Gene SD21_h-2 (S.moellendorffii)

SD21_h-2

Species: S.moellendorffii
Alias: SD21_h-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: SD21

Sequence

Name Sequence Type Origin Length Description Download
SD21_h-2.AA Protein None 822 None Fasta, JSON
SD21_h-2.NA RNA None 2469 None Fasta, JSON
SD21_h-2.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of SD21_h-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin SD21_h-2.AA B_lectin 92-193 30 6e-24 83.88 Pfam 1-137 (137) Show / Hide 
Range on Protein: 92-193
Range on HMM: 1-137/137
Sequence Identity: 30% (42 aa)

PDHLVWTANGN---DPVSPQS-----TIVLTA-QGNLELRDAR-R---GLVWST--NTSNLG---VRMLKLKMSGNLVLVT-AN--GTEVWRS--FDHPT
.   ||.|| .   .||.. |     | ....  ||| | |.      . ||||  |||. |      ...  |||||| . .|  .. .|.|  |||||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DTLMPEQMLHI------GKK----LEAYKSSS--GLD
||. | . |        ...    | . ||..     
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin SD21_h-2.AA B_lectin 42-167 25 9e-09 36.38 SMART 1-126 (126) Show / Hide 
Range on Protein: 42-167
Range on HMM: 1-126/126
Sequence Identity: 25% (34 aa)

SKQVAEGMVLLVNNATKNIGCGFSSVQCPNRSQKCLVFGVSFLGKDGGFLPDHLVWTA--NGNDPVS---PQSTIVLTAQGNLELRDARRGLVWSTNTS-
.    .| .|  .| .  . .|| . .        .  |... .. .   ..  || |  | . ||.   . .. ...  ||| . |     |||.||. 
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ------WCNGIWYKNISNK--QRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTR

NLGVRMLKLKMSGNLVLVTAN----GTEVWRSFDHP
| |.  ..|  .||.|..  .    |  .| |||||
NNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
Kinase SD21_h-2.AA TKL 515-783 22 9.3e-65 221.45 In-house 1-364 (364) Show / Hide 
Range on Protein: 515-783
Range on HMM: 1-364/364
Sequence Identity: 22% (89 aa)

LGRGGFGTVYHGMLED---------GTKVAIKRLESSRGGGD---------------------------DQFRAEVIAIGSVHHSNLVKLIGFCCDEHK-
.|.||||.||.| .           |. ||.|.. |     .                           .... |.  . . .| |.|...|.||.. . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------HTLLVYEYMPNGSLDMWIFARDDNNFLDWRTRSKIALDIAKGLSYLHE----GCDQS--ILHLDIKPQNILLDVEFK------------
           .  .|.||.|.|||   .          |  | ..|||||.|..|||     .|     |.| |.|..|||.|  ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKISDFGLAIFAAKGSNNLRDTA-----------------LRGTPGYMAPEWLR-----------------YEVSRKIDVYSFGIVLLEIVSGKQALE
  .||.||||. |  . .|. .                     .|||..|||| ||                 .| | |.||||||||| ||.....   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

FLDAIDHHSDSDDHHHPFHAE---------------RSDLVELLDPRLK-GWSY------SSSEVERFVLVALCCIQDDPSARPGMGNVVKML
                |.. .                 . .. | | ..  |..       ..  ...   . .| . ||..|| .  ..| |
----------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase SD21_h-2.AA IRAK 510-711 36 1.5e-53 184.22 In-house 2-225 (317) Show / Hide 
Range on Protein: 510-711
Range on HMM: 2-225/317
Sequence Identity: 36% (81 aa)

NFSRKLGRGGFGTVYHGMLEDGT-KVAIKRL----ESSRGGGDDQFRA---EVIAIGSVHHSNLVKLIGFCCDEHKHTLLVYEYMPNGSLDMWIFARDDN
. ....| ||||.||.| .   |  .|.|.|    ..| .. . .|..   |. .  . .| |.| | |.| .. .|  |||.|||||||     ..|  
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHC-LVYPYMPNGSLEDRLWCQDGQ

