Gene IRAKg_h (S.moellendorffii)

IRAKg_h

Species: S.moellendorffii
Alias: IRAKg_h
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_h.AA Protein None 659 None Fasta, JSON
IRAKg_h.NA RNA None 1980 None Fasta, JSON
IRAKg_h.kin_dom Protein Kinase Domain None 113 None Fasta, JSON

Protein domain

Protein domains of IRAKg_h.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_h.AA B_lectin 77-168 35 7.3e-20 69.83 Pfam 1-109 (137) Show / Hide 
Range on Protein: 77-168
Range on HMM: 1-109/137
Sequence Identity: 35% (39 aa)

PNTVVWSAMSNDTGGFPI-GLI--KGDQLVFQT-DGRLVLTSNAAG--I--IWGT--STSTLG---VTKALLQENGNLQLLT-SN--GVPVWQS--FDRP
. ||||.|  .  .| |. .     . .|..|. || |||. ...|  .  .| |  .||. |    . | .|..||| |.. .|  . ..|||  || |
NQTVVWVANRDL-TGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHP

TDTILPDQQL
|||.|| . |
TDTWLPGMKL
B_lectin IRAKg_h.AA B_lectin 36-158 26 7.9e-16 59.82 SMART 1-126 (126) Show / Hide 
Range on Protein: 36-158
Range on HMM: 1-126/126
Sequence Identity: 26% (36 aa)

NVRGEDPQTWITSPNATFS--TGFSHLNPKSPLYSFSIWYTKM---PNTVVWSAMSNDTGGFPIGLIKG----DQLVFQTDGRLVLTSNAAGIIWGTSTS
.    . || . |.| .|.   ||  ...       .||| ..   . ||||.|    ..    .. ..      |..|.|| ||.      ..| ..|.
DNTLSSGQT-LVSGNSLFEFYLGFFTFIMQ---WCNGIWYKNISNKQRTVVWVAQP-NRD----NPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTT

-TLGVTKALLQENGNLQLLTSN----GVPVWQSFDRP
 . |.. | ||..||. .  ..    |  .||||| |
RNNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_h.AA S_locus_glycop 263-325 31 3.9e-14 50.75 Pfam 55-117 (117) Show / Hide 
Range on Protein: 263-325
Range on HMM: 55-117/117
Sequence Identity: 31% (20 aa)

RLTLDDDGNLRIYTLDEIKKRWIITWQAVLLECDIFGKCGRFGICAYRPTATCICPPGFHPTN
|.|.. .| | ..|  .  ..|.  | |   .||. . ||..|.|    . .| | .||.| |
RFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFVPKN
B_lectin IRAKg_h.AA B_lectin 263-275 50 9.933461 0.64 Pfam 27-40 (137) Show / Hide 
Range on Protein: 263-275
Range on HMM: 27-40/137
Sequence Identity: 50% (7 aa)

RLTLDD-DGNLRIY
.||... |||| .|
TLTMQNRDGNLVLY
Kinase IRAKg_h.AA TKL 502-557 34 7.8e-19 64.46 In-house 131-205 (364) Show / Hide 
Range on Protein: 502-557
Range on HMM: 131-205/364
Sequence Identity: 34% (26 aa)

WASRFNIALGIARGITYLHDEC-----QECILHCDIKPQNILLDESFC--------------PKVADFGLAKLMK
|  |...||.||||. ||| .         |.|.|.|..|||.|| .               .|..||||.. |.
WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMS
Kinase IRAKg_h.AA IRAK 502-553 49 1.5e-17 58.93 In-house 108-160 (317) Show / Hide 
Range on Protein: 502-553
Range on HMM: 108-160/317
Sequence Identity: 49% (26 aa)

WASRFNIALGIARGITYLHDEC-QECILHCDIKPQNILLDESFCPKVADFGLA
|  |. |..|.|.|| .||.      | | |||. |||||. | || .||||.
WHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLH
Kinase IRAKg_h.AA Pkinase_Tyr 442-504 39 1.8e-16 56.42 Pfam 2-74 (270) Show / Hide 
Range on Protein: 442-504
Range on HMM: 2-74/270
Sequence Identity: 39% (29 aa)

NFCDKLGSGGFGTVYKGRLP-----NGTLVAVKEL-EIAMQAD---KQFQAEVKTLGKI-HHINLVRLLGWAS
 |  |||.| ||.||||..      ... |||| | | ||. .   . | .|.|.. .. || |.|||.|  .
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT
Kinase IRAKg_h.AA Dicty4 508-563 41 3.7e-15 47.17 In-house 117-171 (277) Show / Hide 
Range on Protein: 508-563
Range on HMM: 117-171/277
Sequence Identity: 41% (23 aa)

IALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALK
.|. .|||...|| .|   |.| |.|. |.| |...  ||.||||...||..  .|
MAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHK
Kinase IRAKg_h.AA LISK 500-560 41 3.6e-14 42.22 In-house 98-159 (296) Show / Hide 
Range on Protein: 500-560
Range on HMM: 98-159/296
Sequence Identity: 41% (27 aa)

LGWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDES----FCPKVADFGLAKLMKRER
| |  | .|||.||.| .|||.    .|.| | | .|.|..|.    .  ||.|||.|..|  |.
LPWPQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCEN
Kinase IRAKg_h.AA TyrKc 441-628 17 3.1e-13 -8.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 441-628
Range on HMM: 1-280/280
Sequence Identity: 17% (49 aa)

DNFCDKLGSGGFGTVYKGRLPNGTLVAVKELE-IAMQADKQFQAEVKTLGKI--HHINLVRLLGWASRF-------------------------------
  . .|||.| ||.||||..   . |||| |   |    . |  | . . |.  || |.|||.| ..                                 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

--------NIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRE-------RALKN----NRW-----------CLSDWAYN-
        .... ||.|  |||.    .. | |.   |.|..| .. |..||||..  . .          .     ..            |. .  .. 
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

-------------------MYQAG---------DLESIVDKKLVQEEVNVV-------QFKRLLKVALWCIQHDANARPSMGKVVQMM
                   .   |         ..   |..    .    .         . . .. ..| ..|.. ||..  ... .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKg_h.AA TKL 447-501 22 3.7e-13 43.74 In-house 1-92 (364) Show / Hide 
Range on Protein: 447-501
Range on HMM: 1-92/364
Sequence Identity: 22% (21 aa)

LGSGGFGTVYKGRLPN---------GTLVAVKELEI----------------------------AMQADKQFQAEVKTLGKIHHINLVRLLG
.||||||.||||.. .         |. |||| . .                            |... ...  |.. . ...| |.|...|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMG
Kinase IRAKg_h.AA TKL-Unique 505-566 34 1.1e-12 41.17 In-house 112-177 (290) Show / Hide 
Range on Protein: 505-566
Range on HMM: 112-177/290
Sequence Identity: 34% (23 aa)

RFNIALGIARGITYLHDECQECILHCDIKPQNILLDES-----FCPKVADFGLAKLMKRERALKNNR
| ..|. ||.|  ||| .    |.|.|.|..|.|.|.      .  |..||||.|. ... . .||.
RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNE
Kinase IRAKg_h.AA IRAK 439-501 31 1.7e-12 40.75 In-house 1-70 (317) Show / Hide 
Range on Protein: 439-501
Range on HMM: 1-70/317
Sequence Identity: 31% (23 aa)

FTDNFCDKLGSGGFGTVYKGRLPNGT-LVAVK------ELEIAMQADKQFQA---EVKTLGKIHHINLVRLLG
|  ..  ..|.||||.||.|.. | |  .|||      .... .  ...||.   |.|.. ...| |.| |.|
FHKDN--RIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNE-HWQRFQQSYNELKVCCRCRHPNIVPLYG
Kinase IRAKg_h.AA Pkinase 507-566 35 1.9e-12 45.11 Pfam 112-167 (293) Show / Hide 
Range on Protein: 507-566
Range on HMM: 112-167/293
Sequence Identity: 35% (23 aa)

NIALGIARGITYLHDECQECILHCDIKPQNILLDESFCP----KVADFGLAKLMKRERALKNNR
.... |.||. |.|..    |.|.|.||.|||.|.   .    |..||||||...    . ||.
FYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS
Kinase IRAKg_h.AA MLK 503-554 37 2.8e-12 39.0 In-house 124-181 (291) Show / Hide 
Range on Protein: 503-554
Range on HMM: 124-181/291
Sequence Identity: 37% (22 aa)

ASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDE------SFCPKVADFGLAK
.. .|.|| .|||. ||| . .  | | |.|..|||.||          |..|||...
DHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase IRAKg_h.AA ULK 445-502 25 1e-11 37.92 In-house 5-83 (324) Show / Hide 
Range on Protein: 445-502
Range on HMM: 5-83/324
Sequence Identity: 25% (20 aa)

DKLGSGGFG-TVYKGR-LPN---GTLVAVKELE---IAMQADK--------QFQAEVKTLGKIH---HIN--LVRLLGW
..||.| || .|||||   .   . .||.|  .   . ..  .        ... |.... |..   | |   |.|. |
HCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDW
Kinase IRAKg_h.AA ULK 527-554 42 1.3e-11 36.86 In-house 151-190 (329) Show / Hide 
Range on Protein: 527-554
Range on HMM: 151-190/329
Sequence Identity: 42% (17 aa)

ILHCDIKPQNILLDESF------------CPKVADFGLAK
| |.||||||||... .            . |.||||.||
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK
Kinase IRAKg_h.AA ULK 527-554 42 2.9e-11 36.26 In-house 147-186 (324) Show / Hide 
Range on Protein: 527-554
Range on HMM: 147-186/324
Sequence Identity: 42% (17 aa)

ILHCDIKPQNILLDESF------------CPKVADFGLAK
| |.||||||||. . .            . |.||||.||
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK
Kinase IRAKg_h.AA S_TKc 441-632 20 3.8e-11 -13.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 441-632
Range on HMM: 1-231/231
Sequence Identity: 20% (52 aa)

DNFCDKLGSGGFGTVYKGRLPN-GTLVAVKELEIAMQADKQFQAEVKTLGKIHHINLVRLLGWAS--RFNIALGIARG-----ITYLHDEC---------
  . .|.|.|.||.|||.|  . | .||.|..       .... |.. | | || |.|.|...    .. . .  . |      .|...           
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

------------------QECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALKNNRW----------C-LSDW------AYNMYQ-----AGDLE
                  .  |.|.|.||.||||||  . |..|||||...   . .   .|          .  .||       | |.        ...
EHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP-QMQ

SIVDKKLVQEEVNVVQFKRLLKVALWCIQHDANARPSMGKVVQ-----MMEDIV
 . .| .          . ..     | | | . ||.  .. |     ..   .
MMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_h.AA RAF 506-559 35 5.2e-11 31.62 In-house 106-156 (282) Show / Hide 
Range on Protein: 506-559
Range on HMM: 106-156/282
Sequence Identity: 35% (19 aa)

FNIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRE
..|.. .. |  |||   .  |.| |.| .||.|.|    |. ||||... .|.
IDISRQVCQGMDYLH---AKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRW
Kinase IRAKg_h.AA CAMK 446-502 14 5.6e-11 30.87 In-house 1-106 (425) Show / Hide 
Range on Protein: 446-502
Range on HMM: 1-106/425
Sequence Identity: 14% (15 aa)

KLGSGGFGTVYKGRLP-NG------------TLVAVKELEIA-----------------------------MQADKQFQAEVKTLGK-------IHHINL
.||.|.||.|....   ..            . ||.| ..                                .  |... |.. . |       ..| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLLGW
..|. .
IKLYEV
Kinase IRAKg_h.AA ULK 445-502 26 1.2e-10 33.46 In-house 5-86 (329) Show / Hide 
Range on Protein: 445-502
Range on HMM: 5-86/329
Sequence Identity: 26% (22 aa)

DKLGSGGFGTVYKGR-LPN----GTLVAVKELEIA-MQADK----------QFQAEVKTLGKIH----HIN----LVRLLGW
..||.| ||.|||||   .    . .||.| ...  |. ..          ... |.|.. |..    |.|     |.|. |
HCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDW
Kinase IRAKg_h.AA CAMK 527-558 30 1.4e-10 29.58 In-house 200-248 (425) Show / Hide 
Range on Protein: 527-558
Range on HMM: 200-248/425
Sequence Identity: 30% (15 aa)

ILHCDIKPQNILLDES-----------------FCPKVADFGLAKLMKR
| |.|.|| |||||..                 .  |..|||.|. ...
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDP
Kinase IRAKg_h.AA TKL-Unique 443-502 36 1.8e-10 33.29 In-house 1-64 (290) Show / Hide 
Range on Protein: 443-502
Range on HMM: 1-64/290
Sequence Identity: 36% (24 aa)

FCDKLGSGGFGTVYKGRLPNGTLVAVKELEI-AMQADK--Q-FQAEVKTLGKIH-HINLVRLLGW
|  |.|.||.|.||||   .|. ||.| ... . .  .  | |  ||... |.| |.|.|.. |.
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGY
Kinase IRAKg_h.AA LISK 446-498 28 1.9e-10 29.96 In-house 1-60 (296) Show / Hide 
Range on Protein: 446-498
Range on HMM: 1-60/296
Sequence Identity: 28% (17 aa)

KLGSGGFGTVYKGRLP-NGTLVAVKELEI------AMQADKQFQAEVKTLGKIHHINLVR
..|.|.|| ||||..   |. .|.|....         . | .. ||... .. | | |.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQ
Kinase IRAKg_h.AA RAF 442-505 35 1.3e-09 27.01 In-house 2-69 (282) Show / Hide 
Range on Protein: 442-505
Range on HMM: 2-69/282
Sequence Identity: 35% (25 aa)

NFCDKLGSGGFGTVYKGRLPNGTLVAVKELEIAMQADKQFQA------EVKTLGKIHHINLVRLLGWASR
    . ||| |||||.|.   |. |||| | ..    .|.||      ||  . |  |.| .  .|. |.
MVMTRIGSGSFGTVYRGHW-HGD-VAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSK
Kinase IRAKg_h.AA MLK 442-501 28 8.7e-09 26.75 In-house 2-76 (291) Show / Hide 
Range on Protein: 442-501
Range on HMM: 2-76/291
Sequence Identity: 28% (21 aa)

NFCDKLGSGGFGTVYKGRLPNGT----LVAVKELEI---AMQA----DKQFQAEVKTLGKIHHIN----LVRLLG
.|  ..|||.|| |.|||  | .     ||||. ..   ...     ...|. |.. | .. | |     ....|
QFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYG
Kinase IRAKg_h.AA Dicty4 442-501 36 3e-08 23.81 In-house 2-65 (277) Show / Hide 
Range on Protein: 442-501
Range on HMM: 2-65/277
Sequence Identity: 36% (24 aa)

NFCDKLGSGGFGTVYKGRLPNGTLVAVKELEIAMQAD-----KQFQAEVKTLGKIHHINLVRLLG
|. ...|.|.||.||||.   |. |||| |    | .     . | .||. ..|| | |.. ..|
NIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMG
Kinase IRAKg_h.AA Pkinase 446-502 33 3.6e-08 29.95 Pfam 6-68 (293) Show / Hide 
Range on Protein: 446-502
Range on HMM: 6-68/293
Sequence Identity: 33% (21 aa)

KLGSGGFGTVYKGRLPNG-TLVAVKELEIAMQADKQFQA-----EVKTLGKIHHINLVRLLGW
|.|||.||.|||..  .   .||||...   . ... |.     |.. . ...| | |||..|
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDW
Kinase IRAKg_h.AA TKL 601-628 25 0.000138 12.45 In-house 337-364 (364) Show / Hide 
Range on Protein: 601-628
Range on HMM: 337-364/364
Sequence Identity: 25% (7 aa)

KRLLKVALWCIQHDANARPSMGKVVQMM
... | . .| .||...|||. .... .
PSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKg_h.AA Pkinase_Tyr 507-556 32 0.003853 11.26 Pfam 115-161 (270) Show / Hide 
Range on Protein: 507-556
Range on HMM: 115-161/270
Sequence Identity: 32% (16 aa)

NIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLM
.... ||.|  ||..     . | |.   |.|..|... |..|||||...
QMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase IRAKg_h.AA RAF 601-630 13 0.013359 3.91 In-house 253-282 (282) Show / Hide 
Range on Protein: 601-630
Range on HMM: 253-282/282
Sequence Identity: 13% (4 aa)

KRLLKVALWCIQHDANARPSMGKVVQMMED
| . . .. |.. . . ||. ........ 
KAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase IRAKg_h.AA IRAK 601-628 35 0.02597 4.2 In-house 290-317 (317) Show / Hide 
Range on Protein: 601-628
Range on HMM: 290-317/317
Sequence Identity: 35% (10 aa)

KRLLKVALWCIQHDANARPSMGKVVQMM
| .. .|. |  | || |..| .|.| .
KEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAKg_h.AA LISK 603-628 30 0.026662 3.05 In-house 271-296 (296) Show / Hide 
Range on Protein: 603-628
Range on HMM: 271-296/296
Sequence Identity: 30% (8 aa)

LLKVALWCIQHDANARPSMGKVVQMM
.|.....|.  | . |||  ..||  
FLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAKg_h.AA Dicty4 609-630 37 0.04906 2.78 In-house 254-277 (277) Show / Hide 
Range on Protein: 609-630
Range on HMM: 254-277/277
Sequence Identity: 37% (9 aa)

WCIQHDANARPSMGKVVQM--MED
||  || . |||.  ..|   .| 
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKg_h.AA Pkinase_Tyr 608-628 19 0.969059 3.13 Pfam 250-270 (270) Show / Hide 
Range on Protein: 608-628
Range on HMM: 250-270/270
Sequence Identity: 19% (4 aa)

LWCIQHDANARPSMGKVVQMM
. | ..|.. ||..  .....
KQCWHYDPEDRPTFSEIHEQL