Gene IRAKf_a (S.moellendorffii)
IRAKf_a
Species: S.moellendorffii
Alias: IRAKf_a
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| IRAKf_a.AA | Protein | None | 869 | None | Fasta, JSON |
| IRAKf_a.NA | RNA | None | 2610 | None | Fasta, JSON |
| IRAKf_a.kin_dom | Protein Kinase Domain | None | 201 | None | Fasta, JSON |
Protein domains of IRAKf_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| LRRNT_2 | IRAKf_a.AA | LRRNT_2 | 1-30 | 31 | 8.3e-09 | 31.52 | Pfam | 12-46 (46) | Show / Hide |
Range on Protein: 1-30 Range on HMM: 12-46/46 Sequence Identity: 31% (11 aa) RADLHD-PR--RALASWSEDS--ASPCNWTGIQCS .. |.| .. .|.||. .| ...|.|||. |. KSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 39-62 | 37 | 0.005565 | 14.74 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 39-62 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) LLSLLDVSH-N--SFSGSVPPELFANC | ||.|. | ...|..||. | |. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_TYP | IRAKf_a.AA | LRR_TYP | 36-61 | 30 | 0.414182 | 2.99 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 36-61 Range on HMM: 1-24/24 Sequence Identity: 30% (8 aa) VTQLLSLLDVSHNSFSGSVPPELFAN ..| || |.| . ..||..|.. LPNL-RELDLSNNQL-THLPPGAFQG |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 65-87 | 33 | 0.000193 | 19.92 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 65-87 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) SLRYVFLSG-N--QLEGDLPDS-IASC .|.. ||| | .|.|..|.| . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 113-135 | 40 | 0.000239 | 19.59 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 113-135 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) RLGSLDLSH-N--SLSGEIPPE-LGQC .| .||||. | .|.|.|||. . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_TYP | IRAKf_a.AA | LRR_TYP | 111-135 | 44 | 0.008549 | 16.53 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 111-135 Range on HMM: 1-24/24 Sequence Identity: 44% (11 aa) LSRLGSLDLSHNSLSGEIPPELGQC |. | .||||.| | ..||.. |. LPNLRELDLSNNQL-THLPPGAFQG |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 89-111 | 33 | 0.131504 | 9.87 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 89-111 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) SLEALGASE-N--RLSGSIPAG-VGSL .|. | | | .|.|.|| . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 137-159 | 40 | 0.004022 | 15.24 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 137-159 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) MLVSLDLSY-N--LLSGEIPSF-LESL | .||||. | |.|.||. . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 210-232 | 33 | 0.000434 | 18.67 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 210-232 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) ALRRLYLHN-N--NLQGALPPA-LAGC |..|.| . | ||.| .|| . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_TYP | IRAKf_a.AA | LRR_TYP | 208-232 | 40 | 0.032019 | 12.1 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 208-232 Range on HMM: 1-24/24 Sequence Identity: 40% (10 aa) MKALRRLYLHNNNLQGALPPALAGC . .||.|.|.||.| .||| . .. LPNLRELDLSNNQL-THLPPGAFQG |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 186-208 | 33 | 0.041935 | 11.63 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 186-208 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) ELQELNLAE-N--DLGGTLPSS-IGSM ||.|.| | | |..|.| . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 161-184 | 25 | 0.494614 | 7.83 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 161-184 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) RLEVLRLPG-N--SFSGGVPEWIVTGF .|..| | | | ...| .|... .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_TYP | IRAKf_a.AA | LRR_TYP | 184-207 | 36 | 0.751364 | 0.87 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 184-207 Range on HMM: 1-24/24 Sequence Identity: 36% (9 aa) FPELQELNLAENDLGGTLPSSI-GS |.|.||.| | | .||. . .. LPNLRELDLSNNQL-THLPPGAFQG |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 234-256 | 40 | 0.000748 | 17.83 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 234-256 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) NLSTIDLSS-N--NFSGAIPDE-IFEL || ..|||. | |..| ||.. . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_TYP | IRAKf_a.AA | LRR_TYP | 234-256 | 34 | 0.732606 | 0.96 | SMART | 3-24 (24) | Show / Hide |
Range on Protein: 234-256 Range on HMM: 3-24/24 Sequence Identity: 34% (8 aa) NLSTIDLSSNNFSGAIPDEIFEL || . |||.|.. ..|...|. NLRELDLSNNQL-THLPPGAFQG |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 257-279 | 22 | 20.413357 | 2.1 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 257-279 Range on HMM: 1-26/26 Sequence Identity: 22% (6 aa) ELERLALAM-N--SFSGGLPVA-LSSS |..| | | ...| .| . . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 311-334 | 33 | 0.000743 | 17.84 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 311-334 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) HLRSLNLGQ-N--GLSGSIPEELVAGL .|..|.|. | |.|.||.. .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 336-358 | 48 | 0.002271 | 16.12 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 336-358 Range on HMM: 1-26/26 Sequence Identity: 48% (13 aa) ELSSLDLSS-N--FLTGYIPRS-FGGS | .||||. | |||.|| | | . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 287-309 | 40 | 0.003945 | 15.27 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 287-309 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) VIQSLDLSR-N--SLEGEIPPQ-VSGC .|.||||. | .|.|.||| .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 360-382 | 33 | 0.006174 | 14.58 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 360-382 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) SLETLKLDD-N--ALVGIIPEG-LGNC .|..| |.. | |.| ||.. . |. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_TYP | IRAKf_a.AA | LRR_TYP | 334-357 | 50 | 0.026899 | 12.72 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 334-357 Range on HMM: 1-24/24 Sequence Identity: 50% (12 aa) LSELSSLDLSSNFLTGYIPRSFGG |..| .||||.| || |. |.| LPNLRELDLSNNQLTHLPPGAFQG |
|||||||||
| LRR_TYP | IRAKf_a.AA | LRR_TYP | 359-382 | 33 | 0.545465 | 2.01 | SMART | 2-24 (24) | Show / Hide |
Range on Protein: 359-382 Range on HMM: 2-24/24 Sequence Identity: 33% (8 aa) PSLETLKLDDNALVGIIPEGLGNC |.|..| |..|.| .|.|. .. PNLRELDLSNNQL-THLPPGAFQG |
|||||||||
| LRR_TYP | IRAKf_a.AA | LRR_TYP | 309-333 | 32 | 0.679096 | 1.23 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 309-333 Range on HMM: 1-24/24 Sequence Identity: 32% (8 aa) CQHLRSLNLGQNGLSGSIPEELVAG .||.|.|. | | ..|... .| LPNLRELDLSNNQL-THLPPGAFQG |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 408-430 | 55 | 9e-06 | 24.56 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 408-430 Range on HMM: 1-26/26 Sequence Identity: 55% (15 aa) SLQSLDLSS-N--HLTGQIPTS-FAQL .||.||||. | .|||.|| | | .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 384-406 | 48 | 6.2e-05 | 21.67 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 384-406 Range on HMM: 1-26/26 Sequence Identity: 48% (13 aa) SLRYLDLSQ-N--NLTGGIPVE-LADL .|..|||| | |||| || . . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
|||||||||
| LRR_TYP | IRAKf_a.AA | LRR_TYP | 406-429 | 45 | 0.021665 | 13.49 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 406-429 Range on HMM: 1-24/24 Sequence Identity: 45% (11 aa) LSSLQSLDLSSNHLTGQIPTSFAQ |..|..||||.|.|| | |. LPNLRELDLSNNQLTHLPPGAFQG |
|||||||||
| LRR_1 | IRAKf_a.AA | LRR_1 | 432-456 | 35 | 0.138516 | 9.79 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 432-456 Range on HMM: 1-26/26 Sequence Identity: 35% (10 aa) NLSLFNVSH-N--SLAGPIPSDGAFPLL || ..|. | .| | ||.. .| | NLQHLDLSGCNCCNLTGHIPPS-CF-NL |
|||||||||
| Kinase | IRAKf_a.AA | TKL | 596-858 | 21 | 2e-61 | 210.39 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 596-858
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)
IGRGGFGTVYKATLAA---------GRTVAVKKLSVPG-----------------------MVETQDEFEKRVQFL---GKIQHENLVNFQGYYFTPKL-
||.||||.|||... |..|||||... . |.. ....... . ...|.|.| | || . |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------QLLIYDFVPNGNLHSKLHEQSVLPWELRFKVALGAAQGLCYLHHKCR-----PRVIHYNFKSSNVLLDDGFN--------------AR
......|.|.|.. || |..|.. ||..|.|..||| . | .|| . ||.|.|.|. .. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
VSDYGLAKLLHSRDRFVVM----------------NKLQS-SLGYLAPEC---------------GCESFKVTEKCDVYGFGVVLLELITGKPPVE-YLE
..|.||.. .. . . . | .....|||. |..|. .|||||| ||.|| |..|...| . | .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY
NDVVIL---CDFVRSLADDGKPLLC------VDPKMVVYPEEEVMT-LIKLGLVCTSPVPANRPSMTEVVQIL
..... .. .|.|..... . | . .|.. ... ..|| | .. | .|||..|....|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
|||||||||
| Kinase | IRAKf_a.AA | IRAK | 591-858 | 24 | 6.3e-42 | 145.61 | In-house | 2-317 (317) | Show / Hide |
Range on Protein: 591-858
Range on HMM: 2-317/317
Sequence Identity: 24% (79 aa)
NKNSEIGRGGFGTVYKATLAAGR-TVAVKKLSVPGMVETQD---EFEK---RVQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPNGNLHSKLHEQSV--
.|. || ||||.||.. . ..||||| .... .| .. . ...|.|.| . || . . |.|.. ||| |. |. |
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC
----LPWELRFKVALGAAQGLCYLHHKCRPR--VIHYNFKSSNVLLDDGFNARVSDYGLAKLL----HSRDRFV---VMNKLQSSLGYLAPECGC-ESFK
|.| |.....|.| |. .|| . .| .|| . ||.|.|||. |.. .| ||. |. . . .... .. |..|| . .
PPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ
VTEKCDVYGFGVVLLELITGKPPVEYLENDVVILCDFVRSLADDGK--------------------PLLC------VDPKMVVYPEEEVMTLIKLGLVCT
| | ||| ||.||||..|| ..| . | | .. ... . | .|..| |.... . . . |.
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG
SPVPANRPSMTEVVQIL
..|..|..|.| |
HHRANRRCDMAWVMQQL
|
|||||||||
| Kinase | IRAKf_a.AA | TKL-Unique | 594-788 | 31 | 1.4e-41 | 144.45 | In-house | 3-225 (290) | Show / Hide |
Range on Protein: 594-788 Range on HMM: 3-225/290 Sequence Identity: 31% (70 aa) SEIGRGGFGTVYKATLAAGRTVAVKKLSV-PGMV-ETQDEFEKRVQFLGKIQ-HENLVNFQGYYF----TPKLQLLIYDFVPNGNLHSKLH--------- . ||.||.|.|||.. .| ||.|.... . | .|||. | . |.. |.|.| . || . .|. .. ...| |.|.. || NKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN -EQSVLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDG-----FNARVSDYGLAKLLHSR-DRFVVMN------KLQSSLGYLAPECGCE . . |....| | |. .|||..||||. | .|| . ||||.|.| . .|....| ||.|.. .. . .. .. ..|. ..||| . NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM S-FKVTEKCDVYGFGVVLLELITGK . .. .||.||| ||.|| |..|.| NFCQYSEKSDVYSFGIVLWEIATRK |
|||||||||
| Pkinase | IRAKf_a.AA | Pkinase | 590-790 | 22 | 5.1e-33 | 117.82 | Pfam | 1-211 (293) | Show / Hide |
Range on Protein: 590-790 Range on HMM: 1-211/293 Sequence Identity: 22% (48 aa) LNKNSEIGRGGFGTVYKATLAAGRT-VAVKKLSVPGMVETQDEFEKR---VQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPNG----NLHSKLH--EQ . . . ||.|.||.|||.. . ||||...... . .|. | .| . ...|.| | . ... ... .. .....| |.. .. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH SVL--PWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNA----RVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPECGCE-SFKVTEKC .. ... .... ..|| |.| . ..|| |..|.|.|. . ...| ||||.. . . |. . ...|.||| . . . . |. GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKV DVYGFGVVLLELITGKPP |....|..| |...|.|| DMWSCGCILYEMLCGRPP |
|||||||||
| Kinase | IRAKf_a.AA | TK | 590-858 | 13 | 7.8e-33 | 106.82 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 590-858
Range on HMM: 1-486/486
Sequence Identity: 13% (68 aa)
LNKNSEIGRGGFG---TVYKATLAAGR--------------------------TVAVKKLSVPGMVETQDEFE-----------------KRVQFLG-KI
. ..|.| || .|||... .. .|||| | . ...|. . ... .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
QHENLVNFQGYYFTP------------KLQLLIYDFVPNGN----LHSKLHEQSV---------------------------------------------
.|.|.|.. |. . . . ... ..|.|. |.. |.. .
