Gene LLEC_o (S.moellendorffii)

LLEC_o

Species: S.moellendorffii
Alias: LLEC_o
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LLEC

Sequence

Name Sequence Type Origin Length Description Download
LLEC_o.AA Protein None 265 None Fasta, JSON
LLEC_o.NA RNA None 798 None Fasta, JSON
LLEC_o.kin_dom Protein Kinase Domain None 176 None Fasta, JSON

Protein domain

Protein domains of LLEC_o.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LLEC_o.AA TKL 88-263 19 3.7e-30 105.81 In-house 10-277 (364) Show / Hide 
Range on Protein: 88-263
Range on HMM: 10-277/364
Sequence Identity: 19% (55 aa)

YRGILPGEN--------SPVAIKTMAR---------------------------DSHQGEREFLAELQIISKLSHRNLVPLRGWHCVRDHRE--------
|.|.. |..         .||.|.. .                           .... . ..  |. ..|.|.| |.|.. |  |  ....        
YKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGP

---LVLVYDYMPQGSVESALFHKGDALLLLWDARLRILSGLAAALIYLHEDW-------EHIHRDVKCSNVMPDDEFR--------------ARLGDFGL
   | .|..|.| || .. |          |. |.|.  . | .. ||| ..         |||| | .|.. |. ..              . ..||||
WGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGL

VRTASHDVS------------------SRTTTLAGTLGYIAPEV--GVTY--------------KFTPASDVYSYGV
 |. |.. .                  ..| |  ||... ||||  | ..              ......||||.|.
SRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI
Kinase LLEC_o.AA IRAK 88-263 31 7.4e-30 103.07 In-house 16-212 (317) Show / Hide 
Range on Protein: 88-263
Range on HMM: 16-212/317
Sequence Identity: 31% (62 aa)

YRGILPGENSPVAIK--TMARDSHQGE--REFLA---ELQIISKLSHRNLVPLRGWHCVRDHRELVLVYDYMPQGSVESALF-HKGDALL--LLWDARLR
||| . ..  ..|.|     .|. ..|  ..|..   ||.. ... | |.||| |    |.  .. |||.||| || |  |  ..|.  .  | |  |. 
YRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQ--CHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCS

ILSGLAAALIYLHEDW---EHIHRDVKCSNVMPDDEFRARLGDFGLVRT---AS--HDVSS---RTTTLAGTLGYIAPEVGV--TYKFTPASDVYSYGV
|..|.| .. .||..     .||.|.| .|.  |. | . ..||||.|    ||   . ..   .| .. ||. | .||     . . |. .|||| |.
ICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGI
Kinase LLEC_o.AA Pkinase 88-263 24 1.9e-26 94.63 Pfam 16-200 (293) Show / Hide 
Range on Protein: 88-263
Range on HMM: 16-200/293
Sequence Identity: 24% (47 aa)

YRGILPGENSPVAIKTMARDSHQGEREF-----LAELQIISKLSHRNLVPLRGWHCVRDHRELVLVYDYMPQG----SVESALF-HKGDALLLLWDARLR
|...  |..  ||.|.. .. |. . .      |.|.||  .|.| | | |..|     .... .| .|.. |    .  . .  ... .... ..   .
YKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF

ILSGLAAALIYLHEDWEHIHRDVKCSNVMPDDEFRA----RLGDFGLVRTASHDVSSRTTTLAGTLGYIAPEVGV-TYKFTPASDVYSYGV
..  .. .| |.|.    ||||.| .|.. |..       ...|||| . ...  .| .||..||..|.||||     . .|..|..|.|.
YMYQILRGLEYCHSM-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC
Kinase LLEC_o.AA TK 88-263 14 5.7e-20 62.94 In-house 19-382 (486) Show / Hide 
Range on Protein: 88-263
Range on HMM: 19-382/486
Sequence Identity: 14% (52 aa)

