Gene SD21_g (S.moellendorffii)

SD21_g

Species: S.moellendorffii
Alias: SD21_g
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: SD21

Sequence

Name Sequence Type Origin Length Description Download
SD21_g.AA Protein None 223 None Fasta, JSON
SD21_g.NA RNA None 672 None Fasta, JSON
SD21_g.kin_dom Protein Kinase Domain None 102 None Fasta, JSON

Protein domain

Protein domains of SD21_g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SD21_g.AA TKL 89-210 24 3.5e-29 102.24 In-house 11-175 (364) Show / Hide 
Range on Protein: 89-210
Range on HMM: 11-175/364
Sequence Identity: 24% (44 aa)

QGVYRG-----------DMAMKNITTVN----------------------------QAEKQFKAEVSTIGRVHHVNLVRLLGYCAEGGC-----------
.|..||           |.|.| . . |                            ....... |.  . | .| |.|...||| ...|           
KGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPW

--HLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETRHSIALGIAKGLTYLHE----KCGER--IIHCDIKPQNVLLDE
  . .|.|..|.||| |.|               |. |...||.||.|. |||      |.    |||.|.|..|.|.||
GQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDE
Kinase SD21_g.AA IRAK 102-210 38 7.7e-29 99.41 In-house 38-148 (317) Show / Hide 
Range on Protein: 102-210
Range on HMM: 38-148/317
Sequence Identity: 38% (44 aa)

TTVNQAEKQFKA---EVSTIGRVHHVNLVRLLGYCAEGGCHLLVYEFMPNGSLDHHLSASSSFAASQEIF--STWETRHSIALGIAKGLTYLHEKC-GER
.. |. ...| .   |. .  | .| |.| |.|||.|..|| |||..||||||   |..     . |      .| .|.||..|.|.|. .||..  .  
MSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWC----QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTP

IIHCDIKPQNVLLDE
||| |||. |.|||.
IIHGDIKSANILLDQ
Kinase SD21_g.AA TKL-Unique 89-210 27 2e-19 65.3 In-house 15-147 (290) Show / Hide 
Range on Protein: 89-210
Range on HMM: 15-147/290
Sequence Identity: 27% (37 aa)

QGVY-RGDMAMKNITT----VNQAEKQFKAEVSTIGRVH-HVNLVRLLGYCA----EGGCHLLVYEFMPNGSLDHHLS--ASSSFAASQEIFSTWETRHS
.|.. . . |.| .       |. .. |. ||... . | | |.|.. |||.      .   .| |..| |||. .|.     .   ....  ... | .
KGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVK

IALGIAKGLTYLHEKCGERIIHCDIKPQNVLLDE
.|. ||.|. ||| . .  |||.|.|..|.|.|.
MAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDN
Kinase SD21_g.AA MLK 78-210 24 1.4e-18 61.22 In-house 1-162 (291) Show / Hide 
Range on Protein: 78-210
Range on HMM: 1-162/291
Sequence Identity: 24% (39 aa)

LKFPVVLNLSSQG-VYRGDMAMKN----ITTVNQAE-------------KQFKAEVSTIGRVHHVN----LVRLLGYCAEGGCH-LLVYEFMPNGSLDHH
..|  ... .|.| |..| .  |.    |  |....             ..|. |.    .. | |     ....| |.. .|| ..| |....||| . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LSA-SSSFAAS-----QEIFSTWETRHSIALGIAKGLTYLHEKCGERIIHCDIKPQNVLLDE
| . .|  ...       .  . .   ..|| .|.|. |||..    ||| |.|..|.|.||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE
Kinase SD21_g.AA Pkinase 89-219 21 4.1e-18 65.14 Pfam 17-151 (293) Show / Hide 
Range on Protein: 89-219
Range on HMM: 17-151/293
Sequence Identity: 21% (31 aa)

QGVYRGD---MAMKNITTVNQAEKQFKA-----EVSTIGRVHHVNLVRLLGYCAEGGCHLLVYEFMPNG----SLDHHLSASSSFAASQEIFS--TWETR
... .|.    |.| |  ... ... ..     |..   |..| | |||.... ...   .| |....|    .| ...|.      ...     .... 
KCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST------WRHGCFYFSEWEC

HSIALGIAKGLTYLHEKCGERIIHCDIKPQNVLLDESSGQRCPTL
 .... |..|| |.|..   .|||.|.||.|.|.| . |. ....
KFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACV
Kinase SD21_g.AA Pkinase_Tyr 97-201 26 9.5e-17 57.34 Pfam 32-137 (270) Show / Hide 
Range on Protein: 97-201
Range on HMM: 32-137/270
Sequence Identity: 26% (30 aa)

AMKNI--TTVNQA--EKQFKAEVSTIGRV-HHVNLVRLLGYCA-EGGC--HLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETRHSIALGIAKGLTYL
| | .  ..  ..   . | .|...     || |.|||.| |  .|.   ...| |.||.|.|...| . .    ... ... .   .... ||||. ||
AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---EDKQPLTMKD-LLQMCWQIAKGMEYL

HEKCGERIIHCDI
..|    .|| |.
ESKN---CIHRDL
Kinase SD21_g.AA LRRK 114-212 34 6.7e-16 52.72 In-house 107-203 (351) Show / Hide 
Range on Protein: 114-212
Range on HMM: 107-203/351
Sequence Identity: 34% (37 aa)

