Gene IRAKg_e-2 (S.moellendorffii)

IRAKg_e-2

Species: S.moellendorffii
Alias: IRAKg_e-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_e-2.AA Protein None 700 None Fasta, JSON
IRAKg_e-2.NA RNA None 2103 None Fasta, JSON
IRAKg_e-2.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of IRAKg_e-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_e-2.AA B_lectin 1-29 64 3.4e-12 43.46 Pfam 71-104 (137) Show / Hide 
Range on Protein: 1-29
Range on HMM: 71-104/137
Sequence Identity: 64% (22 aa)

MQDDGNLVLK-HSN--NSVLWQS--FDLPTDTLL
|||.|||||. ..|  |.|||||  || ||||.|
MQDSGNLVLYDDNNDSNNVLWQSNTFDHPTDTWL
S_locus_glycop IRAKg_e-2.AA S_locus_glycop 119-188 25 4.2e-11 40.26 Pfam 43-114 (117) Show / Hide 
Range on Protein: 119-188
Range on HMM: 43-114/117
Sequence Identity: 25% (18 aa)

FTF--ANTRVMRMLKLEPSGNLRIYSLSTDNSSWNIVWQAMLLECQIHGVCGPFGLCTYAPRSTCVCPPGFH
.|.  .|....  . . ..| | ..    .. .||  | |.  .| . ..|||.|.|      .| | .||.
YTYHMTNNSIYSRFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFV
B_lectin IRAKg_e-2.AA B_lectin 130-155 37 1.47215 3.49 Pfam 69-92 (137) Show / Hide 
Range on Protein: 130-155
Range on HMM: 69-92/137
Sequence Identity: 37% (10 aa)

LKLEPSGNLRIY-SLSTDNSSWNIVWQ
...  |||| .| . . |  | |..||
AQMQDSGNLVLYDD-NND--SNNVLWQ
PAN_1 IRAKg_e-2.AA PAN_1 209-274 15 0.000641 14.73 Pfam 1-61 (84) Show / Hide 
Range on Protein: 209-274
Range on HMM: 1-61/84
Sequence Identity: 15% (11 aa)

CNGSSNHHDWVRVDRASYDGNDYVKDLSPT-SLEGCRRRCDRDCG--CLGFVYRVDRHGTCYTKGSAPG
|..     ...|.. ... |   .. .. . |.| |...|  . .  |  | |  .  ..|. . . ..
CHR----WHFERHPNYIL-G-H-IWVMKNVDSAEECQQKCQNNPRFTCRSFTYNYK-TKQCHLHDEDRH
Kinase IRAKg_e-2.AA TKL 398-592 23 8.8e-60 204.92 In-house 1-289 (364) Show / Hide 
Range on Protein: 398-592
Range on HMM: 1-289/364
Sequence Identity: 23% (69 aa)

LGAGAFGTVYKGVLADGT--------SLVAVKSLMM----------------------------ATHAEKQFKAEVATLGKIHHINLVRMLGYCAEGSH-
.| |.||.||||..   .          |||| . .                            | ....... |.  . ...| |.|...||| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEYMANSSLEKVLSQVPQTLCEWKTRLAIALGISRGITYLHE------QCQECIIHCDIKPQNILLDDNFR-------------
              .|.||. . ||. .|         |  |. .||.|.||. |||       .    |||.|.|..|||.|.|..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKVSDFGLAKLMKRESS------------------ANVTTARGTRGYMAPEWISNV----------------AITPKVDVYSFGMVLLELMSGRDKF
 .|..||||.. |.....                   .  | .|| ..|||| . .                   ..|.||||||.|| |.....  .
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY
Kinase IRAKg_e-2.AA IRAK 393-589 35 8.3e-58 198.37 In-house 2-221 (317) Show / Hide 
Range on Protein: 393-589
Range on HMM: 2-221/317
Sequence Identity: 35% (78 aa)

NFKDKLGAGAFGTVYKGVLADGTSLVAVK-----SLMMATHAEKQFKA---EVATLGKIHHINLVRMLGYCAEGSHRLLVYEYMANSSLEKVLSQVPQ--
.   ..| |.||.||.|..   |  .|||       |  .  ...| .   |. .. ...| |.|  .|||.|..   |||.||.| |||  |.   .  
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

