Gene LRR8x_a-2 (S.moellendorffii)

LRR8x_a-2

Species: S.moellendorffii
Alias: LRR8x_a-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8x

Sequence

Name Sequence Type Origin Length Description Download
LRR8x_a-2.AA Protein None 478 None Fasta, JSON
LRR8x_a-2.NA RNA None 1437 None Fasta, JSON
LRR8x_a-2.kin_dom Protein Kinase Domain None 146 None Fasta, JSON

Protein domain

Protein domains of LRR8x_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 LRR8x_a-2.AA LRR_1 32-55 44 0.06564 10.94 Pfam 1-26 (26) Show / Hide 
Range on Protein: 32-55
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

WLNHLDLSG-N--SFRGSIPVTYCALL
 | |||||| |  .. |.||   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR8x_a-2.AA LRR_1 57-79 28 0.272148 8.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 57-79
Range on HMM: 1-26/26
Sequence Identity: 28% (8 aa)

NISYLNLAE-N--KLV-SRIPEN-IGYL
|. .|.|   |  .|. . ||.. .  |
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 LRR8x_a-2.AA LRR_1 81-100 50 0.00083 17.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 81-100
Range on HMM: 1-26/26
Sequence Identity: 50% (13 aa)

NLRWLDLSD-N--KLTGNIPY---SL
||. ||||. |  .|||.||    .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR8x_a-2.AA LRR_1 105-126 22 2.607446 5.27 Pfam 1-26 (26) Show / Hide 
Range on Protein: 105-126
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

QIKKLRLMN-N--SLSGKVPD--TQTM
....| | . |  .|.|..|.     .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase LRR8x_a-2.AA TKL 204-397 20 1e-33 118.32 In-house 1-285 (364) Show / Hide 
Range on Protein: 204-397
Range on HMM: 1-285/364
Sequence Identity: 20% (61 aa)

LSVGGLWTIYKGVFFN---------GKTVAVKRVRPEYYNGEGK-----------------------LFEEERKFLKAMS---HPNIVKYLGACSTPKL-
.  ||  ..|||.. .         ||.||||. . .. . . |                       ....|.. .. ||   |||||...|.|  |.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KVLVYEHMSNGSLDMHLHKERAGISSLSWSSRMDIAAGVAQGLAYLHGEW-----KEPQMHCDLNGSSVLLDDKFN------------
              .|.| ...|||  .||          |. |...| ..|.|..||| ..     | |  |.||. . .|.|....            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--ARIADI---RSKNASKHFTSLE---------------TNIGR-STGYHPPAE------YSITN---------EPTPEGEVFSFGTLLMELLTG
  . |.|    |... |.. .  .               |.  . .... .|        |.  .         | ..   |.||| .| |.||.
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR
Kinase LRR8x_a-2.AA MLK 198-343 25 6.4e-23 76.43 In-house 1-176 (291) Show / Hide 
Range on Protein: 198-343
Range on HMM: 1-176/291
Sequence Identity: 25% (46 aa)

FNNNKILSVGGLWTIYKGVFFNGK----TVAVKRVRPEYYNGEGK------LFEEERKFLKAMSHPN----IVKYLGACSTP-KLKVLVYEHMSNGSLDM
... ... .|.    .||.. |      .||||||| . .   ..       ||.| . |. .||||    |.. .|.|. | .  ..| | ...|||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HLHKERAGIS----------SLSWSSRMDIAAGVAQGLAYLHGEWKEPQMHCDLNGSSVLLDD------KFNARIAD
 || .| ...            . .. |..|  .|.|..||| . . |  | ||. . .|.|.      . ...|.|
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICD
Kinase LRR8x_a-2.AA TKL-Unique 211-343 31 1.7e-21 72.71 In-house 12-160 (290) Show / Hide 
Range on Protein: 211-343
Range on HMM: 12-160/290
Sequence Identity: 31% (48 aa)

TIYKGVFFNGKTVAVKRVRP-EYYNGEGKL-FEEERKFLKAMS-HPNIVKYLGACS----TPKLKVLVYEHMSNGSLDMHLH------KERAGISSLSWS
..|||.. .|. ||.|.  | |  . | .  ||.| . .|    |||||.| |.|     .|.   .| | .. |||. .||         .  . |...
QVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQ

SRMDIAAGVAQGLAYLHGEWKEPQMHCDLNGSSVLLDDK-----FNARIAD
 |...|  .|||. ||| . .   .|.||  |..|.| .     .|..|.|
QRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICD
Kinase LRR8x_a-2.AA IRAK 198-401 29 9.8e-21 70.32 In-house 1-224 (317) Show / Hide 
Range on Protein: 198-401
Range on HMM: 1-224/317
Sequence Identity: 29% (67 aa)

FNNNKILSVGGLWTIYKGVFFNGK-TVAVKRVRPEYYNGEGKL---FEE---ERKFLKAMSHPNIVKYLGACSTPKLKVLVYEHMSNGSLDMHLHKERAG
|. .  .. ||  ..|.|.. |   ..|||... .    ....   |     | | .    |||||  .| |. .    |||. |.||||   |.   . 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

IS--SLSWSSRMDIAAGVAQGLAYLHGEW-KEPQMHCDLNGSSVLLDDKFNARIAD---IR-SKNAS-KHFTSL---ETNIGRSTGYHPPAEYSI--TNE
 .   |||  | .|. | | |. .||    . |  | |   . .|||. |.. |.|    | .. || |  ...   .|.. | |    | |.    . .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

PTPEGEVFSFGTLLMELLTGTEAA
 |.   |.|||  |.|.|||  |.
LTKKTDVYSFGIVLLEVLTGCRAV
Kinase LRR8x_a-2.AA TK 211-314 14 6e-20 62.87 In-house 17-251 (486) Show / Hide 
Range on Protein: 211-314
Range on HMM: 17-251/486
Sequence Identity: 14% (34 aa)

TIYKGVFFNGK--------------------------TVAVKRVRPEYYNGEGKLFE-------------EERKFLKAMS-----HPNIVKYLGACSTPK
..|||  ....                          .|||| ....  . .   |.             ||   .| |.     |||||. .|.|. ..
EVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGE

LK------------VLVYEHMSNGS----LDMHLHKERAGISS---------------------------------------------------------
 |             .| |.|..|.    |. .|.| | . .                                                          
PKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKD

---------------LSWSSRMDIAAGVAQGLAYLH
               |.   .. ... .|.|..|||
LLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH
Kinase LRR8x_a-2.AA HH498 220-343 28 3.6e-17 50.61 In-house 22-167 (284) Show / Hide 
Range on Protein: 220-343
Range on HMM: 22-167/284
Sequence Identity: 28% (41 aa)

GKTVAVKRVRPEYYNGEGK-------LFEEERKFLKAMSHPNIVKYLGAC-STPKLKVLVYEHMSNGSLDMHL--------------HKERAGISSLSWS
.| |||||.| . .   ..        |  |   .   .||. |....||   |.   .| .  .||||   |              | ..     ..  
NKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQ

SRMDIAAGVAQGLAYLHGEWKEPQMHCDLNGSSVLLDDKFNARIAD
|.| |.  ||.|  |||   | |  | |||   .|..    | .||
SKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVAD
Kinase LRR8x_a-2.AA Pkinase_Tyr 211-314 28 6.9e-17 57.81 Pfam 14-128 (270) Show / Hide 
Range on Protein: 211-314
Range on HMM: 14-128/270
Sequence Identity: 28% (33 aa)

TIYKGVFF-----NGKTVAVKRVRPEYYNGEG---KLFEEERKFLKAM-SHPNIVKYLGACSTPKLK---VLVYEHMSNGSLDMHLHKERAGISSLSWSS
..|||. .     .. .|||| . .|..  |    . | .| | .| . .|||||...|.|.  .      .| |.| .|.|. .|.| | .  .|. . 
EVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD

RMDIAAGVAQGLAYLH
  .... .|.|..||.
LLQMCWQIAKGMEYLE
Kinase LRR8x_a-2.AA TKL-ciliate2 199-326 34 9.3e-13 38.33 In-house 3-125 (273) Show / Hide 
Range on Protein: 199-326
Range on HMM: 3-125/273
Sequence Identity: 34% (44 aa)

NNNKILSVGGLWTIYKGVFFNGKTVAVKRVRPEYYNG-EGKLFEEERKFLKAMSHPNIVKYLGACSTPKLKVLVYEHMSNGSLDMHLHKERAGISSLSWS
 .||| . ||   |||  .    .||||. . .. |  . . | .| . . |. ||||| .||||       .. |    |||   |  .      |.| 
IQNKI-TEGGYGIIYKAKWRE-IVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDV---RLTWE

