Gene IRAKg_u-2 (S.moellendorffii)

IRAKg_u-2

Species: S.moellendorffii
Alias: IRAKg_u-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_u-2.AA Protein None 814 None Fasta, JSON
IRAKg_u-2.NA RNA None 2445 None Fasta, JSON
IRAKg_u-2.kin_dom Protein Kinase Domain None 191 None Fasta, JSON

Protein domain

Protein domains of IRAKg_u-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_u-2.AA B_lectin 122-162 42 1.3e-14 51.79 Pfam 67-113 (137) Show / Hide 
Range on Protein: 122-162
Range on HMM: 67-113/137
Sequence Identity: 42% (20 aa)

ATASLEETGNFVLL-DRS--SDRIWQS--FDFPTDTLLPGQELRG-N
..| . ..||.||. | .  .. .|||  ||.||||.|||. |.  |
CRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPTDTWLPGMKLGWDN
B_lectin IRAKg_u-2.AA B_lectin 25-149 25 3e-06 20.15 SMART 1-126 (126) Show / Hide 
Range on Protein: 25-149
Range on HMM: 1-126/126
Sequence Identity: 25% (35 aa)

DKLGARQPPWMSLNNTFA--FGFHTSDGIGELFTLAIWHQSTG----TVVWEA---TEALIKNGSTTEKPKIKVGKTGELELKETGLIVTDKSMTVWLVR
| .      . | | .|   .||.| ..    ... ||. .      |||| |   .. . ..|  .   . . .. |.| .            .||   
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ---WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDG--NNSCYLTMQSDGNLVIYD--------NRPVWSSN

CE-NCSIATASLEETGNFVLLDRS-SDR---IWQSFDFP
.  | .  .| | ..||||. | . .|    ||||||.|
TTRNNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_u-2.AA S_locus_glycop 247-315 23 4e-09 33.41 Pfam 49-117 (117) Show / Hide 
Range on Protein: 247-315
Range on HMM: 49-117/117
Sequence Identity: 23% (16 aa)

DTSVTRRLTLEKNGTLRSYSCGSREKRWRVVWQSALLECEVFGTCGAFGLCGYKPRKSCSCPPGFYAVD
..|.  |.|.  .|.|  .    . ..|.. | .   .|.. ..||..|.|  .    |.| .||    
NNSIYSRFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFVPKN
PAN_AP IRAKg_u-2.AA PAN_AP 337-417 17 0.000342 19.68 SMART 1-85 (85) Show / Hide 
Range on Protein: 337-417
Range on HMM: 1-85/85
Sequence Identity: 17% (16 aa)

SSASKMVEVQRAMYVGNLLQQ----LSKDPISLEQCKVSCLKDCRCLGATYMLAGTKRCSLLGGEDGRLFNGV-------QAMERASIALLK
..   .| . .. .     ..    . .  .|||.|.  ||..|.| ...|    || | |   .|..|..         ..... ..   .
CCDDCFVRMPNMKL---FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN--TKGCHLWS-WDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKg_u-2.AA TKL 521-774 21 5e-61 209.07 In-house 1-364 (364) Show / Hide 
Range on Protein: 521-774
Range on HMM: 1-364/364
Sequence Identity: 21% (79 aa)

LGAGGFGSVYKGVLPD---------MTVVAVKTLEG---------------------------AASHGEKQFKAEVATLGRVHHVNLVKLLGYCAEGSH-
.| |||| ||||..            ..||||..                              ||. ..... |.  . | .| |.|...||| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFLSNGSLDQECIDLWGTRYSIALGVAKGITYLHEECY-----DCVLHCDIKPQNVLLDENFC--------------PKVSDF
              .|.|. ..|||    .  |  | ..||..|.|. ||| .         ..|.|.|..|.|.|||.               .|..||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDF

GLAKLIDKE------------------RALDVTTIRGTRGYMAPEWVGDR----------------PITSKVDVYSYGMVLLELLSGNDKSRIGQNRYFP
||.. ....                  ..    |..|| ..||||   .                 . . |.||||.|.|| |.|..          |. 
GLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------PYYD

VWAFQKYVA----GELHAIADPGLKNLEW-------------NEFERMIKVAFWCIQLDARSRPSMSRVVQML
 . .. ...     ..  ..| ||. .               .  ..|.| . .| . |...|||...... |
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKg_u-2.AA IRAK 516-705 37 4e-50 172.85 In-house 2-220 (317) Show / Hide 
Range on Protein: 516-705
Range on HMM: 2-220/317
Sequence Identity: 37% (82 aa)

