Gene LRR8_y-1 (S.moellendorffii)

LRR8_y-1

Species: S.moellendorffii
Alias: LRR8_y-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR8

Sequence

Name Sequence Type Origin Length Description Download
LRR8_y-1.AA Protein None 469 None Fasta, JSON
LRR8_y-1.NA RNA None 1410 None Fasta, JSON
LRR8_y-1.kin_dom Protein Kinase Domain None 174 None Fasta, JSON

Protein domain

Protein domains of LRR8_y-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LRR8_y-1.AA TKL 206-445 16 2.1e-31 110.34 In-house 1-364 (364) Show / Hide 
Range on Protein: 206-445
Range on HMM: 1-364/364
Sequence Identity: 16% (63 aa)

LGQGGFGTVYKATLNN---------GSQVAVKKLSLQSNQG--------------------------KREFVNKII-IITGIQHRNLVRLKGYCVEADE-
.|.||||.|||.....         |  |||||.. ....                            |.| .. | ..  ..| |.|...||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFLNKGS-LDRALFITLSNCHWD---------SRGLAYLHEESH-------------------VHDKLQ--------------
              .|.|.  .|| |.. .        |.         .||..||| .                     |.....              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

PKISDFGISKLFDLDKSFIRTK------------------VAGTFGYMAPKYAT----------------RGRLTAKANVFSYGILVLELASGRKCVDPA
.||.|||.|. .. ...  .|.                  . ||...|||                     .  . |. |.|.||.  |......   | 
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---PY

L-PAEEELLLQ----LSWKLVMANRMSECID-----KRLGSAYVVEEVSK---LLRVAMLCTQKHEEARPTMSEVVAML
  . ... ..|    . ...|  ...   |.     ..      . . .    . . .. | .   |.||...|..  |
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR8_y-1.AA TK 200-371 14 2.9e-22 70.77 In-house 1-389 (486) Show / Hide 
Range on Protein: 200-371
Range on HMM: 1-389/486
Sequence Identity: 14% (56 aa)

FSEKNKLGQGGFG---TVYKATLNNGS--------------------------QVAVKKLSLQSNQGKREFVN----------------KIIIITG---I
    .|||.| ||   .|||.......                          .|||| | . ... ..||                   .. .      
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHRNLVRLKGYCVEADE------------RLLVYEFLNKGS----LD------RALFIT-----------------------------------------
.| |.||| |.|.. ..             ..| |. ..|.    |.      |  |..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------LSNCHWDS-------------------------RGLAYLHEESH-----------------VHDKLQ-----------PKISDFGIS--
           |.  .  .                         .|..|||.                    |.....            ||.||| |  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------KLFDLDKSFIRTKVAGTFG-------------------------YMAPKYAT---------RGRLTAKANVFSYGILVLELAS
      .  . |.   |..  || .                         .|||   .          |. | |  |.|.|.|. |. .
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase LRR8_y-1.AA IRAK 200-281 34 1.1e-18 62.9 In-house 1-90 (317) Show / Hide 
Range on Protein: 200-281
Range on HMM: 1-90/317
Sequence Identity: 34% (31 aa)

FSEKNKLGQGGFGTVYKATLNNGS-QVAVKKL----SLQSNQGKREFVN---KIIIITGIQHRNLVRLKGYCVEADERLLVYEFLNKGSL
|.. |..|.||||.||.. ..|    .|||||    ... |. ...|      . . . ..| |.| | ||| | ..  |||...  |||
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSL
Kinase LRR8_y-1.AA Pkinase_Tyr 200-282 29 1.3e-18 63.61 Pfam 1-95 (270) Show / Hide 
Range on Protein: 200-282
Range on HMM: 1-95/270
Sequence Identity: 29% (28 aa)

FSEKNKLGQGGFGTVYKATLN-----NGSQVAVKKLSLQSNQG---KREFVNKIIIITGI-QHRNLVRLKGYCV-EADE--RLLVYEFLNKGSLD
 .   |||.| ||.|||.|..     .. .||||.|  .. .    ...| . . | . . .| |.||| | |. . .    ..| |.  .|.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL
Kinase LRR8_y-1.AA TKL-Unique 204-282 33 5.1e-16 53.14 In-house 3-88 (290) Show / Hide 
Range on Protein: 204-282
Range on HMM: 3-88/290
Sequence Identity: 33% (29 aa)

NKLGQGGFGTVYKATLNNGSQVAVKKLSL---QSNQGKREFVNKIIIITGIQ-HRNLVRLKGYCV----EADERLLVYEFLNKGSLD
||.|.||.|.|||..  .|..||.|....   .||. ..|| | . ..  .. | |.|.. |||.     . .. .| |... |||.
NKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLY
Kinase LRR8_y-1.AA TyrKc 200-445 22 1e-14 15.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 200-445
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FSEKNKLGQGGFGTVYKATLNNGSQVAVKKLSLQSNQGKREFVNKIIIITGI--QHRNLVRLKGYCVEA-------DERLLVYEFLNKGSLDRAL-----
 . . ||| | ||.|||.|..   |||||.|   .   ...| . . | . .  .| |.||| |.|..        .  ..| |.  .|.|.  |     
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

FITLSNCHWD----SRGLAYLHEESHVH-----------DKLQPKISDFGISKLFDLD------KSFIRTK---VA---GTFGYMAPKYATRGRLTAKAN
 ....  .      ..| .|||.   .|           .... |||||| |.  . |      |. .|.|    .        |||     |. | |  
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VFSYGILVLELASGRKCVDPALPAEEE----LLLQLSWKLVMANRMSECIDK-----RLGSAYVVEEVSKLLRVAMLCTQKHEEARPTMSEVVAML
|.|.|..  |. .     . . | ...    .  |   ..|.. .. .. .             |.  ... ..   | .   | |||.||..  .
VWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LRR8_y-1.AA S_TKc 200-449 19 2.4e-14 33.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 200-449
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

FSEKNKLGQGGFGTVYKATLNN-GSQVAVKKLSLQSNQGKREFVNKIIIITGIQHRNLVRLKGYCVEADERLLVYEFLNK--GSLDRALFIT--------
.   .|.|.|.||.|||.. .. | .||.|...       . . . | |    .| |.|.|...... |.  .| |...   |.| . .           
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSNCHWDS------RGLAYLHEESHVH----------DKLQPKISDFGISKLFDLDKSFIRTKVAGTFGYMAPKYATRGRLTA-KANVFSYGILVLELAS
..  |  .      ..|.|.|.   .|          |. . ||.|||.....        | . ||  ||||        .  |. . | |... |...
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRKCVDPALPAEEELLLQLSWKLVMANRMSECIDKRLGSAYVVEEVSKLLRVAMLCTQKHEEARPTMSEVVA-----MLLGYL
|.   .     ........                           . ..   . | ||  | |||  |. .     ..  ..
GYPPFP-----QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR8_y-1.AA ULK 200-282 24 2.8e-14 46.31 In-house 1-108 (329) Show / Hide 
Range on Protein: 200-282
Range on HMM: 1-108/329
Sequence Identity: 24% (26 aa)

FSEKNKLGQGGFGTVYKAT-LNN----GSQVAVKKLSLQS-NQGKRE---------FVNKIIIITGI--------QHRNLVRLKGYCVEADE--RLLVYE
.. ...||.| ||.|||..  ..    . .||.|....|. || . |         . | | |.  .        .| | |.|. .. ....    ...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FLNKGSLD
. | | |.
YCNGGDLE
Kinase LRR8_y-1.AA TK-Unique 200-282 23 3.4e-14 45.46 In-house 1-93 (294) Show / Hide 
Range on Protein: 200-282
Range on HMM: 1-93/294
Sequence Identity: 23% (22 aa)

FSEKNKLGQGGFGTVYKATLNNGS-------QVAVKKLSLQSNQG-KREFVNKIIIITGIQ-HRNLVRLKGYCVEAD-ERLLVYEFLNKGSLD
.  ....|.| ||.|..... ...       .||||.|   ...  |..| ..| .   .  | |.|.. |.|.. |   ....|.. .|.|.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQ
Kinase LRR8_y-1.AA STE 200-285 21 4.3e-14 46.26 In-house 1-128 (359) Show / Hide 
Range on Protein: 200-285
Range on HMM: 1-128/359
Sequence Identity: 21% (27 aa)

FSEKNKLGQGGFGTVYKATLNN----------------GSQVAVKKLSLQSNQG-----------------KREFVNKIIIITGIQ--HRNLVRLKGYCV
.    |.|.|.|||||||  ..                |  .|.|...|....                  . .. . | |    .  | | |.  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EA-------DERLLVYEFLNKGSLDRAL
         ||  .. |... ||||  .
KEGHNHKNDDELWICMEYMDGGSLDDII
Kinase LRR8_y-1.AA Pkinase 200-285 25 5.2e-14 50.62 Pfam 1-95 (293) Show / Hide 
Range on Protein: 200-285
Range on HMM: 1-95/293
Sequence Identity: 25% (24 aa)

FSEKNKLGQGGFGTVYKATLNNGSQ-VAVKKLSLQSNQG--KREFVN--KIIIITGIQHRNLVRLKGYCVEADERLLVYEFLNKG----SLDRAL
.  . |.|.|.||.|||..  . .. ||||.......    ... ..   | |   ..| | |||.... . |.  .| |....|    .| . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI
Kinase LRR8_y-1.AA ULK 200-282 20 9.6e-13 41.6 In-house 1-105 (324) Show / Hide 
Range on Protein: 200-282
Range on HMM: 1-105/324
Sequence Identity: 20% (22 aa)

FSEKNKLGQGGFG-TVYKAT-LNN---GSQVAVKKLS--LQSNQGKR--------EFVNKIIIITGIQ---HRN--LVRLKGYCVEADE--RLLVYEFLN
.. ...||.| || .|||..  ..   . .||.|. .   .... ..         . | | |.  .    | |   |.|. .. ....    ...|. |
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGSLD
 | |.
GGDLE
Kinase LRR8_y-1.AA IRAK 310-445 22 1e-11 37.92 In-house 148-317 (317) Show / Hide 
Range on Protein: 310-445
Range on HMM: 148-317/317
Sequence Identity: 22% (39 aa)

DKLQPKISDFGISKLF----DLDKSFI---RT-KVAGTFGYMAPKYAT--RGRLTAKANVFSYGILVLELASGRKCVDPALPAEEELLLQLSWKLVMAN-
. ..|||.|||         .. |. .   .| .| ||  ||.| . .   |.|| |  |.| || .||...|.. |.   |  . |.. ..     .. 
QHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGH

---------------------RM---SECIDKRLGSAYVVEEVSKLLRVAMLCTQKHEEARPTMSEVVAML
                     ||      ||.| ... . ... ... .|  |.      |..| .|.. |
LDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPC-PPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase LRR8_y-1.AA LRRK 200-263 18 9.5e-11 34.23 In-house 1-126 (351) Show / Hide 
Range on Protein: 200-263
Range on HMM: 1-126/351
Sequence Identity: 18% (23 aa)

FSEKNKLGQGGFG-TVYKATLNN---------------------------GSQVAVKKLSLQ---------SNQG-------------------------
. . ...|.|||| .||.|....                           .. ||.||. .          .. .                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

KREFVNKIIIITGIQHRNLVRLKGYC
 ||| . . |. . .| |.| |||.|
FREFRHEVWIMSHLNHPNIVSLKGFC
Kinase LRR8_y-1.AA TKL-ciliate2 200-281 30 4.1e-10 29.34 In-house 1-83 (273) Show / Hide 
Range on Protein: 200-281
Range on HMM: 1-83/273
Sequence Identity: 30% (26 aa)

FSEKNKLGQGGFGTVYKATLNNGSQVAVKKLSLQSNQG--KREFVNKIIIITGIQHRNLVRLKGYCVEADERLLVYEFLNKGSL
   .||.  ||.| .|||       |||||  .. ..    |.|||    .  . | |.|   | | .     .. |.  .|||
LEIQNKITEGGYGIIYKAKWRE-IVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSL
Kinase LRR8_y-1.AA TKL-ciliate2 308-371 37 1.9e-07 20.32 In-house 152-213 (273) Show / Hide 
Range on Protein: 308-371
Range on HMM: 152-213/273
Sequence Identity: 37% (24 aa)

VHDKLQPKISDFGISKLFDLDKSFIRTKVAGTFGYMAPKYATRGRLTAKANVFSYGILVLELAS
| | .  |..|||  .    |  ..  |. ||. .|||        | || ||||.|.. |.||
VDDNFRCKLTDFGWTRVKPQDN-YMTNKI-GTYQWMAPEVIKAFYYTEKADVFSYSIILWEIAS
Kinase LRR8_y-1.AA LRRK 315-345 41 1.4e-05 15.66 In-house 218-248 (351) Show / Hide 
Range on Protein: 315-345
Range on HMM: 218-248/351
Sequence Identity: 41% (13 aa)