SRMDIAAGVAQGLAYLHGEWKEPQMHCDL
 |  ||  .|.|  |||   . | .| ||
DRRRIALDIARGVHYLHSS-NPPIIHRDL
Kinase LRR8x_a-2.AA LISK 203-314 27 1e-12 37.42 In-house 1-118 (296) Show / Hide 
Range on Protein: 203-314
Range on HMM: 1-118/296
Sequence Identity: 27% (32 aa)

ILSVGGLWTIYKGVFF-NGKTVAVKRVRPE----YYNGEGKLFEEERKFLKAMSHPNIVKYLGACST-PKLKVLVYEHMSNGSLDMHLHKERAGISSLSW
... |.   .|||  .  |. .|.|         ...   | .. | . .| ..|||||.. |.|    .   .| | .. | |   |...    . |.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

SSRMDIAAGVAQGLAYLH
. |..|| ..|.|..|||
PQRVKIALDIACGMSYLH
Kinase LRR8x_a-2.AA TyrKc 198-469 21 2.1e-12 -22.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 198-469
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FNNNKILSVGGLWTIYKGVFFNGKTVAVKRVRPEYYNGEGKLFEEERKFLKAM--SHPNIVKYLGACSTP-------KLKVLVYEHMSNGSLDMHLHKER
   .|.|  |   ..|||.     .|||| ....      . | .| . ..    .|||||. .|.|...       .   .| |.|..|.|. .|.| |
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

AGISSLSWSSRMDIAAGVAQGLAYLHGEWKEPQMHCDLNGSSVLLDDKFNARIAD------IRSK----NASKHFTSLETNIGR--STGYHPPAEYSITN
     |...   ...  .|.| .|||     .  | ||    .|..... ..|.|      | ..     ...  .. |.  |.        . |   ..
PK---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

EPTPEGEVFSFGTLLMELLTGTEA--AG-----PVKNGVKGGLQGIMDRAFPDNLQCVLDPAILNGASHDQIVLCTKIALDCTRTNPEERPKMEHILGMF
. |..  |.||| .. |..|  .    |          |   ..  . .  |.|      | .     .    . . | ..| . .||.|| .. |   |
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----P-MSF--VCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase LRR8x_a-2.AA CZAK 220-343 28 3.1e-12 40.86 In-house 22-165 (279) Show / Hide 
Range on Protein: 220-343
Range on HMM: 22-165/279
Sequence Identity: 28% (42 aa)

GKTVAVKRV-RPEYYNGEG----KLFEEERKFLKAMSHPNIVKYLGACSTPK--LKVLVYEHMSNGSLDMHLHKERAGISSLSWSSRMDIAAGVAQGLAY
|| ||.| . |  . |  .      |. |   .    |||.| .|||||     ..  | | |  |||.  |  ..        . .. .|  .|.|  |
GKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLT-DHYFYHKQNPHLQWNMAIDIARGMNY

LHGEWKE-PQMHCDLNGSSVLLDDKFN-------------ARIAD
||. ||. | .| ||  . .|||.                . |.|
LHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKIND
Kinase LRR8x_a-2.AA S_TKc 198-469 16 1.2e-11 -6.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 198-469
Range on HMM: 1-231/231
Sequence Identity: 16% (49 aa)

FNNNKILSVGGLWTIYKGVFFN-GKTVAVKRVRPEYYNGEGKLFEEERKFLKAMSHPNIVKYLGACSTPKLKVLVYEHMSN--GSLDMHLHKERAGI--S
.   ...  |.  . ||..  . |. ||.|...        . .. |.. ||   ||||||..... . .   .| |....  |.|  ...| . .   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

SLSWSSRMDIAAGVAQGLAYLHGEWKEPQMHCDLNGSSVLLDDKFNARIAD------IRSKNASKHFTSLETNIGRSTGYHPPAEYSITNEPTP-EGEVF
 ..      ... ....|.|.|  .    .|.||  . .|||.  .  |.|      .             | .  .  | .|         .. .  . 
PFPE-HARFYMYQICCALEYCHSHGI---IHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----GYGKCKCDWW

SFGTLLMELLTGTEAAGPVKNGVKGGLQGIMDRAFPDNLQCVLDPAILNGASHDQIVLCTKIALDCTRTNPEERPKMEHILG---------MF
|.| .| |.|.|              .| ....                         .  .   | . .||.||    .|           |
SCGCILYEMLCGYPPFP--------QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8x_a-2.AA Pkinase 219-317 21 1.2e-11 42.22 Pfam 23-128 (293) Show / Hide 
Range on Protein: 219-317
Range on HMM: 23-128/293
Sequence Identity: 21% (23 aa)

NGKTVAVKRVRPEYYNGEGK-----LFEEERKFLKAMSHPNIVKYLGACSTPKLKVLVYEHMSNG----SLDMHLH-KERAGISSLSWSSRMDIAAGVAQ
.||.||||... .  . . .     |   | . .| ..|||||...... ...   .| |.. .|    .|  ... ... ... .|.    ...  ...
TGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILR

GLAYLHGEW
||.|.| ..
GLEYCHSMG
Kinase LRR8x_a-2.AA DRK 240-315 30 1.3e-11 35.69 In-house 44-116 (258) Show / Hide 
Range on Protein: 240-315
Range on HMM: 44-116/258
Sequence Identity: 30% (23 aa)

FEEERKFLKAMSHPNIVKYLGACSTPKLKVLVYEHMSNGSLDMHLHKERAGISSLSWSSRMDIAAGVAQGLAYLHG
|  |   ..   ||||. ..|.|  |     . | |. |||   || |     ...|. .. ..  .| |. |||.
FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESI---EMDWPLMKQMMFDCAKGMIYLHC
Kinase LRR8x_a-2.AA TKL 446-469 37 0.000164 12.17 In-house 341-364 (364) Show / Hide 
Range on Protein: 446-469
Range on HMM: 341-364/364
Sequence Identity: 37% (9 aa)

KIALDCTRTNPEERPKMEHILGMF
|.. ||  ..||.|| .. ||  .
KLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8x_a-2.AA LISK 446-469 25 0.000464 8.86 In-house 273-296 (296) Show / Hide 
Range on Protein: 446-469
Range on HMM: 273-296/296
Sequence Identity: 25% (6 aa)

KIALDCTRTNPEERPKMEHILGMF
....||.. .|..||. ..|.  .
DLCFDCCKYDPKNRPSFKEIVQWL
Kinase LRR8x_a-2.AA DRK 450-471 36 0.00077 8.93 In-house 237-258 (258) Show / Hide 
Range on Protein: 450-471
Range on HMM: 237-258/258
Sequence Identity: 36% (8 aa)

DCTRTNPEERPKMEHILGMFEQ
||  ..|  || |. .|   | 
DCWNEDPQHRPSMQECLERLEA
Kinase LRR8x_a-2.AA TK 447-469 21 0.00091 7.66 In-house 464-486 (486) Show / Hide 
Range on Protein: 447-469
Range on HMM: 464-486/486
Sequence Identity: 21% (5 aa)

IALDCTRTNPEERPKMEHILGMF
. ..| . .||.|| .. .. ..
LMQQCWHYDPEDRPTFSQLHEQL
Kinase LRR8x_a-2.AA MLK 450-469 25 0.00187 8.0 In-house 272-291 (291) Show / Hide 
Range on Protein: 450-469
Range on HMM: 272-291/291
Sequence Identity: 25% (5 aa)

DCTRTNPEERPKMEHILGMF
.|  ..|..||.. .|.  .
QCWNQDPHKRPSFRQIVQHL
Kinase LRR8x_a-2.AA LISK 384-400 52 0.219019 0.03 In-house 222-238 (296) Show / Hide 
Range on Protein: 384-400
Range on HMM: 222-238/296
Sequence Identity: 52% (9 aa)

VFSFGTLLMELLTGTEA
||||| .| |. |. .|
VFSFGIVLCEIITRVKA
Kinase LRR8x_a-2.AA Pkinase_Tyr 455-469 33 0.899233 3.24 Pfam 256-270 (270) Show / Hide 
Range on Protein: 455-469
Range on HMM: 256-270/270
Sequence Identity: 33% (5 aa)

NPEERPKMEHILGMF
.||.|| .. |. ..
DPEDRPTFSEIHEQL