HFSCKLGAGGFGSVYKGVLPDMT-VVAVKTLEGAAS----HGEKQFKA---EVATLGRVHHVNLVKLLGYCAEGSHRLLVYEFLSNGSLDQ--ECID---
| . ..| |||| ||.|..   | ..||| |   |.      ...| .   |. .. | .| |.| |.|||.|..   |||....||||    .| |   
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

-L----WGTRYSIALGVAKGITYLHEEC-YDCVLHCDIKPQNVLLDENFCPKVSDFGLAKLI----DKERALD----VTTIRGTRGYMAPEWVG--DRPI
 .    | .| ||..| |.|| .||.      . | |||. |.|||..| || .||||.       .||..      . ..|||  ||.||      . .
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

TSKVDVYSYGMVLLELLSG
| |.|||| | ||||.|.|
TKKTDVYSFGIVLLEVLTG
Kinase IRAKg_u-2.AA Pkinase 515-774 23 1.7e-47 168.88 Pfam 1-293 (293) Show / Hide 
Range on Protein: 515-774
Range on HMM: 1-293/293
Sequence Identity: 23% (73 aa)

NHFSCKLGAGGFGSVYKGVLPDMTV-VAVKTLEGAASHGEKQFKA-----EVATLGRVHHVNLVKLLGYCAEGSHRLLVYEFLSNG----SLD-------
 |.  |.|.|.||.|||..  .    ||||...   .  ... ..     |.. . |..| | |.|.... ...|  .| |.. .|    .|        
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QECI--DLWGTRYSIALGVAKGITYLHEECYDCVLHCDIKPQNVLLDENFCP----KVSDFGLAKLIDKERALDVTTIRGTRGYMAPEWVG-DRPITSKV
. |.  . |  . .... ...|. |.|..    ..|.|.||.|.|.|.|  .    |..||||||..|  .    ||. ||..|||||..  ......||
HGCFYFSEWECK-FYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSYGMVLLELLSGNDKSRIGQNRYFPVWAFQK----YVAGELHAIADPGLKNLEWNEF-----------------------ERMIKVAFWCIQLDARS
|..|.| .| |.|.|.           | .  ..      . ... |.  . . |.....                       | ....  ||...|  .
DMWSCGCILYEMLCGR-----------PPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RPSMSRVVQM--L
||.   ..|   .
RPTAEQILQHPWF
Kinase IRAKg_u-2.AA TKL-Unique 517-705 28 9.5e-38 130.74 In-house 1-224 (290) Show / Hide 
Range on Protein: 517-705
Range on HMM: 1-224/290
Sequence Identity: 28% (65 aa)

FSCKLGAGGFGSVYKGVLPDMTVVAVKTLE-GAASHGE--KQFKAEVATLGRVH-HVNLVKLLGYCA----EGSHRLLVYEFLSNGSLDQECID------
|. |.|.||.|.||||. .  . ||.|...  . |. |  . |. || .. . | | |.|.. |||.      ... .| |... |||. . ..      
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLY-DVLHQNNNNN

---------LWGTRYSIALGVAKGITYLHEECYDCVLHCDIKPQNVLLDEN-----FCPKVSDFGLAKLIDKERALDVTTI--------RGTRGYMAPEW
          .  |...|. .|.|  ||| .    ..|.|.|..|.|.|.|     .  |..||||.|. .|. .  ....         |.  .|||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

VGD--RPITSKVDVYSYGMVLLELLSG
  .    .. |.||||.|.|| |....
LRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKg_u-2.AA Dicty4 516-703 30 2.2e-34 112.17 In-house 2-211 (277) Show / Hide 
Range on Protein: 516-703
Range on HMM: 2-211/277
Sequence Identity: 30% (66 aa)

HFSCKLGAGGFGSVYKGVLPDMTVVAVKTL----EGAASHGEKQFKAEVATLGRVHHVNLVKLLGYCA----EGSHRLLVYEFLSNGSL-----D-----
 .  ..| |.||.||||     . |||| |    ... .   . |..||. ..   | |.....|.|     . .  . | |... |.|     |     
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

QECIDL-WGTRYS---IALGVAKGITYLHE-ECYDCVLHCDIKPQNVLLDENFCPKVSDFGLAKLIDKERALDV--TTIRGTRGYMAPEWVGDRPITSKV
|. | | |... .   .|. .|.|...||.  .   ..| |.|. | | |.|.  ||.||||.... |.  .    .|  || ..||||    .| ..|.
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP--VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSYGMVLLELL
||||.|.|| |.|
DVYSFGIVLWEIL
Kinase IRAKg_u-2.AA MLK 515-705 25 3.5e-34 116.01 In-house 1-232 (291) Show / Hide 
Range on Protein: 515-705
Range on HMM: 1-232/291
Sequence Identity: 25% (59 aa)

NHFSCKLGAGGFGSVYKGVLPDMT----VVAVKTLE------GAASHGEKQFKAEVATLGRVHHVN----LVKLLGYCAE-GSHRLLVYEFLSNGSLDQE
  |. ..|.|.||.|.||.   ..    .||||  .      . ..   ..|. |.  | .. | |     ....| |.. ..| ..| |....|||   
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

C-------------------IDLWGTRYSIALGVAKGITYLHEECYDCVLHCDIKPQNVLLDE------NFCPKVSDFGLAKLIDKERALDVTTIRGTRG
.                   .|. .   ..|| .|.|. |||..  . . | |.|..|.|.||      .   |..|||... . .      .  .||  
LHGARSKWMDANHNQKNDRVYDH-DHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YMAPEWV---GDRPITSKVDVYSYGMVLLELLSG
.||||        . . |.||.|.|.|| |.|..
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAKg_u-2.AA S_TKc 515-774 21 2.3e-31 111.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 515-774
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

NHFSCKLGAGGFGSVYKGVLPD-MTVVAVKTLEGAASHGEKQFKAEVATLGRVHHVNLVKLLGYCAEGSHRLLVYEFLSN--GSLDQECIDLWG------
 ..  |.| |.||.|||..  .   .||.| .        .... |.. | . || |.|||.... . .|  .| |....  |.| .   .  .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

---TRYSIALGVAKGITYLHEECYDCVLHCDIKPQNVLLDENFCPKVSDFGLAKLIDKERALDVTTIRGTRGYMAPEWVGDRPITS-KVDVYSYGMVLLE
   .  ...  ..... |.|.     ..|.|.||.|.||||  . |..|||||...        ||. ||. ||||| .   . .  |.|..| | .| |
FPEHARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLS-----GNDKSRIGQNRYFPVWAFQKYVAGELHAIADPGLKNLEWNEFERMIKVAFWCIQLDARSRPSMSRVVQ---------ML
.|.       .  .. ..                                . ..     | | | . ||.   . |          .
MLCGYPPFP-QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_u-2.AA TK 515-704 16 1.8e-29 95.39 In-house 1-389 (486) Show / Hide 
Range on Protein: 515-704
Range on HMM: 1-389/486
Sequence Identity: 16% (65 aa)

NHFSCKLGAGGFG---SVYKGVLPDM--------------------------TVVAVKTLEGAASHGEKQFKA--------------EVATLGRVH----
 ..  |||.| ||    |||| . ..                          | ||||.|   ... ...|..              |.. .   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HVNLVKLLGYCAEG------------SHRLLVYEFLSNGS----LD---QECI----------------------------------------------
 | |.|.|.|.| .|             . ..| |. ..|.    |.   ..|                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------DLWG----------------TRYSIALGVAKGITYLHEE----CYDCVLHCDIKPQNVLLDENFC-----------PKVSDFG--
               ||.                 ..  ... .|.|  |||.         . | |.   |.|..||              |..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAKLIDKERALDVTTIRGTRG-------------------------YMAPEWVGDRP---------ITSKVDVYSYGMVLLELLS
      ||. |...    ... .||..                         .|||| . ||           |.| ||.|.| .. |...
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKg_u-2.AA Pkinase_Tyr 516-704 29 2.5e-29 99.98 Pfam 2-209 (270) Show / Hide 
Range on Protein: 516-704
Range on HMM: 2-209/270
Sequence Identity: 29% (62 aa)

HFSCKLGAGGFGSVYKGVLP-----DMTVVAVKTLEGAASHGE---KQFKAEVATLGRV-HHVNLVKLLGYCA-EGSH--RLLVYEFLSNGSLD------
.|  |||.| ||.||||..      . . ||||.|   |.| .   . | .|....    || |.|.|.| |  .| .   ..| |.  .|.|.      
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