NF---LDWRTRSKIALDIAKGLSYLHEGC-DQSILHLDIKPQNILLDVEFKAKISDFGLAIFA----AKGSNNL---RDTALRGTPGYMAPEWLR---YE
.    | | .| .|.. .|.|. .||.     .| | |||. |||||  | .||.||||. |     .| .  .   .   .|||  ||.|| .|    .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VSRKIDVYSFGIVLLEIVSGK-QAL
 . | |||||||||||...|  ...
LTKKTDVYSFGIVLLEVLTGCRAVY
Pkinase SD21_h-2.AA Pkinase 509-783 23 5.3e-52 183.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 509-783
Range on HMM: 1-293/293
Sequence Identity: 23% (74 aa)

ANFSRKLGRGGFGTVYHGMLEDGTK-VAIKRLESSRGGGDDQFRA-----EVIAIGSVHHSNLVKLIGFCCDEHKHTLLVYEYMPNG----SLDMWIFAR
  . ||.|.|.||.||...  .  | ||.|... . .  ... ..     |.    ...| | |.|.... | ..|  .| ||...|    .|  .| ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTW

DDNNF-LDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVEFKA----KISDFGLAIFAAKGSNNLRDTALRGTPGYMAPEWLR--YEVSRK
....| .....  .... |..|| |.|. .  .|.| |.||.|||.| .       ||.||||| ..    ||   | . |||.|||||..|   . ..|
RHGCFYFSEWECKFYMYQILRGLEYCHS-M--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDVYSFGIVLLEIVSGKQALEFLDAIDHHSDSDDHHHPFHAE-----RSDLVELLDPRLKGWSYSSSEV---------------------ERFVLVALCC
.|..|.|..| | ..|.                    ||  .     ..... .   . . .......                      | .  .  .|
VDMWSCGCILYEMLCGR-------------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

IQDDPSARPGMGNVVKM--L
.. ||. ||.   ...   .
LCKDPKKRPTAEQILQHPWF
Kinase SD21_h-2.AA TKL-Unique 511-709 35 2.1e-51 177.07 In-house 1-226 (290) Show / Hide 
Range on Protein: 511-709
Range on HMM: 1-226/290
Sequence Identity: 35% (82 aa)

FSRKLGRGGFGTVYHGMLEDGTKVAIKRLE-SSRGGGD--DQFRAEVIAIGSVH-HSNLVKLIGFCCD---EHKHTLLVYEYMPNGSLDMWIF-------
|. |.|.||.|.||.|.   |..||||...  .    .  . |. ||  .   | | |.|...|.| |     ..  .| ||.| |||.  .        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

ARDDNNFLDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVE-----FKAKISDFGLAIFAAKG----SNNL---RDTALRGTPGYMAPEWL
   .|. |..  | |.|.|||.|. |||  |.  |.|.|.|..|.|.| .     ...||.||||..|..|     .|..   |..   |.. .|||| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLH-HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

RY---EVSRKIDVYSFGIVLLEIVSGKQ
|      |.|.||||||||| ||...|.
RMNFCQYSEKSDVYSFGIVLWEIATRKI
S_TKc SD21_h-2.AA S_TKc 509-783 25 3.8e-43 150.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 509-783
Range on HMM: 1-231/231
Sequence Identity: 25% (75 aa)

ANFSRKLGRGGFGTVYHGMLED-GTKVAIKRLESSRGGGDDQFRAEVIAIGSVHHSNLVKLIGFCCDEHKHTLLVYEYMPN--GSLDMWIFARDDNNF--
  . ||.|.|.||.|| .   . | .||||..        ...| |.    . || |.|||.... |  .|  .| ||...  |.|   |  |  .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVEFKAKISDFGLAIFAAKGSNNLRDTALRGTPGYMAPEWLRYEVSR-KIDVYSFGIVL
 ..  .  ...  |...| |.|.   . |.| |.||.|||||     ||.||||| .          | . ||| ||||| |    .. |.|..|.|..|
PFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL

LEIVSGKQALEFLDAIDHHSDSDDHHHPFHAERSDLVELLDPRLKGWSYSSSEVERFVLVALCCIQDDPSARPGMGNVVK---------ML
 | ..|.   .            ...  |.  .                     . .      | | ||. ||.   . .          .
YEMLCGYPPFP------------QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SD21_h-2.AA LRRK 509-712 26 4e-40 139.64 In-house 1-284 (351) Show / Hide 
Range on Protein: 509-712
Range on HMM: 1-284/351
Sequence Identity: 26% (76 aa)

ANFSRKLGRGGFG-TVYHGMLED---------------------------GTKVAIKRLESSR---------------------GGGDDQ----------
  . ...|||||| .|| . ...                           ...|||| ..  .                     . ..|           
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

---FRAEVIAIGSVHHSNLVKLIGFCCDEHKHTLLVYEYMPNGSLDMWIFARDDNNF------LDWRTRSKIALDIAKGLSYLHEGCDQS--ILHLDIKP
   || ||  . . .|.|.|.|.|||   ...  .| ||.|.|.|.  ....  . |      ..| .. ||||.||||. |||   ...  |.| | |.
FREFRHEVWIMSHLNHPNIVSLKGFC---IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH---SHNPPIIHRDLKS

QNILL---D---------VEFKAKISDFGLAI-FAAKGSNNLRDTALRGTPGYMAPEWLRY----EVSRKIDVYSFGIVLLEIVSGK-QALE
 ||||   .          . .|||.|||.   |.. ..  ...    |.||.|||| .||    | . |.|.||||..| |..... .. .
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV--GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase SD21_h-2.AA STE 509-708 23 4.5e-37 128.49 In-house 1-265 (359) Show / Hide 
Range on Protein: 509-708
Range on HMM: 1-265/359
Sequence Identity: 23% (65 aa)

ANFSRKLGRGGFGTVYHGMLED----------------GTKVAIKRLESSRGGG-----------------DDQFRAEVIAIGSVH--HSNLVKLIGFCC
  . .|.|.|.||||| .|  .                |. .|||... ..                     .|.  |.      .  | | || .| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE------HKHTLLVYEYMPNGSLD-----MWIFARDDN------NFLDWRTRSKIALDIAKG-LSYLHEGCDQSILHLDIKPQNILLDVEFKAKISDFG
.|      . .  .. |||..||||      ..  ...|       ...    ..|. .| || |.|||.     | | ||||.||||     .|..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAIFAAKG--------------SNNLRDTALRGTPGYMAPEWLRYE-------VSRKIDVYSFGIVLLEIVSGK
..   ..               ..  . . . ||| .|||| .. .        ..| |..|.|....| . ||
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase SD21_h-2.AA CAMK 514-701 19 8.9e-37 115.52 In-house 1-324 (425) Show / Hide 
Range on Protein: 514-701
Range on HMM: 1-324/425
Sequence Identity: 19% (64 aa)

KLGRGGFGTVYHGMLE-DG------------TKVAIKRLESS----------------------------RGGGDDQFRAEVIAIGS-------VHHSNL
.||||.||.|. ..   ..            .||||| .. .                            |.   ...| |.    .       ..| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLIGFCCDEHK------------------HTLLVY---EYMPNG----SLDMWIFARDDN------------NFLDWRTRSKIALDIAKGLSYLHEGCD
.||. .  |.|.                  |  .|    ||...|     |  .| .. ..              .. |  ...   |. .. |.|   .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH---S

QSILHLDIKPQNILLDVE-----------------FKAKISDFGLA--IFA---------AKGSNNLRDT------------ALRGTPGYMA-PEWLRYE
. | |.|.|| |||||                   .. ||.|||.|  ..           || . . ..               |||.||| ||.|...
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGK

---------------VSRKIDVYSFGIVL
               ...|.|. | |..|
GHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase SD21_h-2.AA MLK 509-708 26 1.4e-36 124.41 In-house 1-233 (291) Show / Hide 
Range on Protein: 509-708
Range on HMM: 1-233/291
Sequence Identity: 26% (62 aa)

ANFSRKLGRGGFGTVYHGMLEDGTK-----VAIKRLE------SSRGGGDDQFRAEVIAIGSVHHSN----LVKLIGFCCDEHKHTLLVYEYMPNGSLDM
 .|....| |.|| |. |    ..      ||.|| .      |. .  ...|. |.     . | |     ... | | .. .| ..| ||...|||  
IQFHEWIGSGSFGKVWKGRWR-NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WIFARDDNNF-----------LDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDV------EFKAKISDFGLAIFAAKG-SNNLRDTALRGT
 . ..... .            |     ..||..|.|..|||.   . | | |.|..|||.|       . ..||.|||.. .  .  .|    .  .||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN---MMSNAGT

PGYMAPEWL----RYEVSRKIDVYSFGIVLLEIVSGK
. .|||| .       .|.| ||.|.|.|| |.....
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase SD21_h-2.AA Dicty4 510-705 33 5e-36 117.76 In-house 2-211 (277) Show / Hide 
Range on Protein: 510-705
Range on HMM: 2-211/277
Sequence Identity: 33% (72 aa)

NFSRKLGRGGFGTVYHGMLEDGTKVAIKRLESSRGGGDDQ----FRAEVIAIGSVHHSNLVKLIGFCC--DEHK-HTLLVYEYMPNGSLDMWIFA----R
|.  ..|.|.||.|| |    |..||.| | .   . |      ||.||   ..  | |.... | |     |.   . | |||| |.|   . .     
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

DDNNFLDWRTRSK---IALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVEFKAKISDFGLAIFAAKGSNNLR-DTALRGTPGYMAPEWLRYEV-SRKID
 ..  ||| .. .   .|.|.|.|. .||. |.  |.|.|.|. |.| |  ...|..||||.    |....    ..  |||..|||| .. .    | |
QQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKAD

VYSFGIVLLEIV
|||||||| ||.
VYSFGIVLWEIL
Kinase SD21_h-2.AA TK 509-783 14 5.4e-36 117.59 In-house 1-486 (486) Show / Hide 
Range on Protein: 509-783
Range on HMM: 1-486/486
Sequence Identity: 14% (75 aa)

ANFSRKLGRGGFG---TVYHGMLEDG--------------------------TKVAIKRLESSRGGGDDQFRA--------------EVIAIGSVH----
  . .|||.| ||   .|| |.....                          |.||.| | .  .  ...|..              |. ..   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HSNLVKLIGFCCDEH-----------KHTLLVYEYMPNGS----LDMWIFARDD---------------------------------------------
 | |.|.|.| |...            .. ..| ||||.|.    |. .  ....                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------NNFLDWRTRSKIALDIAKGLSYLHEG----CDQSILHLDIKPQNILLDVEFK-----------AKISDFG--
                            ...|. ...  ....||.|..|||.       | . | |.   |.|.. . .           .||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAIFAAKGSNNLRDTALRGTPG------------------------YMAPEWLRYEV----------SRKIDVYSFGIVLLEIVS-GKQALEFL
      ||    ....  |..  ... .                        .|||| |.. |          . | ||.|||... ||.. |..     
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

DAI-----DHHSDSDDHHHPFHAERSDLVELLD----------------PRLKGWSYSSSEV-----------ERFVLVALCCIQDDPSARPGMGNVVKM
        |            . .  ...|.|                  |..   . .. .           | . .. ..| . ||. || .  ....
MSNQDVWKD------------G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQ

L
|
L
Kinase SD21_h-2.AA RIPK 515-712 29 4.2e-33 110.13 In-house 1-229 (290) Show / Hide 
Range on Protein: 515-712
Range on HMM: 1-229/290
Sequence Identity: 29% (69 aa)

LGRGGFGTVYHGMLED-GTKVAIKRLESSR------GGGDDQFRAEVIAIGSVHHSNLVKLIGFCCDE-----HKHTLLVYEYMPNGSLDMWIFARD--D
.|.||||.|.     . |. ||.|   .             .   |. .  .  ... |.. ||| .|      |   .| |||.||||     ..    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

NNFLDWRTRSKIALDIAKGLSYLHEGCDQS--ILHLDIKPQNILLDVEFKAKISDFGLAIFAAKGSNNL----------RDTALR-GTPGYMAPEWLR--
.  . |  |  .   |. |  |||   ..   |.|.| ||.|||.| .| .||.||||| .    . .            . ..| ||  ||.|| .|  
HHPDPWPLRCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

--YE---VSRKIDVYSFGIVLLEIVSGKQALE
       |. | |||||.||. |. ..|.. |
NKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYE
Kinase SD21_h-2.AA Pkinase_Tyr 509-709 29 9.3e-33 111.56 Pfam 1-213 (270) Show / Hide 
Range on Protein: 509-709
Range on HMM: 1-213/270
Sequence Identity: 29% (64 aa)

ANFSRKLGRGGFGTVYHGMLE-----DGTKVAIKRLESSRGGGD---DQFRAEVIAIGSV-HHSNLVKLIGFCCDEHKH--TLLVYEYMPNGSLDMWIFA
  | .|||.| ||.||.| .      ....||.| |  .    .   . | .|.    .  || |.|.|.| | |. ..   ..| ||||.|.|.    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R-DDNNFLDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVEFKAKISDFGLAIFAAKGSNN-LRDTALRGTPGYMAPE-WLRYEVSRKIDV
. .|.. |.  .  .....||||..||..     . | |.   |.|.. ....||.|||||    . ..     .  .     |||| .  .. . | ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGIVLLEIVS-GKQ
.|||... ||.. |.|
WSFGVLMWEIFTYGEQ
Kinase SD21_h-2.AA TyrKc 509-783 22 3.7e-25 90.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 509-783
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

ANFSRKLGRGGFGTVYHGMLEDGTKVAIKRLESSRGGGDDQFRAEVIAIGSV--HHSNLVKLIGFCCDEH------KHTLLVYEYMPNGSLDMWIFARDD
  . .|||.| ||.||.|..   ..||.| | ..       |. |     ..  || |.|.|.| | ..       .  ..| ||||.|.|.  . .. .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NNFLDWRTRSKIALDIAKGLSYLHEGCDQSILHLDIKPQNILLDVEFKAKISDFGLAIFAAKG------SNNLRDT---ALR--GTPGYMAPEWLRYEV-
.  | ...  .....||.| .|||.     . | |.   |.|.. .. .|||||||. .   .      .   | .     .       |||| ..| . 
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SRKIDVYSFGIVLLEI---------------VSGKQALEFLDAI---DHHSD----SDDHHHPFHAERSDLVELLDPRLKGWSYSSSEVERFVLVALCCI
. | ||.|||... ||               .| ....|....    .   .    |                         .      | .  . ..| 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------F-VCCPDEMYQ-IMKQCW

QDDPSARPGMGNVVKML
. ||. || . .... .
HEDPEDRPTFSEIHECF
Kinase SD21_h-2.AA MLK 764-783 35 0.00785 5.81 In-house 272-291 (291) Show / Hide 
Range on Protein: 764-783
Range on HMM: 272-291/291
Sequence Identity: 35% (7 aa)

CCIQDDPSARPGMGNVVKML
.| ..||. || .  .|. |
QCWNQDPHKRPSFRQIVQHL