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LPWELRFKVALGAAQGLCYLHHK----CRPRVIHYNFKSSNVLLDDGFN-----------ARVSDYG--
|. . . .. .|.|. ||| | ....| . |.|.... . ....|.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS
------LAKLLHSRDRFVVMN-------------------KLQSSLG-----YLAPECGCESF--------KVTEKCDVYGFGVVLLELIT-G-KPPVEY
||. ..|.| .... ..|.| | ..|||| . | |.| ||. |||.. |. | | .|. ..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG
LENDVVIL----CDFVRSLADD-----------GKPLLCVDP---------KMVVYPEEEVMTLIKL-GLVCTSPVPANRPSMTEVVQIL
. |. |. .... | . | . . | .| |... ... . . | .. |. ||....... |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
|
|||||||||
| Kinase | IRAKf_a.AA | LRRK | 590-792 | 22 | 1.5e-29 | 101.75 | In-house | 1-284 (351) | Show / Hide |
Range on Protein: 590-792 Range on HMM: 1-284/351 Sequence Identity: 22% (67 aa) LNKNSEIGRGGFG-TVYKATLAA---------------------------GRTVAVKKLSVP---------------------------------GMVET | ....||||||| .||.|.. . .||.||. .. .. . LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA QDEFEKRVQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPNGNLHSKLH---EQS------VLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNV || . | . . .| |.|. |. . | .. ...|.|.|.. || . . ...| |. |.|| | |. || |...| .|| . || |. FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI LL---D---------DGFNARVSDYGLAK----LLHSRDRFVVMNKLQSSLGYLAPECGCES--FKVTEKCDVYGFGVVLLELITGK-PPVE || . . .| ..|.|. .... ...| |. |..|||. . ||| |.| ||..| ||.|.. .| . LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNP-----GWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD |
|||||||||
| Kinase | IRAKf_a.AA | MLK | 590-790 | 25 | 3.2e-29 | 98.57 | In-house | 1-235 (291) | Show / Hide |
Range on Protein: 590-790 Range on HMM: 1-235/291 Sequence Identity: 25% (60 aa) LNKNSEIGRGGFGTVYKATLAAGR----TVAVKKLS---VPGMVET---QDEFEKRVQFLGKIQHEN----LVNFQGY-YFTPKLQLLIYDFVPNGNLHS .. || |.|| |.|.. . . .||||. ...| |..||. . | ...|.| . | | .|. ... ....| |.. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN KLHEQS--------------VLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDD------GFNARVSDYGLAKLLHSRDRFVVMNKLQSSL ||... | . .. .. || |.|. ||| . .. .||. ||.|.|.|. . .....| |... .|... | . . .. VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGTY GYLAPECG--CESFKVTEKCDVYGFGVVLLELITGKPP . ||| .. |..|||||. .|||| |..|.. | AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP |
|||||||||
| Kinase | IRAKf_a.AA | S_TKc | 590-861 | 20 | 3.4e-29 | 104.24 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 590-861 Range on HMM: 1-231/231 Sequence Identity: 20% (58 aa) LNKNSEIGRGGFGTVYKATLAA-GRTVAVKKLSVPGMVETQDEFEKRVQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPN--GNLHSKLHEQSV----- . .||.|.||.|||.. || ||.|... . ... .| | | .|.|.|.. ... . . .. ..... |.|.. .... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPECGCESFKVTE-KCDVYGFGV .| ... ...| |.| . .|| | .|.|||. . ..| |||..| . . .. |.||| . . |||.. .|. PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC VLLELITGKPPVEYLENDVVILCDFVRSLADDGKPLLCVDPKMVVYPEEEVMTLIKLGLVCTSPVPANRPSMTEVVQ------ILELI .| |...|.|| . .. . . .. .|. .|. |. |..||. |. | . . . ILYEMLCGYPPFP----QMQMMFKKIG--------------------SPEAKDFIRKCLQ---KDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | IRAKf_a.AA | RIPK | 596-858 | 25 | 3.9e-28 | 92.95 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 596-858
Range on HMM: 1-290/290
Sequence Identity: 25% (75 aa)
IGRGGFGTVYKATLAAGRTVAVKKLSV-PGMVET-----QDEFEKRVQFLGKIQHENLVNFQGYYFTP------KLQLLIYDFVPNGNLHSKLHEQSV--
.|.||||.|.||. . .....|| . . . .. . . .. . |...|. | | . ||. . . .||.| || ..
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ
---LPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSR----DRF-----VVMNKLQS--SLGYLAPECGC--ES
.|| ||. . | |||| . | .|| | .|.|.| |.. ..| |||. . || | .... | |..|| ..
HHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK
FK---VTEKCDVYGFGVVLLELITGKPPVEYLENDVVILCDFVRSLADDGKPLLCVDPKMVVYPEE-EVMTLIKLGLVCTSPVPANRPSMTEVVQIL
||.| ||| |..|. |. |.| | | ... .|. ... . | |..| . .|| .. .|.| | . | .||. |.
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMM----CCKQGHRP--CLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
|
|||||||||
| Kinase | IRAKf_a.AA | Pkinase_Tyr | 590-790 | 25 | 6.8e-26 | 88.32 | Pfam | 1-214 (270) | Show / Hide |
Range on Protein: 590-790
Range on HMM: 1-214/270
Sequence Identity: 25% (55 aa)
LNKNSEIGRGGFGTVYKATLA-----AGRTVAVKKLSVPGMVET--QDEFEKRVQFLGKI-QHENLVNFQGYYF-TPKL--QLLIYDFVPNGNLHSKLHE
. .. ..|.| ||.|||.|. . .||||.| | | ...| . .. . .. .|.|.|.. | . ... ..|.|.|.. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK
----QSVLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRF-VVMNKLQSSLGYLAPECGCESFKVTEKCD
. |. . . .. |.|. ||. | || |.|..... ....| |||..... | .. . .|||| | |.| |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC-INYGKFTTKSD
VYGFGVVLLELIT-GKPP
|. |||.. |..| |. |
VWSFGVLMWEIFTYGEQP
|
|||||||||
| Kinase | IRAKf_a.AA | Dicty4-Unclassified | 590-790 | 32 | 1.1e-24 | 81.39 | In-house | 1-207 (263) | Show / Hide |
Range on Protein: 590-790 Range on HMM: 1-207/263 Sequence Identity: 32% (70 aa) LNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPGMVETQ----DEFEKRVQFLGKIQHENLVNFQGYYFTP---KLQLLI-YDFVPNGNLHSKLH---- . .||.| | |.| |. |||||. . ..| | | || ||| ||| || | | . | | . ||| | IQIDQFIGKGHFSKVHKGNW-KGKDVAVKKFNE-NKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS -EQSVLPWEL--RFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPEC-GCESFKVTEKCD | . . |.|. |||. .|| . .|| ||||.|.| ||... | |.. | | .||| ||. . | | EQQQPIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI---DFNFNMTTIAGTPKWESPECLMHESY--NQKSD VYGFGVVLLELITGKPP || ....| ||.|| | VYSYAMMLYELATGDEP |
|||||||||
| Kinase | IRAKf_a.AA | Dicty4 | 590-736 | 35 | 6.1e-24 | 76.87 | In-house | 1-162 (277) | Show / Hide |
Range on Protein: 590-736 Range on HMM: 1-162/277 Sequence Identity: 35% (59 aa) LNKNSEIGRGGFGTVYKATLAAGRTVAVKKL--SVPGM-VETQDEFEKRVQFLGKIQHENLVNFQGYYF----TPKLQLLIYDFVPNGNLHSKLHE---- .|. ..||.|.||.|||.| | |||||| . .. || | | ..||.| |.. | |. .| . ..| |||.| || INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE --QSV-LPWELRFK---VALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAK ||. |.|.|. . |. ||.|. .|| | |..|| ||.| | |. ... |.| ||.. QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQ |
|||||||||
| Kinase | IRAKf_a.AA | LISK | 595-738 | 31 | 2.6e-22 | 69.13 | In-house | 1-155 (296) | Show / Hide |
Range on Protein: 595-738 Range on HMM: 1-155/296 Sequence Identity: 31% (49 aa) EIGRGGFGTVYKATLA-AGRTVAVKKLSV----PGMVETQDEFEKRVQFLGKIQHENLVNFQGYYFT-PKLQLLIYDFVPNGNLHSKLH-EQS---VLPW |||.|.|| ||| |. |. .|.|... | |.| ... || . ...| | |.| | . . .. .. |.|| |. . . .||| EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW ELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLD----DGFNARVSDYGLAKLL ..| | ||. |.|. ||| .. .|| || |.|.. ......| | |.|... PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMM |
|||||||||
| Kinase | IRAKf_a.AA | TyrKc | 590-858 | 22 | 4.9e-22 | 80.46 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 590-858 Range on HMM: 1-280/280 Sequence Identity: 22% (65 aa) LNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPGMVETQDEFEKRVQFLGKI--QHENLVNFQGYYFTP-------KLQLLIYDFVPNGNLHSKLHEQS . .. ..|.| ||.|||.|. ..||||.| . .| . . . |. .|.|.|.. |. .. . ... ..|.|.|.. |.. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR V-LPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSR-------DRFVVMN--KLQ--SSLGYLAPECGCESFKV |... . .. .|.| |||.| ..|| |.|..... ...|| ||.. ... | ... . .|||| | PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF TEKCDVYGFGVVLLELIT-GKPPVEYLENDVVILCDFVRSLADDGKPLLCVDP----KMVVYPEEEVMTLIKLGLVCTSPVPANRPSMTEVVQIL |.| ||. |||.. |. | |..| . . .. . |. . ..|. . . . | .|. ...| | |..||...|..... TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQ---CWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | IRAKf_a.AA | LISK | 769-794 | 44 | 1.2e-08 | 23.95 | In-house | 217-243 (296) | Show / Hide |
Range on Protein: 769-794 Range on HMM: 217-243/296 Sequence Identity: 44% (12 aa) TEKCDVYGFGVVLLELITGKPPVE-YL .|.|||. ||.||.|.||.. . . |. DESCDVFSFGIVLCEIITRVKADPDYW |
|||||||||
| Kinase | IRAKf_a.AA | MLK | 840-858 | 42 | 0.000108 | 12.36 | In-house | 273-291 (291) | Show / Hide |
Range on Protein: 840-858 Range on HMM: 273-291/291 Sequence Identity: 42% (8 aa) CTSPVPANRPSMTEVVQIL | .. |..|||. ..||.| CWNQDPHKRPSFRQIVQHL |
|||||||||
| Kinase | IRAKf_a.AA | Dicty4 | 845-860 | 44 | 0.000218 | 10.74 | In-house | 260-277 (277) | Show / Hide |
Range on Protein: 845-860 Range on HMM: 260-277/277 Sequence Identity: 44% (8 aa) PANRPSMTEVVQI--LEL | .|||. |..|. || PQHRPSFEEIIQRRILEH |
|||||||||
| Kinase | IRAKf_a.AA | Dicty4 | 769-790 | 54 | 0.000584 | 9.29 | In-house | 195-216 (277) | Show / Hide |
Range on Protein: 769-790 Range on HMM: 195-216/277 Sequence Identity: 54% (12 aa) TEKCDVYGFGVVLLELITGKPP .|| ||| || || |. |.. | NEKADVYSFGIVLWEILTRQEP |
|||||||||
| Kinase | IRAKf_a.AA | LRRK | 840-860 | 28 | 0.000933 | 9.15 | In-house | 331-351 (351) | Show / Hide |
Range on Protein: 840-860 Range on HMM: 331-351/351 Sequence Identity: 28% (6 aa) CTSPVPANRPSMTEVVQILEL | . | .||.....|..|. CWQHDPKKRPHFSQIVKRLSQ |
|||||||||
| Kinase | IRAKf_a.AA | LISK | 833-858 | 42 | 0.00507 | 5.43 | In-house | 271-296 (296) | Show / Hide |
Range on Protein: 833-858 Range on HMM: 271-296/296 Sequence Identity: 42% (11 aa) LIKLGLVCTSPVPANRPSMTEVVQIL ...| . |.. | |||| .|.||.| FLDLCFDCCKYDPKNRPSFKEIVQWL |
|||||||||
| Kinase | IRAKf_a.AA | Dicty4-Unclassified | 840-858 | 36 | 0.009752 | 5.16 | In-house | 245-263 (263) | Show / Hide |
Range on Protein: 840-858 Range on HMM: 245-263/263 Sequence Identity: 36% (7 aa) CTSPVPANRPSMTEVVQIL | . | ||.| ...| | CWHNDPNKRPTMNQIIQYL |
|||||||||
| Kinase | IRAKf_a.AA | Pkinase_Tyr | 845-858 | 35 | 0.17234 | 5.67 | Pfam | 257-270 (270) | Show / Hide |
Range on Protein: 845-858 Range on HMM: 257-270/270 Sequence Identity: 35% (5 aa) PANRPSMTEVVQIL |..||...|....| PEDRPTFSEIHEQL |
|||||||||