---QECIDLWGTRYSIALGVAKGITYLHEECYDCVLHCDIKPQNVLLDENFCPKVSDFGLAKLIDKERALDVTTIRGTRG---YMAPEWVGDRPITSKVD
   .. ...     .... .|||  ||..       | |.   |.|..||.. |..|||||..| ..    ...  |..     ||||   ..  |.| |
REDKQPLTMKD-LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

VYSYGMVLLELLS
|.|.| .. |...
VWSFGVLMWEIFT
Kinase IRAKg_u-2.AA LISK 520-702 27 7.4e-29 90.73 In-house 1-232 (296) Show / Hide 
Range on Protein: 520-702
Range on HMM: 1-232/296
Sequence Identity: 27% (65 aa)

KLGAGGFGSVYKGVLP-DMTVVAVKTLEG-----AASHGEKQFKAEVATLGRVHHVNLVKLLGYCAE-GSHRLLVYEFLSNGSLDQECIDL--------W
..| |.||.|||| .  . .|.|.| ..           .| .. ||... .  | | |.  | | .  ..  .| |. . | | |   |         |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

GTRYSIALGVAKGITYLHEECYDCVLHCDIKPQNVLLDEN----FCPKVSDFGLAKLIDKER---------------------------------ALDVT
  | .|||..|.| .|||.    ...| | | .|.|..||    .  || |||.|...|.|.                                 .    
PQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

TIRGTRGYMAPEWVGDRPITSKVDVYSYGMVLLEL
|| ||   |||| . ..  . ..||.|.|.||.|.
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEI
Kinase IRAKg_u-2.AA Dicty4-Unclassified 516-706 34 8.9e-29 95.66 In-house 2-205 (263) Show / Hide 
Range on Protein: 516-706
Range on HMM: 2-205/263
Sequence Identity: 34% (73 aa)

HFSCKLGAGGFGSVYKGVLPDMTVVAVKTL-EGAASHG---EKQFKAEVATLGRVHHVNLVKLLGYCAEG-SHR---LLVYEFLSNGSL----------D
     .| | |  |.||.      |||| . |.  .      . ||.||. || . | ||||. |||    ||.     | ||.  | |           
QIDQFIGKGHFSKVHKGNWKGKD-VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

QECIDLWGTR-YSIALGVAKGITYLHEECYDCVLHCDIKPQNVLLDENFCPKVSDFGLAKLIDKERALDVTTIRGTRGYMAPEWVGDRPITSKVDVYSYG
|  | |  |    .|. .|.|. .||      . | |||  |.|.| .|  |. |||..  ||    .  ||| ||    .||       ..| |||||.
QQPIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNM--TTIAGTPKWESPECLMHESYNQKSDVYSYA

MVLLELLSGN
|.| ||. |.
MMLYELATGD
Kinase IRAKg_u-2.AA LRRK 505-705 21 4.2e-28 96.51 In-house 1-278 (351) Show / Hide 
Range on Protein: 505-705
Range on HMM: 1-278/351
Sequence Identity: 21% (65 aa)

FSYEQLEVATNHFSCKLGAGGFG-SVYKGVLPD---------------------------MTVVAVKTLEGA----------------------------
. .|..          .| |||| .||.. . .                            . ||.|...                              
LKIEEQ----------IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDM

------ASHGEKQFKAEVATLGRVHHVNLVKLLGYCAEGSHRLLVYEFLSNGSLDQECI----D-L--------WGTRYSIALGVAKGITYLHEECYDC-
      ...    |  ||. . . .| |.|.|.|.| .  .. .| |....|.|.. .     | .        |.... ||| .|||. |||       
DQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH---NP

-VLHCDIKPQNVLL---D---------ENFCPKVSDFGLAK--LIDKER-ALDVTTIRGTRGYMAPEWVGDR---PITSKVDVYSYGMVLLELLSG
 ..|.| |. |.||   .         .. | |..|||.     ....  | ...   |. |.|||| ...      | |||.||.||.| |||..
PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV---GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTR
Kinase IRAKg_u-2.AA STE 515-706 20 2.7e-26 89.94 In-house 1-265 (359) Show / Hide 
Range on Protein: 515-706
Range on HMM: 1-265/359
Sequence Identity: 20% (56 aa)

