Gene IRAKm_d-1 (S.moellendorffii)

IRAKm_d-1

Species: S.moellendorffii
Alias: IRAKm_d-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_d-1.AA Protein None 848 None Fasta, JSON
IRAKm_d-1.NA RNA None 2547 None Fasta, JSON
IRAKm_d-1.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of IRAKm_d-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKm_d-1.AA B_lectin 99-197 32 1.6e-24 85.86 Pfam 1-137 (137) Show / Hide 
Range on Protein: 99-197
Range on HMM: 1-137/137
Sequence Identity: 32% (44 aa)

SGVCVWSANRD---NPV-----SENATLQLSD-QGLLQVMDSD-G-RV--VWNS----PRGV--S--GIEVQDSGNVVLY-DST--GGVSWQS--FDHPT
.   ||.||||   |||     ..|.||....  | | ..|.. | .|  ||..    ...   .    . ||||| ||| |.   . | |||  |||||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DVLLEGQVIVT------GQS----LVSSSSSS--SLS
| .| |. . .      ...    |.|..|..    |
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAKm_d-1.AA B_lectin 53-171 29 1.8e-20 75.28 SMART 1-126 (126) Show / Hide 
Range on Protein: 53-171
Range on HMM: 1-126/126
Sequence Identity: 29% (40 aa)

RLLQAGNTSLVSQDGRFA--LSFFRFNDSPRYYFALVFGASNYTSNSASGVCVWSA--NRDNPVSE---NATLQLSDQGLLQVMDSDGRVVWNSPRG---
...  .. .||| .. |   | ||.|. .   .   ... ..         .||.|  ||||||..   ...| ... | | . |  .|.|| |  .   
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ--WCNGIWYKNISNK----QRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNN

-VSGIEVQDSGNVVLYDST----GGVSWQSFDHP
 ..  ..||.||.|.||.     |.. |||||||
GNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
PAN_AP IRAKm_d-1.AA PAN_AP 374-450 17 3.9e-05 24.3 SMART 1-85 (85) Show / Hide 
Range on Protein: 374-450
Range on HMM: 1-85/85
Sequence Identity: 17% (16 aa)

AENHHFFNVTGAGYFSNNYT----KADRVSTLSDCWNLCLSNCSCSALFYNKQASTCFFVD--RMYGGLT------RDPNFDGFLKLQN
 . ..|  . .. .  .. .    .   | .| .|. .|| |||| .  |..  ..| . .  .. |. .        ||.  ..  .|
CCDDCFVRMPNMKL--FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN-TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKm_d-1.AA TKL 526-803 20 2.7e-69 236.51 In-house 1-364 (364) Show / Hide 
Range on Protein: 526-803
Range on HMM: 1-364/364
Sequence Identity: 20% (81 aa)

VGKGGYGTVFKGTLAD---------GRQVAVKRLE----------------------------DPKHSEKGFIAEMASLGRISHHNVVQLYGFCSEKNQ-
.|.||.|.|.||..           |. ||||..                             .... .. .. |. .. |..| |.||..|.| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LILVYEFMANGSLDKWLFEDGCLGWEIRRSIALGLARGLAYLHEESR-----QLIIHLDIKPDNVLLDDKFC--------------PK
            | .|.|.. .|||   |       |. | ..||. |||..||| .         ||| |.|..|.|.|...               .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

LADFGLAKLAKSR-----------------DASQTVTDVRGTPGYLAPEWLLNS----------------AATKKCDVYSYGMVLLELIGGRRNLSKRFI
..||||..  . .                 . ..|   ..|||...||| | ..                 ...||||||.|.|| |.. ..|       
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------

FGSGGHDDRSMDEEERALWWYFPAWVVALARKGEFLRVADAKIRDTVE------------EDQVRKLVQVALWCIQDDPRRRPSMDAVVQML
              .. .. . . .   .  . .|  |.| . | ..             .|  . . . . .| . ||. |||.. ... |
-------------PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase IRAKm_d-1.AA Pkinase 520-715 27 1.9e-58 205.25 Pfam 1-209 (293) Show / Hide 
Range on Protein: 520-715
Range on HMM: 1-209/293
Sequence Identity: 27% (60 aa)

ASFSSSVGKGGYGTVFKGTLADGRQ-VAVKRLEDPKHSEKGFIA-----EMASLGRISHHNVVQLYGFCSEKNQLILVYEFMANG----SLDKWLF--ED
  . . .|.|..|.|.|..  . .. ||||... .. ...  ..     | . . |..| |.|.||... .|. . .| |.. .|    .|  ..   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GCL--GWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDKFCP----KLADFGLAKLAKSRDASQTVTDVRGTPGYLAPEWLL-NSAATKKCD
||.   ..  ..... ..|||.|.|..    ||| |.||.|.|.|..  .    |..||||||...    ..  |.. |||.|.|||... ..  ..|.|
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSYGMVLLELIGGR
..|.| .| |.. ||
MWSCGCILYEMLCGR
Kinase IRAKm_d-1.AA IRAK 522-716 37 2.5e-53 183.5 In-house 1-222 (317) Show / Hide 
Range on Protein: 522-716
Range on HMM: 1-222/317
Sequence Identity: 37% (84 aa)

FSSS--VGKGGYGTVFKGTLADGR-QVAVKRLED-----PKHSEKGFIA---EMASLGRISHHNVVQLYGFCSEKNQLILVYEFMANGSL-DKWLFEDG-
|. .   |.||.|.|..| .      .|||.|       .. ... | .   |. .. |. | |.| |||.|.|  .. |||..|.|||| |     || 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-C---LGWEIRRSIALGLARGLAYLHEES-RQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLA--KSRDASQTV-----TDVRGTPGYLAPEWLL--NSA
     | | .| ||..|.|.|. .||. .    ||| |||. |.|||. | ||..||||.     .|   .||.       ||||  |..|| .      
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

ATKKCDVYSYGMVLLELIGGRR
 ||| |||| | ||||.. |.|
LTKKTDVYSFGIVLLEVLTGCR
Kinase IRAKm_d-1.AA MLK 520-712 27 1.3e-40 138.66 In-house 1-230 (291) Show / Hide 
Range on Protein: 520-712
Range on HMM: 1-230/291
Sequence Identity: 27% (64 aa)

ASFSSSVGKGGYGTVFKGTLADGRQ-----VAVKRLE---DPKHSE-----KGFIAEMASLGRISHHN----VVQLYGFCSEKNQ-LILVYEFMANGSLD
  |.  .|.|..| |.||.   ..      ||||| .   .   |.     . |  |   | ..|| |    ..|.|| |.. .. . .| |....||| 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

KWLFE--------------DGCLGWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDD------KFCPKLADFGLAKLAKSRDASQTVTDVRGT
  | .              |.    .   ..||  |||..|||.. ...||| |.|. |.|.|.      .   | .|||...  ....  .. .. .||
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGT

PGYLAPEWL---LNSAATKKCDVYSYGMVLLELI
. . ||| .    ..  ..||||.|.|.|| |..
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase IRAKm_d-1.AA TKL-Unique 522-712 28 1.3e-40 140.94 In-house 1-222 (290) Show / Hide 
Range on Protein: 522-712
Range on HMM: 1-222/290
Sequence Identity: 28% (64 aa)

FSSSVGKGGYGTVFKGTLADGRQVAVKRLE---DPK-HSEKGFIAEMASLGRIS-HHNVVQLYGFCS----EKNQLILVYEFMANGSLDKWLF-------
|....| ||||.|.||. . | .||.|...   |.   ... |. |   . ..  | |.|...|.|       .....| |..  |||.. |        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--EDGC-LGWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDK-----FCPKLADFGLAKLAKSRDASQTV-------TDVRGTPGYLAPEWL
  .. | | .. | ..|.  |.|. ||| ..   |||.|.|. |.|.| .     .  |..||||.|........ .        ... |.. ..||| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

LN--SAATKKCDVYSYGMVLLELI
 .  .  ..|.||||.|.|| |..
RMNFCQYSEKSDVYSFGIVLWEIA
Kinase IRAKm_d-1.AA S_TKc 520-803 23 2.5e-39 137.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 520-803
Range on HMM: 1-231/231
Sequence Identity: 23% (71 aa)

ASFSSSVGKGGYGTVFKGTLAD-GRQVAVKRLEDPKHSEKGFIAEMASLGRISHHNVVQLYGFCSEKNQLILVYEFMAN--GSLDKWLFEDGC------L
  .   .|||..|.|.|..  . ||.||.|..       . .. |.. | .  | |.|.||... . . | .| |.. .  |.| . . . |.      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

GWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRDASQTVTDVRGTPGYLAPEWLLNSAATK-KCDVYSYGMVLL
     |...  ....|.|.|.   . ||| |.||.|.|||.  . |..|||||..          | . ||| |.||| |     .| |||..| | .| 
PE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELIGGRR--NLSKRFIFGSGGHDDRSMDEEERALWWYFPAWVVALARKGEFLRVADAKIRDTVEEDQVRKLVQVALWCIQDDPRRRPSMDAVVQ------
|.. |.         .|   |                                               . . .    | | ||..||.   . |      
EMLCGYPPFP-QMQMMFKKIG----------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

---ML
    .
CHPWF
Kinase IRAKm_d-1.AA LISK 525-716 28 2.8e-38 121.83 In-house 1-237 (296) Show / Hide 
Range on Protein: 525-716
Range on HMM: 1-237/296
Sequence Identity: 28% (68 aa)

SVGKGGYGTVFKGTLA-DGRQVAVKRLE------DPKHSEKGFIAEMASLGRISHHNVVQLYGFCSE-KNQLILVYEFMANGSLDKWLF-EDG---CLGW
. |||..| |.|||.  .|. .|.| ..      . .  .| .. |.. . ...| |.|| .| | . . || .| |..  | |   |. .|     | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDK----FCPKLADFGLAKLAKSRDAS---------------------QTVTDV-----R---
. | .|||. |.|..|||.   . ||| | |  |.|....    .  |..|||.|...  .. |                      .  .      .   
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

---GTPGYLAPEWLLNSAATKKCDVYSYGMVLLELIGGRR
   |||   ||| || .  . .|||.|.|.||.|.|....
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKm_d-1.AA STE 520-715 22 4.9e-37 128.34 In-house 1-265 (359) Show / Hide 
Range on Protein: 520-715
Range on HMM: 1-265/359
Sequence Identity: 22% (62 aa)

ASFSSSVGKGGYGTVFKGTLAD----------------GRQVAVKRLE----DP--------------KHSEKGFIAEMASLGRIS--HHNVVQLYGFCS
  . . .|||..|||.|.   .                |. .|.|...    ..              .  .. .. |.  . . .  | |.|. || . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EK-------NQLILVYEFMANGSLDKWLFED-GCLG-------------WEIRRSIALGLARG-LAYLHEESRQLIIHLDIKPDNVLLDDKFCPKLADFG
 .       ..| .. |.|..||||. . .  ||..              .. . |.  . .| |.|||.     ||| ||||.|.||      ||.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAK-LAKSRD-------------ASQTVTDVRGTPGYLAPEWLLN------SAATKKCDVYSYGMVLLELIGGR
... |..| .              .|  . . ||| . ||| ...      .  . |||..| | ...|.. |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKm_d-1.AA RIPK 526-715 28 2.8e-35 117.68 In-house 1-225 (290) Show / Hide 
Range on Protein: 526-715
Range on HMM: 1-225/290
Sequence Identity: 28% (65 aa)

VGKGGYGTVFKGTLADGRQVAVKRLEDPKH--------SEKGFIAEMASLGRISHHNVVQLYGFCSEKNQ------LILVYEFMANGSLDKWLFEDGC--
||.|| |.||| . .. . ...|     ||         ..  . | . . .. . ..|..|||| ....      . .| |.|.|||| . |       
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LGWEIRRSIALGLARGLAYLHEESRQ-LIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRDASQTVTDVR--------------GTPGYLAPEWLL
   . |  |  .    ..|  |||  | .  |||.| || |.|.|  |  |.||||||.    .  |.  .| .              ||  |..|| ..
HHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATW---MMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFR

--NSAA----TKKCDVYSYGMVLLELIGGR
  |...    |.| ||||...|. |.  ..
TDNKKPIKVVTPKYDVYSFAIVMWEVLTQK
Kinase IRAKm_d-1.AA Dicty4-Unclassified 521-714 33 5.5e-35 117.25 In-house 2-204 (263) Show / Hide 
Range on Protein: 521-714
Range on HMM: 2-204/263
Sequence Identity: 33% (70 aa)

SFSSSVGKGGYGTVFKGTLADGRQVAVKRLEDPKHSEK-----GFIAEMASLGRISHHNVVQLYGFC----SEKNQLILVYEFMANGSLDKWLF-----E
     .|||    | ||    |. |||| . . | .        | .| . || |.| | |..|| |    | |  .. | |||  | |           
QIDQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

DGCLGWEI--RRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRDASQTVTDVRGTPGYLAPEWLLNSAATKKCDVYSY
.  .  .      .|.  |.|...||  .|  .|| |||  |.|.|  |  | ||||..      |  .. | . |||   .|| |   . . | |||||
QQPIKLDDTLIIKYAFDIAQGMQHLH--TRN-FIHRDIKSSNILMDKHFNIKIADFGISRVI---DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY

GMVLLELIGG
.|.| ||. |
AMMLYELATG
Kinase IRAKm_d-1.AA Dicty4 521-711 30 4.8e-33 107.68 In-house 2-210 (277) Show / Hide 
Range on Protein: 521-711
Range on HMM: 2-210/277
Sequence Identity: 30% (65 aa)

SFSSSVGKGGYGTVFKGTLADGRQVAVKRL--EDPKHSE---KGFIAEMASLGRISHHNVVQLYGFCS----EKNQLILVYEFMANGSLDKWLFE-----
 . .  |||..|.|.|||   | .|||| |     . .|   . | .| . .. |.| |.....| |     ..  .  | |.|  |.| . |       
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

--DGCLGWEIRRS---IALGLARGLAYLHE-ESRQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRDASQT-VTDVRGTPGYLAPEWLLNSAATKKC
     | |. ...   .|.  |||...||.  ..  |||.|.|..| | |. .  | .||||... |     ..  . . |||.. ||| . . . . | 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSYGMVLLEL
||||.|.|| |.
DVYSFGIVLWEI
Kinase IRAKm_d-1.AA TK 520-711 15 4.1e-32 104.37 In-house 1-387 (486) Show / Hide 
Range on Protein: 520-711
Range on HMM: 1-387/486
Sequence Identity: 15% (59 aa)

ASFSSSVGKGGYG---TVFKGTLADGR--------------------------QVAVKRLEDP-KHSEKGFIA--------------EMASLGRIS----
  .    |.| .|   .|.||.. ...                          .|||| | .   .|.. |..              |.. .   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HHNVVQLYGFCSEK------------NQLILVYEFMANGS----LDKWLFEDGC---------------------------------------------
 | |.|.||| |...              ...| |.|..|.    |...| .                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LGWEIRRSIALGLARGLAYLHEE----SRQLIIHLDIKPDNVLLDDKFC-----------PKLADFGLA
                               |  . .  ... .|.|..|||.       | ..| |.   |.|....              |.|||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----LAKSRDA--SQTVTDVRGTPG-------------------------YLAPEWLL---------NSAATKKCDVYSYGMVLLEL
.     ||.  .     .... .||..                         ..||| |.         .   | | ||.|.| .. |.
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase IRAKm_d-1.AA Pkinase_Tyr 520-712 26 8.2e-30 101.6 Pfam 1-208 (270) Show / Hide 
Range on Protein: 520-712
Range on HMM: 1-208/270
Sequence Identity: 26% (57 aa)

ASFSSSVGKGGYGTVFKGTLA-----DGRQVAVKRL-EDPKHSE---KGFIAEMASLGRI-SHHNVVQLYGFCS-EKNQ--LILVYEFMANGSLDKWLFE
 .|    |.| .|.|.|||.      .. .|||| | |.  |..   . |..|.. .  . .|.|.|.||| |. .. .  ...| |.|..|.|.. | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----DGCLGWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRDASQ-TVTD-----VRGTPGYLAPEWLLNSAAT
    .. |  .   ....  |.|..||..     .|| |.   |.|...... | .|||||..    |    ....     .. .    ||| . ..  |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWM----APECINYGKFT

KKCDVYSYGMVLLELI
 | ||.|.| .. |..
TKSDVWSFGVLMWEIF
Kinase IRAKm_d-1.AA TyrKc 520-803 21 2.7e-21 77.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 520-803
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

ASFSSSVGKGGYGTVFKGTLADGRQVAVKRLEDPKHSEKGFIAEMASLGRI--SHHNVVQLYGFCSEK-------NQLILVYEFMANGSLDKWLFEDGC-
 ..    | | .|.|.|||.   .||||| | . .  .. |. |.  . ..  .| |.|.||| |...        .| .| |.|..|.|.. | . .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LGWEIRRSIALGLARGLAYLHEESRQLIIHLDIKPDNVLLDDKFCPKLADFGLAKLAKSRD---ASQTVTDVR---GTPG-----YLAPEWLLNSAATKK
| ..   |...  |.| .|||.     .|| |.   |.|...... | .||||..  .. |   .|. . ...   |. .      .||| .  .  | |
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

CDVYSYGMVLLELIGGRRNLSKRFIFGSGGHDDRSMDEEERALWWYFPAWVVALARKGEFLRVADAKIRDTVEED-------QVRKLVQVALWCIQDDPR
 ||.|.| .. |.              . |    . ....      .  .  ...      .| . . ..  ..|          .. |. ..| . || 
SDVWSFGVCMWEIF-------------TYGQQPYPGMIQQ------MMSNQEVIE------YVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE

RRPSMDAVVQML
 ||.. .... .
DRPTFSEIHECF
Kinase IRAKm_d-1.AA Dicty4-Unclassified 784-803 45 2e-06 17.65 In-house 244-263 (263) Show / Hide 
Range on Protein: 784-803
Range on HMM: 244-263/263
Sequence Identity: 45% (9 aa)

WCIQDDPRRRPSMDAVVQML
||  .||..||.|. ..| |
WCWHNDPNKRPTMNQIIQYL
Kinase IRAKm_d-1.AA TK 780-803 25 3.3e-05 12.57 In-house 463-486 (486) Show / Hide 
Range on Protein: 780-803
Range on HMM: 463-486/486
Sequence Identity: 25% (6 aa)

QVALWCIQDDPRRRPSMDAVVQML
.. . | . ||..||........|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKm_d-1.AA MLK 785-803 47 0.000122 12.17 In-house 273-291 (291) Show / Hide 
Range on Protein: 785-803
Range on HMM: 273-291/291
Sequence Identity: 47% (9 aa)

CIQDDPRRRPSMDAVVQML
| ..||..|||.. .|| |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKm_d-1.AA Dicty4 784-805 41 0.001034 8.45 In-house 254-277 (277) Show / Hide 
Range on Protein: 784-805
Range on HMM: 254-277/277
Sequence Identity: 41% (10 aa)

WCIQDDPRRRPSMDAVVQM--LEG
||   || .|||.  ..|   || 
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKm_d-1.AA LISK 776-803 32 0.001386 7.29 In-house 269-296 (296) Show / Hide 
Range on Protein: 776-803
Range on HMM: 269-296/296
Sequence Identity: 32% (9 aa)

RKLVQVALWCIQDDPRRRPSMDAVVQML
. .......|.  ||. ||| . .|| |
PPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAKm_d-1.AA IRAK 770-803 26 0.002698 7.73 In-house 284-317 (317) Show / Hide 
Range on Protein: 770-803
Range on HMM: 284-317/317
Sequence Identity: 26% (9 aa)

VEEDQVRKLVQVALWCIQDDPRRRPSMDAVVQML
.... . .. |.|. |     .||..|. |.| |
CPPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAKm_d-1.AA TKL-Unique 785-803 42 0.061922 2.83 In-house 272-290 (290) Show / Hide 
Range on Protein: 785-803
Range on HMM: 272-290/290
Sequence Identity: 42% (8 aa)

CIQDDPRRRPSMDAVVQML
|  .||  ||| | ..  |
CWHHDPSQRPSFDEIIHRL
Kinase IRAKm_d-1.AA Pkinase_Tyr 783-803 28 0.079393 6.81 Pfam 250-270 (270) Show / Hide 
Range on Protein: 783-803
Range on HMM: 250-270/270
Sequence Identity: 28% (6 aa)

LWCIQDDPRRRPSMDAVVQML
. | . || .||.. .....|
KQCWHYDPEDRPTFSEIHEQL
Kinase IRAKm_d-1.AA Pkinase 784-803 31 1.176968 3.4 Pfam 272-293 (293) Show / Hide 
Range on Protein: 784-803
Range on HMM: 272-293/293
Sequence Identity: 31% (7 aa)

WCIQDDPRRRPSMDAVVQM--L
||.. || .||. . ..|   .
WCLCKDPKKRPTAEQILQHPWF