EVSTIGRVHHVNLVRLLGYCAEGGCHLLVYEFMPNGSLDHHLSASS----SFAASQEIFS-TWETRHSIALGIAKGLTYLHEKCGER--IIHCDIKPQNV
||. . . .| |.| |.|.| .  |  .| |..|.|.|.|.|....    .|       . .| ... ||| ||||. ||| .   .  |||.| |. |.
EVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMK----AHISWMLKLKIALQIAKGMEYLHSH---NPPIIHRDLKSPNI

LLDESS
|| .|.
LLWSSP
Kinase SD21_g.AA TK 91-210 13 2.5e-15 47.12 In-house 18-275 (486) Show / Hide 
Range on Protein: 91-210
Range on HMM: 18-275/486
Sequence Identity: 13% (35 aa)

VYRG--------------------------------DMAMKNITTV-NQAEKQFKA--------------EVSTIGRVH-----HVNLVRLLGYCAEGGC
||.|                                . | | ..   ......|..              |.. .   .     | |.|||.|.| .|..
VYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEP

------------HLLVYEFMPNGS----LDHHLSASSSFAASQEI-------------------------------------------------------
             ..| |.||.|.    |...| ...  .  ..                                                        
KPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDL

-------------FSTWETRHSIALGIAKGLTYLHEK----CGERIIHCDIKPQNVLLDE
             . | .... ... ||.|. |||.|       ...| |.   |.|..|
LQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGE
Kinase SD21_g.AA UTK 119-216 26 8.2e-15 47.11 In-house 64-164 (296) Show / Hide 
Range on Protein: 119-216
Range on HMM: 64-164/296
Sequence Identity: 26% (28 aa)

GRVH-HVNLVRLLGYCAEGGCHLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETRHSIALGIAKGLTYLHEKCGERIIHCDIKPQNVLLDESS-----
...| |.|..||.|.|  ..  ..|.|.|.||.|.. |  ..  .  .. . | ..| . |. || |. |||..   ...|.|.  .|.|.....     
KQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC---GFVHRDLAARNCLVHMHRMMWHC

GQRC
.. |
MMVC
Kinase SD21_g.AA Dicty4 111-211 29 2.4e-13 41.07 In-house 45-150 (277) Show / Hide 
Range on Protein: 111-211
Range on HMM: 45-150/277
Sequence Identity: 29% (32 aa)

FKAEVSTIGRVHHVNLVRLLGYCA----EGGCHLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETRHS---IALGIAKGLTYLHE-KCGERIIHCDIK
|..||.  .   | |.. ..|.|     . |  . | |.|| |.|   | .  |    |.| . |... .   .|. .|.|...||.  .  .||| |.|
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS-EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP--VIIHRDLK

PQNVLLDES
. | | |..
SHNLLVDKN
Kinase SD21_g.AA TAK1 108-208 35 9.8e-13 39.25 In-house 42-138 (284) Show / Hide 
Range on Protein: 108-208
Range on HMM: 42-138/284
Sequence Identity: 35% (36 aa)

EKQFKAEVSTIGRVHHVNLVRLLG-YCAEGGCHLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETRHSIALGIAKGLTYLHEKCGERIIHCDIKPQNV
.|... |.    || |.| ..| | |   ..| .|| |.|  |||   |     ..| . .  | .   | .. .|.|. ||| .    .|| |||||| 
QKNIEREIMQWSRVDHPNIIKLYGMYACHRQCQCLVMEYMDCGSLHNFL-----HGAKPKWEYTHAHAMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNM

LL
||
LL
Kinase SD21_g.AA LISK 89-215 30 1.1e-12 37.38 In-house 12-142 (296) Show / Hide 
Range on Protein: 89-215
Range on HMM: 12-142/296
Sequence Identity: 30% (42 aa)

QGVYR--G-DMAMKNITT------VNQAEKQFKAEVSTIGRVHHVNLVRLLGYCAE-GGCHLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETRHSIA
.| .|  | .||.| |..       . ..| .. || .. .  | | |.  | | .  |   .| |..  | |   |.....    . |  .|. | .||
KGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDK----HKIPLPWPQRVKIA

LGIAKGLTYLHEKCGERIIHCDIKPQNVLLDES-SGQR
|.||.|..|||...   ||| | | .|.|..|. ..|.
LDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQW
Kinase SD21_g.AA TyrKc 84-221 13 5e-06 -124.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 84-221
Range on HMM: 1-280/280
Sequence Identity: 13% (39 aa)

LNLSSQ-------GVYRGDM----AMKNITTVNQAEKQFKAEVSTIGRV--HHVNLVRLLGYCAEG-------GCHLLVYEFMPNGSLDHHLSASSSFAA
. |  .        ||.| .    | | .      .. |  | .   ..  || |.|||.|.| ..       . ...| |.||.|.|...| ..     
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

SQEIFSTWETRHSIALGIAKGLTYLHEKCGERIIHCDIKPQNVLLDESS--------------------------------GQR----------------
      .... .|... ||.|  |||.|   ..|| |.   |.|..|                                  | .                
-----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

--------------------------------------------------CPTL------------------------------------GW
                                                  .|                                       .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF