Gene IRAKg_e-1 (S.moellendorffii)

IRAKg_e-1

Species: S.moellendorffii
Alias: IRAKg_e-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_e-1.AA Protein None 823 None Fasta, JSON
IRAKg_e-1.NA RNA None 2472 None Fasta, JSON
IRAKg_e-1.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of IRAKg_e-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_e-1.AA B_lectin 117-151 55 6.1e-12 42.62 Pfam 65-104 (137) Show / Hide 
Range on Protein: 117-151
Range on HMM: 65-104/137
Sequence Identity: 55% (22 aa)

SGVRLDMQDDGNLVLK-HSN--NSVLWQS--FNLPTDTLL
...|. |||.|||||. ..|  |.|||||  |. ||||.|
NNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPTDTWL
B_lectin IRAKg_e-1.AA B_lectin 31-146 20 1e-06 24.64 SMART 1-126 (126) Show / Hide 
Range on Protein: 31-146
Range on HMM: 1-126/126
Sequence Identity: 20% (27 aa)

GESLKADEILISPGKNFG--FGFVNDTGAPGKLNVAIRVRSVE----TIIWTA--TALKGVTA---NAQLVLNEAQGLFVLDNGVAQVIVSCKSS-NCSG
 . |. .. | |... |   .||.. ..    . . |   . .    |..| |     . |.    .. |....   | ..|    ... | ... | ..
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ---WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD---NRPVWSSNTTRNNGN

VRLDMQDDGNLVLKHSN----NSVLWQSFNLP
...  |||||.|. ...    . ..||||  |
YVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_e-1.AA S_locus_glycop 241-310 25 8.1e-11 39.27 Pfam 43-114 (117) Show / Hide 
Range on Protein: 241-310
Range on HMM: 43-114/117
Sequence Identity: 25% (18 aa)

FTF--ANTRVMRMLKLEPSGNLRIYGLSTDNSSWNIVWQAMLLECQIHGVCGPFGLCTYAPRSTCVCPPGFH
.|.  .|....  . . ..| | ..    .. .||  | |.  .| . ..|||.|.|      .| | .||.
YTYHMTNNSIYSRFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFV
B_lectin IRAKg_e-1.AA B_lectin 252-277 37 2.17125 2.91 Pfam 69-92 (137) Show / Hide 
Range on Protein: 252-277
Range on HMM: 69-92/137
Sequence Identity: 37% (10 aa)

LKLEPSGNLRIY-GLSTDNSSWNIVWQ
...  |||| .| . . |  | |..||
AQMQDSGNLVLYDD-NND--SNNVLWQ
Kinase IRAKg_e-1.AA TKL 520-714 23 1.5e-60 207.44 In-house 1-289 (364) Show / Hide 
Range on Protein: 520-714
Range on HMM: 1-289/364
Sequence Identity: 23% (69 aa)

LGAGAFGTVYKGVLADGT--------SLVAVKSLMM----------------------------ATHAEKQFKAEVATLGKIHHINLVRMLGYCAEGSH-
.| |.||.||||..   .          |||| . .                            | ....... |.  . ...| |.|...||| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEYMENSSLEKVLSQVPKTLCEWKTRLAIALGISRGITYLHE------QCQECIIHCDIKPQNILLDDNFR-------------
              .|.||... ||. .|         |  |. .||.|.||. |||       .    |||.|.|..|||.|.|..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKVSDFGLAKLMKRESS------------------ANVTTARGTRGYMAPEWISNV----------------AITPKVDVYSFGMVLLELMSGRDKF
 .|..||||.. |.....                   .  | .|| ..|||| . .                   ..|.||||||.|| |.....  .
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY
Kinase IRAKg_e-1.AA IRAK 515-711 35 7.9e-57 195.11 In-house 2-221 (317) Show / Hide 
Range on Protein: 515-711
Range on HMM: 2-221/317
Sequence Identity: 35% (78 aa)

NFKDKLGAGAFGTVYKGVLADGTSLVAVK-----SLMMATHAEKQFKA---EVATLGKIHHINLVRMLGYCAEGSHRLLVYEYMENSSLEKVLSQVPK--
.   ..| |.||.||.|..   |  .|||       |  .  ...| .   |. .. ...| |.|  .|||.|..   |||.|| | |||  |.      
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

TL--CEWKTRLAIALGISRGITYLHEQC-QECIIHCDIKPQNILLDDNFRPKVSDFGLAK------LMKRESS--ANVTTARGTRGYMAPEWIS--NVAI
..   .| .|. |..|...|| .||.      ||| |||. |||||..| || .||||.        ... ..  . . . |||  ||.|| |      .
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

TPKVDVYSFGMVLLELMSGR
|.|.|||||| ||||. .|.
TKKTDVYSFGIVLLEVLTGC
Pkinase IRAKg_e-1.AA Pkinase 514-711 31 9e-54 189.76 Pfam 1-209 (293) Show / Hide 
Range on Protein: 514-711
Range on HMM: 1-209/293
Sequence Identity: 31% (67 aa)

GNFKDKLGAGAFGTVYKGVLADGTSLVAVKSLMMATHAEKQFKA-----EVATLGKIHHINLVRMLGYCAEGSHRLLVYEYMENS----SLEKVLS---Q
  .. |.|.|.||.|||..  .   .|||| .   .  ... ..     |.. . ...| | ||..... ...|  .| ||.|.     .|  ..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VPKTLCEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDNFRP----KVSDFGLAKLMKRESSANVTTARGTRGYMAPEWIS-NVAITPKVD
 . .  ....   ... | ||. |.|..    |||.|.||.|||.|.|  .    |..||||||...  ..   ||  ||..|||||.|  .  ..||||
GCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSFGMVLLELMSGR
..|.| .| |...||
MWSCGCILYEMLCGR
Kinase IRAKg_e-1.AA TKL-Unique 516-710 30 5.4e-47 162.45 In-house 1-224 (290) Show / Hide 
Range on Protein: 516-710
Range on HMM: 1-224/290
Sequence Identity: 30% (70 aa)

FKDKLGAGAFGTVYKGVLADGTSLVAVKSLMM--ATHAE--KQFKAEVATLGKIH-HINLVRMLGYCA----EGSHRLLVYEYMENSSLEKVLSQ-----
|  |.|.|..|.||||. .  .. ||.|..      . |  . |. || .. |.| |.|.|.  |||.      ... .| ||.. .|| .||.|     
FWNKIGEGGYGQVYKGKWR--GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---VPKTLCEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDN-----FRPKVSDFGLAKLMKRESSANVT--------TARGTRGYMAPEW
    ...   .. |. .|. |..|  |||      |||.|.|..|.|.| |     .. |..||||.|. ....  ...        |  |.  .|||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

ISN--VAITPKVDVYSFGMVLLELMSG
...    .. |.||||||.|| |. ..
LRMNFCQYSEKSDVYSFGIVLWEIATR
S_TKc IRAKg_e-1.AA S_TKc 514-786 24 7e-42 146.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 514-786
Range on HMM: 1-231/231
Sequence Identity: 24% (72 aa)

GNFKDKLGAGAFGTVYKGVLADGTSLVAVKSLMMATHAEKQFKAEVATLGKIHHINLVRMLGYCAEGSHRLLVYEYMEN--SSLEKVLSQVPK-----TL
  . .|.| ||||.|||..  .   .||.| .       .... |.. | | || |.|...... . .|  .| ||...   .| ... . ..      .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

CEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSANVTTARGTRGYMAPEWISNVAITP-KVDVYSFGMVLL
 |  .|  ..  | ... |.|..    |||.|.||.|||||.  . |..|||||...        ||  ||. ||||| .     .. |.|..|.| .| 
PE-HARF-YMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELMSGRDKFMFTPSAMNSGRWYFPVWAFEQCATGNMKSTADPRMAETIDWEQFEMALRVAFWCIQPEPESRPSMSKVVQ---------ML
|...|.  |              .   |...                      . |.     | | .|| ||.  .. |          .
EMLCGYPPFP------------QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKg_e-1.AA Dicty4 555-707 34 2.2e-41 135.89 In-house 45-210 (277) Show / Hide 
Range on Protein: 555-707
Range on HMM: 45-210/277
Sequence Identity: 34% (58 aa)

FKAEVATLGKIHHINLVRMLGYCA----EGSHRLLVYEYMENSSLEKVLSQ-----VPKTLCEWKTRLA---IALGISRGITYLHE-QCQECIIHCDIKP
|..||. ..|| | |..  .|.|     . .  . | |||   .|...|        ...  .| ....   .|. . ||...||.  .   ||| |.|.
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKS

QNILLDDNFRPKVSDFGLAKLMKRES--SANVTTARGTRGYMAPEWISNVAITPKVDVYSFGMVLLEL
 |.| |.|.| ||.||||...||...  ..| .|| || ..||||   . . . |.||||||.|| |.
HNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEI
Kinase IRAKg_e-1.AA Pkinase_Tyr 515-709 30 9.1e-40 135.31 Pfam 2-209 (270) Show / Hide 
Range on Protein: 515-709
Range on HMM: 2-209/270
Sequence Identity: 30% (66 aa)

NFKDKLGAGAFGTVYKGVLA----DGTSLVAVKSLMMATHAE----KQFKAEVATLGKI-HHINLVRMLGYCA-EGSH--RLLVYEYMENSSLEKVLSQV
 |  |||.||||.||||..     ...  ||||.|   .. |    . | .|.... .. || |.||..| |  .| .   ..| |||.. .| . | . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

---PKTLCEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSANVTTARGTRG---YMAPEWISNVAITPKVD
   .. |.     | ... |..|  ||...    .|| |.   |.|...|.  |..|||||...  ..   .... |..     |||| |..   | | |
REDKQPLTMKD-LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

VYSFGMVLLELMS
|.||| .. |...
VWSFGVLMWEIFT
Kinase IRAKg_e-1.AA MLK 514-711 27 4.5e-39 133.22 In-house 1-233 (291) Show / Hide 
Range on Protein: 514-711
Range on HMM: 1-233/291
Sequence Identity: 27% (65 aa)

GNFKDKLGAGAFGTVYKGVLADGT---SLVAVKSLM-------MATHAEKQFKAEVATLGKIHHIN----LVRMLGYCAE-GSHRLLVYEYMENSSLEKV
 .|. ..|.|.|| |.||.    .     ||||           .    ..|. |.  | .. | |     .. .| |.. ..| ..| ||.|..||  |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

L-SQVPKTL-----------CEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDD------NFRPKVSDFGLAKLMKRESSANVTTARGTRGY
| .. .|                   . .|| ..||. |||.. .  ||| |.|..|||.|.      .   |..|||... ...   .| . ..||  .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

MAPEWI---SNVAITPKVDVYSFGMVLLELMSGR
|||| |    .   . |.||.|.|.|| |.....
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAKg_e-1.AA TK 514-709 16 1.5e-37 122.89 In-house 1-389 (486) Show / Hide 
Range on Protein: 514-709
Range on HMM: 1-389/486
Sequence Identity: 16% (64 aa)

GNFKDKLGAGAFG---TVYKGVLADGT-------------------------SLVAVKSLMM-ATHAEKQFKA--------------EVATLGKIH----
  . .|||.|.||   .|||| . ..                            |||| |.  .......|..              |.. . . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HINLVRMLGYCAEG------------SHRLLVYEYMENSS----LEKVLSQ-VPKTLCEWK--------------------------------------
 | |.||..|.| .|             . ..| |||.. .    | . | .  ||. .|                                        
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------------TRLAIALGISRGITYLHEQ----CQECIIHCDIKPQNILLDDNFR-----------PKVSDFGLA
                                   ..| ... |..|  |||..        ..| |.   |.|...| .            |..||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----LMKRESSANVTTARGTRG----------------------------YMAPEWIS---------NVAITPKVDVYSFGMVLLELMS
.     | ..  |    ......|                            .|||| .          .   |.| ||.||| .. |...
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKg_e-1.AA RIPK 520-711 31 4.9e-35 116.82 In-house 1-225 (290) Show / Hide 
Range on Protein: 520-711
Range on HMM: 1-225/290
Sequence Identity: 31% (71 aa)

LGAGAFGTVYKGVLADGTSLVAVKS---LMMATH----AEKQFKAEVATLGKIHHINLVRMLGYCAEG-----SH-RLLVYEYMENSSLEKVLSQVPKT-
.| |.||.|.| . ..    ||.|    . ..||     ... | |.. . |. . . |...| | .      .    .| ||||| ||...|.  ..  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LCEWKTRLAIALGISRGITYLHEQCQE-CIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSAN----------VTTAR--GTRGYMAPEWIS--
   .. |. |  .   ||.|  |||  ..   ||| | ||.|||.| ||  |..|||||. |   .| .           . .   ||  ||.|| .   
HHPDP-WPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

NVAI----TPKVDVYSFGMVLLELMSGR
| .     ||| |||||..|. |.....
NKKPIKVVTPKYDVYSFAIVMWEVLTQK
Kinase IRAKg_e-1.AA STE 516-711 21 4.8e-34 117.64 In-house 1-265 (359) Show / Hide 
Range on Protein: 516-711
Range on HMM: 1-265/359
Sequence Identity: 21% (59 aa)

FKD--KLGAGAFGTVYKGVLADGT---------------SLVAVKSLMMAT------------------HAEKQFKAEVATLGKIH--HINLVRMLGYCA
...  |.| ||||||||..  . .                ..|.| . . .                    ..|.. |. .. | .  | | |. .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------SHRLLVYEYMENSSLEKVLSQVPKTLCE------------WKTRLAIALGISRG-ITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFG
 .       ..  .. |||.. ||.... .. .....             .   .|.  | .|   |||..    ||| ||||.||||      | .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLMKRE--------------SSANVT-TARGTRGYMAPEWISN------VAITPKVDVYSFGMVLLELMSGR
... .  .              ...  . |  ||  .|||| |..         . |.|..|.| ...|.  |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKg_e-1.AA CZAK 515-712 31 2.4e-31 110.47 In-house 2-220 (279) Show / Hide 
Range on Protein: 515-712
Range on HMM: 2-220/279
Sequence Identity: 31% (70 aa)

NFKDKLGAGAFGTVYKGVLADGTSLVAVKSLMMA---THAE----KQFKAEVATLGKIHHINLVRMLGYCAEGS--HRLLVYEYMENSSLEKVLSQVPKT
 |    | | || |||..   |.. ||.| .      .  |      |  ||. . |  | | |  || | |.   |.  | |.|.  || . |      
KFGQTIGQGFFGEVYKAYWR-GKD-VAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFY

LCE-WKTRLAIALGISRGITYLHEQCQE-CIIHCDIKPQNILLDDNFR-------------PKVSDFGLAKLMKRESSANVTTARGTRGYMAPEWISNVA
.      .. .|. | ||  |||    .  |.| |   .|||||..                |..|||| ..|. |     | . |   .||||      
HKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMM-EQPFEMTQTMGCLCWMAPECFKGEN

ITPKVDVYSFGMVLLELMSGRD
 |.|||||||||.| ..  ...
YTEKVDVYSFGMILWCIITCDQ
Kinase IRAKg_e-1.AA LRRK 514-711 23 1.3e-30 105.45 In-house 1-279 (351) Show / Hide 
Range on Protein: 514-711
Range on HMM: 1-279/351
Sequence Identity: 23% (68 aa)

GNFKDKLGAGAFG-TVYKGVLA--------------------------DGTSLVAVKSLMM-----------------------------------ATHA
  .  ..| |.|| .||.. .                           |  . ||.|.. .                                   ...|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EKQFKAEVATLGKIHHINLVRMLGYCAEGSHRLLVYEYMENSSLEKVLS---QVP----KTLCEWKTRLAIALGISRGITYLHEQCQEC--IIHCDIKPQ
   |  ||. . . .| |.| ..|.| .  .. .| ||. . .| ..|.   | .    |.   | ..| ||| |..|. ||| .      |||.| |. 
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH---NPPIIHRDLKSP

NILL---D---------DNFRPKVSDFGLAKLMKRESSAN--VTTARGTRGYMAPEWIS---NVAITPKVDVYSFGMVLLELMSGR
||||   .         ..   |..|||.   |   .  .  . .  |. |.|||| .    ..  | |||.|||||.| ||....
NILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAKg_e-1.AA TyrKc 514-786 25 1e-28 102.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 514-786
Range on HMM: 1-280/280
Sequence Identity: 25% (77 aa)

GNFKDKLGAGAFGTVYKGVLADGTSLVAVKSLMMATHAEKQFKAEVATLGKI--HHINLVRMLGYCAEG-------SHRLLVYEYMENSSLEKVLSQVPK
  ...||| ||||.||||..      ||||.|   .  .. |  |   . |.  || |.||..|.| ..          ..| |||.. .| . |    .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TLCEWKTRLAIALGISRGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRE----SSANVTTAR---GTRG-----YMAPEWISNVAIT
.   .|. | ... |..|  |||..   ..|| |.   |.|...|.. |.|||||..  . .     |  . ...   |...      |||| |     |
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PKVDVYSFGMVLLELMSGRDKFMFTPSAMNSGRWYFPV-----WAFEQCATGNMKSTADPRMAETIDWEQF-------EMALRVAFWCIQPEPESRPSMS
.| ||.||| .. |...              |    |         ..     ..    |....    .         ||   .  .| . .||.||..|
TKSDVWSFGVCMWEIFTY-------------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQ-IMKQCWHEDPEDRPTFS

KVVQML
 ... .
EIHECF
Kinase IRAKg_e-1.AA LRRK 767-788 36 1.6e-05 15.49 In-house 330-351 (351) Show / Hide 
Range on Protein: 767-788
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

WCIQPEPESRPSMSKVVQMLEE
.| | .|..||..|..|. |..
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKg_e-1.AA Dicty4 767-788 37 3.3e-05 13.49 In-house 254-277 (277) Show / Hide 
Range on Protein: 767-788
Range on HMM: 254-277/277
Sequence Identity: 37% (9 aa)

WCIQPEPESRPSMSKVVQM--LEE
||  ..|..|||.. ..|   ||.
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKg_e-1.AA Dicty4 515-531 52 3.7e-05 13.35 In-house 2-18 (277) Show / Hide 
Range on Protein: 515-531
Range on HMM: 2-18/277
Sequence Identity: 52% (9 aa)

NFKDKLGAGAFGTVYKG
|. ...| |.||.||||
NIEQRIGKGSFGEVYKG
Kinase IRAKg_e-1.AA TK 768-786 36 4.6e-05 12.09 In-house 468-486 (486) Show / Hide 
Range on Protein: 768-786
Range on HMM: 468-486/486
Sequence Identity: 36% (7 aa)

CIQPEPESRPSMSKVVQML
| ...|| ||..| ....|
CWHYDPEDRPTFSQLHEQL
Kinase IRAKg_e-1.AA TKL 767-786 35 8.9e-05 13.15 In-house 345-364 (364) Show / Hide 
Range on Protein: 767-786
Range on HMM: 345-364/364
Sequence Identity: 35% (7 aa)

WCIQPEPESRPSMSKVVQML
.| ...||.|||...... |
DCWDHDPEKRPSFQEILKRL
Kinase IRAKg_e-1.AA MLK 768-786 42 0.000156 11.79 In-house 273-291 (291) Show / Hide 
Range on Protein: 768-786
Range on HMM: 273-291/291
Sequence Identity: 42% (8 aa)

CIQPEPESRPSMSKVVQML
| ...|..|||.. .|| |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKg_e-1.AA Pkinase_Tyr 768-786 36 0.005914 10.63 Pfam 252-270 (270) Show / Hide 
Range on Protein: 768-786
Range on HMM: 252-270/270
Sequence Identity: 36% (7 aa)

CIQPEPESRPSMSKVVQML
| ...|| ||..| ....|
CWHYDPEDRPTFSEIHEQL
Kinase IRAKg_e-1.AA CZAK 773-786 42 0.02248 4.62 In-house 266-279 (279) Show / Hide 
Range on Protein: 773-786
Range on HMM: 266-279/279
Sequence Identity: 42% (6 aa)

PESRPSMSKVVQML
|..||| . ..| |
PDERPSFKQILQHL
Kinase IRAKg_e-1.AA TKL-Unique 768-786 31 0.239758 0.73 In-house 272-290 (290) Show / Hide 
Range on Protein: 768-786
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CIQPEPESRPSMSKVVQML
|  ..|. ||| . ..  |
CWHHDPSQRPSFDEIIHRL
Kinase IRAKg_e-1.AA Pkinase 754-786 16 1.981554 2.6 Pfam 238-293 (293) Show / Hide 
Range on Protein: 754-786
Range on HMM: 238-293/293
Sequence Identity: 16% (9 aa)

DWEQF---------------------EMALRVAFWCIQPEPESRPSMSKVVQM--L
||..                      | .. .  ||... |..||.   ..|   .
DWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF