Gene IRAKg_r-2 (S.moellendorffii)

IRAKg_r-2

Species: S.moellendorffii
Alias: IRAKg_r-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_r-2.AA Protein None 860 None Fasta, JSON
IRAKg_r-2.NA RNA None 2583 None Fasta, JSON
IRAKg_r-2.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAKg_r-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_r-2.AA B_lectin 67-171 28 8.5e-19 66.17 Pfam 1-127 (137) Show / Hide 
Range on Protein: 67-171
Range on HMM: 1-127/137
Sequence Identity: 28% (36 aa)

KKTVIWMAMAN---GLLVQ--VSENAKLELKA-EGGLSVTDGSSS---VPLWQT--N-PGQCCAE--SATLLENGNLVVL-GKD--KKVVWQS--FDSPT
..|| | |  .     ..   ...|..|.. .  | | ..||..     |.|.|  | .|   |   .|.....||||.. ...   .|.|||  || ||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DNLLPEQQLRTQGNPSLGYTR---LIS
| .|| . |.. .|  .. ..   |.|
DTWLPGMKLGWDNNVTIYMNWIGYLTS
B_lectin IRAKg_r-2.AA B_lectin 25-146 25 1.3e-18 69.04 SMART 1-126 (126) Show / Hide 
Range on Protein: 25-146
Range on HMM: 1-126/126
Sequence Identity: 25% (34 aa)

GSTVTTGSPWRSPGGTFG--LGFVMPESSSTRNFNLAIWYDIDP--KKTVIWMAMANGLLVQVSE---NAKLELKAEGGLSVTDGSSSVPLWQTNPG-QC
 .| ..|  . |....|   |||. ....    . . |||.  .   .||.| | . .  . |..   ...|..   | | . |     |.|..| . . 
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ----WCNGIWYKNISNKQRTVVWVAQP-NRDNPVHDGNNSCYLTMQSDGNLVIYD---NRPVWSSNTTRNN

CAESATLLENGNLVVLGKD----KKVVWQSFDSP
   .| |...||.|. . |    ....|||||.|
GNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_r-2.AA S_locus_glycop 273-343 25 2.1e-12 44.76 Pfam 49-117 (117) Show / Hide 
Range on Protein: 273-343
Range on HMM: 49-117/117
Sequence Identity: 25% (18 aa)

DANVLRRLTLDDDGNLRIYSFGPKNKSGSWSVVWQAVMLECDIFGTCGPFALCTYRPTKICSCPPGFHRVD
. ... |.|.. .| | ..   |....  | . | | . .||. ..|||...|    . .|.| .||.   
NNSIYSRFTMSSEGYLQRFTWNPNSQD--WNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFVPKN
B_lectin IRAKg_r-2.AA B_lectin 279-307 30 0.321692 5.76 Pfam 68-92 (137) Show / Hide 
Range on Protein: 279-307
Range on HMM: 68-92/137
Sequence Identity: 30% (10 aa)

RLTLDDDGNLRIY----SFGPKNKSGSWSVVWQ
|... |.||| .|    .        | .|.||
RAQMQDSGNLVLYDDNND--------SNNVLWQ
PAN_AP IRAKg_r-2.AA PAN_AP 364-444 15 0.000128 22.59 SMART 1-85 (85) Show / Hide 
Range on Protein: 364-444
Range on HMM: 1-85/85
Sequence Identity: 15% (14 aa)

PNSVKLVQVNRADYYFNDYNFD------SSIKSLEKCKDTCMQDCKCLAAAYKYDGTGLCFLKGNSNKLYNGKQ-----TLNEMNMVFMKLS
..    | .... .    ..        .   ||| |.. | ..| | ...| .  |. | |  ....| . .|     ..........   
CCDDCFVRMPNMKL----FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN--TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKg_r-2.AA TKL 549-831 22 8.7e-65 221.55 In-house 1-364 (364) Show / Hide 
Range on Protein: 549-831
Range on HMM: 1-364/364
Sequence Identity: 22% (89 aa)

LGSGGFGSVYRGNIPE--------KGGIVAVKKITTVN----------------------------QAKKQFKAEVSTIGRVHHVNLVRLLGYCAEGDH-
.|||||| ||.|.           .|  |||||. . |                            ....... |.  . | .| |.|...||| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------HLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETRHSIALGIAKGLTYLHE----KCGER--IVHCDIKPQNVLLNESFR-------
            . .|.|..|.||| |.|               |. |...||.||.|. |||      |.    |.|.|.|..|.|..| ..       
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMY

-------PKVSDFGLARMMTKE-SMSITT------------------VQGTRGYLAPEWLESQ----------------SITPKADVYSFGMLLLDILGG
       .|..||||.|.|... .|. |                   . || ...||| |. |                . ..|.||||||..|  || .
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR

KRKALMELGSGDKEYENAPLPPPREWYFPIYAFHKYMTSELESVA----DPTLASGSVD----WGQFET---ALKIALSCIHQDPGSRPAMSRVVQIL
.|                  |   ..|.|.....     ... |.     |.. .   .    .    .     |..  | ..|| .|| .......|
CR------------------PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKg_r-2.AA IRAK 545-749 37 1e-55 191.44 In-house 1-225 (317) Show / Hide 
Range on Protein: 545-749
Range on HMM: 1-225/317
Sequence Identity: 37% (86 aa)

FRDE--LGSGGFGSVYRGNIPEKGGIVAVKKI-----TTVNQAKKQFKA---EVSTIGRVHHVNLVRLLGYCAEGDHHLLVYEFMPNGSLDHHLSASSSF
|  .  .|.|||| |||| .  ..||.||||.     .. |. ...| .   |. .  | .| |.| |.|||.|.. | |||..||||||   |..    
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWC----

AASQEIF--STWETRHSIALGIAKGLTYLHEKC-GERIVHCDIKPQNVLLNESFRPKVSDFGLARMM----TKESMSI-----TTVQGTRGYLAPEWLE-
 . |      .| .|.||..|.|.|. .||..  .  | | |||. |.|| . | || .||||.|       ||. ..      .|.||  |..|| .  
QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRD

-SQSITPKADVYSFGMLLLDILGGKRKAL
 .  .|.| ||||||  || .| | | ..
PQGQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAKg_r-2.AA Pkinase 549-745 29 1.5e-50 179.02 Pfam 7-209 (293) Show / Hide 
Range on Protein: 549-745
Range on HMM: 7-209/293
Sequence Identity: 29% (63 aa)

LGSGGFGSVYRGNIPEKGGIVAVKKITTVNQAKKQFKA-----EVSTIGRVHHVNLVRLLGYCAEGDHHLLVYEFMPNG----SLDHHLSASSSFAASQE
.|||.||.||..     | |||||.|  ... ... ..     |..   |..| | |||.... ..||  .| |....|    .| ...|.      ...
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST------WRH

IFS--TWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRP----KVSDFGLARMM-TKESMSITTVQGTRGYLAPEWLE-SQSITPKADV
     ....  .... |..|| |.|..   .|.|.|.||.|.|...   .    |..|||||. . .  .   ||. ||..|.|||..  .| ..||.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFGMLLLDILGGK
.|.| .|   | |.
WSCGCILYEMLCGR
Kinase IRAKg_r-2.AA Dicty4 544-742 33 4.3e-41 134.9 In-house 2-211 (277) Show / Hide 
Range on Protein: 544-742
Range on HMM: 2-211/277
Sequence Identity: 33% (72 aa)

NFRDELGSGGFGSVYRGNIPEKGGIVAVKKITTVNQAK-----KQFKAEVSTIGRVHHVNLVRLLGYCA----EGDHHLLVYEFMPNGSLDHHLSASSSF
|. ...|.|.||.||.|.   .| .|||||    ||       . |..||.  .   | |.. ..|.|     .    . | |.|| |.|   | .  | 
NIEQRIGKGSFGEVYKGTW--RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS-

AASQEIFSTWETRHS---IALGIAKGLTYLHE-KCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKESMSIT---TVQGTRGYLAPEWLESQSITP
   |.| . |... .   .|. .|.|...||.  .  .|.| |.|. | |  ...| ||.||||...| |...  .   |. || .. ||| . .|. . 
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP--VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

KADVYSFGMLLLDIL
||||||||..|  ||
KADVYSFGIVLWEIL
Kinase IRAKg_r-2.AA TKL-Unique 545-738 29 2.4e-40 140.02 In-house 1-218 (290) Show / Hide 
Range on Protein: 545-738
Range on HMM: 1-218/290
Sequence Identity: 29% (65 aa)

FRDELGSGGFGSVYRGNIPEKGGIVAVKKITT---VNQAKKQ-FKAEVSTIGRVH-HVNLVRLLGYCA----EGDHHLLVYEFMPNGSLDHHLS--ASSS
|   .|.||.|.||.|    .| .||.|..     ..  ..| |. ||... . | | |.|.. |||.       .  .| |..| |||. .|.     .
FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

FAASQEIFSTWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNES-----FRPKVSDFGLARMMTKE-SMSIT--------TVQGTRGYLAPEW
   ....  ... | ..|. ||.|. ||| . .  | |.|.|..|.|...      .. |..||||..  .|.  |...        |..|.  ..||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

LES--QSITPKADVYSFGMLL
|..    .. |.||||||. |
LRMNFCQYSEKSDVYSFGIVL
Kinase IRAKg_r-2.AA TK 543-738 16 3.5e-38 125.09 In-house 1-384 (486) Show / Hide 
Range on Protein: 543-738
Range on HMM: 1-384/486
Sequence Identity: 16% (63 aa)

DNFRDELGSGGFG---SVYRGNIPEKGG-------------------------IVAVKKITTV-NQAKKQFKA--------------EVSTIGRVH----
  . ..||.| ||    ||.|   ....                          |||| ..   ......|..              |.. .   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HVNLVRLLGYCAEG------------DHHLLVYEFMPNGS----LDHHLSASSSFAASQEI--------------------------------------
 | |.|||.|.| .|             . ..| |.||.|.    |...| ...  .  ..                                       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------FSTWETRHSIALGIAKGLTYLHEK----CGERIVHCDIKPQNVLLNESFR-----------PKVSDFG--
                              . | .... ... ||.|. |||.|       ..|| |.   |.|..|. .            |..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARMMTKESMSITTVQGTRGY--------------------------LAPEWLESQS---------ITPKADVYSFGMLL
      ||| . ...   .. ....|                           .||| |...           |.| ||.||| |.
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
Kinase IRAKg_r-2.AA Pkinase_Tyr 544-738 29 1.3e-37 128.04 Pfam 2-204 (270) Show / Hide 
Range on Protein: 544-738
Range on HMM: 2-204/270
Sequence Identity: 29% (62 aa)

NFRDELGSGGFGSVYRGNIP----EKGGIVAVKKI--TTVNQA--KKQFKAEVSTIGRV-HHVNLVRLLGYCA-EGDH--HLLVYEFMPNGSLDHHLSAS
 |  .||.| ||.||.|       ...  ||||..  ..  ..  .. | .|...     || |.|||.| |  .|..  ...| |.||.|.|...| . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

SSFAASQEIFSTWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKESMSITTVQG-----TRGYLAPEWLESQSIT
.    ... ... .   .... ||||. ||..|    ..| |.   |.|..|..  |..|||||| .....   ....|      . . ||| .     |
R---EDKQPLTMKD-LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGKFT

PKADVYSFGMLL
 | ||.||| |.
TKSDVWSFGVLM
Kinase IRAKg_r-2.AA S_TKc 543-830 22 1.3e-36 128.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 543-830
Range on HMM: 1-231/231
Sequence Identity: 22% (69 aa)

DNFRDELGSGGFGSVYRGNIPEKGGIVAVKKITTVNQAKKQFKAEVSTIGRVHHVNLVRLLGYCAEGDHHLLVYEFMPN--GSLDHHLSASSS------F
  . ...|.|.||.||..   . | |||.|.|       .... |..   . || |.|.|.... . ||  .| |....  |.| ...    .      |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

AASQEIFSTWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKESMSITTVQGTRGYLAPEWLESQSITP-KADVYS
   .  |        ..  |...| |.|..    |.|.|.||.|.||.|  . |..|||||| .       ||. ||. |.||| |   . .. |.|..|
PE-HARF--------YMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGMLLLDILGGKR-----KALMELGSGDKEYENAPLPPPREWYFPIYAFHKYMTSELESVADPTLASGSVDWGQFETALKIALSCIHQDPGSRPAMSRVV
.| .|   | |.      ......                                                   . |. .   | . ||  ||    . 
CGCILYEMLCGYPPFPQMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

Q----------I
|          .
QDEWDIKCHPWF
Kinase IRAKg_r-2.AA MLK 544-738 25 2.4e-36 123.6 In-house 2-226 (291) Show / Hide 
Range on Protein: 544-738
Range on HMM: 2-226/291
Sequence Identity: 25% (58 aa)

NFRDELGSGGFGSVYRGNIPEKG---GIVAVKKIT----TVNQA---KKQFKAEVSTIGRVHHVN----LVRLLGYCAE-GDHHLLVYEFMPNGSLDHHL
.|   .|||.||.|..|.   |     |||||...     . ..   ...|. |.    .. | |     ....| |.. . | ..| |....||| . |
QFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVL

SA-SSSFAAS-----QEIFSTWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNE------SFRPKVSDFGLARMMTKESMS-ITTVQGTRGYL
 . .|  ...       .  . .   ..|| .|.|. |||..    |.| |.|..|.|. |          |..|||..|....   .  .  .||  . 
HGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWM

APEWL---ESQSITPKADVYSFGMLL
||| .   ...  . |.||.|.|..|
APEVIQQFRCEKYSEKCDVWSWGVVL
Kinase IRAKg_r-2.AA LRRK 533-746 23 2.7e-33 115.11 In-house 1-281 (351) Show / Hide 
Range on Protein: 533-746
Range on HMM: 1-281/351
Sequence Identity: 23% (71 aa)

FTYRQLQDATDNFRDELGSGGFG-SVYRGNIP--------------------------EKGGIVAVKKITT-----------------------------
. . ..          .|.|||| .|||..                             ..  ||.||...                             
LKIEEQ----------IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDM

------VNQAKKQFKAEVSTIGRVHHVNLVRLLGYCAEGDHHLLVYEFMPNGSLDHHLSASS----SFAASQEIFS-TWETRHSIALGIAKGLTYLHEKC
         |   |  ||. . . .| |.| |.|.| .  .  .| |..|.|.|.|.|....    .|       . .| ... ||| ||||. ||| . 
DQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMK----AHISWMLKLKIALQIAKGMEYLHSH-

GER--IVHCDIKPQNVLLNESFRP------------KVSDFGLARMMTKESMS-ITTVQGTRGYLAPEWLESQ---SITPKADVYSFGMLLLDILGGK-R
  .  |.|.| |. |.||..|  .            |..|||. || .   |. . .. |. |..||| .      . | |.|.|||||.| ..| .. .
--NPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHH
Kinase IRAKg_r-2.AA TK-Unique 544-738 27 2.8e-30 101.65 In-house 2-229 (294) Show / Hide 
Range on Protein: 544-738
Range on HMM: 2-229/294
Sequence Identity: 27% (64 aa)

NFRDELGSGGFGSVYRGNIP------EKGGIVAVKKIT-TVNQA-KKQFKAEVSTIGRVH-HVNLVRLLGYCAEGD-HHLLVYEFMPNGSLDHHLSASSS
.. |..|.| || |.|| .       .|  .||||.    ...  |..|. | .    .  | |.|..||.| . |  .....|..|.|.|.|.|  .  
EVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRP

FAASQ-------EIFSTWETRHS-----------IALGIAKGLTYLHE--KCGERIVHCDIKPQNVLLNESFRPKVSDFGLAR--MMTKESMSITT-VQG
 . ..       ..| . . . .           .| .||.|. ||..  |   .||| |.   ||||.| .. |..|||.||  . ... .....    
AMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRK---KIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRI

TRGYLAPEWLE--SQSI-TPKADVYSFGMLL
   ..||| |    . . |.| ||.||| |.
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLM
Kinase IRAKg_r-2.AA TyrKc 543-831 23 9.3e-27 96.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 543-831
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

DNFRDELGSGGFGSVYRGNIPEKGGIVAVKKITTVNQAKKQFKAEVSTIGRV--HHVNLVRLLGYCAEG-------DHHLLVYEFMPNGSLDHHLSASSS
  . ..||.| || ||.|        ||||..      .. |  | .   ..  || |.|||.|.| ..       . ...| |.||.|.|...| ..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

FAASQEIFSTWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKE-----SMSITTVQ---GTRG-----YLAPEWL
         .... .|... ||.|  |||.|   ...| |.   |.|..| .. |.|||||.|  . .     | .  ...   |...      .||| .
K-------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

ESQSITPKADVYSFGMLLLDILGGKRKALMELGSGDKEYENAPLPPPREWY--FPIYAFHKYMTSE--LESVAD--PTLASGSVDWGQFETALKIALSCI
     |.| ||.||| .           . |.      . .   |.| .     . .  ..|  .   ..  ..  | ...     .  .   .| ..| 
NYGKFTTKSDVWSFGVC-----------MWEI------FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSF----VCCPDEMYQIMKQCW

HQDPGSRPAMSRVVQIL
| || .|| .| .....
HEDPEDRPTFSEIHECF
Kinase IRAKg_r-2.AA Dicty4-Unclassified 650-744 35 1.5e-20 67.05 In-house 114-204 (263) Show / Hide 
Range on Protein: 650-744
Range on HMM: 114-204/263
Sequence Identity: 35% (34 aa)

IALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKESMSITTVQGTRGYLAPEWLESQSITPKADVYSFGMLLLDILGG
.|. ||.|. .|| .    ..| |||  |.|.   |  |. |||..|  .      ||. ||    .|| |   | . |.||||..|.|   . |
YAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISR-VIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAKg_r-2.AA STE 650-745 29 1.2e-19 66.19 In-house 156-265 (359) Show / Hide 
Range on Protein: 650-745
Range on HMM: 156-265/359
Sequence Identity: 29% (35 aa)

IALGIAKG-LTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKE--------------SMSIT--TVQGTRGYLAPEWLES------QSIT
|.  | || | |||..    |.| ||||.|.||      | .|||..  .|..              .|.    |. ||  . ||| ..       .  .
ICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

PKADVYSFGMLLLDILGGK
 |.|..|.| ...  . ||
TKCDIWSLGCTIIEMATGK
Kinase IRAKg_r-2.AA STE 545-625 20 4.1e-13 42.78 In-house 1-125 (359) Show / Hide 
Range on Protein: 545-625
Range on HMM: 1-125/359
Sequence Identity: 20% (25 aa)

FRD--ELGSGGFGSVYRG---------NIPEK------GGIVAVKKITTVN------------------QAKKQFKAEVSTIGRVH--HVNLVRLLGYCA
...  ..|.|.||.||..            |.      | |.|.|..   |                  . ..|.. |...  . .  | | |. .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------DHHLLVYEFMPNGSLD
 .       |.  .. |.|..||||
KEGHNHKNDDELWICMEYMDGGSLD
Kinase IRAKg_r-2.AA Dicty4-Unclassified 544-624 34 4.2e-10 30.77 In-house 2-89 (263) Show / Hide 
Range on Protein: 544-624
Range on HMM: 2-89/263
Sequence Identity: 34% (31 aa)

NFRDELGSGGFGSVYRGNIPEKGGIVAVKKITTVNQAKK-----QFKAEVSTIGRVHHVNLVRLLGYCAEG----DHHLLVYEFMPNGSL
    ..| | |  |..||   ||  |||||.              ||.||   | . | |||.. |||            | |||. | |
QIDQFIGKGHFSKVHKGNW--KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNL
Kinase IRAKg_r-2.AA MLK 813-831 47 0.000129 12.08 In-house 273-291 (291) Show / Hide 
Range on Protein: 813-831
Range on HMM: 273-291/291
Sequence Identity: 47% (9 aa)

CIHQDPGSRPAMSRVVQIL
| .|||..|| .. .||.|
CWNQDPHKRPSFRQIVQHL
Kinase IRAKg_r-2.AA TK 809-831 34 0.000219 9.77 In-house 464-486 (486) Show / Hide 
Range on Protein: 809-831
Range on HMM: 464-486/486
Sequence Identity: 34% (8 aa)

IALSCIHQDPGSRPAMSRVVQIL
. ..| | ||  || .| ... |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKg_r-2.AA LRRK 812-833 36 0.000504 10.11 In-house 330-351 (351) Show / Hide 
Range on Protein: 812-833
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

SCIHQDPGSRPAMSRVVQILEG
.| ..|| .|| .| .|..|. 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_r-2.AA Dicty4-Unclassified 813-831 47 0.000953 8.67 In-house 245-263 (263) Show / Hide 
Range on Protein: 813-831
Range on HMM: 245-263/263
Sequence Identity: 47% (9 aa)

CIHQDPGSRPAMSRVVQIL
| | ||  || |  ..| |
CWHNDPNKRPTMNQIIQYL
Kinase IRAKg_r-2.AA Dicty4 813-833 34 0.002216 7.33 In-house 255-277 (277) Show / Hide 
Range on Protein: 813-833
Range on HMM: 255-277/277
Sequence Identity: 34% (8 aa)

CIHQDPGSRPAMSRVVQI--LEG
| . || .|| .. ..|.  || 
CWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKg_r-2.AA TK-Unique 812-831 30 0.007749 5.76 In-house 275-294 (294) Show / Hide 
Range on Protein: 812-831
Range on HMM: 275-294/294
Sequence Identity: 30% (6 aa)

SCIHQDPGSRPAMSRVVQIL
||.. .| .||  . ....|
SCWQWEPEERPSFRQIKHRL
Kinase IRAKg_r-2.AA Pkinase_Tyr 811-831 38 0.014707 9.29 Pfam 250-270 (270) Show / Hide 
Range on Protein: 811-831
Range on HMM: 250-270/270
Sequence Identity: 38% (8 aa)

LSCIHQDPGSRPAMSRVVQIL
..| |.||  || .| ....|
KQCWHYDPEDRPTFSEIHEQL