YRGILPGEN-------------------------SPVAIKTMARDSHQGEREFLA--------------ELQIISKLS-----HRNLVPLRG-WHCVRD-
|.|.. |.|                          |||.|..  .... ..||..              |........     | |.| | |  . ..  
YKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPK

--------HRELVLVYDYMPQGS----VESALF-HKGDALL-----------------------------------------------------------
         . . .|  ||| |.      . |  .....                                                             
PCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLL

-------------LLWDARLRILSGLAAALIYLHEDW-----EHIHRDVKCSNVMPDDEFR-----------ARLGDFG--------LVRTASHDVSSRT
             |    .| .   .|... |||.         .|||. . |.. ... .           ....|||        | |   .|   ..
QMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYR

TTLAGTLG-------------------------YIAPEVGV---------TYKFTPASDVYSYGV
..  || .                         . |||.           . |||..|||.|.||
KSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV
Kinase LLEC_o.AA TKL-Unique 97-263 27 1e-17 59.18 In-house 21-216 (290) Show / Hide 
Range on Protein: 97-263
Range on HMM: 21-216/290
Sequence Identity: 27% (55 aa)

SPVAIKTMAR--DSH-QGEREFLAELQIISKLS-HRNLVPLRGWHCVR---DHRELVLVYDYMPQGSVESALFHK--------GDALLLLWDARLRILSG
.|||||. .   ||. . ..||  |. ...||  | |.| . |. |.    .  .. .| .|.| ||  . | |          . . | .  |...   
YPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGY-CMDHQVYPPNMCIVMEYCPGGSLYDVL-HQNNNNNNNNNNNCKLNMQQRVKMAID

LAAALIYLHEDWE-HIHRDVKCSNVMPDDE-----FRARLGDFGLVRTASHDVSSRTT--------TLAGTLGYIAPEVGVT--YKFTPASDVYSYGV
 | ...|||      |||| | ||.  | .     ..... ||||....| .  . ..        |  |.. ..||||     ....  |||||.|.
IAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGI
Kinase LLEC_o.AA Pkinase_Tyr 88-263 26 2.7e-17 59.18 Pfam 16-202 (270) Show / Hide 
Range on Protein: 88-263
Range on HMM: 16-202/270
Sequence Identity: 26% (51 aa)

YRGILP----GENSPVAIKTMARDSHQGE---REFLAELQIISKL-SHRNLVPLRGWHCVRDHRE--LVLVYDYMPQGSVESALFHK---GDALLLLWDA
|.|..     ... |||.|..  .... .   ..|..|..| ..| .| |.| | |  |... .   . .|  ||| |.  . |  .   ...| . .  
YKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV-CTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD--

RLRILSGLAAALIYLHEDWEHIHRDVKCSNVMPDDEFRARLGDFGLVRTA-SHDVS-SRTTTLAGTLGYIAPEVGVTYKFTPASDVYSYGV
 | .    |... || |.   ||||. . |.. .... .. .|||| |.  . |     ..         |||.  ..||| .|||.|.||
LLQMCWQIAKGMEYL-ESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGV
Kinase LLEC_o.AA Dicty4 114-262 31 3.5e-17 54.01 In-house 44-204 (277) Show / Hide 
Range on Protein: 114-262
Range on HMM: 44-204/277
Sequence Identity: 31% (51 aa)

EFLAELQIISKLSHRNLVPLRGWHCV--RDHR-ELVLVYDYMPQGSVESALFHK-----GDALLLLWDARLR-ILSGLAAAL--IYLHE-DWEHIHRDVK
||..|  | .|..| |.. . |  |   | |  ... |  |||.|...| | |.      .   | |  ..| .. .. ||.  ..||. .   |||| |
EFRKEVHIMCKIRHPNICLFMG-ACTAPRSHPGKMCIVTEYMPKGNLYS-LLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLK

CSNVMPDDEFRARLGDFGLVR-TASHDVSSR-TTTLAGTLGYIAPEVGVTYKFTPASDVYSYG
 .| . |. .|.  .|||| .    |   .  ..| .|| .. |||| .   .. ..||||.|
SHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFG
Kinase LLEC_o.AA STE 99-246 22 2.6e-16 54.19 In-house 42-233 (359) Show / Hide 
Range on Protein: 99-246
Range on HMM: 42-233/359
Sequence Identity: 22% (45 aa)

VAIKTMARDS-----------------HQGEREFLAELQIISKLS--HRNLVPLRGWHCVRDHR-----ELVLVYDYMPQGSVESALFHKGDALLLLW--
.||| |  ..                 |. . ..| |..| .|..  | | |   | . . .|      || ..  ||. ||... . ||.  .  |   
MAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHN

--------DARL-RILSGLAAA-LIYLHEDWEHIHRDVKCSNVMPDDEFRARLGDFGLVRTASH---------------DVSSRTTTLAGTLGYIAPEV
           . .|.  .  . | |||.    ||||.|..|..      . | |||.    ..               . .....|..||  . ||||
RQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEV
Kinase LLEC_o.AA RIPK 99-263 27 8.7e-16 50.25 In-house 21-216 (290) Show / Hide 
Range on Protein: 99-263
Range on HMM: 21-216/290
Sequence Identity: 27% (53 aa)

VAIKT---MARDSH---QGEREFLAELQIISKLSHRNLVPLRGWHCVRDH---RE-LVLVYDYMPQGSVESALFHKG--DALLLLWDARLRILSGLAAAL
||.|      .. |   | . . . | ..  || ... ||. |     .     . . .|  ||. || .  |  |       ..|. | |..   . . 
VAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGM

IYLHEDW-EHIHRDVKCSNVMPDDEFRARLGDFGL--VRTAS--HD-------VSSRTTTLA-GTLGYIAPEVGV--TYKF----TPASDVYSYGV
 |||      |||| | .|.  | .| . . ||||   .. |  |.       |.| .  .  ||| |..||  .    |     ||..||||...
CYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAI
Kinase LLEC_o.AA Dicty4-Unclassified 114-263 28 1.3e-15 49.86 In-house 44-196 (263) Show / Hide 
Range on Protein: 114-263
Range on HMM: 44-196/263
Sequence Identity: 28% (45 aa)

EFLAELQIISKLSHRNLVPLRGWHCV--RDHRE-LVLVYDYMPQGSVESALFH-----KGDALLLLWDARLRILSGLAAALIYLHEDWEHIHRDVKCSNV
.|..|  |   ..| ||| ..|  |.  | |.  .. |   |..|     . |     .   . |     ...    |  . .||   . ||||.| ||.
DFKKEVEILGSIQHPNLVKCYGY-CINPRSHKSTMCIVMEFMHKGNL-FEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHT-RNFIHRDIKSSNI

MPDDEFRARLGDFGLVRTASHDVSSRTTTLAGTLGYIAPEVGVTYKFTPASDVYSYGV
. |  | .. .|||. |  .       || |||    .||.     .. .||||||..
LMDKHFNIKIADFGISRVIDFNFN--MTTIAGTPKWESPECLMHESYNQKSDVYSYAM
Kinase LLEC_o.AA RTKE 109-263 26 1.9e-13 42.15 In-house 53-215 (293) Show / Hide 
Range on Protein: 109-263
Range on HMM: 53-215/293
Sequence Identity: 26% (44 aa)

HQGEREFLAELQIISKLSHRNLVPLRGWHCVRDHRELVLVYDYMPQGSVESALFHKGD-ALLLLWDARLRILSGLAAALIYLHEDWEHIHRDVKCSNVMP
|. ..|| .|. . .|| |.|.| |   | | . ... .||.|||.|..|..|   .. .  .  . ....|  .|... .| |.   .|||.   ||  
HECHHEFVQEMTMMCKLHHPNVVHL--LHVVQMKQHFMMVYEYMPGGQLEDWL--QDHHGRPTSHEDQIHCLHQVACGMSFL-ERLGIVHRDLCAHNVYC

DDEFR-ARLGDFGLVRTA--SHDVSSRT----TTLAGT-----LGYIAPEVGVTYKFTPASDVYSYGV
.     ... |.|| |.   ... ....    |...       . . ||||  . .|. .|||..||.
CRCWNDVKVADYGLSRDMYLGQEYMQCYYRIKTRRWMPTTWGSRRWWAPEVWKDQHFSFKSDVWAYGC
Kinase LLEC_o.AA Frk 96-263 28 2.2e-13 42.4 In-house 23-190 (260) Show / Hide 
Range on Protein: 96-263
Range on HMM: 23-190/260
Sequence Identity: 28% (50 aa)

NSPVAIKTMARDSHQGEREFLAELQIISKLSHRNLVPLRGWHCVRDHRELVLVYDYMPQGSVESALF---HKGDALLLLWDARLRILSGLAAALIYLHED
. |||.||.   .    ..||.| ||. || |  |. |    | ..   . .. . | .||.   |    .||  . .     . .   .|| . || |.
TTPVAVKTLKPGTMD-PNDFLREAQIMKKLRHPKLIQLYAV-CTVEE-PIYIITELMRHGSLQEYLQAINDKGRQCQM--QQLVDMAAQVAAGMAYL-ES

WEHIHRDVKCSNVMPDDEFRARLGDFGLVR---TASHDVSSRTTTLAGTLGYIAPEVGVTYKFTPASDVYSYGV
  .||||.   ||. ...   .. |||| |       |.    .     . . |||   . |||  |||.|.|.
QNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGI
TyrKc LLEC_o.AA TyrKc 85-265 20 3.6e-10 -58.3 SMART 1-265 (280) Show / Hide 
Range on Protein: 85-265
Range on HMM: 1-265/280
Sequence Identity: 20% (57 aa)

TTF------------YRGILPGENSPVAIKTMARDSHQGEREFLAELQIISKL--SHRNLVPLRGWHCVRDH-------RELVLVYDYMPQGSVESAL-F
 |.            |.|..     .||.|..  |.   ...|. |..| .||  .| |.| | |  .....         | .|  ||| |.  . |  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYG--VCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HKGDALLLLWDARLRILSGLAAALIYLHEDWEHIHRDVKCSNVMPDDEFRARLGDFGLVRTASHD----VSSRTTTL----AGT----LGYIAPEVGVTY
|...   | ..  | .    |.   |||.    ||||  . |.. ....... .|||| |   .|    .|. . .      |     .   |||.  ..
HRPK---LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KFTPASDVYSYGV--------------G------------------------------------------------G
|||..|||.|.||              |                                                 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE
Kinase LLEC_o.AA S_TKc 88-265 20 4e-10 -28.46 SMART 16-220 (231) Show / Hide 
Range on Protein: 88-265
Range on HMM: 16-220/231
Sequence Identity: 20% (48 aa)

YRGILPGENSPVAIKTMARDSHQGEREFLAELQIISKLSHRNLVPLRGWHCVRDHRELVLVYDYMPQ--GSVESALFHKGDAL----LLLWDARLRILSG
|...  . .  |||| .        . .. |.|| .|  | |.| | ..       .| .| .|...  |.. . . ..|       .   .|| ...  
YKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR-FYMYQ

LAAALIYLHEDWEHIHRDVKCSNVMPDDEFRARLGDFGLVRTASHDVSSRTTTLAGTLGYIAPEVGVTYKFTP-ASDVYSYGV-----------------
.. || |.|.    ||||.| .|.. |.  .  ..|||| |          ||. ||. |.||||    .... ..|..| |.                 
ICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQM

------------------------------GG
                                
MFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