Gene IRAKg_o (S.moellendorffii)

IRAKg_o

Species: S.moellendorffii
Alias: IRAKg_o
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_o.AA Protein None 404 None Fasta, JSON
IRAKg_o.NA RNA None 1215 None Fasta, JSON
IRAKg_o.kin_dom Protein Kinase Domain None 98 None Fasta, JSON

Protein domain

Protein domains of IRAKg_o.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_o.AA B_lectin 73-177 28 5.4e-19 66.85 Pfam 1-127 (137) Show / Hide 
Range on Protein: 73-177
Range on HMM: 1-127/137
Sequence Identity: 28% (36 aa)

KKTVVWMAMAN---GQLVQ--VSENAKLELKA-EGGLSVTDGSSS---APLWQT--N-PGQCCAE--SASLLENGNLVVL-GKD--KKVAWQS--FDSPT
..|||| |  .     ..   ...|..|.. .  | | ..||..    .|.|.|  | .|   |   .| ....||||.. ...   .| |||  || ||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

NNLLPEQQLRTQGNPSLGYTR---LIS
. .|| . |.. .|  .. ..   |.|
DTWLPGMKLGWDNNVTIYMNWIGYLTS
B_lectin IRAKg_o.AA B_lectin 31-152 25 1.4e-17 65.61 SMART 1-126 (126) Show / Hide 
Range on Protein: 31-152
Range on HMM: 1-126/126
Sequence Identity: 25% (34 aa)

GSTVTTGSPWRSPEGTFG--FGFVMPESSRTRNFNLAIWYDIDP--KKTVVWMAMANGQLVQVSE---NAKLELKAEGGLSVTDGSSSAPLWQTNPG-QC
 .| ..|  . |....|   .||. ....    . . |||.  .   .|||| | . .  . |..   ...|..   | | . |    .|.|..| . . 
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ----WCNGIWYKNISNKQRTVVWVAQP-NRDNPVHDGNNSCYLTMQSDGNLVIYD---NRPVWSSNTTRNN

CAESASLLENGNLVVLGKD----KKVAWQSFDSP
   .| |...||.|. . |    ... |||||.|
GNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
Kinase IRAKg_o.AA TKL 295-391 30 7.4e-25 86.43 In-house 75-175 (364) Show / Hide 
Range on Protein: 295-391
Range on HMM: 75-175/364
Sequence Identity: 30% (35 aa)

EVSTIGRVHHVNLVRLLGYCAEGGC-------------HLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETQHSIALGIAKGLTYLHE----KCGER-
|.  . | .| |.|...||| ...|             . .|.|..|.||| |.|               |.  ...||.||.|. |||      |.   
EIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCT-KP

-IVHCDIKPQNVLLDE
 |.|.|.|..|.|.||
PIIHRDLKSKNILVDE
Kinase IRAKg_o.AA IRAK 281-391 35 2.4e-23 79.72 In-house 36-148 (317) Show / Hide 
Range on Protein: 281-391
Range on HMM: 36-148/317
Sequence Identity: 35% (42 aa)

RKLMLDKRWQSQDA---EVSTIGRVHHVNLVRLLGYCAEGGCHLLVYEFMPNGSLDHHLSASSSFAASQEIF--STWETQHSIALGIAKGLTYLHEKC-G
...  .. ||. ..   |. .  | .| |.| |.|||.|..|| |||..||||||   |..     . |      .| . .||..|.|.|. .||..  .
ADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWC----QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPC

ERIVHCDIKPQNVLLDE
  | | |||. |.|||.
TPIIHGDIKSANILLDQ
Kinase IRAKg_o.AA TKL-Unique 295-391 28 1.4e-16 55.12 In-house 45-147 (290) Show / Hide 
Range on Protein: 295-391
Range on HMM: 45-147/290
Sequence Identity: 28% (30 aa)

EVSTIGRVH-HVNLVRLLGYCA----EGGCHLLVYEFMPNGSLDHHLS--ASSSFAASQEIFSTWETQHSIALGIAKGLTYLHEKCGERIVHCDIKPQNV
||... . | | |.|.. |||.      .   .| |..| |||. .|.     .   ....  ... . ..|. ||.|. ||| . .  | |.|.|..|.
EVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNF

LLDE
|.|.
LVDN
Kinase IRAKg_o.AA Pkinase 294-400 26 8.5e-16 56.93 Pfam 49-151 (293) Show / Hide 
Range on Protein: 294-400
Range on HMM: 49-151/293
Sequence Identity: 26% (30 aa)

AEVSTIGRVHHVNLVRLLGYCAEGGCHLLVYEFMPNG----SLDHHLSASSSFAASQEIF--STWETQHSIALGIAKGLTYLHEKCGERIVHCDIKPQNV
.|..   |..| | |||.... ...   .| |....|    .| ...|.      ..  |  | || .. ... |..|| |.|..   .|.|.|.||.|.
SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-----WRHGCFYFSEWECKF-YMYQILRGLEYCHSM---GIIHRDLKPENI

LLDESSGQRCPTL
|.| . |. ....
LID-NNGHIDACV
Kinase IRAKg_o.AA LRRK 295-393 33 1e-15 52.05 In-house 107-203 (351) Show / Hide 
Range on Protein: 295-393
Range on HMM: 107-203/351
Sequence Identity: 33% (36 aa)

EVSTIGRVHHVNLVRLLGYCAEGGCHLLVYEFMPNGSLDHHLSASS----SFAASQEIFS-TWETQHSIALGIAKGLTYLHEKCGER--IVHCDIKPQNV
||. . . .| |.| |.|.| .  |  .| |..|.|.|.|.|....    .|       . .| ... ||| ||||. ||| .   .  |.|.| |. |.
EVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMK----AHISWMLKLKIALQIAKGMEYLHSH---NPPIIHRDLKSPNI

LLDESS
|| .|.
LLWSSP
Kinase IRAKg_o.AA Pkinase_Tyr 295-382 28 2.2e-15 52.73 Pfam 53-137 (270) Show / Hide 
Range on Protein: 295-382
Range on HMM: 53-137/270
Sequence Identity: 28% (26 aa)

EVSTIGRV-HHVNLVRLLGYCA-EGGC--HLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETQHSIALGIAKGLTYLHEKCGERIVHCDI
|...     || |.|||.| |  .|.   ...| |.||.|.|...| . .    ... ... .   .... ||||. ||..|    ..| |.
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---EDKQPLTMKD-LLQMCWQIAKGMEYLESKN---CIHRDL
Kinase IRAKg_o.AA MLK 301-391 27 6.3e-15 48.32 In-house 61-162 (291) Show / Hide 
Range on Protein: 301-391
Range on HMM: 61-162/291
Sequence Identity: 27% (28 aa)

RVHHVN----LVRLLGYCAEGGCH-LLVYEFMPNGSLDHHLSA-SSSFAAS-----QEIFSTWETQHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLL
.. | |     ....| |.. .|| ..| |....||| . | . .|  ...       .  . .   ..|| .|.|. |||..    |.| |.|..|.|.
ILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI

DE
||
DE
Kinase IRAKg_o.AA TK 303-391 17 1e-14 45.03 In-house 101-275 (486) Show / Hide 
Range on Protein: 303-391
Range on HMM: 101-275/486
Sequence Identity: 17% (30 aa)

HHVNLVRLLGYCAEGGC------------HLLVYEFMPNGS----LDHHLSASSSFAAS-----------------------------------------
|| |.|||.|.| .|..             ..| |.||.|.    |...| ...  .                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------QEIFSTWETQHS-------------------IALGIAKGLTYLHEK----CGERIVHCDIKPQNVLLDE
       ..   |   ...                   ... ||.|. |||.|       ..|| |.   |.|..|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGE
Kinase IRAKg_o.AA UTK 300-397 26 2.9e-14 45.2 In-house 64-164 (296) Show / Hide 
Range on Protein: 300-397
Range on HMM: 64-164/296
Sequence Identity: 26% (28 aa)

GRVH-HVNLVRLLGYCAEGGCHLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETQHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLDESS-----
...| |.|..||.|.|  ..  ..|.|.|.||.|.. |  ..  .  .. . | ... . |. || |. |||..   ..||.|.  .|.|.....     
KQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC---GFVHRDLAARNCLVHMHRMMWHC

GQRC
.. |
MMVC
Kinase IRAKg_o.AA TAK1 295-389 35 3.8e-11 33.78 In-house 48-138 (284) Show / Hide 
Range on Protein: 295-389
Range on HMM: 48-138/284
Sequence Identity: 35% (34 aa)

EVSTIGRVHHVNLVRLLG-YCAEGGCHLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETQHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLL
|.    || |.| ..| | |   ..| .|| |.|  |||   |     ..| . .  | .   | .. .|.|. ||| .    ..| |||||| ||
EIMQWSRVDHPNIIKLYGMYACHRQCQCLVMEYMDCGSLHNFL-----HGAKPKWEYTHAHAMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLL
Kinase IRAKg_o.AA Dicty4 306-392 28 2.6e-10 30.75 In-house 59-150 (277) Show / Hide 
Range on Protein: 306-392
Range on HMM: 59-150/277
Sequence Identity: 28% (27 aa)

NLVRLLGYCA----EGGCHLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETQHS---IALGIAKGLTYLHE-KCGERIVHCDIKPQNVLLDES
|.. ..|.|     . |  . | |.|| |.|   | .  |    |.| . |..  .   .|. .|.|...||.  .  .|.| |.|. | | |..
NICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS-EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP--VIIHRDLKSHNLLVDKN
Kinase IRAKg_o.AA TK-Unique 304-391 26 3.3e-10 31.53 In-house 63-168 (294) Show / Hide 
Range on Protein: 304-391
Range on HMM: 63-168/294
Sequence Identity: 26% (29 aa)

HVNLVRLLGYCAEGG-CHLLVYEFMPNGSLDHHLSASSSFAASQ-------EIFSTWETQHS-----------IALGIAKGLTYLHE--KCGERIVHCDI
| |.|..||.| . .  .....|..|.|.|.|.|  .   . ..       ..| . . . .           .| .||.|. ||..  |   .||| |.
HPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRK---KIVHRDL

KPQNVLLDE
   |||| |
CARNVLLTE
TyrKc IRAKg_o.AA TyrKc 244-402 12 0.0001 -146.21 SMART 1-280 (280) Show / Hide 
Range on Protein: 244-402
Range on HMM: 1-280/280
Sequence Identity: 12% (38 aa)

VLNLSVL------SFYDATGKSWASGSMSSQDYALDYDDANVLRKLML-DKRWQSQDAEVSTIGRV--HHVNLVRLLGYCAEG-------GCHLLVYEFM
.  . .|        | .| |                   .|  | .  |.  .    | .   ..  || |.|||.|.| ..       . ...| |.|
ITLGKKLGEGAFGEVYKGTWK------------------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM

PNGSLDHHLSASSSFAASQEIFSTWETQHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLDESS--------------------------------GQ
|.|.|...| ..           .... .|... ||.|  |||.|   ...| |.   |.|..|                                  | 
PHGDLKDYLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

R------------------------------------------------------------------CPTL-----------------------------
.                                                                  .|                               
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

-------GW
        .
TFSEIHECF