TL--CEWKTRLAIALGISRGITYLHEQC-QECIIHCDIKPQNILLDDNFRPKVSDFGLAK------LMKRESS--ANVTTARGTRGYMAPEWIS--NVAI
..   .| .|. |..|...|| .||.      ||| |||. |||||..| || .||||.        ... ..  . . . |||  ||.|| |      .
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

TPKVDVYSFGMVLLELMSGR
|.|.|||||| ||||. .|.
TKKTDVYSFGIVLLEVLTGC
Pkinase IRAKg_e-2.AA Pkinase 392-589 30 3.1e-53 187.99 Pfam 1-209 (293) Show / Hide 
Range on Protein: 392-589
Range on HMM: 1-209/293
Sequence Identity: 30% (66 aa)

GNFKDKLGAGAFGTVYKGVLADGTSLVAVKSLMMATHAEKQFKA-----EVATLGKIHHINLVRMLGYCAEGSHRLLVYEYMANS----SLEKVLS---Q
  .. |.|.|.||.|||..  .   .|||| .   .  ... ..     |.. . ...| | ||..... ...|  .| ||. .     .|  ..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VPQTLCEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDNFRP----KVSDFGLAKLMKRESSANVTTARGTRGYMAPEWIS-NVAITPKVD
 . .  ....   ... | ||. |.|..    |||.|.||.|||.|.|  .    |..||||||...  ..   ||  ||..|||||.|  .  ..||||
GCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSFGMVLLELMSGR
..|.| .| |...||
MWSCGCILYEMLCGR
Kinase IRAKg_e-2.AA TKL-Unique 394-588 30 1.7e-45 157.45 In-house 1-224 (290) Show / Hide 
Range on Protein: 394-588
Range on HMM: 1-224/290
Sequence Identity: 30% (70 aa)

FKDKLGAGAFGTVYKGVLADGTSLVAVKSLMM--ATHAE--KQFKAEVATLGKIH-HINLVRMLGYCA----EGSHRLLVYEYMANSSLEKVLSQ-----
|  |.|.|..|.||||. .  .. ||.|..      . |  . |. || .. |.| |.|.|.  |||.      ... .| ||.  .|| .||.|     
FWNKIGEGGYGQVYKGKWR--GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---VPQTLCEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDN-----FRPKVSDFGLAKLMKRESSANVT--------TARGTRGYMAPEW
    . .   .. |. .|. |..|  |||      |||.|.|..|.|.| |     .. |..||||.|. ....  ...        |  |.  .|||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

ISN--VAITPKVDVYSFGMVLLELMSG
...    .. |.||||||.|| |. ..
LRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKg_e-2.AA Dicty4 433-585 34 4.1e-41 134.97 In-house 45-210 (277) Show / Hide 
Range on Protein: 433-585
Range on HMM: 45-210/277
Sequence Identity: 34% (58 aa)

FKAEVATLGKIHHINLVRMLGYCA----EGSHRLLVYEYMANSSLEKVLSQ-----VPQTLCEWKTRLA---IALGISRGITYLHE-QCQECIIHCDIKP
|..||. ..|| | |..  .|.|     . .  . | |||   .|...|        . .  .| ....   .|. . ||...||.  .   ||| |.|.
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKS

QNILLDDNFRPKVSDFGLAKLMKRES--SANVTTARGTRGYMAPEWISNVAITPKVDVYSFGMVLLEL
 |.| |.|.| ||.||||...||...  ..| .|| || ..||||   . . . |.||||||.|| |.
HNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEI
S_TKc IRAKg_e-2.AA S_TKc 392-664 24 1.6e-40 141.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 392-664
Range on HMM: 1-231/231
Sequence Identity: 24% (72 aa)

GNFKDKLGAGAFGTVYKGVLADGTSLVAVKSLMMATHAEKQFKAEVATLGKIHHINLVRMLGYCAEGSHRLLVYEYMAN--SSLEKVLSQVPQ-----TL
  . .|.| ||||.|||..  .   .||.| .       .... |.. | | || |.|...... . .|  .| ||. .   .| ... . .       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

CEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSANVTTARGTRGYMAPEWISNVAITP-KVDVYSFGMVLL
 |  .|  ..  | ... |.|..    |||.|.||.|||||.  . |..|||||...        ||  ||. ||||| .     .. |.|..|.| .| 
PE-HARF-YMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELMSGRDKFMFTPSAMNSGRWYFPVWAFEQCATGNMKSTADPRMAETIDWEQFEMALRVAFWCIQPEPESRPSMSRVVQ---------ML
|...|.  |              .   |...                      . |.     | | .|| ||.   . |          .
EMLCGYPPFP------------QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_e-2.AA Pkinase_Tyr 393-587 31 6.2e-40 135.86 Pfam 2-209 (270) Show / Hide 
Range on Protein: 393-587
Range on HMM: 2-209/270
Sequence Identity: 31% (67 aa)

NFKDKLGAGAFGTVYKGVLA----DGTSLVAVKSLMMATHAE----KQFKAEVATLGKI-HHINLVRMLGYCA-EGSH--RLLVYEYMANSSLEKVLSQV
 |  |||.||||.||||..     ...  ||||.|   .. |    . | .|.... .. || |.||..| |  .| .   ..| |||.. .| . | . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

---PQTLCEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSANVTTARGTRG---YMAPEWISNVAITPKVD
   .| |.     | ... |..|  ||...    .|| |.   |.|...|.  |..|||||...  ..   .... |..     |||| |..   | | |
REDKQPLTMKD-LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

VYSFGMVLLELMS
|.||| .. |...
VWSFGVLMWEIFT
Kinase IRAKg_e-2.AA MLK 392-589 26 1.5e-38 131.4 In-house 1-233 (291) Show / Hide 
Range on Protein: 392-589
Range on HMM: 1-233/291
Sequence Identity: 26% (63 aa)

GNFKDKLGAGAFGTVYKGVLADGT---SLVAVKSLM-------MATHAEKQFKAEVATLGKIHHIN----LVRMLGYCAE-GSHRLLVYEYMANSSLEKV
 .|. ..|.|.|| |.||.    .     ||||           .    ..|. |.  | .. | |     .. .| |.. ..| ..| ||....||  |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

L-SQVPQTL-----------CEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDD------NFRPKVSDFGLAKLMKRESSANVTTARGTRGY
| .. ..                   . .|| ..||. |||.. .  ||| |.|..|||.|.      .   |..|||... ...   .| . ..||  .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

MAPEWI---SNVAITPKVDVYSFGMVLLELMSGR
|||| |    .   . |.||.|.|.|| |.....
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAKg_e-2.AA TK 392-587 16 4.4e-37 121.33 In-house 1-389 (486) Show / Hide 
Range on Protein: 392-587
Range on HMM: 1-389/486
Sequence Identity: 16% (63 aa)

GNFKDKLGAGAFG---TVYKGVLADGT-------------------------SLVAVKSLMM-ATHAEKQFKA--------------EVATLGKIH----
  . .|||.|.||   .|||| . ..                            |||| |.  .......|..              |.. . . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HINLVRMLGYCAEG------------SHRLLVYEYMANSS----LEKVLS-------------------------------------------------
 | |.||..|.| .|             . ..| |||.. .    | . |                                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------QVPQTLCE-------------------WKTRLAIALGISRGITYLHEQ----CQECIIHCDIKPQNILLDDNFR-----------PKVSDFGLA
      ..|..|..                    ...| ... |..|  |||..        ..| |.   |.|...| .            |..||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----LMKRESSANVTTARGTRG----------------------------YMAPEWIS---------NVAITPKVDVYSFGMVLLELMS
.     | ..  |    ......|                            .|||| .          .   |.| ||.||| .. |...
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKg_e-2.AA RIPK 398-589 30 2.1e-34 114.63 In-house 1-225 (290) Show / Hide 
Range on Protein: 398-589
Range on HMM: 1-225/290
Sequence Identity: 30% (70 aa)

LGAGAFGTVYKGVLADGTSLVAVKS---LMMATH----AEKQFKAEVATLGKIHHINLVRMLGYCAEG-----SH-RLLVYEYMANSSLEKVLSQVPQT-
.| |.||.|.| . ..    ||.|    . ..||     ... | |.. . |. . . |...| | .      .    .| |||.| ||...|.  ..  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LCEWKTRLAIALGISRGITYLHEQCQE-CIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSAN----------VTTAR--GTRGYMAPEWIS--
   .. |. |  .   ||.|  |||  ..   ||| | ||.|||.| ||  |..|||||. |   .| .           . .   ||  ||.|| .   
HHPDP-WPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

