Gene LRR10b_b-1 (S.moellendorffii)

LRR10b_b-1

Species: S.moellendorffii
Alias: LRR10b_b-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR10b

Sequence

Name Sequence Type Origin Length Description Download
LRR10b_b-1.AA Protein None 1310 None Fasta, JSON
LRR10b_b-1.NA RNA None 3933 None Fasta, JSON
LRR10b_b-1.kin_dom Protein Kinase Domain None 209 None Fasta, JSON

Protein domain

Protein domains of LRR10b_b-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR10b_b-1.AA LRRNT_2 26-60 30 6e-06 22.19 Pfam 8-46 (46) Show / Hide 
Range on Protein: 26-60
Range on HMM: 8-46/46
Sequence Identity: 30% (13 aa)

LLDFRSGLTN----SQALGDWIIG---SSPCGAKKWTGISCA
||.|.|.|..    . .| .|      |..|    |||..| 
LLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS---WTGVTCD
LRR_1 LRR10b_b-1.AA LRR_1 90-112 44 0.000218 19.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 90-112
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

ALEELDLSS-N--ALSGEIPPQ-LWQL
 |..||||. |   |.|.|||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-1.AA LRR_TYP 88-112 52 0.000456 20.76 SMART 1-24 (24) Show / Hide 
Range on Protein: 88-112
Range on HMM: 1-24/24
Sequence Identity: 52% (13 aa)

LPALEELDLSSNALSGEIPPQLWQL
||.|.|||||.|.|  ..||...| 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10b_b-1.AA LRR_1 114-127 41 1.998 5.68 Pfam 1-17 (26) Show / Hide 
Range on Protein: 114-127
Range on HMM: 1-17/26
Sequence Identity: 41% (7 aa)

KIKRLDLSH-N--LLQG
....||||. |   |.|
NLQHLDLSGCNCCNLTG
LRR_1 LRR10b_b-1.AA LRR_1 140-161 37 0.012613 13.48 Pfam 1-26 (26) Show / Hide 
Range on Protein: 140-161
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLEELNLAS-N--SLTGRIDL--CALL
||..|.| . |  .||| |    .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-1.AA LRR_TYP 163-187 44 0.647427 1.4 SMART 2-24 (24) Show / Hide 
Range on Protein: 163-187
Range on HMM: 2-24/24
Sequence Identity: 44% (11 aa)

GQLRKLDLSANFFSSLDQQPCAGQD
..||.|||| | ...|   | | |.
PNLRELDLSNNQLTHLP--PGAFQG
LRR_1 LRR10b_b-1.AA LRR_1 164-186 22 1.623132 6.0 Pfam 1-26 (26) Show / Hide 
Range on Protein: 164-186
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

QLRKLDLSA-N--FFS-SLDQQPCAGQ
.|..||||  |   .. ..    . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 236-258 51 2.1e-05 23.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 236-258
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

SLQILDLAN-N--SLTGEIPPS-IGDL
.||.||| . |  .|||.|||| .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 189-211 44 0.000933 17.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 189-211
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

RLEELVLGG-N--SLFGYIPPS-IFSL
.|..| |.| |  .| |.|||| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 213-233 50 0.021623 12.65 Pfam 1-26 (26) Show / Hide 
Range on Protein: 213-233
Range on HMM: 1-26/26
Sequence Identity: 50% (13 aa)

ALRQLDLSS-N--LLFGTIPAS--NL
 |. ||||. |   | |.|| |  ||
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR10b_b-1.AA LRR_1 260-283 44 0.036117 11.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 260-283
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

NLTELSLGL-N-SALLGSIPPS-IGKL
||..|.|.  | . | |.|||| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-1.AA LRR_TYP 211-236 38 0.142787 6.78 SMART 1-24 (24) Show / Hide 
Range on Protein: 211-236
Range on HMM: 1-24/24
Sequence Identity: 38% (10 aa)