KISDFGISKLFDLDKSFIRTKVAGTFGYMAP
||.||||| .|  ... .. .. |..|.|||
KIADFGISRMFQCFHMGVAKGCVGNPGWMAP
Kinase LRR8_y-1.AA STE 315-373 20 3e-05 14.65 In-house 187-265 (359) Show / Hide 
Range on Protein: 315-373
Range on HMM: 187-265/359
Sequence Identity: 20% (16 aa)

KISDFGISKLFDL---------------DKSFIRTKVAGTFGYMAPKYATRGR------LTAKANVFSYGILVLELASGR
|..|||... ..                . .  |. ..||  .|||   ....       ..|. . | |....|.| |.
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase LRR8_y-1.AA TKL-Unique 315-372 27 5.5e-05 13.73 In-house 157-224 (290) Show / Hide 
Range on Protein: 315-372
Range on HMM: 157-224/290
Sequence Identity: 27% (19 aa)

KISDFGISKLFD--LDKSFIRT------KVAGTFGYMAPKYATR--GRLTAKANVFSYGILVLELASG
||.|||.||. .  .......        . |.| .|||   ..     . |. |.|.|| . |.|..
KICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase LRR8_y-1.AA Pkinase 308-373 29 8.1e-05 18.11 Pfam 141-209 (293) Show / Hide 
Range on Protein: 308-373
Range on HMM: 141-209/293
Sequence Identity: 29% (21 aa)

VHDKLQP----KISDFGISKLFDLDKSFIRTKVAGTFGYMAPKYAT-RGRLTAKANVFSYGILVLELASGR
.... ..    ||.|||..|.||. ..   | ..|| .||||     .   . |. ..|.|... |...||
IDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase LRR8_y-1.AA ULK 308-345 27 8.3e-05 13.06 In-house 159-216 (324) Show / Hide 
Range on Protein: 308-345
Range on HMM: 159-216/324
Sequence Identity: 27% (16 aa)

VHDKL------------QPKISDFGISKLFD---LDKSFIRTKVA-----GTFGYMAP
.|..             . ||.||| .| .|   ...  . | |      ||  ||||
IHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAP
Kinase LRR8_y-1.AA ULK 308-345 29 0.000249 11.12 In-house 163-220 (329) Show / Hide 
Range on Protein: 308-345
Range on HMM: 163-220/329
Sequence Identity: 29% (17 aa)

VHDKL------------QPKISDFGISKLFDLD---KSFIRTKVA-----GTFGYMAP
.|..             . ||.||| .| .| |   .  . | |      ||  ||||
IHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAP
Kinase LRR8_y-1.AA TK 422-445 29 0.000436 8.75 In-house 463-486 (486) Show / Hide 
Range on Protein: 422-445
Range on HMM: 463-486/486
Sequence Identity: 29% (7 aa)

RVAMLCTQKHEEARPTMSEVVAML
.. . | ..  | |||.|... .|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase LRR8_y-1.AA TK-Unique 427-445 31 0.001291 8.48 In-house 276-294 (294) Show / Hide 
Range on Protein: 427-445
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CTQKHEEARPTMSEVVAML
|.|. .| ||. .... .|
CWQWEPEERPSFRQIKHRL
Kinase LRR8_y-1.AA TK-Unique 310-371 26 0.154231 1.22 In-house 168-234 (294) Show / Hide 
Range on Protein: 310-371
Range on HMM: 168-234/294
Sequence Identity: 26% (18 aa)

DKLQPKISDFGISKLFDLDK----SFIRTKVAGTFGYMAPKYAT--RGRL-TAKANVFSYGILVLELAS
.... ||.|||...  |...    | ....      .||| .    .|   | | .| |.|.|  |...
EDKVCKICDFGMAR--DVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase LRR8_y-1.AA LRRK 425-447 30 0.251286 0.43 In-house 329-351 (351) Show / Hide 
Range on Protein: 425-447
Range on HMM: 329-351/351
Sequence Identity: 30% (7 aa)

MLCTQKHEEARPTMSEVVAMLLG
..| | . . ||..|..|  |  
QHCWQHDPKKRPHFSQIVKRLSQ
Kinase LRR8_y-1.AA Pkinase_Tyr 433-445 53 0.748433 3.51 Pfam 258-270 (270) Show / Hide 
Range on Protein: 433-445
Range on HMM: 258-270/270
Sequence Identity: 53% (7 aa)

EARPTMSEVVAML
| |||.||.. .|
EDRPTFSEIHEQL