||| || |
DVYSFGIVLWE
TyrKc SD21_k.AA TyrKc 563-833 25 8.9e-41 142.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 563-833
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

DNFSKVLGTGGFGGVYEGVLPDGRKVAVKKLESTGQGKKEFYAEVAVLGTI--HHWNLVKLLGFCSEG-------LNRLLVYEHMENGSLDKWIYQDFLE
  . |.|| | || ||.|..   ..||||.| .    ...|. |  ..  .  || |.|.|.| |...          ..| |.|..|.|.     |.| 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK-----DYLR

QKV--LNWQQRMEIMLGMARGLAYLHEECVEKIIHLDIKPQNILLNEDLVAKVADFGLSRLMSRD-------QSYVMTTMRGTPG-----YLAPEWLLEA
 .   |....  ....  |.| .|||.    ..|| |.   |.|..|....|..||||||    |       . |.... .|. .      .||| . . 
KHRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

AITEKSDVYSFGVVLLEVIS-GRRNFSRVSEREKFYLPAYALELVTQEKEMELVDPRLKGE-----CDEAVVRAVIRIAFQCLQENGSSRPSMGKVVQML
  |.||||.||||.. |. . |    . . ..  .  .. ..|.| | . |.  .  .  .     | ... . ...   || .|. ..||..  ... .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQ-IMK---QCWHEDPEDRPTFSEIHECF
Kinase SD21_k.AA Pkinase_Tyr 564-759 30 9.3e-41 138.66 Pfam 2-209 (270) Show / Hide 
Range on Protein: 564-759
Range on HMM: 2-209/270
Sequence Identity: 30% (66 aa)

NFSKVLGTGGFGGVYEGVLP-----DGRKVAVKKL--ESTGQG--KKEFYAEVAVLGTI-HHWNLVKLLGFCS-EGLN--RLLVYEHMENGSLDKWIYQD
 | |.|| | || ||.|..      .. .||||.|   .. .   ...| .|.... .. || |.|.|.| |. .|     ..| |.|..|.|.     |
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL-----D

FLEQK-----VLNWQQRMEIMLGMARGLAYLHEECVEKIIHLDIKPQNILLNEDLVAKVADFGLSRLMSRDQSY-VMTTMRGTPG-YLAPEWLLEAAITE
.| ..      |. ..  .. .  |.|..||..     .|| |.   |.|..|..|.|..||||.|..  |  | ....    |   .||| . .   |.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

KSDVYSFGVVLLEVIS
||||.||||.. |...
KSDVWSFGVLMWEIFT
S_TKc SD21_k.AA S_TKc 563-833 24 2.8e-40 141.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 563-833
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

DNFSKVLGTGGFGGVYEGVLPD-GRKVAVKKLESTGQGKKEFYAEVAVLGTIHHWNLVKLLGFCSEGLNRLLVYEHMEN--GSLDKWIYQDFL--EQKVL
  . ...| |.|| || ..  . ||.||.|..       . .. |...|   || |.|||.... .  .  .| |....  |.| . | .      ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NWQQRMEIMLGMARGLAYLHEECVEKIIHLDIKPQNILLNEDLVAKVADFGLSRLMSRDQSYVMTTMRGTPGYLAPEWLLEAAITE-KSDVYSFGVVLLE
.  .   .|  ....|.|.|.    .||| |.||.||||.|  . |..||||.|..        ||. ||| |.||| |     .  |.|..|.|..| |
PE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

VISGRRNFSRVSEREKFYLPAYALELVTQEKEMELVDPRLKGECDEAVVRAVIRIAFQCLQENGSSRPSMGKVVQ---------ML
 ..|.  |.          ..  ....                      . .. .  .||| . . ||.  .. |          .
MLCGYPPFP---------QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SD21_k.AA Dicty4-Unclassified 564-760 32 1.8e-36 122.38 In-house 2-204 (263) Show / Hide 
Range on Protein: 564-760
Range on HMM: 2-204/263
Sequence Identity: 32% (69 aa)

NFSKVLGTGGFGGVYEGVLPDGRKVAVKKLESTGQGKK-----EFYAEVAVLGTIHHWNLVKLLGFCSEGLNR-------LLVYEHMENGSLDKWIY-QD
   . .| | |  |. |.   |. |||||. .           .| .||..|| | | ||||. | |   .|          | | |  | |   |  . 
QIDQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYC---INPRSHKSTMCIVMEFMHKGNLFEVIHSKP

FLEQKVLNWQQ--RMEIMLGMARGLAYLHEECVEKIIHLDIKPQNILLNEDLVAKVADFGLSRLMSRDQSYVMTTMRGTPGYLAPEWLLEAAITEKSDVY
   |. .       . . .  |.|...||      .|| |||  |||.  .  .|.||||.||  .  .   |||  |||   .|| |   . . |||||
SEQQQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFN--MTTIAGTPKWESPECLMHESYNQKSDVY

SFGVVLLEVISG
|....| | . |
SYAMMLYELATG
Kinase SD21_k.AA LRRK 564-764 23 1.1e-34 120.15 In-house 2-283 (351) Show / Hide 
Range on Protein: 564-764
Range on HMM: 2-283/351
Sequence Identity: 23% (68 aa)

NFSKVLGTGGFG-GVYEGVLPD---------------------------GRKVAVKKLEST-------------------------------GQGKKEFY
 . . .| ||||  || . . .                           . .||.||.. .                               .... . .
KIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAF

A----EVAVLGTIHHWNLVKLLGFCSEGLNRLLVYEHMENGSLDKWIYQDFLEQK------VLNWQQRMEIMLGMARGLAYLHEECVEK--IIHLDIKPQ
     ||... . .| |.|.|.||| . |   .| | . .|.|.. . ... . .      ...|. . .|.|  |.|..|||     .  ||| | |. 
REFRHEVWIMSHLNHPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFL-HNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS---HNPPIIHRDLKSP

NILL---N---------EDLVAKVADFGLSRLMSRDQSYVMTTMRGTPGYLAPEWLLEA---AITEKSDVYSFGVVLLEVISGR-RNF
||||   .         .. .||.||||.||. . ... |  .. |.||..||| . .      |||.|.||||..| | .... . |
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPF
Kinase SD21_k.AA CZAK 564-761 31 1.1e-30 108.31 In-house 2-219 (279) Show / Hide 
Range on Protein: 564-761
Range on HMM: 2-219/279
Sequence Identity: 31% (71 aa)

NFSKVLGTGGFGGVYEGVLPDGRKVAVKKLESTG-QGKKE------FYAEVAVLGTIHHWNLVKLLGFCSEGL--NRLLVYEHMENGSLDKWIYQDFLEQ
 | .. | | || || ..   |  ||.|..       | |      |  ||...    | | |  || |||.    .  | | |. |||..     .|  
KFGQTIGQGFFGEVYKAYW-RGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRR-----LLTD

KVLNWQQ----RMEIMLGMARGLAYLHEECVE-KIIHLDIKPQNILLNEDLV-------------AKVADFGLSRLMSRDQSYVMTTMRGTPGYLAPEWL
.    .|    .. . .  |||  |||    .  |.| |   .||||.. .              .|..||||||.| . |   ||   |   . |||  
HYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREM-MEQPFEMTQTMGCLCWMAPECF

LEAAITEKSDVYSFGVVLLEVISGR
     |||.|||||| .| ..| ..
KGENYTEKVDVYSFGMILWCIITCD
Kinase SD21_k.AA Src-Echino1 564-771 30 5.3e-30 100.99 In-house 2-205 (252) Show / Hide 
Range on Protein: 564-771
Range on HMM: 2-205/252
Sequence Identity: 30% (65 aa)

NFSKVLGTGGFGGVYEGVLPDGRKVAVKKLESTGQGKKEFYAEVAVLGTIHHWNLVKLLGFCSEGLNRLLVYEHMENGSLDKWIYQDFLEQKVLNWQQRM
 . | .| | .| |..||     .|||| |      . .| ||  |. .. | ..|..   ||.     .| | |.||.| ... ..  . | .   . .
RMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRG--KCKHVKMTTLI

EIMLGMARGLAYLHEECVEKIIHLDIKPQNILLNEDLVAKVADFGLSRLMSRDQSYVMTTMRGTP-GYLAPEWLLEAAITEKSDVYSFGVVLLEVIS-GR
..   .| |. || .  |   .| |.  .|.|...  | |.||||| |.| .|  |.       |  . |||  |    | ||||.|||... |..  ||
DMGAHIASGMDYLGSKNV---VHRDLAARNVLVGKGNVCKIADFGLARMMQKDV-YCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGR

RNFSRVSERE
  . .. .||
YPYPGMMNRE
Kinase SD21_k.AA MLK 814-833 40 0.000709 9.48 In-house 272-291 (291) Show / Hide 
Range on Protein: 814-833
Range on HMM: 272-291/291
Sequence Identity: 40% (8 aa)

QCLQENGSSRPSMGKVVQML
|| ... ..|||.  .|| |
QCWNQDPHKRPSFRQIVQHL
Kinase SD21_k.AA Dicty4 815-835 30 0.016287 4.4 In-house 255-277 (277) Show / Hide 
Range on Protein: 815-835
Range on HMM: 255-277/277
Sequence Identity: 30% (7 aa)

CLQENGSSRPSMGKVVQM--LEG
|. .. ..|||.  ..|   || 
CWDHDPQHRPSFEEIIQRRILEH
Kinase SD21_k.AA Dicty4-Unclassified 815-833 31 0.020753 4.02 In-house 245-263 (263) Show / Hide 
Range on Protein: 815-833
Range on HMM: 245-263/263
Sequence Identity: 31% (6 aa)

CLQENGSSRPSMGKVVQML
|. .    ||.| ...| |
CWHNDPNKRPTMNQIIQYL
Kinase SD21_k.AA LRRK 814-835 27 0.034822 3.51 In-house 330-351 (351) Show / Hide 
Range on Protein: 814-835
Range on HMM: 330-351/351
Sequence Identity: 27% (6 aa)

QCLQENGSSRPSMGKVVQMLEG
.| |..  .||.. ..|. |. 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase SD21_k.AA Pkinase_Tyr 814-833 25 2.779595 1.58 Pfam 251-270 (270) Show / Hide 
Range on Protein: 814-833
Range on HMM: 251-270/270
Sequence Identity: 25% (5 aa)

QCLQENGSSRPSMGKVVQML
|| ... . ||..  ....|
QCWHYDPEDRPTFSEIHEQL