LAALRQLDLSSNLLFGTIPASNLSRS
| .|| ||||.| |  ..| ... ..
LPNLRELDLSNNQL-THLP-PGAFQG
LRR_TYP LRR10b_b-1.AA LRR_TYP 258-283 38 0.407259 3.05 SMART 1-24 (24) Show / Hide 
Range on Protein: 258-283
Range on HMM: 1-24/24
Sequence Identity: 38% (10 aa)

LSNLTELSLGLNSALLGSIPPSIGKL
|.||.||.|. |   | ..|| .   
LPNLRELDLSNN--QLTHLPPGAFQG
LRR_1 LRR10b_b-1.AA LRR_1 285-304 30 1.092264 6.61 Pfam 1-26 (26) Show / Hide 
Range on Protein: 285-304
Range on HMM: 1-26/26
Sequence Identity: 30% (8 aa)

KLEILYAANC---KLAGPIPH---SL
.|..|.  .|   .| | ||.   .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR10b_b-1.AA LRR_1 307-329 39 0.000123 20.61 Pfam 1-26 (26) Show / Hide 
Range on Protein: 307-329
Range on HMM: 1-26/26
Sequence Identity: 39% (11 aa)

SLRKLDLSN-N--PLQ-SPIPDS-IGDL
.|..||||. |  .|. . ||.| .  |
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_TYP LRR10b_b-1.AA LRR_TYP 306-329 45 0.179788 5.96 SMART 2-24 (24) Show / Hide 
Range on Protein: 306-329
Range on HMM: 2-24/24
Sequence Identity: 45% (11 aa)

PSLRKLDLSNNPLQSPIPDSIGDL
|.||.|||||| | . .|. . . 
PNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10b_b-1.AA LRR_1 331-353 22 6.387677 3.89 Pfam 1-26 (26) Show / Hide 
Range on Protein: 331-353
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

RIQSISIAS-A--QLNGSIPGS-LGRC
..|.... .    .| |.|| | .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 355-377 29 0.001134 17.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 355-377
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLELLNLAF-N--QLSGPLPDD-LAAL
.|. |.|   |  .|.| .|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 379-401 22 10.394168 3.14 Pfam 1-26 (26) Show / Hide 
Range on Protein: 379-401
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

KIITFSVVG-N--SLSGPIPRW-IGQW
.. . .. | |  .|.| || . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 409-425 33 4.411882 4.46 Pfam 7-26 (26) Show / Hide 
Range on Protein: 409-425
Range on HMM: 7-26/26
Sequence Identity: 33% (7 aa)

LST-N--SFSGSIPPE-LGQC
||  |  ...|.|||. . ..
LSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 427-449 33 0.679917 7.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 427-449
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

AVTDLGLDN-N--QLTGSIPPE-LCDA
  . | |.. |  .|||.|||. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 451-474 25 4.298777 4.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 451-474
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

LLSQLTLDH-N--TLTGSLAGGTLRRC
 |  | |.. |   |||..  ...  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 476-498 48 0.000157 20.23 Pfam 1-26 (26) Show / Hide 
Range on Protein: 476-498
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

NLTQLDVTG-N--RLTGEIPRY-FSDL
||. ||. | |  .|||.||   |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 500-522 29 0.050954 11.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 500-522
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KLVILDIST-N--FFMGSIPDE-LWHA
.| .||.|  |   . |.||.. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-1.AA LRR_TYP 498-522 32 0.402707 3.09 SMART 1-24 (24) Show / Hide 
Range on Protein: 498-522
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

LPKLVILDISTNFFMGSIPDELWHA
||.|  || | | .  ..|..... 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10b_b-1.AA LRR_1 548-570 40 0.000186 19.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 548-570
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLQHLYLDR-N--RLSGPLPSE-LGLL
|||||.|.. |  .|.| .|.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 597-619 44 0.003003 15.69 Pfam 1-26 (26) Show / Hide 
Range on Protein: 597-619
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

GLTTLDLGG-N--RLGGAIPPE-IGKL
 |..|||.| |  .| | |||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-1.AA LRR_TYP 570-594 32 0.016449 14.47 SMART 1-24 (24) Show / Hide 
Range on Protein: 570-594
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

LKSLTVLSLAGNAFDGVIPREIFGG
| .|..|.| .|..   .|...|.|
LPNLRELDLSNNQL-THLPPGAFQG
LRR_TYP LRR10b_b-1.AA LRR_TYP 546-569 29 0.234799 5.01 SMART 1-24 (24) Show / Hide 
Range on Protein: 546-569
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

MENLQHLYLDRNRLSGPLPSELGL
. ||..|.|..|.|.   |  .. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRR10b_b-1.AA LRR_1 572-595 33 0.243703 8.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 572-595
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLTVLSLAG-N--AFDGVIPREIFGGT
.|..|.| | |   . | || ..| . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-1.AA LRR_TYP 595-619 32 0.409554 3.03 SMART 1-24 (24) Show / Hide 
Range on Protein: 595-619
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

TTGLTTLDLGGNRLGGAIPPEIGKL
 . |..|||..|.|  ..||..   
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10b_b-1.AA LRR_1 524-546 22 45.326462 0.87 Pfam 1-26 (26) Show / Hide 
Range on Protein: 524-546
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

QLMEIYASD-N--LLEGGLSPL-VGRM
.| ... |. |   |.| ..|     .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 621-643 37 0.033627 11.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 621-643
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

GLDCLVLSH-N--RLSGQIPAE-VASL
 |  | ||. |  .|.|.|| .   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 660-679 41 0.015935 13.12 Pfam 4-26 (26) Show / Hide 
Range on Protein: 660-679
Range on HMM: 4-26/26
Sequence Identity: 41% (10 aa)

VLDLSH-N--SLTGPIPSG-IGQC
.||||. |  .||| ||.. . ..
HLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 705-727 40 0.00147 16.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 705-727
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLTTLDLSS-N--MLQGRIPWQ-LGEN
||..||||. |   |.| ||   .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 681-703 44 0.004463 15.08 Pfam 1-26 (26) Show / Hide 
Range on Protein: 681-703
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

VLVELDLSN-N--LLQGRIPPE-ISLL
 | .||||. |   |.| |||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-1.AA LRR_TYP 703-727 40 0.098536 8.1 SMART 1-24 (24) Show / Hide 
Range on Protein: 703-727
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LANLTTLDLSSNMLQGRIPWQLGEN
| ||..||||.| |  ..| .. ..
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR10b_b-1.AA LRR_1 729-751 48 0.000106 20.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 729-751
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

KLQGLNLGF-N--RLTGQIPPE-LGNL
.|| |.|.  |  .|||.|||. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 777-799 51 0.000146 20.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 777-799
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

GLSHLDASG-N--GLTGSLPDS-FSGL
 | ||| || |   |||..|.| | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 753-775 40 0.000362 18.95 Pfam 1-26 (26) Show / Hide 
Range on Protein: 753-775
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

RLVKLNISG-N--ALTGSIPDH-LGQL
.| .|..|| |   |||.||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-1.AA LRR_TYP 775-798 45 0.068573 9.39 SMART 1-24 (24) Show / Hide 
Range on Protein: 775-798
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LSGLSHLDASGNGLTGSLPDSFSG
|. | .|| |.| ||   |. |.|
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRR10b_b-1.AA LRR_1 824-846 40 0.006632 14.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 824-846
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

GLSFLDLSK-N--SLTGEIPSE-IGGI
 |  ||||  |  .|||.||.. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 804-822 52 0.026103 12.36 Pfam 5-26 (26) Show / Hide 
Range on Protein: 804-822
Range on HMM: 5-26/26
Sequence Identity: 52% (12 aa)

LNLSY-N--ALTGDIPRS-IGNL
|.||. |   |||.|| | . ||
LDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR10b_b-1.AA LRR_TYP 822-846 40 0.205172 5.49 SMART 1-24 (24) Show / Hide 
Range on Protein: 822-846
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LTGLSFLDLSKNSLTGEIPSEIGGI
|. |  |||| | || ..|... . 
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 LRR10b_b-1.AA LRR_1 848-870 44 0.028961 12.2 Pfam 1-26 (26) Show / Hide 
Range on Protein: 848-870
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

QLSYLDLSV-N--KLVGGIPGS-LCEL
.| .||||  |  .|.| || | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR10b_b-1.AA LRR_1 872-896 32 1.204008 6.46 Pfam 1-26 (26) Show / Hide 
Range on Protein: 872-896
Range on HMM: 1-26/26
Sequence Identity: 32% (9 aa)

ELGFFNVSD-N--GLTGDIPQEGICKNF
 |   ..|. |   |||.|| . .. |.
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase LRR10b_b-1.AA IRAK 1025-1230 36 1.5e-62 214.11 In-house 1-220 (317) Show / Hide 
Range on Protein: 1025-1230
Range on HMM: 1-220/317
Sequence Identity: 36% (82 aa)

FSKANVIGDGGYGTVYRAVLPDGRT--VAVKKLAPVRDYRAVRSGSSCREFLA---EMETLGKVKHRNLVTLLGYCSYGEERLLVYDYMVNGSLDVWLRN
|.|.|.|| ||.|.|||... .. |  .|||||   . .. .  ... ..|..   |.... .  | |.| |.|||. ...  |||.|| ||||   |. 
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKL---KEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWC

RTD--ALEALTWDRRLRIAVGAARGLAFLHHGI--VPHVIHRDVKASNILLDADFEPRVADFGLARLI---SAYDTHVS-----TDIAGTFGYIPPEYGM
..   .. .|.| .|. |. |.|.|. |||     .| .||.|.| .|||||..|.|  .||||.|     |.   ...       . ||  | |||.  
QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTP-IIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIR

--TWRATSKGDVYSYGVILLELVTG
  . . | | |||| |. |||..||
DPQGQLTKKTDVYSFGIVLLEVLTG
Kinase LRR10b_b-1.AA TKL 1031-1305 19 2.5e-51 176.86 In-house 1-364 (364) Show / Hide 
Range on Protein: 1031-1305
Range on HMM: 1-364/364
Sequence Identity: 19% (75 aa)

IGDGGYGTVYRAVLPD---------GRTVAVKKLAPVR-DYRAV----------------RSGSSC---REFLAEMETLGKVKHRNLVTLLGYCSYGEE-
|| ||.|.||....           |..|||||.     | .                  ..  ..    ..  |.  . . .| |.| ..||| ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYDYMVNGS-LDVWLRNRTDALEALTWDRRLRIAVGAARGLAFLHHGIV-----PHVIHRDVKASNILLDADFE-----------
              .|..|. .|| |.. .           |..|.|.| ..|||...||  .      | .|||| | .|||.| ...           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---PRVADFGLARLISAY--DTHVSTD----------------IAGTFGYIPPEY----------------GMTWRATSKGDVYSYGVILLELVTGKEPT
   . ..||||.| .|    ... .|.                . ||... .||                  . . .. | ||||.|..| |..|...| 
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

G-PDFKDTEIG----NLVGWVRSMVRQGKSDEVLD-VAVATRATWRS--CMHQVLHIAMVCTADEPMKRPPMMEVVRQL
  ... . ...        .| .  ..   ...   .     . .    |....  ... | . .| ||| . |.. .|
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR10b_b-1.AA Pkinase 1025-1233 24 1e-38 137.99 Pfam 1-211 (293) Show / Hide 
Range on Protein: 1025-1233
Range on HMM: 1-211/293
Sequence Identity: 24% (54 aa)

FSKANVIGDGGYGTVYRAVLPDGRT-VAVKKLAPVRDYR-----AVRSGSSCREFLAEMETLGKVKHRNLVTLLGYCSYGEERLLVYDYMVNG----SLD
. .  .|| |..|.||...  . .  ||||..  ...       ..|         .| . . ...| | |.|.... .. .  .| .|. .|    .| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

VWLR-NRTDALEALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEP----RVADFGLARLISAYDTHVSTDIAGTFGYIPPEYGM-T
 ...  |  ..  ....   ...   .|||...|      .||||.| .|||.| . ..    ...|||||....    .  |...|| .|..||  .  
DYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG

WRATSKGDVYSYGVILLELVTGKEP
   ..| |..|.|.|| |...|. |
QYYGPKVDMWSCGCILYEMLCGRPP
Kinase LRR10b_b-1.AA TK 1025-1305 15 4.1e-38 124.82 In-house 1-486 (486) Show / Hide 
Range on Protein: 1025-1305
Range on HMM: 1-486/486
Sequence Identity: 15% (78 aa)

FSKANVIGDGGYG---TVYRAVLPDGR--------------------------TVAVKKLAPV--RDYRAVRS--------GSSCREFLAEMETLGKVK-
    ...| | .|   .||.. . ...                          .|||| | .    . .. .         |    .||.|.| . . . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGE---DFLEEAEEMKMMCH

----HRNLVTLLGYCSYG------------EERLLVYDYMVNGS----LDVWLRNRTDALEA--------------------------------------
    | |.| |.|.|. |            |  ..|  || .|.    |. .||.. .                                          
SLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEE

----------------------------------LTWDRRLRIAVGAARGLAFLHHG----IVPHVIHRDVKASNILLDADFE-----------PRVADF
                                  ||  ..| ... .|.|...||      | ....|||. | |.|.. .              ..|||
QDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADF

G--------LARLISAYDTHVSTDIAGTFG-------------------------YIPPEYGM---------TWRATSKGDVYSYGVILLELVT-GKEPT
|        ||| |   |  ....  || .                         . .||  .         . . |.| ||.|.|| . |..| |.|| 
GLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPY

GP---------DFKDTEIGNLVGWVRSMVRQGKSDEVLDVAVATR-----------------ATWRSCMH-------------QVLHI-AMVCTADEPMK
..         |                   | ... .   . .                  .    |               .....  . | . .| .
YGGMSNQDVWKD-------------------G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPED

RPPMMEVVRQL
|| . ....||
RPTFSQLHEQL
Kinase LRR10b_b-1.AA MLK 1025-1233 23 9.7e-34 114.46 In-house 1-235 (291) Show / Hide 
Range on Protein: 1025-1233
Range on HMM: 1-235/291
Sequence Identity: 23% (56 aa)

FSKANVIGDGGYGTVYRAVLPDGRT-----VAVKKLAPVRDYRAVRSGSSCREFLAEMETLGKVKHRN----LVTLLGYCSYGEE-RLLVYDYMVNGSLD
.    .|| |..| |....   ...     ||||. .   .  ....... ..|  | . | ...|.|     . ..| |.  .   ..|  |. .||| 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

VWLRNRTDALE----------ALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDA------DFEPRVADFGLARLISAYDTHVSTDIAGTF
  |.....  .            . |  ...|.  |||...||   .. .|||| | .|||.|.      .   ...|||..| ..  .    .. |||.
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

GYIPPEY-----GMTWRATSKGDVYSYGVILLELVTGKEP
 .  ||      . ..   .  ||.|.||.| |..|...|
AWMAPEVIQQFRCEKYSEKC--DVWSWGVVLWEMLTREVP
Kinase LRR10b_b-1.AA RIPK 1031-1233 28 1.7e-33 111.48 In-house 1-227 (290) Show / Hide 
Range on Protein: 1031-1233
Range on HMM: 1-227/290
Sequence Identity: 28% (65 aa)

IGDGGYGTVYRAVLPDGRTVAVKKLAPVRDYRAVRSGSSCREFLAEMETLGKVKHRNLVTLLGYCSYGEE------RLLVYDYMVNGSLDVWLRNRTD-A
.| || |.|..|.  . .....|| .|     .    .   . . | . . | .... | ..| |   |         .|  || ||||   |  ...  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

LEALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLA--RLIS--AYDTH--------VSTDIAGTFGYIPPEYGMTWRA
   . |. | |. .  ..|  .| |.. | .|||| | .|||.|..|   .||||||  .  |    | .         | .  ||  |.|||   |  .
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

