Gene IRAKm_a (S.moellendorffii)

IRAKm_a

Species: S.moellendorffii
Alias: IRAKm_a
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_a.AA Protein None 846 None Fasta, JSON
IRAKm_a.NA RNA None 2547 None Fasta, JSON
IRAKm_a.kin_dom Protein Kinase Domain None 82 None Fasta, JSON

Protein domain

Protein domains of IRAKm_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKm_a.AA B_lectin 107-204 28 2.2e-20 71.62 Pfam 1-137 (137) Show / Hide 
Range on Protein: 107-204
Range on HMM: 1-137/137
Sequence Identity: 28% (39 aa)

TAAPVWIANRN---APV-----SGNSMLAKT--GGRLQLLDAN-G-SV--AWSP------NE--SVAYIGIQNSGNLQLF-DES--ETPVWSS--FDRPW
   .|| |||.    ||     .||..|  .   | | |.|.. | ||   ||       .   . ..  .|.|||| |. |..   ...|.|  || | 
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

SALMPNQKLVT------GQS----VVSNKNAS--DPS
  . |..|| .      ...     .| |...  |||
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAKm_a.AA B_lectin 65-178 23 8e-10 39.88 SMART 1-126 (126) Show / Hide 
Range on Protein: 65-178
Range on HMM: 1-126/126
Sequence Identity: 23% (31 aa)

DNPSSRPESLRSDDENLG--LAFLNFNGSNKYYLALMFGTRNSSTAAPVWIA--NRNAPVSG---NSMLAKT-GGRLQLLDANGSVAWSPNES----VAY
||. |  ..| |..      | | .|...   ..   ..  . ..  .|| |  ||. ||..   .. |  .  | | ..|  ... || | .    .  
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ--WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNNGNYV

IGIQNSGNLQLFDES----ETPVWSSFDRP
   | .||. ..|..    .  .|.||| |
AVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
PAN_AP IRAKm_a.AA PAN_AP 376-453 15 0.000509 17.96 SMART 1-85 (85) Show / Hide 
Range on Protein: 376-453
Range on HMM: 1-85/85
Sequence Identity: 15% (14 aa)

RYETDFVTLAGASYFANTFNPP-----DRTGAAMQDCLEQCKSTCSCAAFFFDQALQNCFFIE--DVLGSLT------VDSNKTQQLFGFL
  ...|| . ....    |.|          . ...|...|   ||| .| ..   ..| .    . ||. .         | .. ..  .
CCDDCFVRMPNMKL----FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN-TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
PAN_1 IRAKm_a.AA PAN_1 373-431 11 0.000552 14.94 Pfam 1-55 (84) Show / Hide 
Range on Protein: 373-431
Range on HMM: 1-55/84
Sequence Identity: 11% (7 aa)

CSSRYETDFVTLAGASYFANTFNPPDRT-GA-AMQDCLEQCKSTCS--CAAFFFDQALQNCFF
|..   ..|.   ....     . .  . ..  ...|...|    .  | .| .. . ..|..
CHR---WHFERHPNYIL-G---H-IWVMKNVDSAEECQQKCQNNPRFTCRSFTYNYKTKQCHL
Kinase IRAKm_a.AA Pkinase_Tyr 534-612 33 2.2e-19 66.24 Pfam 3-95 (270) Show / Hide 
Range on Protein: 534-612
Range on HMM: 3-95/270
Sequence Identity: 33% (31 aa)

FTKVLGSGGCGTVYEGMLH-----NGMKLAVKKL--STQHGQ---KEFVTEVSALGNI-SHINIVKLYGFCA-DASH--RLLVYELMPNGSLD
| |.||.|  |.||.| ..     .... |||.|  .. | |   ..|  |.. . .. .| |||.||| |  .  .   ..| |.||.|.|.
FGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL
Kinase IRAKm_a.AA TKL 538-629 19 5.6e-19 64.99 In-house 1-135 (364) Show / Hide 
Range on Protein: 538-629
Range on HMM: 1-135/364
Sequence Identity: 19% (28 aa)

LGSGGCGTVYEGMLHN---------GMKLAVKKLSTQHGQ-----------------------------KEFVTEVSALGNISHINIVKLYGFCADASH-
.|||| |.|| | ...         |   ||||..... .                             .... |.  . ...| |||...|.| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYELMPNGSLDRWIFSDNKDKLDWKLRH
              .|.|..|.|||   .         | .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRC
Kinase IRAKm_a.AA TKL-Unique 534-628 27 4.5e-18 60.46 In-house 1-112 (290) Show / Hide 
Range on Protein: 534-628
Range on HMM: 1-112/290
Sequence Identity: 27% (31 aa)

FTKVLGSGGCGTVYEGMLHNGMKLAVKKLST---QHGQ--KEFVTEVSALGNIS-HINIVKLYGFCA----DASHRLLVYELMPNGSLDRWIFS------
| ...|.||.|.|| |. ..| . |.|...    .. .  .||  ||. . ..  |.|||...|.|.    ..... .| | .| |||.  .        
FWNKIGEGGYGQVYKGK-WRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--DNKDKLDWKLR
   |. ||....|
NNNNNCKLNMQQR
Kinase IRAKm_a.AA TK 534-614 20 2.7e-14 43.56 In-house 3-149 (486) Show / Hide 
Range on Protein: 534-614
Range on HMM: 3-149/486
Sequence Identity: 20% (30 aa)

FTKVLGSGGCG---TVYEGMLHNG--------------------------MKLAVKKLS--TQHGQKEFVT--------------EVSALGNIS-----H
. |.||.|  |   .||.|.....                          .. ||| |   . . |.||                |....   .     |
LGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHH

INIVKLYGFCADA------------SHRLLVYELMPNGS----LDRW
 |||.||| | .              . ..| |.||.|.    |. .
PNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDY
Kinase IRAKm_a.AA IRAK 534-611 36 4.1e-14 46.56 In-house 1-90 (317) Show / Hide 
Range on Protein: 534-611
Range on HMM: 1-90/317
Sequence Identity: 36% (33 aa)

FTK--VLGSGGCGTVYEGMLHNGM-KLAVK------KLSTQHGQKEFVT---EVSALGNISHINIVKLYGFCADASHRLLVYELMPNGSL
| |  ..|.|| |.|| | ..|     |||      ..|.    ..| .   |. ..  . | ||| |||.|.. .   |||..||||||
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSL
Kinase IRAKm_a.AA STE 534-612 20 4.4e-13 42.64 In-house 1-125 (359) Show / Hide 
Range on Protein: 534-612
Range on HMM: 1-125/359
Sequence Identity: 20% (25 aa)

FTK--VLGSGGCGTVYEGMLHN----------------GMKLAVKKLSTQHG-------------------QKEFVTEVSALGNIS--HINIVKLYGFCA
...  ..|.|..|||| .| |.                |   |.|... ..                    ....  |.. . . .  | |||| || . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DA-------SHRLLVYELMPNGSLD
.        ..  .. |.|..||||
KEGHNHKNDDELWICMEYMDGGSLD
Kinase IRAKm_a.AA Pkinase 534-615 26 8.1e-13 46.41 Pfam 3-95 (293) Show / Hide 
Range on Protein: 534-615
Range on HMM: 3-95/293
Sequence Identity: 26% (25 aa)

FTKVLGSGGCGTVYEGMLHNGMK-LAVKKLSTQHGQKEFVT-------EVSALGNISHINIVKLYGFCADASHRLLVYELMPNG----SLDRWI
. ...|||. |.||... ..  |  |||... . ..|. .        |.. . ...| |||.||... | .|  .| |....|    .| ..|
IGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI
Kinase IRAKm_a.AA LRRK 532-629 17 1.4e-12 40.84 In-house 1-167 (351) Show / Hide 
Range on Protein: 532-629
Range on HMM: 1-167/351
Sequence Identity: 17% (29 aa)

KGFTKVLGSGGCG-TVYEGMLHN---------------------------GMKLAVKKLSTQ------------------------------------HG
  . . .|.|| | .|| . . .                           . . |.||. .                                     . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QKEFVTEVSALGNISHINIVKLYGFCADASHRLLVYELMPNGSLDRWIFSDNKDK-------LDWKLRH
  ||  ||. . .  | |||.|.||| .  .. .| |..|.|.|.. ...  .|.       ..| |..
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKL
Kinase IRAKm_a.AA CAMK 537-615 14 2.5e-12 35.32 In-house 1-155 (425) Show / Hide 
Range on Protein: 537-615
Range on HMM: 1-155/425
Sequence Identity: 14% (22 aa)

VLGSGGCGTVYEGMLH-NG------------MKLAVKKLS------------------------------TQHGQKEFVTEVSALGN-------ISHINI
.||.|. |.|....   ..             | |.| ..                              ... .|..  |.. . .       ..| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYGFCADASH-------------------RLLVY---ELMPNG----SLDRWI
.||| .  |...                     .|    |....|     |  .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYI
Kinase IRAKm_a.AA Src 534-611 30 3.8e-12 37.5 In-house 3-81 (255) Show / Hide 
Range on Protein: 534-611
Range on HMM: 3-81/255
Sequence Identity: 30% (24 aa)

FTKVLGSGGCGTVYEGMLHNGMKLAVKKLSTQH-GQKEFVTEVSALGNISHINIVKLYGFCADASHRLLVYELMPNGSL
. . ||.| .| |..|.  . .| ||| |.  .  .. |  |  .. . .| ..|.||  | .    . | |.| .|||
LCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSL
Kinase IRAKm_a.AA MLK 532-611 29 9.1e-12 37.23 In-house 1-97 (291) Show / Hide 
Range on Protein: 532-611
Range on HMM: 1-97/291
Sequence Identity: 29% (29 aa)

KGFTKVLGSGGCGTVYEGMLHNGMK-----LAVKKLS--------TQHGQKEFVTEVSALGNISHIN----IVKLYGFCADA-SHRLLVYELMPNGSL
  | ...|||. | |. |  .| .      .|||.          |   |..| .|.  |  .|| |    |...|| |..  .| ..| | ...|||
IQFHEWIGSGSFGKVWKGRWRN-KDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSL
Kinase IRAKm_a.AA Fer 534-612 33 1.4e-11 35.78 In-house 3-97 (283) Show / Hide 
Range on Protein: 534-612
Range on HMM: 3-97/283
Sequence Identity: 33% (32 aa)

FTKVLGSGGCGTVYEG------MLH-----NGMKLAVKKL----STQHGQKEFVTEVSALGN-ISHINIVKLYGFCADASHRLLVYELMPNGSLD
..|.||.|  |.|| |      ...     |  . .|||.    .|   .|||  |   . |  .|.|.||.||.|.|    ..| |....||||
LGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLD