Gene RLCK15_c (S.moellendorffii)

RLCK15_c

Species: S.moellendorffii
Alias: RLCK15_c
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: RLCK15

Sequence

Name Sequence Type Origin Length Description Download
RLCK15_c.AA Protein None 322 None Fasta, JSON
RLCK15_c.NA RNA None 969 None Fasta, JSON
RLCK15_c.kin_dom Protein Kinase Domain None 176 None Fasta, JSON

Protein domain

Protein domains of RLCK15_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RLCK15_c.AA TKL 64-311 19 1.1e-45 158.05 In-house 25-364 (364) Show / Hide 
Range on Protein: 64-311
Range on HMM: 25-364/364
Sequence Identity: 19% (70 aa)

DGTQIAVKRLRSGSSLNSDK-------------------------EFAEEAGKMGKML-HKNVMRLRGYCVERDE-------------RILVYSYMPNSS
.|. .|||...| .. ...|                         .| ||  .| ..| | |. .. ||| . .                .|. |.|. |
TGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGS

LLAHLHGAFSYDNLLDWGKRVRVALGCAEGLAYLHHSAN-----PPMIHGNIKASNILLTDDFQ--------------PLYTDYGIAALMKKP-------
|| .||          | .|.| ||..| |..||| .       ||.|| ..| .|||. ....              .  .|.|..  |..        
LLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTM

--------------ALKAKV-ALGYTAPECSSGE----------------AATLQSDVFSFGILLLELISGRRPMEKVEFSMKQHIVDWAEPLILEGKLD
              ..  ..  ... |||.  |.                 .. ..||.||||.| |.....|| ..  ... .      . .....  |
TTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQD-P-FEEMFMMVCD

CLVDPKLQ-----------GRFVPEELKKLVFAATICAQTSSHSRPSMARVVELL
    | .               .|...|||   .. | ..  ..|||. .... |
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKL---MQDCWDHDPEKRPSFQEILKRL
Kinase RLCK15_c.AA IRAK 55-192 34 2e-26 90.76 In-house 13-160 (317) Show / Hide 
Range on Protein: 55-192
Range on HMM: 13-160/317
Sequence Identity: 34% (52 aa)

ACVYWGQLPDGTQ--IAVKRLRSGSSLN---SDKEFAE---EAGKMGKMLHKNVMRLRGYCVERDERILVYSYMPNSSLLAHLHGAFSYDNL--LDWGKR
.||| ||. ..|    |||.|... ...   ....|     |   . .  |.|.  | ||| ||..  ||| |||| || . |..    . .  | | .|
GCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQR

VRVALGCAEGLAYLHHSA-NPPMIHGNIKASNILLTDDFQPLYTDYGIA
. ...| | |. .||      | |||.|| .|||| ..|.|  .| | .
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLH
Kinase RLCK15_c.AA TKL-Unique 65-241 25 4.6e-25 85.42 In-house 20-233 (290) Show / Hide 
Range on Protein: 65-241
Range on HMM: 20-233/290
Sequence Identity: 25% (55 aa)

GTQIAVKRLR--SGSSLNSDKEFAEEAGKMGKML-HKNVMRLRGYCV----ERDERILVYSYMPNSSLLAHLH------GAFSYDNLLDWGKRVRVALGC
|...|.|..   ..||. . .|| .|   | |   |.|. .. |||.       ....| .|.| .||  .||         .  . |.. .||. |. .
GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDI

AEGLAYLHHSANPPMIHGNIKASNILLTDD-----FQPLYTDYGIAALMKKPALKAKVAL------------GYTAPECSSG--EAATLQSDVFSFGILL
| |. ||||.  | .||...| ||.|.. .     ..    | |.. . .|   . .  .             . |||  ..  .  . .|||.|||| |
AQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL

LELISGRR------P
 |.... .      |
WEIATRKITKTYKKP
Kinase RLCK15_c.AA TK 66-241 15 1.9e-21 68.01 In-house 53-394 (486) Show / Hide 
Range on Protein: 66-241
Range on HMM: 53-394/486
Sequence Identity: 15% (54 aa)

TQIAVKRLRSGSSLNSDKEFA-------------EEAGKMGKML-----HKNVMRLRGYCVERDE------------RILVYSYMPNSS----LLAHLH-
|. ||| |..|.. ... .|.             |||  | .|.     |.|. || |.|.. ..             ..|  |||. .    |. .|. 
TPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRK

---------------------------------------------------------GAFSYDNLLD--------------WGKRVRVALGCAEGLAYLH
                                                          ...   ||.                 ..  ..  |.|..|||
CRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH

HS----ANPPMIHGNIKASNILLTDDFQ-----------PLYTDYGIAA-----LMKKPAL--------------------------------KAKVALG
        . ..|... | |.|.... .              .|.| .      | ..                                   ..|. . 
SKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIR

YTAPECSSGEA---------ATLQSDVFSFGILLLELIS-GRRP
..||||  .            | .|||.|||.|. |. . |. |
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase RLCK15_c.AA Frk 57-236 31 8e-19 61.56 In-house 15-196 (260) Show / Hide 
Range on Protein: 57-236
Range on HMM: 15-196/260
Sequence Identity: 31% (58 aa)

VYWGQLPDGTQIAVKRLRSGSSLNSDKEFAEEAGKMGKMLHKNVMRLRGYCVERDERILVYSYMPNSSLLAHLHGAFSYDNLLDWGKRVRVALGCAEGLA
|. |.    | .|||.|..|.    |  |  ||  | |. |  ...|   |   .  ...   | . ||. .|       . .   . | .|   | |.|
VWEGLWNNTTPVAVKTLKPGTMDPND--FLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMA

YLHHSANPPMIHGNIKASNILLTDDFQPLYTDYGIAA-LMKKPA------LKAKVALGYTAPECSSGEAATLQSDVFSFGILLLELI
||  | |   ||  . | |.|. ..      |.|.|  |||           |.. . .||||    .  |..|||.|||||| |.|
YL-ESQN--YIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEII
Kinase RLCK15_c.AA MLK 65-241 23 4.5e-18 59.4 In-house 22-235 (291) Show / Hide 
Range on Protein: 65-241
Range on HMM: 22-235/291
Sequence Identity: 23% (50 aa)

GTQ-----IAVKRLR-----SGSSLNSDKEFAEEAGKMGKMLHKN----VMRLRGYCVERDE-RILVYSYMPNSSLLAHLHGAFSYDN----------LL
..      .|||| |     ....  ....| .|. .  .. |.|    . ...| | .      .|  |....||   |||| |  .            
NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVY

DWGKRVRVALGCAEGLAYLHHSANPPMIHGNIKASNILLTD------DFQPLYTDYGIAALMKKP---ALKAKVALGYTAPEC---SSGEAATLQSDVFS
| .  .. || ||.|..|||  | .| ||  .| .|||...      . .   .| |..  ...      ...  . . |||    . .|  .  .||.|
DHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWS

FGILLLELISGRRP
.|..| |..... |
WGVVLWEMLTREVP
Kinase RLCK15_c.AA LRRK 92-313 23 2e-17 58.23 In-house 111-351 (351) Show / Hide 
Range on Protein: 92-313
Range on HMM: 111-351/351
Sequence Identity: 23% (60 aa)

MGKMLHKNVMRLRGYCVERDERILVYSYMPNSSLLAHLHGAFSYD-----NLLDWGKRVRVALGCAEGLAYLHHSANPPMIHGNIKASNILL-TDD----
| .. | |.. | |.|   . ...|  |.|. .|  .||  ...        ..|. . ..||  |.|..|| ||.||| || . |  |||| . .    
MSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNILLWSSPQNHS

---FQPLYT----DYGIAA----LMKKPALKAKVALGYTAPECSSGE---AATLQSDVFSFGILLLELISGR-RPMEKVE----FSMKQHIVDWAEPLIL
    .. ..    |.||      . .. | .     |. |||.  ..     | ..|..|||..| ||.... .|..  .    ...  .| |    .|.
PNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED----KII

EGKLDCLVDPKLQGR-FVPEELKKLVFAATICAQTSSHSRPSMARVVELLQG
||  . .     ...  .. ....|    . | |.   .||..  .|. |  
EGLRPTIPQH-YCPPCQPWHMYQDLI---QHCWQHDPKKRPHFSQIVKRLSQ
Kinase RLCK15_c.AA Src-Echino1 66-245 28 1.1e-16 54.04 In-house 24-201 (252) Show / Hide 
Range on Protein: 66-245
Range on HMM: 24-201/252
Sequence Identity: 28% (53 aa)

TQIAVKRLRSGSSLNSDKEFAEEAGKMGKMLHKNVMRLRGYCVERDERILVYSYMPNSSLLAHLHGAFSY----DNLLDWGKRVRVALGCAEGLAYLHHS
|..||| |. ..   |. .|  ||  | |. |......   | ...   .|   | | .|...|    .       |.| | ..      | |. ||   
TPVAVKTLKEKT--MSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLIDMGAHI------ASGMDYLGSK

ANPPMIHGNIKASNILLTDDFQPLYTDYGIAALMKKPAL----KAKVALGYTAPECSSGEAATLQSDVFSFGILLLELIS-GRRPMEKV
    ..| .. | |.|. .       |.| | .|.|        ||. . .||||       |..|||.|||||. |..  || | ...
N---VVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPGM
Kinase RLCK15_c.AA Dicty4-Unclassified 65-241 26 2e-15 49.24 In-house 22-207 (263) Show / Hide 
Range on Protein: 65-241
Range on HMM: 22-207/263
Sequence Identity: 26% (51 aa)

GTQIAVKRLRSGSSLNS---DKEFAEEAGKMGKMLHKNVMRLRGYCVER----DERILVYSYMPNSSLLAHLHGAFSYDN---LLDWGKRVRVALGCAEG
|  .||| . ...        ..|  |   .| . | | ....|||.         . |   |.   |.   |   |  .    ||    ...|.  | |
GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQG

LAYLHHSANPPMIHGNIKASNILLTDDFQPLYTDYGIAALMKKPALKAKVA--LGYTAPECSSGEAATLQSDVFSFGILLLELISGRRP
...| |. |  .||  ||.||||.  .|     | ||.           .|     ..|||  .|. .  |||.|....| ||. |  |
MQHL-HTRN--FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEP
Kinase RLCK15_c.AA TK-Unique 53-237 20 2.3e-15 49.57 In-house 18-234 (294) Show / Hide 
Range on Protein: 53-237
Range on HMM: 18-234/294
Sequence Identity: 20% (45 aa)

GTACVYWGQLPDGTQIAVKRLRSGSSLNSDKEFAEEAGKMGKML-HKNVMRLRGYCVERD-ERILVYSYMPNSSLLAHLH--------------------
|...  |.   . ...||| |. .... ....|  |.  | .   |.|. .. |.|.. |    ... |.|...|. .|.                    
GEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFH

--GAFSYDNLLDWGKRVRVALGCAEGLAYLHHSANPPM--IHGNIKASNILLTDDFQPLYTDYGIA------ALMKKPALKAKVALGYTAPECSS--GEA
   ..  .. .. .  .. | ..| |..||.     ..  .|... |.|.|||.|..   .|.|.|          .   . .. . . |||  .  .. 
HMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ---RKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGM

A-TLQSDVFSFGILLLELIS
. | .||| |||.|. |. .
YHTTKSDVWSFGVLMWEIFT
Kinase RLCK15_c.AA TyrKc 57-311 21 1.4e-13 -3.11 SMART 15-280 (280) Show / Hide 
Range on Protein: 57-311
Range on HMM: 15-280/280
Sequence Identity: 21% (61 aa)

VYWGQLPDGTQIAVKRLRSGSSLNSDKEFAEEAGKMGKM--LHKNVMRLRGYCVER-------DERILVYSYMPNSSLLAHLHGAFSYDNLLDWGKRVRV
|| |..   .| ||| |....     ..| .||  | |    |.|. || |.|..        .   .|  |||. .|. .|.        | . . .  
VYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSF

ALGCAEGLAYLHHSANPPMIHGNIKASNILLTDDF----------QPLYTD--YGIAALMKKPAL--KAK--VALGYTAPECSSGEAATLQSDVFSFGIL
..  |.| .|||.    . ||  . | |.|.....            .| |   | .  .....    .|  . .  .||||      | .|||.|||..
CWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVC

LLELIS-GRRPMEKVEFSMKQHIVDWAEPLILEGKLDCLVDPKLQGRF----VPEELKKLVFAATICAQTSSHSRPSMARVVELL
. |. . |  | . ...       . .  .. .|.     .  .         |.|. ..    . | .   ..||... ..|..
MWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQI---MKQCWHEDPEDRPTFSEIHECF
Kinase RLCK15_c.AA S_TKc 53-289 18 2e-12 5.21 SMART 11-231 (231) Show / Hide 
Range on Protein: 53-289
Range on HMM: 11-231/231
Sequence Identity: 18% (47 aa)

GTACVYWGQLPD-GTQIAVKRLRSGSSLNSDKEFAEEAGKMGKMLHKNVMRLRGYCVERDERILVYSYMPN--SSLLAHLHGAFS--YDNLLDWGKRVRV
. ..|| ..  . | . |.|...        . .  |   . |  |.|. .| ..... |.  .|  |...   .|. ...   .  ..  ..     ..
AFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

ALGCAEGLAYLHHSANPPMIHGNIKASNILLTDDFQPLYTDYGIAALMKKPALKAKVALGYTAPECSSGEAATL-QSDVFSFGILLLELISGRRPMEKVE
.   ...|.|.|   .   ||  .| .||||..  .   .| |.|...        . . | |||       .   .|. |.|..| |...|. | .  .
MYQICCALEYCHSH-G--IIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QM

FSMKQHIVDWAEPLILEGKLDCLV-DPKLQGRFVPEELKK-------LVFA
. | ..|.    |  ..    ||. ||.   |    |. .         . 
QMMFKKIG---SPEAKDFIRKCLQKDPEK--RPTA-EALQDEWDIKCHPWF
Kinase RLCK15_c.AA Pkinase_Tyr 57-183 26 3.2e-12 42.0 Pfam 15-149 (270) Show / Hide 
Range on Protein: 57-183
Range on HMM: 15-149/270
Sequence Identity: 26% (36 aa)

VYWGQLP-----DGTQIAVKRLRSGSSLNS--DKEFAEEAGKMGKM-LHKNVMRLRGYCV-ERDE--RILVYSYMPNSSLLAHLHGAFSYDNLLDWGKRV
|| | .      .... ||| |. |..      ..| .||  | ..  |.|. || | |. ...    ..|  |||. .|| .|.   . .. |.    .
VYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLL

RVALGCAEGLAYLHHSANPPMIHGNIKASNILLTDDFQ
  ..  |.|..||.      .||  . | |.|.|....
QMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNV
Kinase RLCK15_c.AA Pkinase 97-239 21 8.6e-12 42.78 Pfam 59-209 (293) Show / Hide 
Range on Protein: 97-239
Range on HMM: 59-209/293
Sequence Identity: 21% (34 aa)

HKNVMRLRGYCVERDERILVYSYMPNS----SLLAHLHGAFSYDNLL--DWGKRVRVALGCAEGLAYLHHSANPPMIHGNIKASNILLTDDFQP----LY
|.|. ||.... ..|.  .|  |...     .| .....  .... .  ..    ....  ..||.|.|       ||  .| .|||. .. ..      
HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKI

TDYGIAALM-KKPALKAKVALG---YTAPECSS-GEAATLQSDVFSFGILLLELISGR
.| |.|...   .   ...  |   | |||    |.  .  .|..|.|..| |...||
CDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase RLCK15_c.AA IRAK 220-244 48 1e-06 19.73 In-house 202-226 (317) Show / Hide 
Range on Protein: 220-244
Range on HMM: 202-226/317
Sequence Identity: 48% (12 aa)

TLQSDVFSFGILLLELISGRRPMEK
| ..||.|||| |||...|.|.. .
TKKTDVYSFGIVLLEVLTGCRAVYD
Kinase RLCK15_c.AA Pkinase_Tyr 220-241 47 0.001979 12.24 Pfam 192-214 (270) Show / Hide 
Range on Protein: 220-241
Range on HMM: 192-214/270
Sequence Identity: 47% (11 aa)

TLQSDVFSFGILLLELIS-GRRP
| .||| |||.|. |... |. |
TTKSDVWSFGVLMWEIFTYGEQP
Kinase RLCK15_c.AA MLK 291-311 33 0.014436 4.88 In-house 271-291 (291) Show / Hide 
Range on Protein: 291-311
Range on HMM: 271-291/291
Sequence Identity: 33% (7 aa)

TICAQTSSHSRPSMARVVELL
..| .. .|.|||.. .|. |
KQCWNQDPHKRPSFRQIVQHL
Kinase RLCK15_c.AA IRAK 279-311 27 0.096738 2.15 In-house 285-317 (317) Show / Hide 
Range on Protein: 279-311
Range on HMM: 285-317/317
Sequence Identity: 27% (9 aa)

VPEELKKLVFAATICAQTSSHSRPSMARVVELL
.|.. |..  .|  |. .    |..|| |...|
PPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL