Gene IRAKm_r-1 (S.moellendorffii)

IRAKm_r-1

Species: S.moellendorffii
Alias: IRAKm_r-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_r-1.AA Protein None 270 None Fasta, JSON
IRAKm_r-1.NA RNA None 813 None Fasta, JSON
IRAKm_r-1.kin_dom Protein Kinase Domain None 148 None Fasta, JSON

Protein domain

Protein domains of IRAKm_r-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKm_r-1.AA TKL 86-234 26 9.7e-35 121.73 In-house 86-287 (364) Show / Hide 
Range on Protein: 86-234
Range on HMM: 86-287/364
Sequence Identity: 26% (57 aa)

NIVKLCGFCIEGAT------------QWLLVYEFMPNGSLDKWLFEQTSENLWLSWQQRIDIALGTAQGLAYLHE----ECREP--ILHLDSREPQNILL
|||.. |.|...              |  .|.|..|.|||   |           |.||...||..|.|..|||      |. .  |.| |   ..|||.
NIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLK-SKNILV

DTEFV--------------AKVADFGMAKLLE---NCNETQVMTI--------------IGGTPGYMAPEWLT----------------HFMATKRCDVY
|  .               .|..||| .. ..   | | |. ..               ..|||..|||| |                 .| ....||||
DENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVY

SYGKVLLELIGGRR
|.| || |.. ..|
SFGIVLWEILTRCR
Kinase IRAKm_r-1.AA IRAK 86-237 39 8.9e-31 106.37 In-house 64-225 (317) Show / Hide 
Range on Protein: 86-237
Range on HMM: 64-225/317
Sequence Identity: 39% (65 aa)

NIVKLCGFCIEGATQWLLVYEFMPNGSLDKWLFEQTSENLW--LSWQQRIDIALGTAQGLAYLHEEC-REPILHLDSREPQNILLDTEFVAKVADFGMAK
||| | |.|.|.  .  |||..||||||   |  |.  .    |||.||..|..||| |. .||.     || | |   . |||||  |..| .|||.. 
NIVPLYGYCTERQ-CHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIK-SANILLDQHFTPKICDFGLHR

LL---ENCNETQV---MT-IIGGTPGYMAPEWLT--HFMATKRCDVYSYGKVLLELIGGRRNID
     ..   . .   || .. ||  ||.|| ..      ||. |||| | ||||.. |.|  .
FGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAKm_r-1.AA TKL-Unique 85-230 29 7.4e-28 95.41 In-house 56-222 (290) Show / Hide 
Range on Protein: 85-230
Range on HMM: 56-222/290
Sequence Identity: 29% (50 aa)

INIVKLCGFCIE---GATQWLLVYEFMPNGSLDKWLF------EQTSENLWLSWQQRIDIALGTAQGLAYLHEECREPILHLDSREPQNILLDTE-----
.|||.. |.|.     . .. .| |..| |||.. |          ..|. |..|||...|.  |||. ||| .    |.|.| . ..|.|.| .     
PNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLK-SSNFLVDNNSNIAE

FVAKVADFGMAKLLENCNETQVMTI-------IGGTPGYMAPEWLTH--FMATKRCDVYSYGKVLLELI
. .|..||| .|.. . |.. . ..         |.. .|||| |.   .. .. .||||.| || |..
WNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Pkinase IRAKm_r-1.AA Pkinase 53-233 25 2.4e-27 97.75 Pfam 22-209 (293) Show / Hide 
Range on Protein: 53-233
Range on HMM: 22-209/293
Sequence Identity: 25% (51 aa)

SDGRVVAVKKLDYSGTQG--AKQFVK-TEIAGTGGI---NIVKLCGFCIEGATQWLLVYEFMPNG----SLDKWLFEQTSENLWL--SWQQRIDIALGTA
..|..||||.......     .. .. .||.    .   |||.| ... ..   . .| |....|    .|  ..    ... ..  |... ..... ..
GTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQIL

QGLAYLHEECREPILHLDSREPQNILLDTEFVA----KVADFGMAKLLENCNETQVMTIIGGTPGYMAPEWLT-HFMATKRCDVYSYGKVLLELIGGR
.||.|.|..    |.| |   |.|||.| . .     |..||| ||...     . || . |||.|||||..  . . ....|..|.| .| |.. ||
RGLEYCHSM---GIIHRDLK-PENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAKm_r-1.AA Dicty4-Unclassified 55-232 33 1.3e-24 81.2 In-house 22-204 (263) Show / Hide 
Range on Protein: 55-232
Range on HMM: 22-204/263
Sequence Identity: 33% (64 aa)

GRVVAVKKLDYSGTQGAK----QFVKTEIAGTGGI---NIVKLCGFCIEG---ATQWLLVYEFMPNGSLDKWLFEQTSE-NLWLSWQQ--RIDIALGTAQ
|. |||||.  ..   .     |  | |..  | |   | ||. | ||           | |||. | |      . || .  ..      | .|.  ||
GKDVAVKKFN-ENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQ

GLAYLHEECREPILHLDSREPQNILLDTEFVAKVADFGMAKLLENCNETQVMTIIGGTPGYMAPEWLTHFMATKRCDVYSYGKVLLELIGG
|...||   |. . | | .   |||.|  | .|.||||..   ..   .. || |.|||   .|| | |   . . |||||. .| ||. |
GMQHLH--TRN-FIHRDIKS-SNILMDKHFNIKIADFGISRVIDF---NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAKm_r-1.AA LISK 127-234 30 3.9e-22 68.55 In-house 98-237 (296) Show / Hide 
Range on Protein: 127-234
Range on HMM: 98-237/296
Sequence Identity: 30% (45 aa)

LSWQQRIDIALGTAQGLAYLHEECREPILH--LDSREPQNILLDTE----FVAKVADFGMAKLLENCNET------------------------------
|.|.||..|||. |.|..|||. .   |.|  | |   .|.|...     . .||.||| |....  |                                
LPWPQRVKIALDIACGMSYLHSMN---IIHRDLKS---KNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMN

---QVMTIIGGTPGYMAPEWLTHFMATKRCDVYSYGKVLLELIGGRR
   . |||  |||  |||| |.    . .|||.|.| ||.|.|....
QRKRRMTIC-GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKm_r-1.AA MLK 86-230 27 1.7e-20 67.92 In-house 66-230 (291) Show / Hide 
Range on Protein: 86-230
Range on HMM: 66-230/291
Sequence Identity: 27% (46 aa)

N----IVKLCGFCIEGATQWLLVYEFMPNGSLDKWLFEQTSENL----------WLSWQQRIDIALGTAQGLAYLHEECREPILHLDSREPQNILLD---
|    |... | |..   . ..| |....|||   | ...|.              . .. ...||  |.|..|||.. . || | |   ..|||.|   
NNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRD-LKSHNILIDEIC

---TEFVAKVADFGMAK-LLENCNETQVMTIIGGTPGYMAPEWL---THFMATKRCDVYSYGKVLLELI
    . ..|..||| .. . ..| ..  |.   ||. .|||| .    . . .. |||.|.| || |..
HDMHHGTLKICDFGTSRDWHQMC-TN--MMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase IRAKm_r-1.AA RIPK 86-233 29 8.8e-20 64.06 In-house 57-225 (290) Show / Hide 
Range on Protein: 86-233
Range on HMM: 57-225/290
Sequence Identity: 29% (50 aa)

NIVKLCGFCIEG--ATQWL---LVYEFMPNGSLDKWLFEQTS-ENLWLSWQQRIDIALGTAQGLAYLHEECRE-PILHLDSREPQNILLDTEFVAKVADF
.||.. |||..   . .     .| |.|.|||| . |  ...  .  . |  |  .   .. |  |||  .   ||.|.|   |.|||.| .| .|.|||
HIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLK-PENILVDNNFHVKIADF

GMAKLLENCNETQ-------VMT----IIGGTPGYMAPEWLT--HFMA----TKRCDVYSYGKVLLELIGGR
| |. ..    .|       |        .||  ||.|| .      .    |.  ||||.. |. |.  ..
GLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQK
Kinase IRAKm_r-1.AA Dicty4 106-229 31 8.4e-19 59.5 In-house 82-210 (277) Show / Hide 
Range on Protein: 106-229
Range on HMM: 82-210/277
Sequence Identity: 31% (42 aa)

EFMPNGSLDKWLFE---QTSENLWLSWQQRID---IALGTAQGLAYLHE-ECREPILHLDSREPQNILLDTEFVAKVADFGMAK-LLENCNETQ-VMTII
|.|| |.| . |        ..  |.|  ..    .|. .|.|...||.  ..  |.|.|   . |.| |  ...||.||| ..   .  . ..  || .
EYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLK-SHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTAC

GGTPGYMAPEWLTHFMATKRCDVYSYGKVLLEL
 |||..|||| . |   .   ||||.| || |.
-GTPCWMAPEVMMHQPYNEKADVYSFGIVLWEI
Kinase IRAKm_r-1.AA LISK-DD1 163-234 40 5.4e-14 47.2 In-house 152-229 (290) Show / Hide 
Range on Protein: 163-234
Range on HMM: 152-229/290
Sequence Identity: 40% (32 aa)

QNILLDTE----FVAKVADFGMAKLLENC-NETQV--MTIIGGTPGYMAPEWLTHFMATKRCDVYSYGKVLLELIGGRR
.|||.|.      ..|| ||| |. .|   | .    |||  ||.. |||| ..      .|||.|.| |||||| ...
KNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMTIC-GTDNWMAPEVILGMSYDWSCDVFSFGMVLLELITRKK
S_TKc IRAKm_r-1.AA S_TKc 44-256 22 1.3e-11 -6.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 44-256
Range on HMM: 1-231/231
Sequence Identity: 22% (58 aa)

WDLLQI-----------GVLSD-GRVVAVKKLDYSGTQGAKQFVKTEIA---GTGGINIVKLCGFCIEGATQWLLVYEFMPN--GSLDKWLFEQTSENLW
...|..           ..  . ||.||.|...        . .. ||.     .  ||||| ... .  .   .| |....  |.| . . .. .. | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSWQQRIDIALGTAQGLAYLHEECREPILHLDSREPQNILLDTEFVAKVADFGMAKLLENCNETQVMTIIGGTPGYMAPEWLTHFMATK-RCDVYSYG
  ..  .   ..  ....|.|.|.     |.| |   |.|||||.  . |..|||.|..|         | . ||| ||||| |     .| .||..| |
FPFPE-HARFYMYQICCALEYCHSHG---IIHRDLK-PENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

KVLLELIGGRR----NIDLSKAVNSGDNTQ----------PE--------E-------SRFF
 .| |.. |.        . | .   .             ||        .         .|
CILYEMLCGYPPFPQMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase IRAKm_r-1.AA TK-Unique 164-229 37 4.7e-11 34.48 In-house 163-232 (294) Show / Hide 
Range on Protein: 164-229
Range on HMM: 163-232/294
Sequence Identity: 37% (26 aa)

NILLDTEFVAKVADFGMAKLLENCNETQVMTIIGGTPG-YMAPEWLT--HFMA-TKRCDVYSYGKVLLEL
|.||   .|.|..|||||. ... .... |.  | .|  .|||| |   | |. | . ||.|.| .. |.
NVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI
TyrKc IRAKm_r-1.AA TyrKc 48-263 18 1e-10 -49.47 SMART 16-280 (280) Show / Hide 
Range on Protein: 48-263
Range on HMM: 16-280/280
Sequence Identity: 18% (51 aa)

QIGVLSDGRVVAVKKLD-YSGTQGAKQFVKTEIAGTGGI-----NIVKLCGFCIEGA------TQWLLVYEFMPNGSLDKWLFEQTSENLWLSWQQRIDI
  |...  . ||||.|  ..     ..    |.     .     |||.| | |...        . ..| |.||.|.|.. | .   .   |.... ...
YKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSF

ALGTAQGLAYLHEECREPILHLD--SREPQNILLDTEFVAKVADFGMAKLLENC----NETQVMTIIG--GTPG-----YMAPEWLTHFMATKRCDVYSY
..  |.| .|||.    .. | |   |   |.|.. ....|..|||... ...      .... .  .  |. .      |||| . . . |   ||.|.
CWQIACGMEYLHSK---NCIHRDLAAR---NCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF

GKVLLELI-------GG-----RRNIDLSKAVNSGDNTQPEES---------------------RF-------FPTWGTRW
| .. |.         |       |... . | .|.   . ..                     ..       | .   ..
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKm_r-1.AA Pkinase_Tyr 86-148 30 4.1e-08 28.12 Pfam 65-129 (270) Show / Hide 
Range on Protein: 86-148
Range on HMM: 65-129/270
Sequence Identity: 30% (20 aa)

NIVKLCGFCI-EGAT-QWLLVYEFMPNGSLDKWLFEQTSENLWLSWQQRIDIALGTAQGLAYLHE
|||.| | |. .|   |...| |.||.|.|.. | .. ...  |. .. .....  |.|..||..
NIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase IRAKm_r-1.AA TK-Unique 85-148 22 2.1e-07 21.7 In-house 64-149 (294) Show / Hide 
Range on Protein: 85-148
Range on HMM: 64-149/294
Sequence Identity: 22% (19 aa)

INIVKLCGFCIEGATQWLLVYEFMPNGSLDKWLFEQTSE--------NLW--------------LSWQQRIDIALGTAQGLAYLHE
.|||...| |..   .|....|..|.|.|.. | .   .        ||               .| .. . .| . |.|..||..
PNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLAS
Kinase IRAKm_r-1.AA Pkinase_Tyr 164-186 39 0.000147 16.06 Pfam 141-163 (270) Show / Hide 
Range on Protein: 164-186
Range on HMM: 141-163/270
Sequence Identity: 39% (9 aa)

NILLDTEFVAKVADFGMAKLLEN
|.|.. ..|.|..|||.|....|
NCLVTENNVVKICDFGLARDIYN
Kinase IRAKm_r-1.AA LISK-DD1 127-148 45 0.001121 9.45 In-house 120-141 (290) Show / Hide 
Range on Protein: 127-148
Range on HMM: 120-141/290
Sequence Identity: 45% (10 aa)

LSWQQRIDIALGTAQGLAYLHE
..|  |. |||. |.. ||||.
IPWKLRVKIALDIACAMAYLHS