NHFSCKLGAGGFGSVYKGVLPDMT----------------VVAVKTLE----GAASHG--------------EKQFKAEVATLGRVH--HVNLVKLLGYC
  .  |.| |.||.|||..  . .                ..|.| ..     . .                ..|.. |. .. . .  | | || .|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

AEG-------SHRLLVYEFLSNGSLDQECIDLWGTRYS------------------IALGVAKG-ITYLHEECYDCVLHCDIKPQNVLLDENFCPKVSDF
  .       ..  .. |....||||.     .|.  .                  |.  . ||   |||.     . | ||||.|.||      | .||
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF

GLAKLIDKERA--------------LDVT-TIRGTRGYMAPEWVG------DRPITSKVDVYSYGMVLLELLSGN
|... .... |                 . |. ||  .|||| .       | . . |.|..| | ...|.. |.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKg_u-2.AA TyrKc 515-774 23 5.5e-25 90.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 515-774
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

NHFSCKLGAGGFGSVYKGVLPDMTVVAVKTLEGAASHGEKQFKAEVATLGRV--HHVNLVKLLGYCAEG-------SHRLLVYEFLSNGSLD---QECI-
 ..  ||| | || ||||..   . ||||.|   |   .. |  |   . ..  || |.|.|.|.| ..          ..| |. ..|.|.   ...  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-DLWGTRYSIALGVAKGITYLHEECYDCVLHCDIKPQNVLLDENFCPKVSDFGLAKLIDKE----RALDVTTIR---GTRG-----YMAPEWVGDRPITS
   . .  |... .|.|  |||.    .. | |.   |.|..||.. |.|||||.. |. .     . |. . .   |...      ||||   ..  |.
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KVDVYSYGMVLLELLSGNDKSRIG---QNRYFPVWAFQKYVAGELHAIADPGLKNLEWN----EFERMIKVAFWCIQLDARSRPSMSRVVQML
| ||.|.| .. |...  ..   |   |    .  ....  .|.   . . ..   .        . | ..  .| . |. .||..| ... .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKg_u-2.AA LISK 750-774 36 4.4e-05 12.25 In-house 272-296 (296) Show / Hide 
Range on Protein: 750-774
Range on HMM: 272-296/296
Sequence Identity: 36% (9 aa)

IKVAFWCIQLDARSRPSMSRVVQML
....|.|. .| ..||| . .|| |
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAKg_u-2.AA LRRK 755-776 36 0.000476 10.2 In-house 330-351 (351) Show / Hide 
Range on Protein: 755-776
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

WCIQLDARSRPSMSRVVQMLEE
.| | | ..||..| .|. |..
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_u-2.AA TK 756-774 31 0.000516 8.5 In-house 468-486 (486) Show / Hide 
Range on Protein: 756-774
Range on HMM: 468-486/486
Sequence Identity: 31% (6 aa)

CIQLDARSRPSMSRVVQML
| ..|.. ||..| ....|
CWHYDPEDRPTFSQLHEQL
Kinase IRAKg_u-2.AA MLK 756-774 42 0.002431 7.6 In-house 273-291 (291) Show / Hide 
Range on Protein: 756-774
Range on HMM: 273-291/291
Sequence Identity: 42% (8 aa)

CIQLDARSRPSMSRVVQML
| . |...|||.. .|| |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKg_u-2.AA Dicty4-Unclassified 755-774 40 0.008485 5.37 In-house 244-263 (263) Show / Hide 
Range on Protein: 755-774
Range on HMM: 244-263/263
Sequence Identity: 40% (8 aa)

WCIQLDARSRPSMSRVVQML
||   | . ||.|  ..| |
WCWHNDPNKRPTMNQIIQYL
Kinase IRAKg_u-2.AA Dicty4 763-776 37 0.033284 3.35 In-house 262-277 (277) Show / Hide 
Range on Protein: 763-776
Range on HMM: 262-277/277
Sequence Identity: 37% (6 aa)

SRPSMSRVVQM--LEE
.|||.. ..|   ||.
HRPSFEEIIQRRILEH
Kinase IRAKg_u-2.AA Pkinase_Tyr 756-774 31 0.145402 5.92 Pfam 252-270 (270) Show / Hide 
Range on Protein: 756-774
Range on HMM: 252-270/270
Sequence Identity: 31% (6 aa)

CIQLDARSRPSMSRVVQML
| . |.  ||..| ....|
CWHYDPEDRPTFSEIHEQL