TS------KGDVYSYGVILLELVTGKEP
 .      | ||||..... |. |.|.|
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase LRR10b_b-1.AA TKL-Unique 1027-1231 30 1.7e-31 108.41 In-house 1-225 (290) Show / Hide 
Range on Protein: 1027-1231
Range on HMM: 1-225/290
Sequence Identity: 30% (70 aa)

KANVIGDGGYGTVYRAVLPDGRTVAVKKLAPVRDYRAVRSGSSCREFLAEMETLGKVK-HRNLVTLLGYCS----YGEERLLVYDYMVNGSLDVWLR---
  |.|| ||||.||... . |  ||.|...|     .  | .. .||  |  .. | . | |.|.. |||     |  .. .| .|.  |||.  |    
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHP-N---EDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNN

---NRTDALEALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDAD-----FEPRVADFGLARLISAYDTHVSTDI--------AGTFGYIP
   |       |.. .|...|  .|.|. .||| . | .|||| | ||.|.| .     .  ...||||... |  ..  .. .         |.| ...
NNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PEYGMT--WRATSKGDVYSYGVILLELVTGK
||  .      . | ||||.|..| |..|.|
PEVLRMNFCQYSEKSDVYSFGIVLWEIATRK
Kinase LRR10b_b-1.AA S_TKc 1025-1281 22 8.1e-30 106.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 1025-1281
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)

FSKANVIGDGGYGTVYRAVLPD-GRTVAVKKLAPVRDYRAVRSGSSCREFLAEMETLGKVKHRNLVTLLGYCSYGEERLLVYDYMVN--GSLDVWLRNRT
. . ..|| |..|.||...  . || ||.|..               . .. |.. | | .| |.|.|....   ..  .| .|. .  |.|   ...| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

DAL--EALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLARLISAYDTHVSTDIAGTFGYIPPEYGMTWRATS-KGDVY
       ..  .  ...   ...|...|     ..||||.| .|||||   .  ..||||||..        | . ||  |..||       .  | |..
RHGLRFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWW

SYGVILLELVTGKEPTGPDFKDTEIGNLVGWVRSMVRQGKSDEVL-------DVAVATRATWRSCM--------HQVL
| |.|| |...|. |      . .. ...|          |.|..       ..  . | |   ..        |. .
SCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR10b_b-1.AA TyrKc 1025-1305 22 4.4e-29 103.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 1025-1305
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

FSKANVIGDGGYGTVYRAVLPDGRTVAVKKLAPVRDYRAVRSGSSCREFLAEMETLGKV--KHRNLVTLLGYCSYG-------EERLLVYDYMVNGSLDV
 ..  ..| | .|.||....   ..||||.| .             ..|. |.. . |.  .| |.| |.|.|. .       |  ..|  || .|.|. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

WLRNRTDALEALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLARLISAY-------DTHVS----TDIA-GTFGYIPP
 ||.. .    |...  | ... .|.| ..||.    ..||||  | |.|.....  ...||||.| |  .       |. ..       .       .|
YLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EYGMTWRATSKGDVYSYGVILLELVT-GKEPTGPD----FKDTEIGNLVGWVRSMVRQGK----SDEVLDVAVATRATWRSCMHQVLHIAMVCTADEPMK
|  .. . |.| ||.|.|| . |. | |..|   .     ...|. ..|   . | .       |                |   .  |   | . .| .
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------FVCCPDEMYQIMKQCWHEDPED

RPPMMEVVRQL
|| . |.....
RPTFSEIHECF
Kinase LRR10b_b-1.AA Dicty4 1025-1233 30 9.8e-29 93.09 In-house 1-216 (277) Show / Hide 
Range on Protein: 1025-1233
Range on HMM: 1-216/277
Sequence Identity: 30% (67 aa)

FSKANVIGDGGYGTVYRAVLPDGRTVAVKKL-APVRDYRAVRSGSSCREFLAEMETLGKVKHRNLVTLLGYCS----YGEERLLVYDYMVNGSLDVWLRN
  . . ||.|..|.||..    |  |||||| .   . .. .      ||..| . ..|  | |.....|.|       .. . |  ||  |.|   |..
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENM----LNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHD

-RTDALEALTWD--RRLR---IAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLARLISAYDTHVS--TDIAGTFGYIPPEYGMTWRA
   .  .  . |  ...|   .|  ||||.. ||  . | .|||| |..|.| |...   |.||||....    .|    .  .|| ..  ||  |  . 
KPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCN-PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPY

TSKGDVYSYGVILLELVTGKEP
..| ||||.| .| |..|..||
NEKADVYSFGIVLWEILTRQEP
Kinase LRR10b_b-1.AA Dicty4-Unclassified 1133-1233 42 1.3e-27 91.57 In-house 112-207 (263) Show / Hide 
Range on Protein: 1133-1233
Range on HMM: 112-207/263
Sequence Identity: 42% (43 aa)

LRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLARLISAYDTHVSTDIAGTFGYIPPEYGMTWRATSKGDVYSYGVILLELVTGKE
...|   |.|...||      .||||.|.||||.| .|  ..||||..| |.   .   | ||||     ||  |    ..| |||||...| ||.|| |
IKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDF--NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDE

P
|
P
Kinase LRR10b_b-1.AA LRRK 1025-1233 25 1.7e-27 94.31 In-house 1-282 (351) Show / Hide 
Range on Protein: 1025-1233
Range on HMM: 1-282/351
Sequence Identity: 25% (72 aa)

FSKANVIGDGGYG-TVYRAVLPD---------------------------GRTVAVKKLAPVR---------------------------DYRAVRSGSS
. . . ||.||.| .|||| . .                           . .||.||.   .                           | ..  .  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

CREFLAEMETLGKVKHRNLVTLLGYCSYGEERLLVYDYMVNGSLDVWLRNRT-DAL----EALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNI
 |||  |.  . . .| |.| |.|.|   . . .| .|. .|.|.  |.|.  |..      ..|  .|.||.  |.|...| |   | .|||| |  ||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LL---D---------ADFEPRVADFGLARLISAYDTH-VSTDIAGTFGYIPPE--YGM-TWRATSKGDVYSYGVILLELVTGK-EP
||   .         |.    .||||. |.  ..... |  .  |..|.  ||   .. .   | | |.||.|.|| ||.|..  |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase LRR10b_b-1.AA Pkinase_Tyr 1025-1188 27 5.6e-27 92.0 Pfam 1-164 (270) Show / Hide 
Range on Protein: 1025-1188
Range on HMM: 1-164/270
Sequence Identity: 27% (49 aa)

FSKANVIGDGGYGTVYRAVLP-----DGRTVAVKKLAPVRDYRAVRSGSSCRE-----FLAEMETLGKV-KHRNLVTLLGYCS-YGEE--RLLVYDYMVN
 ..  ..| | .|.||....      .. .||||.| .         |.. ..     |..|.... .  .| |.| |.| |.  ||    ..|  || .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---------GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH

GSLDVWLRNRTDALEALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDADFEPRVADFGLARLISAYDT
|.|.  ||.. .  ..||  . | ...  |.|...|.     . ||||. | |.|.. ..  ...||||||.|  |..
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK---NCIHRDLAARNCLVTENNVVKICDFGLARDI--YND
Kinase LRR10b_b-1.AA UTK 1031-1195 24 1e-26 88.44 In-house 7-201 (296) Show / Hide 
Range on Protein: 1031-1195
Range on HMM: 7-201/296
Sequence Identity: 24% (49 aa)

IGDGGYGTVYRAVLPDGR------TVAVKKLAPVRDYRAVRSGSSCR-EFLAEME---TLGKVK-HRNLVTLLGYCSYGEERLLVYDYMVNGSLDVWLRN
.| | .|.|..| . . .       ||||.. .  | .  . .     .|. |      ..... |.|.. |.|.|...|  ..|. ||.||.|.  ||.
LGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEP---YPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRR

RTDALE----ALTWDRRLRIAVGAARGLAFLHHGIVPHVIHRDVKASNILLDAD-------FEPRVADFG---LARLISA-----------YDTHVSTDI
 .....    .|| ..||  |.  |||...||     ...|||. | |.|....          ..||||   ..|....           | .. . |.
HRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC---GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

A
.
W
Kinase LRR10b_b-1.AA Dicty4-Unclassified 1047-1095 35 5e-06 16.71 In-house 22-67 (263) Show / Hide 
Range on Protein: 1047-1095
Range on HMM: 22-67/263
Sequence Identity: 35% (19 aa)

GRTVAVKKLAPVRDYRAVRSGSSCR-----EFLAEMETLGKVKHRNLVTLLGYC
|. |||||.   ..        . |     .|..| | || . | |||.. |||
GKDVAVKKFNENKF--------KFREEMIQDFKKEVEILGSIQHPNLVKCYGYC
Kinase LRR10b_b-1.AA ABC1 1037-1053 55 0.000191 17.23 Pfam 25-42 (126) Show / Hide 
Range on Protein: 1037-1053
Range on HMM: 25-42/126
Sequence Identity: 55% (10 aa)

GTVYRAVLPD-GRTVAVK
. |.||.|.| |..||||
AQVHRARLKDDGEEVAVK
Kinase LRR10b_b-1.AA LRRK 1287-1307 33 0.003545 7.07 In-house 331-351 (351) Show / Hide 
Range on Protein: 1287-1307
Range on HMM: 331-351/351
Sequence Identity: 33% (7 aa)

CTADEPMKRPPMMEVVRQLKE
| . .| ||| . ..| .|..
CWQHDPKKRPHFSQIVKRLSQ
Kinase LRR10b_b-1.AA Dicty4-Unclassified 1287-1305 36 0.006864 5.69 In-house 245-263 (263) Show / Hide 
Range on Protein: 1287-1305
Range on HMM: 245-263/263
Sequence Identity: 36% (7 aa)

CTADEPMKRPPMMEVVRQL
|  ..| ||| | ...  |
CWHNDPNKRPTMNQIIQYL
Kinase LRR10b_b-1.AA UTK 1212-1230 47 0.019785 4.13 In-house 218-236 (296) Show / Hide 
Range on Protein: 1212-1230
Range on HMM: 218-236/296
Sequence Identity: 47% (9 aa)

TSKGDVYSYGVILLELVTG
|.| ||.|.|| . |..|.
TTKSDVWSFGVVCWEIWTW
Kinase LRR10b_b-1.AA Dicty4 1291-1307 26 0.163656 1.01 In-house 259-277 (277) Show / Hide 
Range on Protein: 1291-1307
Range on HMM: 259-277/277
Sequence Identity: 26% (5 aa)

EPMKRPPMMEVVRQ--LKE
.| .|| . |.. .  | .
DPQHRPSFEEIIQRRILEH
Kinase LRR10b_b-1.AA IRAK 1284-1305 31 0.186097 1.13 In-house 296-317 (317) Show / Hide 
Range on Protein: 1284-1305
Range on HMM: 296-317/317
Sequence Identity: 31% (7 aa)

AMVCTADEPMKRPPMMEVVRQL
|  |..    .|..| .|. ||
ACCCGHHRANRRCDMAWVMQQL
Kinase LRR10b_b-1.AA MLK 1290-1305 37 0.206186 0.82 In-house 276-291 (291) Show / Hide 
Range on Protein: 1290-1305
Range on HMM: 276-291/291
Sequence Identity: 37% (6 aa)

DEPMKRPPMMEVVRQL
..| ||| . ..| .|
QDPHKRPSFRQIVQHL
Kinase LRR10b_b-1.AA Pkinase_Tyr 1212-1233 47 0.39501 4.45 Pfam 192-214 (270) Show / Hide 
Range on Protein: 1212-1233
Range on HMM: 192-214/270
Sequence Identity: 47% (11 aa)

TSKGDVYSYGVILLELVT-GKEP
|.| ||.|.|| . |..| |..|
TTKSDVWSFGVLMWEIFTYGEQP