Gene IRAKg_c (S.moellendorffii)

IRAKg_c

Species: S.moellendorffii
Alias: IRAKg_c
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_c.AA Protein None 793 None Fasta, JSON
IRAKg_c.NA RNA None 2382 None Fasta, JSON
IRAKg_c.kin_dom Protein Kinase Domain None 197 None Fasta, JSON

Protein domain

Protein domains of IRAKg_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_c.AA B_lectin 65-144 27 1.8e-14 51.27 Pfam 1-107 (137) Show / Hide 
Range on Protein: 65-144
Range on HMM: 1-107/137
Sequence Identity: 27% (30 aa)

LKTIVWTAPGA---PSVAFTA---NARLQLTA-QG-LFVSDGA---QL--ITIA-NVPS-VA--S---AELQDNGNFVVI-SSSG--S---WQS--FDVP
 .|.||.|       .|  ..   |..|....  | | ..||.   .   .  . |. |  .  .   |..||.||.|.  . ..  .   |||  || |
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDD-NNDSNNVLWQSNTFDHP

TDTLLTGQ
|||.| |.
TDTWLPGM
B_lectin IRAKg_c.AA B_lectin 25-136 27 2.7e-12 48.07 SMART 1-126 (126) Show / Hide 
Range on Protein: 25-136
Range on HMM: 1-126/126
Sequence Identity: 27% (36 aa)

GDVLAVNQFLVSPDNTFE--LGFVDDEASGKFTLVIRFHHIN--LKTIVWTA-PGAPSVAFT--ANARLQLTAQG-LFVSDGAQLI--TIAN-VPSVASA
  .|  .|.|||.. .||  |||.  . .  ... | ...|.   .|.|| | |.  . .    ....| ..  | | . |  . .  .  . . .. .|
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ--WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD-NRPVWSSNTTRNNGNYVA

ELQDNGNFVVISSS--GS----WQSFDVP
.|||.||||.....   |    ||||| |
VLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_c.AA S_locus_glycop 238-297 30 4.6e-10 36.65 Pfam 55-114 (117) Show / Hide 
Range on Protein: 238-297
Range on HMM: 55-114/117
Sequence Identity: 30% (18 aa)

RLTLERNGTLRVYSLTQDNSSWNIVWQALTADCKVFGMCGPFGICTYRPGLVCTCPPGFH
|.|.  .|.| ..  . .. .||  | | .  | . ..|||.|.|      .|.| .||.
RFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFV
PAN_AP IRAKg_c.AA PAN_AP 319-397 22 1.7e-08 35.51 SMART 1-85 (85) Show / Hide 
Range on Protein: 319-397
Range on HMM: 1-85/85
Sequence Identity: 22% (20 aa)

GSDNRWVRLERTDYTYNDKT-----YISVISLEDCKSICKENCGCLGIAYRADGSGQCFLKG-PDSTRGPKQ-----VIYNGFQIASGQN
..|. .||.... .  .. .      | |.|||.|.. | .|| | ...| .  ...| |    ... .|.|       .|. ..   .|
CCDDCFVRMPNMKL--FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN--TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
PAN_1 IRAKg_c.AA PAN_1 317-374 19 1.2e-07 26.88 Pfam 1-56 (84) Show / Hide 
Range on Protein: 317-374
Range on HMM: 1-56/84
Sequence Identity: 19% (12 aa)

CNGSDNRWVRLERTDYTYNDKTYISVI-SLEDCKSICKENCG--CLGIAYRADGSGQCFLK
|..  . ..| . ... .. .  .. . |.|.| . | .| .  |  . |  . ..||.|.
CHR--WHFERHPNYIL-GH-IWVMKNVDSAEECQQKCQNNPRFTCRSFTYNYK-TKQCHLH
Kinase IRAKg_c.AA TKL 508-777 19 2.3e-61 210.21 In-house 1-364 (364) Show / Hide 
Range on Protein: 508-777
Range on HMM: 1-364/364
Sequence Identity: 19% (78 aa)

LGTGGFGTVFKGLLPD---------GIIVAVKNIEM---------------------------EIQAEKQFQAEVT-TLGKIHHINLVRLLGYCAEGSH-
.| ||||.|.|| .           |  |||| . .                           |.. ...|  |..  . ...| |.|...||| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEYMQNGSLEKSIISNEDIDESLCDWKTRFSIAVGIARGITYLHE------QCQECIVHCDIKPQNILLDEKFC----------
              .|.||...|||.  ..           |  |...| .||||. |||       .    |.|.|.|..|||.||..           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPN

----PKVSDFGLAKLASRE------------------RTINVTTVQGTRGYMAPEWVRNV----------------TITPKVDVYSYGMVLFELLSGGKI
    .|..||||..  |..                  .  .  |. || ..||||  |.                 . ..|.||||.|.||.|.|.. . 
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-

IPVDGAPATNSERGHFPIWAFQ-HYVAGSV---------SSIADTKMAEKID---------MVQFNM---VLRVAFWCVQPDASLRPNMSKVVEML
                    .. .     .         . ..| ..   |.         .   ..   . . . .| ..|.. ||....... |
-------------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKg_c.AA TKL-Unique 504-700 30 2.6e-51 176.77 In-house 1-224 (290) Show / Hide 
Range on Protein: 504-700
Range on HMM: 1-224/290
Sequence Identity: 30% (70 aa)

FKDKLGTGGFGTVFKGLLPDGIIVAVKNIEM--EIQAE--KQFQAEVTTLGKIH-HINLVRLLGYCA----EGSHRLLVYEYMQNGSLEKSII-----SN
|  |.|.||.|.|.||  . |..||.| ..   ..  |  . |  ||... |.| |.|.|.. |||.      ... .| ||.. ||| . .      .|
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

EDIDESLCDWKTRFSIAVGIARGITYLHEQCQECIVHCDIKPQNILLDEK-----FCPKVSDFGLAKLASRERTINVT--------TVQGTRGYMAPEWV
  ....  ... | ..|  ||.|  |||      | |.|.|..|.|.|..     .  |..||||.|..|.. . ...        |..|.  .||||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

RN--VTITPKVDVYSYGMVLFELLSG
|.   ... |.||||.|.|| |....
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKg_c.AA Pkinase 504-700 32 1.4e-45 162.28 Pfam 3-208 (293) Show / Hide 
Range on Protein: 504-700
Range on HMM: 3-208/293
Sequence Identity: 32% (69 aa)

FKDKLGTGGFGTVFKGLLPDG-IIVAVKNIEMEIQAEKQFQA-----EVTTLGKIHHINLVRLLGYCAEGSHRLLVYEYMQNG----SLEKSIIS-NEDI
.. |.| |.||.|.|.   .  .||||| |. . . ... |.     |.  . ...| | |||.... ...|  .| ||...|    .|  ..||  .. 
IGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTWRHG

DESLCDWKTRFSIAVGIARGITYLHEQCQECIVHCDIKPQNILLDEKFCP----KVSDFGLAKLA-SRERTINVTTVQGTRGYMAPEWVR-NVTITPKVD
  .  ....  ...  |.||. |.|..    |.|.|.||.|||.|..  .    |..||||||..     .   ||. ||..|||||..| .  ..||||
CFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSYGMVLFELLSG
..|.| .|.|.|.|
MWSCGCILYEMLCG
Kinase IRAKg_c.AA Dicty4 504-698 31 5.3e-41 134.58 In-house 3-211 (277) Show / Hide 
Range on Protein: 504-698
Range on HMM: 3-211/277
Sequence Identity: 31% (69 aa)

FKDKLGTGGFGTVFKGLLPDGIIVAVKNI--------EMEIQAEKQFQAEVTTLGKIHHINLVRLLGYCA----EGSHRLLVYEYMQNGSLEKSIISN--
. ...|.|.||.|.||    |..||||          | ....   | .||. ..|| | |.. ..|.|     . .  . | |||  |.|. |.. .  
IEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNE---FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLY-SLLHDKP

-EDIDESLCDWKTRFS---IAVGIARGITYLHE-QCQECIVHCDIKPQNILLDEKFCPKVSDFGLAKLASRER--TINVTTVQGTRGYMAPEWVRNVTIT
 |  ..   || .. .   .|  .|||...||.  .   |.| |.|. |.| |. .  ||.||||...  ..   . | .|. || ..||||  ..   .
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYN

PKVDVYSYGMVLFELL
 |.||||.|.||.|.|
EKADVYSFGIVLWEIL
Kinase IRAKg_c.AA MLK 502-700 28 8.9e-40 135.68 In-house 1-232 (291) Show / Hide 
Range on Protein: 502-700
Range on HMM: 1-232/291
Sequence Identity: 28% (66 aa)

NFFKDKLGTGGFGTVFKGLLPDGI----IVAVKNIEMEI----QAE---KQFQAEVTTLGKIHHIN----LVRLLGYCAE-GSHRLLVYEYMQNGSLEKS
  |. ..| |.|| |.||     .    |||||... .|    ...   ..|. |.  | .. | |     ....| |.. ..| ..| ||...|||  .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY-N

IISNEDIDES----------LCDWKTRFSIAVGIARGITYLHEQCQECIVHCDIKPQNILLDE------KFCPKVSDFGLAKLASRERTINVTTVQGTRG
.. .... ..            |    ...|. .|||. |||.. .  |.| |.|..|||.||      .   |..|||...  ..    | .  .||  
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YMAPEWV---RNVTITPKVDVYSYGMVLFELLSG
.||||     |. . . |.||.|.|.|| |.|..
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAKg_c.AA TK 502-777 15 1.3e-35 116.34 In-house 1-486 (486) Show / Hide 
Range on Protein: 502-777
Range on HMM: 1-486/486
Sequence Identity: 15% (76 aa)

NFFKDKLGTGGFG---TVFKGLLPDG--------------------------IIVAVKNIE----MEIQAEKQ--------------FQAEVTTLG--KI
  . .||| | ||   .|.||.. ..                          . |||| .     |. .....              . .|   .   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHINLVRLLGYCAEG------------SHRLLVYEYMQNGS----LEKSIISNEDIDESL----------------------------------------
|| |.|||.|.| .|             . ..| |||..|.    | .   .. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------CDWKTRFSIAVGIARGITYLHEQ----CQECIVHCDIKPQNILLDEKFC-----------PKVSDFGLA
                                . ...  ... ||.|  |||..        .|| |.   |.|..|.              |..||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----LASRERTINVTTVQGTRG----------------------------YMAPEWVR---------NVTITPKVDVYSYGMVLFELLSGGKIIPVDG
.     || .       ......|                            .|||| ..         . . |.| ||.|.| ...|... |.  .  |
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

AP-------------ATNSERG---------------------HFPIWAFQHYVAGSVSSIADTKMAEKIDMVQFNMVLRVAFWCVQPDASLRPNMSKVV
 .               . .||                     | | |.              ..|   .  .   .. ..   | ..|.. ||..| ..
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWM-R------------YRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLH

EML
|.|
EQL
Kinase IRAKg_c.AA S_TKc 502-777 24 2.4e-34 121.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 502-777
Range on HMM: 1-231/231
Sequence Identity: 24% (73 aa)

NFFKDKLGTGGFGTVFKGLLPD-GIIVAVKNIEMEIQAEKQFQAEVTTLGKIHHINLVRLLGYCAEGSHRLLVYEYMQN--GSLEKSIISNED------I
  . .|.| |.||.|.|.   . | |||.| |       .... |.  | | || |.|.|.... . .|  .| ||. .  |.| . | ..        .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DESLCDWKTRFSIAVGIARGITYLHEQCQECIVHCDIKPQNILLDEKFCPKVSDFGLAKLASRERTINVTTVQGTRGYMAPEWVRNVTITP-KVDVYSYG
.|  .      ...  |.... |.|..    |.|.|.||.||||||  . |..|||||..         ||. ||. ||||| .     .. |.|..| |
PE-HAR-----FYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

MVLFELLSGGKIIPVDGAPATNSERGHFPIWAFQHYVAGSVSSIADTKMAEKIDMVQFNMVLRVAFWCVQPDASLRPNMSKVVE---------ML
 .|.|.|.|    |              .   |.. .                       ..     | | | . ||   .. .          .
CILYEMLCGYPPFP-------------QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_c.AA IRAK 599-700 44 4e-33 114.81 In-house 108-220 (317) Show / Hide 
Range on Protein: 599-700
Range on HMM: 108-220/317
Sequence Identity: 44% (50 aa)

WKTRFSIAVGIARGITYLHEQC-QECIVHCDIKPQNILLDEKFCPKVSDFGLAK---LAS--RERTI---NVTTVQGTRGYMAPEWVR--NVTITPKVDV
| .|.||. |.|.|| .||.      | | |||. |||||. | || .||||.     ||     |.    . .|.||  ||.||  |     .|.|.||
WHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDV

YSYGMVLFELLSG
|| | || |.|.|
YSFGIVLLEVLTG
Kinase IRAKg_c.AA ULK 502-700 24 7e-33 114.03 In-house 1-248 (324) Show / Hide 
Range on Protein: 502-700
Range on HMM: 1-248/324
Sequence Identity: 24% (63 aa)

NFFKDKLGTGGFG-TVFKGL-LPD---GIIVAVKNIE---MEIQAEK--------QFQAEVTTLGKIH---HIN--LVRLLGYCAEG--SHRLLVYEYMQ
   ...|| | || .|.||    .   . .||.| |.   | ..  .        ... |. .. |..   | |   |.|. .. .    .  ...|| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGSLEKSIISNED---------IDESLCDWKTRFSIAVGIARGITYLHEQCQECIVHCDIKPQNILLDEKF------------CPKVSDFGLAKLAS---
 | ||. |  |           . |. .      ..   |. |  .||.   . |.|.||||||||. ...            . |..|||.||      
GGDLEQYIKKNKKLPETEEKKRLSEQEA-----IQFFKQICNGFKELHK---HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNN

RERTINVTTV-----QGTRGYMAPEWVR----NVTIT-PKVDVYSYGMVLFELLSG
 | ... |.|      ||  ||||. .     .   .  |.|..| |....|.| |
MEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG
Kinase IRAKg_c.AA TyrKc 502-777 23 4.3e-31 110.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 502-777
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

NFFKDKLGTGGFGTVFKGLLPDGIIVAVKNIEMEIQAEKQFQAEVTTLGKI--HHINLVRLLGYCAEG-------SHRLLVYEYMQNGSLEKSIISNEDI
  ...||| | ||.|.|| .   | |||| .  .   .. |  |   . |.  || |.|||.|.| ..          ..| ||| .|.| . . .... 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

DESLCDWKTRFSIAVGIARGITYLHEQCQECIVHCDIKPQNILLDEKFCPKVSDFGLAKLASRE-------RTINVTTVQGTRG-----YMAPEWVRNVT
      .|.  |... ||.|  |||..   ...| |.   |.|..|... |.|||||..    .        .. ... .|...      ||||  .  .
----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

ITPKVDVYSYGMVLFELLSGGKIIPVD---GAPATNSERGHFPIWAFQHYVAGSVSSIADTKMAEKIDMV----QFNMVLRVAFWCVQPDASLRPNMSKV
 |.| ||.|.| ...|... |.  . .     . .|.|       ....  .|    . .         .        . ..  .| . |.. ||..| .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQE-------VIEYVKQGYRMPQPPNDY----P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

VEML
.| .
HECF
Kinase IRAKg_c.AA ULK 502-700 24 5.7e-31 105.4 In-house 1-252 (329) Show / Hide 
Range on Protein: 502-700
Range on HMM: 1-252/329
Sequence Identity: 24% (63 aa)

NFFKDKLGTGGFGTVFKGL-LPD----GIIVAVKNIE---MEIQAEK--------QFQAEVTTLGKIH----HIN----LVRLLGYCAEG--SHRLLVYE
   ...|| | ||.|.||    .    ...||.| |.   | ..           ... |. .. |..    |.|     |.|. .. .    .  ...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YMQNGSLEKSIISNED----------IDESLCDWKTRFSIAVGIARGITYLHEQCQECIVHCDIKPQNILLDEKF------------CPKVSDFGLAKLA
| . | ||. |  |            . |. .      ..   |. |  .||.   . |.|.||||||||.....            . |..|||.||  
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEA-----IQFFKQILNGFKELHK---HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHV

S---RERTINVTTV-----QGTRGYMAPEWVR----NVTIT-PKVDVYSYGMVLFELLSG
.    |  ...|.|      ||  ||||. .     .   .  |.|..| |....|.| |
DNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG
Kinase IRAKg_c.AA STE 504-700 22 6.1e-31 106.55 In-house 1-264 (359) Show / Hide 
Range on Protein: 504-700
Range on HMM: 1-264/359
Sequence Identity: 22% (62 aa)

FKD--KLGTGGFGTVFKGLLPD----------------GIIVAVKNIEMEI------------------QAEKQFQAEVTTLGKIH--HINLVRLLGYCA
...  |.| |.||||.|..  .                | |.|.| ...|                   . ..|.. |. .. | .  | | |. .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------SHRLLVYEYMQNGSLEKSIISN-ED-------------IDESLCDWKTRFSIAVGIARG-ITYLHEQCQECIVHCDIKPQNILLDEKFCPK
 .       ..  .. ||| .|||.. | .. .              ..||.        |.. | .|   |||..    |.| ||||.||||      |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQI-----AYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VK

VSDFGLAKLASR---------------ERTINVTTVQGTRGYMAPEWVRN------VTITPKVDVYSYGMVLFELLSG
 .|||...  .                 .  . .|. ||  .|||| ...         . |.|..| | .. |.. |
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG
Kinase IRAKg_c.AA Pkinase_Tyr 504-652 30 5.3e-30 102.23 Pfam 3-160 (270) Show / Hide 
Range on Protein: 504-652
Range on HMM: 3-160/270
Sequence Identity: 30% (50 aa)

FKDKLGTGGFGTVFKGLLP-----DGIIVAVKNI--EMEIQA--EKQFQAEVTTLGKI-HHINLVRLLGYCA-EGSH--RLLVYEYMQNGSLEKSIISNE
|  ||| | ||.|.|| .      ..| |||| .      ..   . | .|. .. .. || |.|||.| |  .| .   ..| |||..|.| .   .. 
FGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR

DIDESLCDWKTRFSIAVGIARGITYLHEQCQECIVHCDIKPQNILLDEKFCPKVSDFGLAKL
  |.   . |.  .... ||.|  ||...    ..| |.   |.|..|... |..|||||..
-EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAKg_c.AA LRRK 504-701 23 4.1e-29 100.14 In-house 3-279 (351) Show / Hide 
Range on Protein: 504-701
Range on HMM: 3-279/351
Sequence Identity: 23% (67 aa)

FKDKLGTGGFG-TVFKGLLPD---------------------------GIIVAVKNIEME-----------------------------------IQAEK
.  ..| |||| .|... . .                           .  ||.| ....                                   . |  
IEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAFR

QFQAEVTTLGKIHHINLVRLLGYCAEGSHRLLVYEYMQNGSLEKSIISNEDIDE------SLCDWKTRFSIAVGIARGITYLHEQCQEC--IVHCDIKPQ
 |. ||. . . .| |.| |.|.| .  .. .| ||...|.|  . ..|.  |.      .. .| ..  ||. ||.|. ||| .      |.|.| |. 
EFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLY-HFLHNKKQDGFHFMKAHI-SWMLKLKIALQIAKGMEYLHSH---NPPIIHRDLKSP

NILL---D---------EKFCPKVSDFGLAK--LASRERTINVTTVQGTRGYMAPEWVR---NVTITPKVDVYSYGMVLFELLSGG
||||   .         .  | |..|||.     . ..  ..  .. |. |.|||| .|   ... | |||.||.||.|.|||...
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAK--GCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAKg_c.AA IRAK 503-583 39 4.8e-21 71.45 In-house 1-91 (317) Show / Hide 
Range on Protein: 503-583
Range on HMM: 1-91/317
Sequence Identity: 39% (36 aa)

FFKD-KLGTGGFGTVFKGLLPDGI-IVAVK----NIEMEI-QAEKQFQA---EVTTLGKIHHINLVRLLGYCAEGSHRLLVYEYMQNGSLE
| || ..| ||||.|..| .     |.|||    . .|.. . ...||.   |. .. ...| |.| |.|||.|..   |||.|| |||||
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLE
Kinase IRAKg_c.AA Pkinase_Tyr 671-703 36 0.000144 16.09 Pfam 181-213 (270) Show / Hide 
Range on Protein: 671-703
Range on HMM: 181-213/270
Sequence Identity: 36% (12 aa)

MAPEWVRNVTITPKVDVYSYGMVLFELLSGGKI
||||  ..   | | ||.|.| ...|... |..
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase IRAKg_c.AA LRRK 758-779 36 0.005962 6.26 In-house 330-351 (351) Show / Hide 
Range on Protein: 758-779
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

WCVQPDASLRPNMSKVVEMLEE
.| | |   || .|..|. |..
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_c.AA MLK 759-777 31 0.050436 2.97 In-house 273-291 (291) Show / Hide 
Range on Protein: 759-777
Range on HMM: 273-291/291
Sequence Identity: 31% (6 aa)

CVQPDASLRPNMSKVVEML
| ..|.. ||... .|. |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKg_c.AA Pkinase_Tyr 759-777 36 1.86119 2.17 Pfam 252-270 (270) Show / Hide 
Range on Protein: 759-777
Range on HMM: 252-270/270
Sequence Identity: 36% (7 aa)

CVQPDASLRPNMSKVVEML
| ..|.. || .| ..|.|
CWHYDPEDRPTFSEIHEQL