Gene IRAKg_o-2 (S.moellendorffii)

IRAKg_o-2

Species: S.moellendorffii
Alias: IRAKg_o-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_o-2.AA Protein None 833 None Fasta, JSON
IRAKg_o-2.NA RNA None 2499 None Fasta, JSON
IRAKg_o-2.kin_dom Protein Kinase Domain None 210 None Fasta, JSON

Protein domain

Protein domains of IRAKg_o-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_o-2.AA B_lectin 63-179 29 1.3e-21 75.8 Pfam 1-137 (137) Show / Hide 
Range on Protein: 63-179
Range on HMM: 1-137/137
Sequence Identity: 29% (41 aa)

TGTVVWEATLD---NGASTKERVSVSRNGVLELTA-TG-LVVTDAS-----KPVWTS-NLRC-NNRCSVTVASLEENGNLVLL--GN--GTRLWQS--FD
  |||| |  |   |  .     |...|..|....  | ||..|..     .||| . |    ... . ..| . ..|||||.  .|  .. ||||  ||
NQTVVWVANRDLTGNPVT---DSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFD

SPTDTILPEQDLVGNMTLV-SGKY--RLSMNKSSV--GLY
 ||||.|| ..|  .  ..  ...  .|.  ||.      
HPTDTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAKg_o-2.AA B_lectin 26-146 26 1.5e-17 65.52 SMART 1-126 (126) Show / Hide 
Range on Protein: 26-146
Range on HMM: 1-126/126
Sequence Identity: 26% (35 aa)

EKLSAGNPPWISRGNTFA--FGFYSTTSGMSTLAIWYQSTG----TVVWEATLDNGASTKERVSV-SRNGVLELTATG-LVVTDASKPVWTSNLRCNNRC
  .  ..  . |.. .|   .||.....   .. ||| .      |||| |       . . |.  .... |...  | ||. |  .||| ||    .. 
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ-WCNGIWYKNISNKQRTVVWVAQP----NRDNPVHDGNNSCYLTMQSDGNLVIYD-NRPVWSSNTT--RNN

SVTVASLEENGNLVLLGNG-----TRLWQSFDSP
...|| | ..||.|. ...       .|||||.|
GNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_o-2.AA S_locus_glycop 243-311 26 2.7e-08 30.55 Pfam 49-117 (117) Show / Hide 
Range on Protein: 243-311
Range on HMM: 49-117/117
Sequence Identity: 26% (18 aa)

NSSVLRRLTLEKNGTLRSYSTYGERSLWRVVWQSLLLECDVFGTCGNFGLCKYQPRKSCVCPPGFHTVR
|.|.. |.|.  .|.|  .        |.. | .   .||. ..||..|.|       | | .||.   
NNSIYSRFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFVPKN
PAN_AP IRAKg_o-2.AA PAN_AP 333-411 17 0.000336 19.76 SMART 1-85 (85) Show / Hide 
Range on Protein: 333-411
Range on HMM: 1-85/85
Sequence Identity: 17% (16 aa)

CSNSKMVELARADFLGSGYI---VGLNSSMSLEQCKKLCLDDCQCVGAAYTLDGSGQCRLRK--GGSTPYN------IVQSPQKASIALI
|.   .| . ..    .  |   |    .||||.|...||..|.| ...|.   ...| | .  . .. .       ....  .     .
CCDDCFVRMPNMKL--FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN--TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKg_o-2.AA TKL 520-794 20 8.9e-63 214.88 In-house 1-364 (364) Show / Hide 
Range on Protein: 520-794
Range on HMM: 1-364/364
Sequence Identity: 20% (81 aa)

LGSGGFGSVYKGVLPD---------KTVVAVKTLEV---ATHGE-------------------------NQFKAEVATLGTIHHVNLVKLLGYCVEGSH-
.|||||| ||||..            ..||||.. .     . .                          ... |.  .  ..| |.|...||| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RVLVYEYMTNGSLDKVLTSIRAPWKTRYCHRKSQSPKVKLTLLFRYSIAMGIARGITYLHEECY-----ECILHCDIKPQNILLDQNL
              .|.||. .|||  .|.                       .  | ..|..||||. ||| .         |.|.|.|..|||.|.|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENW

C--------------PKVADFGLAKLTKKEMALNVTT------------------IRGTRGYLAPEWISNR----------------PITTKVDVYSYGM
               .|..||||..  ....  | |                   ..|| ...||| . .                 . ..|.||||.|.
TNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI

VLLELLSGHDKSRSGQNTYFSVWAFQKYMA----GEFESIVDPK--PVTSVEWS----------QFERMLKTAFWCIQLDANLRPSMSRVIQML
|| |.|..          |.  . .. ...     .|. ..| .  |    .|.            ..| | . .| . |.. |||...... |
VLWEILTRCR-------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKg_o-2.AA Pkinase 514-794 22 3.2e-48 171.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 514-794
Range on HMM: 1-293/293
Sequence Identity: 22% (73 aa)

GNFRHKLGSGGFGSVYKGVLPDKTV-VAVKTLEVATHGENQFKA-----EVATLGTIHHVNLVKLLGYCVEGSHRVLVYEYMTNG----SLDKVLTSIRA
  .  |.|||.||.|||..  .    ||||.... .  ... ..     |.. .  ..| | |.|.... ...|  .| ||. .|    .|  ...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

PWKTRYCHRKSQSPKVKL--TLLFRYSIAMGIARGITYLHEECYECILHCDIKPQNILLDQNLCP----KVADFGLAK-LTKKEMALNVTTIRGTRGYLA
            . . ..  .     ...  |.||. |.|..    |.|.|.||.|||.|.|  .    |..|||||| .         ||. ||..|.|
------------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMA

PEWIS-NRPITTKVDVYSYGMVLLELLSGHDKSRSGQNTYFSVWAFQ----KYMAGEFESIVDPKPVTSVEWSQF---------------------ERML
||.|  ......|||..|.| .| |.|.|.             .  .    . .   .    . .| .. .|..                      | ..
PEVIRGGQYYGPKVDMWSCGCILYEMLCGR-----------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

KTAFWCIQLDANLRPSMSRVIQM--L
.   ||...| . ||.   . |   .
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase IRAKg_o-2.AA TKL-Unique 516-725 29 1.2e-44 154.7 In-house 1-225 (290) Show / Hide 
Range on Protein: 516-725
Range on HMM: 1-225/290
Sequence Identity: 29% (70 aa)

FRHKLGSGGFGSVYKGVLPDKTVVAVKTLEVATHGENQ----FKAEVATLGTIH-HVNLVKLLGYCV----EGSHRVLVYEYMTNGSLDKVLT-SIRAPW
|  |.|.||.|.||||. . .. ||.|....    .|.    |. || .. ..| | |.|.. |||.      ... .| ||.  |||..||. .     
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN--

KTRYCHRKSQSPKVKLTLLFRYSIAMGIARGITYLHEECYECILHCDIKPQNILLDQN-----LCPKVADFGLAKLTKKEMALNVTTI--------RGTR
          ... ||... |...|  ||.|  ||| .    |.|.|.|..|.|.|.|     .  |..||||.|. .|... .....         |. 
------NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSF

GYLAPEWISN--RPITTKVDVYSYGMVLLELLSGH
 ..||| ...    ...|.||||.|.|| |.....
RWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRK
Kinase IRAKg_o-2.AA MLK 514-724 28 1.2e-40 138.76 In-house 1-232 (291) Show / Hide 
Range on Protein: 514-724
Range on HMM: 1-232/291
Sequence Identity: 28% (67 aa)

GNFRHKLGSGGFGSVYKGVLPDKT----VVAVKTLE-------VATHGENQFKAEVATLGTIHHVN----LVKLLGYCVE-GSHRVLVYEYMTNGSLDKV
 .| ...|||.||.|.||.   |.    .||||  .       ..     .|. |.  |  . | |     ....| | . ..| ..| ||. .|||  |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LTSIRAPWKTRYCHRKSQSPKVKLTLLFRYSIAMGIARGITYLHEECYECILHCDIKPQNILLDQ------NLCPKVADFGLAK-LTKKEMALNVTTIRG
| ..|  |  .    . .   .  .. .  ..|. .|||. |||..    | | |.|..|||.|.      ..  |..|||... .....   | .  .|
LHGARSKWMDAN--HNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAG

TRGYLAPEWI---SNRPITTKVDVYSYGMVLLELLSG
|  . ||| |    . . . |.||.|.|.|| |.|..
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAKg_o-2.AA Dicty4 515-722 33 3.2e-39 128.58 In-house 2-211 (277) Show / Hide 
Range on Protein: 515-722
Range on HMM: 2-211/277
Sequence Identity: 33% (75 aa)

NFRHKLGSGGFGSVYKGVLPDKTVVAVKTL----EVATHGE-NQFKAEVATLGTIHHVNLVKLLGYCV----EGSHRVLVYEYMTNGSLDKVLTSIRAPW
|.  ..|.|.||.||||    |  |||| |    ...   . | |..||. .. | | |.....|.|     . .  . | |||  |.| ..| .  .  
NIEQRIGKGSFGEVYKGTWRGKE-VAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS--

KTRYCHRKSQSPKVKLT--LLFR-YSIAMGIARGITYLHE-ECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKKEMALNV--TTIRGTRGYLAPEW
         | ...||   |  |   .|  .|||...||.  .   |.| |.|. |.| |.|.  ||.||||... ||.  ..   .|  || .. ||| 
--------EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP--VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEV

ISNRPITTKVDVYSYGMVLLELL
  ..| . |.||||.|.|| |.|
MMHQPYNEKADVYSFGIVLWEIL
Kinase IRAKg_o-2.AA Pkinase_Tyr 515-723 30 3.4e-36 123.19 Pfam 2-209 (270) Show / Hide 
Range on Protein: 515-723
Range on HMM: 2-209/270
Sequence Identity: 30% (70 aa)

NFRHKLGSGGFGSVYKGVLP-----DKTVVAVKTL-EVATHGE---NQFKAEVATLGTI-HHVNLVKLLGYCV-EGSH--RVLVYEYMTNGSLDKVLTSI
 | .|||.| ||.||||..      .|. ||||.| | |.| .     | .|.... .. || |.|.|.| |. .| .    .| ||| .|.|.. | . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

RAPWKTRYCHRKSQSPKVKLTLLFRYSIAMGIARGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLT-KKEMALNVTT-----IRGTRGYL
|             ..| .||.    .... ||.|  ||..     . | |.   |.|.. |.. |..|||||..  ...  . ...     |. .    
R-------------EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----

APEWISNRPITTKVDVYSYGMVLLELLS
||| |...  ||| ||.|.| .. |...
APECINYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKg_o-2.AA LRRK 504-724 21 1.5e-34 119.62 In-house 1-278 (351) Show / Hide 
Range on Protein: 504-724
Range on HMM: 1-278/351
Sequence Identity: 21% (67 aa)

FSYEQLEIATGNFRHKLGSGGFG-SVYKGVLPD---------------------------KTVVAVKTLEV-----------------------------
. .|..          .|.|||| .||.. . .                            . ||.|....                             
LKIEEQ----------IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDM

------ATHGENQFKAEVATLGTIHHVNLVKLLGYCVEGSHRVLVYEYMTNGSLDKVLT-SIRAPW---KTRYCHRKSQSPKVKLTLLFRYSIAMGIARG
      ...  . |  ||. . . .| |.|.|.|.| .  .. .| ||...|.|...|  . . .    |             ...  ... ||. ||.|
DQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMK------------AHISWMLKLKIALQIAKG

ITYLHEECYEC--ILHCDIKPQNILL---D---------QNLCPKVADFGLAK---LTKKEMALNVTTIRGTRGYLAPEWISNR---PITTKVDVYSYGM
. |||        |.|.| |. ||||   .         .. | |.||||.      .... |  ..   |. |..||| . .      |.|||.||.||
MEYLHS---HNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV---GNPGWMAPEIMRYNGEEEYTEKVDCYSFGM

VLLELLSG
.| |||..
ILWELLTR
Kinase IRAKg_o-2.AA TK 514-723 17 3.4e-33 108.06 In-house 1-389 (486) Show / Hide 
Range on Protein: 514-723
Range on HMM: 1-389/486
Sequence Identity: 17% (67 aa)

GNFRHKLGSGGFG---SVYKGVLPDK--------------------------TVVAVKTLEV-ATHGENQFKA--------------EVATLGTIH----
  . .|||.| ||    |||| . ..                          | ||||.|   ... ...|..              |.. .   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HVNLVKLLGYCVEG------------SHRVLVYEYMTNGS----LDKVLTSIRAP-------------------------------WKTRYCHRKSQS-
 | |.|.|.|.|..|             .  .| ||| .|.    |.. | . | .                                . ....  ... 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

----------------------------PKVKLTLLFRYSIAMGIARGITYLHEECYE---CILHCDIKPQNILLDQNLC-----------PKVADFGLA
                            .| .||.  .  ... ||.|  |||.  .|    . | |.   |.|...|.             |.|||||.
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----LTKKEMALNVTTIRGTRG----------------------------YLAPEWIS---------NRPITTKVDVYSYGMVLLELLS
.     |...       . ....|                            ..||| .          ..  ||| ||.|.| .. |...
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKg_o-2.AA IRAK 626-724 42 1.3e-32 112.95 In-house 111-220 (317) Show / Hide 
Range on Protein: 626-724
Range on HMM: 111-220/317
Sequence Identity: 42% (47 aa)

RYSIAMGIARGITYLHEEC-YECILHCDIKPQNILLDQNLCPKVADFGLAKL-----TKKEMAL---NVTTIRGTRGYLAPEWIS--NRPITTKVDVYSY
| ||. |.|.|| .||.      | | |||. ||||||.. || .||||.        |.   .    . ..|||  |..|| |    . .|.|.|||| 
RCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSF

GMVLLELLSG
| ||||.|.|
GIVLLEVLTG
Kinase IRAKg_o-2.AA RIPK 520-724 28 1.4e-32 108.31 In-house 1-224 (290) Show / Hide 
Range on Protein: 520-724
Range on HMM: 1-224/290
Sequence Identity: 28% (68 aa)

LGSGGFGSVYKGVLPDKTVVAVKTL----EVATH----GENQFKAEVATLGTIHHVNLVKLLGYCVEG-----SH-RVLVYEYMTNGSLDKVLTSIRAPW
.|.|||| |.| .  .  ....|.     ...||     ... | |.. .  . . . |...| | .      .    .| ||| |||| ..|..     
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHT-----

KTRYCHRKSQSPKVKLTLLFRYSIAMGIARGITYLHEECYE-CILHCDIKPQNILLDQNLCPKVADFGLAKLTKKEMALNVT--------TI-----R-G
|..|     | . . . |..|  .   |..|  |||  .    |.| | ||.|||.| |.  |.||||||.   ...    .         .     | |
KWPY-----QHHPDPWPLRCR--MIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATW--MMWSHSHQDRCNQREVYSMKSKNRWG

TRGYLAPEWIS---NRPI---TTKVDVYSYGMVLLELLSG
|  |..|| .      ||   |.| ||||...|. |.|..
TLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAKg_o-2.AA Dicty4-Unclassified 515-724 35 1.6e-32 108.69 In-house 2-204 (263) Show / Hide 
Range on Protein: 515-724
Range on HMM: 2-204/263
Sequence Identity: 35% (78 aa)

NFRHKLGSGGFGSVYKGVLPDKTVVAVKTLEVATHGEN-----QFKAEVATLGTIHHVNLVKLLGYCVEG-SHR---VLVYEYMTNGSLDKVLTSIRAPW
     .| | |  |.||.   |  |||| .              ||.||. || | | ||||. |||.   ||.   . | | |  | |  |  |  .  
QIDQFIGKGHFSKVHKGNWKGKD-VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS--

KTRYCHRKSQSPKVKLTLLFRYSIAMGIARGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKKEMALNVTTIRGTRGYLAPEWISNRPI
       . |. |   ||  .|  |. ||.|. .||      . | |||  |||.| .   |.||||..  .  .   | ||| ||    .||       
------EQQQPIKLDDTLIIKY--AFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESY

TTKVDVYSYGMVLLELLSG
. | |||||.|.| ||. |
NQKSDVYSYAMMLYELATG
Kinase IRAKg_o-2.AA S_TKc 514-794 22 2.2e-30 108.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 514-794
Range on HMM: 1-231/231
Sequence Identity: 22% (67 aa)

GNFRHKLGSGGFGSVYKGVLPD-KTVVAVKTLEVATHGENQFKAEVATLGTIHHVNLVKLLGYCVEGSHRVLVYEYMTN--GSLDKVLTSIRAPWKTRYC
  .  |.|.|.||.|||..  . . .||.| .       .... |.. |   || |.|||...... .|  .| ||. .  |.| ... . . . .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL----

HRKSQSPKVKLTLLFRYSIAMGIARGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKKEMALNVTTIRGTRGYLAPEWISNRPITT-KV
       .....     ...  |.... |.|.     |.|.|.||.|||||.  . |..|||||..         ||. ||. |.||| .   . .. |.
-------RFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKC

DVYSYGMVLLELLSGHDKSRSGQNTYFSVWAFQKYMAGEFESIVDPKPVTSVEWSQFERMLKTAFWCIQLDANLRPSMSRVIQ---------ML
|..| | .| |.|.|    .  ... | .                            . ..     | | | . ||.   . |          .
DWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_o-2.AA TK-Unique 514-723 24 2.4e-30 101.88 In-house 1-234 (294) Show / Hide 
Range on Protein: 514-723
Range on HMM: 1-234/294
Sequence Identity: 24% (57 aa)

GNFRHKLGSGGFGSVYKGVLP------DKT-VVAVKTLEVATHGEN--QFKAEVATLGTIH-HVNLVKLLGYCVEGS-HRVLVYEYMTNGSLDKVLTSIR
 ..  ..|.| || |..| .       ||. .||||.|.   ...   .|. | . .  .  | |.|..||.|.. .    ...||. .|.|.. | . |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

APWKTRY---------CHRKSQSPKVKLTLLFRYSIAMGIARGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKKEMALNVTT--IRGT
 . .. .          |.... ..  ... . |..| .||.|  ||..  ...  | |.   |.||  ..  |..|||.|. . .. ... ..   |  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI-VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

RGYLAPEWIS--NRPI-TTKVDVYSYGMVLLELLS
  ..||| ..   ... ||| ||.|.| .. |...
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAKg_o-2.AA TyrKc 514-794 23 3.3e-29 104.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 514-794
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

GNFRHKLGSGGFGSVYKGVLPDKTVVAVKTLEVATHGENQFKAEVATLGTI--HHVNLVKLLGYCVEG-------SHRVLVYEYMTNGSLDKVLTSIRAP
  . .|||.| || ||||..   . ||||.|   .  .  |  |   .  .  || |.|.|.|.|...           .| ||| .|.|.. | . |  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

WKTRYCHRKSQSPKVKLTLLFRYSIAMGIARGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKKE----MALNVTTIR---GTRG----
                |..    |..  ||.|  |||.    .. | |.   |.|.. |.. |..||||..  . .     .  . . .   |...    
----------------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

-YLAPEWISNRPITTKVDVYSYGMVLLELLSGHDKSRSGQ----NTYFSVWAFQKYMAGEFESIVDP--------KPVTSVEWSQFERMLKTAFWCIQLD
  .||| |  .  ||| ||.|.| .. |...  ..  .|.     . . |  ... ..|.   . .          |         . | .   .| . |
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV--IEYVKQGYRMPQPPNDYPMSFVCCP---------DEMYQIMKQCWHED

ANLRPSMSRVIQML
.. ||..| ... .
PEDRPTFSEIHECF
Kinase IRAKg_o-2.AA IRAK 515-594 35 7e-21 70.84 In-house 2-90 (317) Show / Hide 
Range on Protein: 515-594
Range on HMM: 2-90/317
Sequence Identity: 35% (32 aa)

NFRHKLGSGGFGSVYKGVLPDKT-VVAVK------TLEVATHGENQFKA---EVATLGTIHHVNLVKLLGYCVEGSHRVLVYEYMTNGSL
.  ...|.|||| ||.|..  .| ..|||       ..   | . .| .   |. .. ...| |.| |.||| |..   |||.||.||||
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEH-WQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSL
Kinase IRAKg_o-2.AA Dicty4-Unclassified 775-794 50 0.001218 8.3 In-house 244-263 (263) Show / Hide 
Range on Protein: 775-794
Range on HMM: 244-263/263
Sequence Identity: 50% (10 aa)

WCIQLDANLRPSMSRVIQML
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WCWHNDPNKRPTMNQIIQYL
Kinase IRAKg_o-2.AA TK-Unique 776-794 31 0.004427 6.61 In-house 276-294 (294) Show / Hide 
Range on Protein: 776-794
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CIQLDANLRPSMSRVIQML
|.|...  ||| . ....|
CWQWEPEERPSFRQIKHRL
Kinase IRAKg_o-2.AA LRRK 775-796 31 0.004982 6.54 In-house 330-351 (351) Show / Hide 
Range on Protein: 775-796
Range on HMM: 330-351/351
Sequence Identity: 31% (7 aa)

WCIQLDANLRPSMSRVIQMLED
.| | | . ||..| ... |..
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_o-2.AA TK 776-794 31 0.005121 5.1 In-house 468-486 (486) Show / Hide 
Range on Protein: 776-794
Range on HMM: 468-486/486
Sequence Identity: 31% (6 aa)

CIQLDANLRPSMSRVIQML
| ..|.. ||..| . ..|
CWHYDPEDRPTFSQLHEQL
Kinase IRAKg_o-2.AA MLK 776-794 36 0.054919 2.84 In-house 273-291 (291) Show / Hide 
Range on Protein: 776-794
Range on HMM: 273-291/291
Sequence Identity: 36% (7 aa)

CIQLDANLRPSMSRVIQML
| . |.. |||.. ..| |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKg_o-2.AA Dicty4 784-796 46 0.158181 1.06 In-house 263-277 (277) Show / Hide 
Range on Protein: 784-796
Range on HMM: 263-277/277
Sequence Identity: 46% (7 aa)

RPSMSRVIQM--LED
|||.. .||   || 
RPSFEEIIQRRILEH
Kinase IRAKg_o-2.AA IRAK 767-794 35 0.302989 0.37 In-house 290-317 (317) Show / Hide 
Range on Protein: 767-794
Range on HMM: 290-317/317
Sequence Identity: 35% (10 aa)

ERMLKTAFWCIQLDANLRPSMSRVIQML
. |.  |  |    ||.|..|  | | |
KEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAKg_o-2.AA Pkinase_Tyr 776-794 31 0.48438 4.15 Pfam 252-270 (270) Show / Hide 
Range on Protein: 776-794
Range on HMM: 252-270/270
Sequence Identity: 31% (6 aa)

CIQLDANLRPSMSRVIQML
| . |.. ||..| ....|
CWHYDPEDRPTFSEIHEQL