NVAI----TPKVDVYSFGMVLLELMSGR
| .     ||| |||||..|. |.....
NKKPIKVVTPKYDVYSFAIVMWEVLTQK
Kinase IRAKg_e-2.AA STE 394-589 21 7.1e-33 113.46 In-house 1-265 (359) Show / Hide 
Range on Protein: 394-589
Range on HMM: 1-265/359
Sequence Identity: 21% (59 aa)

FKD--KLGAGAFGTVYKGVLADGT---------------SLVAVKSLMMAT------------------HAEKQFKAEVATLGKIH--HINLVRMLGYCA
...  |.| ||||||||..  . .                ..|.| . . .                    ..|.. |. .. | .  | | |. .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------SHRLLVYEYMANSSLEKVLSQVPQTLCE------------WKTRLAIALGISRG-ITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFG
 .       ..  .. |||.. ||.... ..  ....             .   .|.  | .|   |||..    ||| ||||.||||      | .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLMKRE--------------SSANVT-TARGTRGYMAPEWISN------VAITPKVDVYSFGMVLLELMSGR
... .  .              ...  . |  ||  .|||| |..         . |.|..|.| ...|.  |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKg_e-2.AA LRRK 392-589 23 7e-31 106.47 In-house 1-279 (351) Show / Hide 
Range on Protein: 392-589
Range on HMM: 1-279/351
Sequence Identity: 23% (67 aa)

GNFKDKLGAGAFG-TVYKGVLA--------------------------DGTSLVAVKSLMM-----------------------------------ATHA
  .  ..| |.|| .||.. .                           |  . ||.|.. .                                   ...|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EKQFKAEVATLGKIHHINLVRMLGYCAEGSHRLLVYEYMANSSLEKVLS---QVPQ----TLCEWKTRLAIALGISRGITYLHEQCQEC--IIHCDIKPQ
   |  ||. . . .| |.| ..|.| .  .. .| ||. . .| ..|.   | ..    .   | ..| ||| |..|. ||| .      |||.| |. 
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH---NPPIIHRDLKSP

NILL---D---------DNFRPKVSDFGLAKLMKRESSAN--VTTARGTRGYMAPEWIS---NVAITPKVDVYSFGMVLLELMSGR
||||   .         ..   |..|||.   |   .  .  . .  |. |.|||| .    ..  | |||.|||||.| ||....
NILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAKg_e-2.AA UTK 393-588 26 7.8e-31 102.72 In-house 2-236 (296) Show / Hide 
Range on Protein: 393-588
Range on HMM: 2-236/296
Sequence Identity: 26% (63 aa)

NFKDKLGAGAFGTVYKGVLAD-----GTSLVAVKSLM---MATHAEK---QFKAEVA---TLGKIH-HINLVRMLGYCAEGSHRLLVYEYMANSSLEKVL
 . ..||.||||.|.|. . .     ....|||| .    .|....    .|  | .    ... | | |..|..|.|  ..  ..|.|||.|..| ..|
QLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYL

SQVPQTLC---EWKT---RLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDN-------FRPKVSDFG---LAKLMK------RESSANVTTARGT
   ..|.    .| |   ||  |. |.||  |||..    ..|.|.  .|.|....          |..|||   ......      |.....  .|.. 
RRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC---GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

RG----YMAPEWISNV-AITPKVDVYSFGMVLLELMSG
.      |||| . .    | | ||.||| |. |....
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase IRAKg_e-2.AA TyrKc 392-664 25 1.2e-27 99.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 392-664
Range on HMM: 1-280/280
Sequence Identity: 25% (77 aa)

GNFKDKLGAGAFGTVYKGVLADGTSLVAVKSLMMATHAEKQFKAEVATLGKI--HHINLVRMLGYCAEG-------SHRLLVYEYMANSSLEKVLSQVPQ
  ...||| ||||.||||..      ||||.|   .  .. |  |   . |.  || |.||..|.| ..          ..| |||.. .| . |     
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TLCEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRE----SSANVTTAR---GTRG-----YMAPEWISNVAIT
.   .|. | ... |..|  |||..   ..|| |.   |.|...|.. |.|||||..  . .     |  . ...   |...      |||| |     |
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PKVDVYSFGMVLLELMSGRDKFMFTPSAMNSGRWYFPV-----WAFEQCATGNMKSTADPRMAETIDWEQF-------EMALRVAFWCIQPEPESRPSMS
.| ||.||| .. |...              |    |         ..     ..    |....    .         ||   .  .| . .||.||..|
TKSDVWSFGVCMWEIFTY-------------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQ-IMKQCWHEDPEDRPTFS

RVVQML
 ... .
EIHECF
Kinase IRAKg_e-2.AA Dicty4 393-409 52 3.7e-05 13.35 In-house 2-18 (277) Show / Hide 
Range on Protein: 393-409
Range on HMM: 2-18/277
Sequence Identity: 52% (9 aa)

NFKDKLGAGAFGTVYKG
|. ...| |.||.||||
NIEQRIGKGSFGEVYKG
Kinase IRAKg_e-2.AA TK 646-664 36 4.2e-05 12.21 In-house 468-486 (486) Show / Hide 
Range on Protein: 646-664
Range on HMM: 468-486/486
Sequence Identity: 36% (7 aa)

CIQPEPESRPSMSRVVQML
| ...|| ||..| ....|
CWHYDPEDRPTFSQLHEQL
Kinase IRAKg_e-2.AA Dicty4 645-666 37 6.3e-05 12.55 In-house 254-277 (277) Show / Hide 
Range on Protein: 645-666
Range on HMM: 254-277/277
Sequence Identity: 37% (9 aa)

WCIQPEPESRPSMSRVVQM--LEE
||  ..|..|||.. ..|   ||.
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKg_e-2.AA LRRK 645-666 36 7.4e-05 13.09 In-house 330-351 (351) Show / Hide 
Range on Protein: 645-666
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

WCIQPEPESRPSMSRVVQMLEE
.| | .|..||..| .|. |..
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_e-2.AA TKL 645-664 35 0.000102 12.92 In-house 345-364 (364) Show / Hide 
Range on Protein: 645-664
Range on HMM: 345-364/364
Sequence Identity: 35% (7 aa)

WCIQPEPESRPSMSRVVQML
.| ...||.|||...... |
DCWDHDPEKRPSFQEILKRL
Kinase IRAKg_e-2.AA MLK 646-664 42 0.000225 11.23 In-house 273-291 (291) Show / Hide 
Range on Protein: 646-664
Range on HMM: 273-291/291
Sequence Identity: 42% (8 aa)

CIQPEPESRPSMSRVVQML
| ...|..|||.. .|| |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKg_e-2.AA UTK 646-664 31 0.001104 8.48 In-house 278-296 (296) Show / Hide 
Range on Protein: 646-664
Range on HMM: 278-296/296
Sequence Identity: 31% (6 aa)

CIQPEPESRPSMSRVVQML
| ...|. ||.. ..|| .
CWHYDPQERPDFEDLVQQM
Kinase IRAKg_e-2.AA Pkinase_Tyr 646-664 36 0.004567 11.01 Pfam 252-270 (270) Show / Hide 
Range on Protein: 646-664
Range on HMM: 252-270/270
Sequence Identity: 36% (7 aa)

CIQPEPESRPSMSRVVQML
| ...|| ||..| ....|
CWHYDPEDRPTFSEIHEQL
Kinase IRAKg_e-2.AA TKL-Unique 646-664 31 0.339568 0.19 In-house 272-290 (290) Show / Hide 
Range on Protein: 646-664
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CIQPEPESRPSMSRVVQML
|  ..|. ||| . ..  |
CWHHDPSQRPSFDEIIHRL
Kinase IRAKg_e-2.AA Pkinase 632-664 16 2.060505 2.54 Pfam 238-293 (293) Show / Hide 
Range on Protein: 632-664
Range on HMM: 238-293/293
Sequence Identity: 16% (9 aa)

DWEQF---------------------EMALRVAFWCIQPEPESRPSMSRVVQM--L
||..                      | .. .  ||... |..||.   ..|   .
DWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF