Gene IRAKg_r-1 (S.moellendorffii)

IRAKg_r-1

Species: S.moellendorffii
Alias: IRAKg_r-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_r-1.AA Protein None 855 None Fasta, JSON
IRAKg_r-1.NA RNA None 2568 None Fasta, JSON
IRAKg_r-1.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAKg_r-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_r-1.AA B_lectin 63-160 29 2.6e-17 61.09 Pfam 1-118 (137) Show / Hide 
Range on Protein: 63-160
Range on HMM: 1-118/137
Sequence Identity: 29% (35 aa)

KKTVIWMAMAN---GQLIQ--VSENAKLELKA-EGGLSVTDGS---SV-PLWQT--N-PGQCCAE--SAALLENGNLVVL-GKD--KKVAWQS--FDSPT
..|| | |  .     .    ...|..|.. .  | | ..||.   || |.|.|  | .|   |   .| ....||||.. ...   .| |||  || ||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

NNLLPEQQLRTQGNPSLG
. .|| . |.. .|  ..
DTWLPGMKLGWDNNVTIY
B_lectin IRAKg_r-1.AA B_lectin 25-141 25 4.6e-14 53.95 SMART 1-126 (126) Show / Hide 
Range on Protein: 25-141
Range on HMM: 1-126/126
Sequence Identity: 25% (33 aa)

GSTVTTGSPWRSPGGTFG--FGFVMSTRNFNLAIWYDIDP--KKTVIWMAMANGQLIQVSE---NAKLELKAEGGLSVTDGSSVPLWQTNPG-QCCAESA
 .| ..|  . |....|   .||.  . .. . |||.  .   .||.| | . .    |..   ...|..   | | . |    |.|..| . .    .|
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQWCNGIWYKNISNKQRTVVWVAQP-NRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNNGNYVA

ALLENGNLVVLGKD----KKVAWQSFDSP
 |...||.|. . |    ... |||||.|
VLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_r-1.AA S_locus_glycop 268-338 25 2.1e-12 44.76 Pfam 49-117 (117) Show / Hide 
Range on Protein: 268-338
Range on HMM: 49-117/117
Sequence Identity: 25% (18 aa)

DANVLRRLTLDDDGNLRIYSFGPKNKSGSWSVVWQAVMLECDIFGTCGPFALCTYRPTKICSCPPGFHRVD
. ... |.|.. .| | ..   |....  | . | | . .||. ..|||...|    . .|.| .||.   
NNSIYSRFTMSSEGYLQRFTWNPNSQD--WNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFVPKN
B_lectin IRAKg_r-1.AA B_lectin 274-302 30 0.321692 5.76 Pfam 68-92 (137) Show / Hide 
Range on Protein: 274-302
Range on HMM: 68-92/137
Sequence Identity: 30% (10 aa)

RLTLDDDGNLRIY----SFGPKNKSGSWSVVWQ
|... |.||| .|    .        | .|.||
RAQMQDSGNLVLYDDNND--------SNNVLWQ
PAN_AP IRAKg_r-1.AA PAN_AP 359-439 15 0.000128 22.59 SMART 1-85 (85) Show / Hide 
Range on Protein: 359-439
Range on HMM: 1-85/85
Sequence Identity: 15% (14 aa)

PNSVKLVQVNRADYYFNDYNFD------SSIKSLEKCKDTCMQDCKCLAAAYKYDGTGLCFLKGNSNKLYNGKQ-----TLNEMNMVFMKLS
..    | .... .    ..        .   ||| |.. | ..| | ...| .  |. | |  ....| . .|     ..........   
CCDDCFVRMPNMKL----FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN--TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAKg_r-1.AA TKL 544-826 22 2e-64 220.32 In-house 1-364 (364) Show / Hide 
Range on Protein: 544-826
Range on HMM: 1-364/364
Sequence Identity: 22% (89 aa)

LGSGGFGSVYRGNIPE--------KGGIVAVKKITTVN----------------------------QAKKQFKAEVSTIGRVHHVNLVRLLGYCAEGDH-
.|||||| ||.|.           .|  |||||. . |                            ....... |.  . | .| |.|...||| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------HLLVYEFMPNGSLDHHLSASSSFAASQEIFSTWETRHSIALGIAKGLTYLHE----KCGER--IVHCDIKPQNVLLNESFR-------
            . .|.|..|.||| |.|               |. |...||.||.|. |||      |.    |.|.|.|..|.|..| ..       
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMY

-------PKVSDFGLARMMTKE-SMSITT------------------VQGTRGYLAPEWLESQ----------------SITPKADVYSFGMLLLDILGG
       .|..||||.|.|... .|. |                   . || ...||| |. |                . ..|.||||||..|  || .
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR

KRKALMELGSGDREYENAPLPPPREWYFPIYAFHKYMTSELESVA----DPNLASGSV-----DWEQFE--TALKIALSCIHQDPGSRPAMSRVVQIL
.|                  |   ..|.|.....     ... |.     | . .         ..        |..  | ..|| .|| .......|
CR------------------PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKg_r-1.AA IRAK 540-744 37 1e-55 191.44 In-house 1-225 (317) Show / Hide 
Range on Protein: 540-744
Range on HMM: 1-225/317
Sequence Identity: 37% (86 aa)

FRDE--LGSGGFGSVYRGNIPEKGGIVAVKKI-----TTVNQAKKQFKA---EVSTIGRVHHVNLVRLLGYCAEGDHHLLVYEFMPNGSLDHHLSASSSF
|  .  .|.|||| |||| .  ..||.||||.     .. |. ...| .   |. .  | .| |.| |.|||.|.. | |||..||||||   |..    
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWC----

AASQEIF--STWETRHSIALGIAKGLTYLHEKC-GERIVHCDIKPQNVLLNESFRPKVSDFGLARMM----TKESMSI-----TTVQGTRGYLAPEWLE-
 . |      .| .|.||..|.|.|. .||..  .  | | |||. |.|| . | || .||||.|       ||. ..      .|.||  |..|| .  
QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRD

-SQSITPKADVYSFGMLLLDILGGKRKAL
 .  .|.| ||||||  || .| | | ..
PQGQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAKg_r-1.AA Pkinase 544-740 29 1.5e-50 179.02 Pfam 7-209 (293) Show / Hide 
Range on Protein: 544-740
Range on HMM: 7-209/293
Sequence Identity: 29% (63 aa)

LGSGGFGSVYRGNIPEKGGIVAVKKITTVNQAKKQFKA-----EVSTIGRVHHVNLVRLLGYCAEGDHHLLVYEFMPNG----SLDHHLSASSSFAASQE
.|||.||.||..     | |||||.|  ... ... ..     |..   |..| | |||.... ..||  .| |....|    .| ...|.      ...
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST------WRH

IFS--TWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRP----KVSDFGLARMM-TKESMSITTVQGTRGYLAPEWLE-SQSITPKADV
     ....  .... |..|| |.|..   .|.|.|.||.|.|...   .    |..|||||. . .  .   ||. ||..|.|||..  .| ..||.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFGMLLLDILGGK
.|.| .|   | |.
WSCGCILYEMLCGR
Kinase IRAKg_r-1.AA Dicty4 539-737 33 4.3e-41 134.9 In-house 2-211 (277) Show / Hide 
Range on Protein: 539-737
Range on HMM: 2-211/277
Sequence Identity: 33% (72 aa)

NFRDELGSGGFGSVYRGNIPEKGGIVAVKKITTVNQAK-----KQFKAEVSTIGRVHHVNLVRLLGYCA----EGDHHLLVYEFMPNGSLDHHLSASSSF
|. ...|.|.||.||.|.   .| .|||||    ||       . |..||.  .   | |.. ..|.|     .    . | |.|| |.|   | .  | 
NIEQRIGKGSFGEVYKGTW--RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS-

AASQEIFSTWETRHS---IALGIAKGLTYLHE-KCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKESMSIT---TVQGTRGYLAPEWLESQSITP
   |.| . |... .   .|. .|.|...||.  .  .|.| |.|. | |  ...| ||.||||...| |...  .   |. || .. ||| . .|. . 
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP--VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

KADVYSFGMLLLDIL
||||||||..|  ||
KADVYSFGIVLWEIL
Kinase IRAKg_r-1.AA TKL-Unique 540-733 29 2.4e-40 140.02 In-house 1-218 (290) Show / Hide 
Range on Protein: 540-733
Range on HMM: 1-218/290
Sequence Identity: 29% (65 aa)

FRDELGSGGFGSVYRGNIPEKGGIVAVKKITT---VNQAKKQ-FKAEVSTIGRVH-HVNLVRLLGYCA----EGDHHLLVYEFMPNGSLDHHLS--ASSS
|   .|.||.|.||.|    .| .||.|..     ..  ..| |. ||... . | | |.|.. |||.       .  .| |..| |||. .|.     .
FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

FAASQEIFSTWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNES-----FRPKVSDFGLARMMTKE-SMSIT--------TVQGTRGYLAPEW
   ....  ... | ..|. ||.|. ||| . .  | |.|.|..|.|...      .. |..||||..  .|.  |...        |..|.  ..||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

LES--QSITPKADVYSFGMLL
|..    .. |.||||||. |
LRMNFCQYSEKSDVYSFGIVL
Kinase IRAKg_r-1.AA TK 538-733 16 3.5e-38 125.09 In-house 1-384 (486) Show / Hide 
Range on Protein: 538-733
Range on HMM: 1-384/486
Sequence Identity: 16% (63 aa)

DNFRDELGSGGFG---SVYRGNIPEKGG-------------------------IVAVKKITTV-NQAKKQFKA--------------EVSTIGRVH----
  . ..||.| ||    ||.|   ....                          |||| ..   ......|..              |.. .   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HVNLVRLLGYCAEG------------DHHLLVYEFMPNGS----LDHHLSASSSFAASQEI--------------------------------------
 | |.|||.|.| .|             . ..| |.||.|.    |...| ...  .  ..                                       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------FSTWETRHSIALGIAKGLTYLHEK----CGERIVHCDIKPQNVLLNESFR-----------PKVSDFG--
                              . | .... ... ||.|. |||.|       ..|| |.   |.|..|. .            |..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARMMTKESMSITTVQGTRGY--------------------------LAPEWLESQS---------ITPKADVYSFGMLL
      ||| . ...   .. ....|                           .||| |...           |.| ||.||| |.
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
Kinase IRAKg_r-1.AA Pkinase_Tyr 539-733 29 1.3e-37 128.04 Pfam 2-204 (270) Show / Hide 
Range on Protein: 539-733
Range on HMM: 2-204/270
Sequence Identity: 29% (62 aa)

NFRDELGSGGFGSVYRGNIP----EKGGIVAVKKI--TTVNQA--KKQFKAEVSTIGRV-HHVNLVRLLGYCA-EGDH--HLLVYEFMPNGSLDHHLSAS
 |  .||.| ||.||.|       ...  ||||..  ..  ..  .. | .|...     || |.|||.| |  .|..  ...| |.||.|.|...| . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

SSFAASQEIFSTWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKESMSITTVQG-----TRGYLAPEWLESQSIT
.    ... ... .   .... ||||. ||..|    ..| |.   |.|..|..  |..|||||| .....   ....|      . . ||| .     |
R---EDKQPLTMKD-LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGKFT

PKADVYSFGMLL
 | ||.||| |.
TKSDVWSFGVLM
Kinase IRAKg_r-1.AA S_TKc 538-825 22 1.3e-36 128.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 538-825
Range on HMM: 1-231/231
Sequence Identity: 22% (69 aa)

DNFRDELGSGGFGSVYRGNIPEKGGIVAVKKITTVNQAKKQFKAEVSTIGRVHHVNLVRLLGYCAEGDHHLLVYEFMPN--GSLDHHLSASSS------F
  . ...|.|.||.||..   . | |||.|.|       .... |..   . || |.|.|.... . ||  .| |....  |.| ...    .      |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

AASQEIFSTWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKESMSITTVQGTRGYLAPEWLESQSITP-KADVYS
   .  |        ..  |...| |.|..    |.|.|.||.|.||.|  . |..|||||| .       ||. ||. |.||| |   . .. |.|..|
PE-HARF--------YMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGMLLLDILGGKR-----KALMELGSGDREYENAPLPPPREWYFPIYAFHKYMTSELESVADPNLASGSVDWEQFETALKIALSCIHQDPGSRPAMSRVV
.| .|   | |.      ......                                                   . |. .   | . ||  ||    . 
CGCILYEMLCGYPPFPQMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

Q----------I
|          .
QDEWDIKCHPWF
Kinase IRAKg_r-1.AA MLK 539-733 25 2.4e-36 123.6 In-house 2-226 (291) Show / Hide 
Range on Protein: 539-733
Range on HMM: 2-226/291
Sequence Identity: 25% (58 aa)

NFRDELGSGGFGSVYRGNIPEKG---GIVAVKKIT----TVNQA---KKQFKAEVSTIGRVHHVN----LVRLLGYCAE-GDHHLLVYEFMPNGSLDHHL
.|   .|||.||.|..|.   |     |||||...     . ..   ...|. |.    .. | |     ....| |.. . | ..| |....||| . |
QFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVL

SA-SSSFAAS-----QEIFSTWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNE------SFRPKVSDFGLARMMTKESMS-ITTVQGTRGYL
 . .|  ...       .  . .   ..|| .|.|. |||..    |.| |.|..|.|. |          |..|||..|....   .  .  .||  . 
HGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWM

APEWL---ESQSITPKADVYSFGMLL
||| .   ...  . |.||.|.|..|
APEVIQQFRCEKYSEKCDVWSWGVVL
Kinase IRAKg_r-1.AA LRRK 528-741 23 2.7e-33 115.11 In-house 1-281 (351) Show / Hide 
Range on Protein: 528-741
Range on HMM: 1-281/351
Sequence Identity: 23% (71 aa)

FTYRQLQDATDNFRDELGSGGFG-SVYRGNIP--------------------------EKGGIVAVKKITT-----------------------------
. . ..          .|.|||| .|||..                             ..  ||.||...                             
LKIEEQ----------IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDM

------VNQAKKQFKAEVSTIGRVHHVNLVRLLGYCAEGDHHLLVYEFMPNGSLDHHLSASS----SFAASQEIFS-TWETRHSIALGIAKGLTYLHEKC
         |   |  ||. . . .| |.| |.|.| .  .  .| |..|.|.|.|.|....    .|       . .| ... ||| ||||. ||| . 
DQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMK----AHISWMLKLKIALQIAKGMEYLHSH-

GER--IVHCDIKPQNVLLNESFRP------------KVSDFGLARMMTKESMS-ITTVQGTRGYLAPEWLESQ---SITPKADVYSFGMLLLDILGGK-R
  .  |.|.| |. |.||..|  .            |..|||. || .   |. . .. |. |..||| .      . | |.|.|||||.| ..| .. .
--NPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHH
Kinase IRAKg_r-1.AA TK-Unique 539-733 27 2.8e-30 101.65 In-house 2-229 (294) Show / Hide 
Range on Protein: 539-733
Range on HMM: 2-229/294
Sequence Identity: 27% (64 aa)

NFRDELGSGGFGSVYRGNIP------EKGGIVAVKKIT-TVNQA-KKQFKAEVSTIGRVH-HVNLVRLLGYCAEGD-HHLLVYEFMPNGSLDHHLSASSS
.. |..|.| || |.|| .       .|  .||||.    ...  |..|. | .    .  | |.|..||.| . |  .....|..|.|.|.|.|  .  
EVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRP

FAASQ-------EIFSTWETRHS-----------IALGIAKGLTYLHE--KCGERIVHCDIKPQNVLLNESFRPKVSDFGLAR--MMTKESMSITT-VQG
 . ..       ..| . . . .           .| .||.|. ||..  |   .||| |.   ||||.| .. |..|||.||  . ... .....    
AMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRK---KIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRI

TRGYLAPEWLE--SQSI-TPKADVYSFGMLL
   ..||| |    . . |.| ||.||| |.
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLM
Kinase IRAKg_r-1.AA TyrKc 538-826 23 6.5e-27 96.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 538-826
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

DNFRDELGSGGFGSVYRGNIPEKGGIVAVKKITTVNQAKKQFKAEVSTIGRV--HHVNLVRLLGYCAEG-------DHHLLVYEFMPNGSLDHHLSASSS
  . ..||.| || ||.|        ||||..      .. |  | .   ..  || |.|||.|.| ..       . ...| |.||.|.|...| ..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

FAASQEIFSTWETRHSIALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKE-----SMSITTVQ---GTRG-----YLAPEWL
         .... .|... ||.|  |||.|   ...| |.   |.|..| .. |.|||||.|  . .     | .  ...   |...      .||| .
K-------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

ESQSITPKADVYSFGMLLLDILGGKRKALMELGSGDREYENAPLPPPREWY--FPIYAFHKYMTSE--LESVAD--PNLASGSVDWEQFETALKIALSCI
     |.| ||.||| .           . |.      . .   |.| .     . .  ..|  .   ..  ..  | ...     .  .   .| ..| 
NYGKFTTKSDVWSFGVC-----------MWEI------FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSF----VCCPDEMYQIMKQCW

HQDPGSRPAMSRVVQIL
| || .|| .| .....
HEDPEDRPTFSEIHECF
Kinase IRAKg_r-1.AA Dicty4-Unclassified 645-739 35 1.5e-20 67.05 In-house 114-204 (263) Show / Hide 
Range on Protein: 645-739
Range on HMM: 114-204/263
Sequence Identity: 35% (34 aa)

IALGIAKGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKESMSITTVQGTRGYLAPEWLESQSITPKADVYSFGMLLLDILGG
.|. ||.|. .|| .    ..| |||  |.|.   |  |. |||..|  .      ||. ||    .|| |   | . |.||||..|.|   . |
YAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISR-VIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAKg_r-1.AA STE 645-740 29 1.2e-19 66.19 In-house 156-265 (359) Show / Hide 
Range on Protein: 645-740
Range on HMM: 156-265/359
Sequence Identity: 29% (35 aa)

IALGIAKG-LTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKE--------------SMSIT--TVQGTRGYLAPEWLES------QSIT
|.  | || | |||..    |.| ||||.|.||      | .|||..  .|..              .|.    |. ||  . ||| ..       .  .
ICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

PKADVYSFGMLLLDILGGK
 |.|..|.| ...  . ||
TKCDIWSLGCTIIEMATGK
Kinase IRAKg_r-1.AA STE 540-620 20 4.1e-13 42.78 In-house 1-125 (359) Show / Hide 
Range on Protein: 540-620
Range on HMM: 1-125/359
Sequence Identity: 20% (25 aa)

FRD--ELGSGGFGSVYRG---------NIPEK------GGIVAVKKITTVN------------------QAKKQFKAEVSTIGRVH--HVNLVRLLGYCA
...  ..|.|.||.||..            |.      | |.|.|..   |                  . ..|.. |...  . .  | | |. .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------DHHLLVYEFMPNGSLD
 .       |.  .. |.|..||||
KEGHNHKNDDELWICMEYMDGGSLD
Kinase IRAKg_r-1.AA Dicty4-Unclassified 539-619 34 4.2e-10 30.77 In-house 2-89 (263) Show / Hide 
Range on Protein: 539-619
Range on HMM: 2-89/263
Sequence Identity: 34% (31 aa)

NFRDELGSGGFGSVYRGNIPEKGGIVAVKKITTVNQAKK-----QFKAEVSTIGRVHHVNLVRLLGYCAEG----DHHLLVYEFMPNGSL
    ..| | |  |..||   ||  |||||.              ||.||   | . | |||.. |||            | |||. | |
QIDQFIGKGHFSKVHKGNW--KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNL
Kinase IRAKg_r-1.AA MLK 808-826 47 0.000129 12.08 In-house 273-291 (291) Show / Hide 
Range on Protein: 808-826
Range on HMM: 273-291/291
Sequence Identity: 47% (9 aa)

CIHQDPGSRPAMSRVVQIL
| .|||..|| .. .||.|
CWNQDPHKRPSFRQIVQHL
Kinase IRAKg_r-1.AA TK 804-826 34 0.000219 9.77 In-house 464-486 (486) Show / Hide 
Range on Protein: 804-826
Range on HMM: 464-486/486
Sequence Identity: 34% (8 aa)

IALSCIHQDPGSRPAMSRVVQIL
. ..| | ||  || .| ... |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKg_r-1.AA LRRK 807-828 36 0.000504 10.11 In-house 330-351 (351) Show / Hide 
Range on Protein: 807-828
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

SCIHQDPGSRPAMSRVVQILEG
.| ..|| .|| .| .|..|. 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_r-1.AA Dicty4-Unclassified 808-826 47 0.000953 8.67 In-house 245-263 (263) Show / Hide 
Range on Protein: 808-826
Range on HMM: 245-263/263
Sequence Identity: 47% (9 aa)

CIHQDPGSRPAMSRVVQIL
| | ||  || |  ..| |
CWHNDPNKRPTMNQIIQYL
Kinase IRAKg_r-1.AA Dicty4 808-828 34 0.002216 7.33 In-house 255-277 (277) Show / Hide 
Range on Protein: 808-828
Range on HMM: 255-277/277
Sequence Identity: 34% (8 aa)

CIHQDPGSRPAMSRVVQI--LEG
| . || .|| .. ..|.  || 
CWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKg_r-1.AA TK-Unique 807-826 30 0.007749 5.76 In-house 275-294 (294) Show / Hide 
Range on Protein: 807-826
Range on HMM: 275-294/294
Sequence Identity: 30% (6 aa)

SCIHQDPGSRPAMSRVVQIL
||.. .| .||  . ....|
SCWQWEPEERPSFRQIKHRL
Kinase IRAKg_r-1.AA Pkinase_Tyr 806-826 38 0.014707 9.29 Pfam 250-270 (270) Show / Hide 
Range on Protein: 806-826
Range on HMM: 250-270/270
Sequence Identity: 38% (8 aa)

LSCIHQDPGSRPAMSRVVQIL
..| |.||  || .| ....|
KQCWHYDPEDRPTFSEIHEQL