LRRIc-2

Species: S.moellendorffii
Alias: LRRIc-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRRIc

Sequence

Name Sequence Type Origin Length Description Download
LRRIc-2.AA Protein None 120 None Fasta, JSON
LRRIc-2.NA RNA None 363 None Fasta, JSON
LRRIc-2.kin_dom Protein Kinase Domain None 82 None Fasta, JSON

Protein domain

Protein domains of LRRIc-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LRRIc-2.AA TKL-Unique 29-113 33 1.2e-17 58.94 In-house 1-92 (290) Show / Hide
Range on Protein: 29-113
Range on HMM: 1-92/290
Sequence Identity: 33% (31 aa)

FSRKLGEGGFGPVYHGILPDSHEIAVKVQSYDSKQGAN---EFFNEVQLLSRAH-HRHVVSLVGYCH----EANSRMLVYEYLSGGTLERNLH
|. |.||||.|.||.|. . . ..|.|. .  ...      || ||| .... | |  .| ..|||.     .. . .| ||..||.|  .||
FWNKIGEGGYGQVYKGKWRGY-PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLH

Kinase LRRIc-2.AA IRAK 28-114 31 2e-16 54.87 In-house 2-96 (317) Show / Hide
Range on Protein: 28-114
Range on HMM: 2-96/317
Sequence Identity: 31% (30 aa)

SFSRKLGEGGFGPVYHGILPDSH-EIAVK----VQSYDSKQGANEFFN---EVQLLSRAHHRHVVSLVGYCHEANSRMLVYEYLSGGTLERNLHG
. ....|||||| ||.| .       |||    . .   ..   .|     |.....| .| ..|.| ||| |     |||.|...|.||  |..
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWC

Kinase LRRIc-2.AA TKL 33-113 21 2.1e-16 55.55 In-house 1-130 (364) Show / Hide
Range on Protein: 33-113
Range on HMM: 1-130/364
Sequence Identity: 21% (28 aa)

LGEGGFGPVYHGILPD---------SHEIAVKVQSYDSKQG--------------------------ANEFFNEVQ-LLSRAHHRHVVSLVGYCHEANS-
.|.|||| ||.|..           . ..|||. . .. .                           ...|..|.  ..|| .| ..|...||| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RMLVYEYLSGGTLERNLH
             ..|.|| .||.|. .||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH

Kinase LRRIc-2.AA Pkinase_Tyr 28-108 30 4.1e-14 48.43 Pfam 2-94 (270) Show / Hide
Range on Protein: 28-108
Range on HMM: 2-94/270
Sequence Identity: 30% (28 aa)

SFSRKLGEGGFGPVYHGILP-----DSHEIAVKVQ--SYDSKQ-GANEFFNEVQLLSRA-HHRHVVSLVGYCH-EANS--RMLVYEYLSGGTL
.| .||||| || ||.|..      .  . |||.   .....|    .|..|.....   || ..|.|.| |  .  .   ..| ||  .| |
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

Kinase LRRIc-2.AA TK 27-113 19 2.6e-13 40.22 In-house 1-151 (486) Show / Hide
Range on Protein: 27-113
Range on HMM: 1-151/486
Sequence Identity: 19% (30 aa)

ESFSRKLGEGGFG---PVYHGILPDS--------------------------HEIAVKVQSYDSKQGANEFFN-----------------EVQLLS--RA
  . .||||| ||    || |.. .                           .. |||.   .. . ..|||                  | ....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHRHVVSLVGYCHEA------------NSRMLVYEYLSGGT----LERNLH
|| ..|.|.|.|..                |.| || ..|     |   |.
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLR

Kinase LRRIc-2.AA ULK 28-113 22 1.4e-12 40.3 In-house 2-112 (329) Show / Hide
Range on Protein: 28-113
Range on HMM: 2-112/329
Sequence Identity: 22% (25 aa)

SFSRKLGEGGFGPVYHGILPDS-----HEIAVKVQSYDS-KQGANE---------FFNEVQLLSRAH--------HRHVVSLVGYCHEA--NSRMLVYEY
. ...||.| || || |.  ..       .|.|. . .. .|  ||         . ||.... . .        | ..| |  .. ..  |   ...||
CLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEY

LSGGTLERNLH
  ||.||  ..
CNGGDLEQYIK

Kinase LRRIc-2.AA TK-Unique 29-109 24 4.1e-12 38.18 In-house 3-93 (294) Show / Hide
Range on Protein: 29-109
Range on HMM: 3-93/294
Sequence Identity: 24% (22 aa)

FSRKLGEGGFGPVYHGILPD-------SHEIAVKVQS-YDSKQGANEFFNEVQLLSRAH-HRHVVSLVGYCHEA-NSRMLVYEYLSGGTLE
. ...||| ||.|..| .          . .|||    . ...   .|..| |...    | ..|...|.| .  .. |...||...|.|.
VGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQ

Kinase LRRIc-2.AA ULK 28-109 23 8e-11 34.69 In-house 2-105 (324) Show / Hide
Range on Protein: 28-109
Range on HMM: 2-105/324
Sequence Identity: 23% (25 aa)

SFSRKLGEGGFG-PVYHGI-LPD---SHEIAVKVQS--YDSKQGAN--------EFFNEVQLLSRAH------HRHVVSLVGYCHEA--NSRMLVYEYLS
. ...||.| ||  || |.   .      .|.|. .  . .|.  .         . ||.|..   .      | |.| |  .. ..  |   ...||  
CLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYCN

GGTLE
||.||
GGDLE

Kinase LRRIc-2.AA STE20 28-108 20 6e-10 32.85 In-house 2-95 (288) Show / Hide
Range on Protein: 28-108
Range on HMM: 2-95/288
Sequence Identity: 20% (19 aa)

SFSRKLGEGGFGPVYHGIL-PDSHE----IAVKVQSYDSK----QGANEFFNEVQLLSRAHHRHVVSLVGYCHEA----NSRMLVYEYLSGGTL
 . .|.|.|..| || ..  |   .    .|.|. .....    .  .. ..|.. ... .| ..|.  |         ..  .| ||..||.|
ELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSL

Kinase LRRIc-2.AA ALK 28-108 29 7.2e-10 30.26 In-house 2-89 (273) Show / Hide
Range on Protein: 28-108
Range on HMM: 2-89/273
Sequence Identity: 29% (26 aa)

SFSRKLGEGGFGPVYHGILPD----SHEIAVKVQSYD---SKQGANEFFNEVQLLSRAHHRHVVSLVGYCHEANSRMLVYEYLSGGTL
   | || | || || |        | ...|.. .     |.|    | .|   ...  |  ||...| | ..  .| | ||..|| .
TLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDM

Kinase LRRIc-2.AA UTK 28-112 28 7.4e-10 29.9 In-house 2-101 (296) Show / Hide
Range on Protein: 28-112
Range on HMM: 2-101/296
Sequence Identity: 28% (28 aa)

SFSRKLGEGGFGPVYHGILPD----SHEIAVKVQSYD---SKQGANE----FFNEVQ---LLSRAH-HRHVVSLVGYCHEANSRMLVYEYLSGGTLERNL
 ..|.||.| || |... . .    . | .|.|   .   ..| . |    | .| .   .... | |..|. |||.|      |.|.|| ..| |   |
QLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYL





Kinase LRRIc-2.AA Pkinase 27-108 25 2.2e-09 34.25 Pfam 1-91 (293) Show / Hide
Range on Protein: 27-108
Range on HMM: 1-91/293
Sequence Identity: 25% (23 aa)

ESFSRKLGEGGFGPVYHGILPDSHE-IAVKVQSYDSKQGANE--FFN--EVQLLSRAHHRHVVSLVGYCHEANSRMLVYEYLSGG----TL
  . ||.|.|.|| ||...  .. .  |||. .....    .   ..  |.|.. | .| ..| | ..... ..  .| ||. ||     |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDL