Gene IRAKf_m-2 (S.moellendorffii)

IRAKf_m-2

Species: S.moellendorffii
Alias: IRAKf_m-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKf

Sequence

Name Sequence Type Origin Length Description Download
IRAKf_m-2.AA Protein None 944 None Fasta, JSON
IRAKf_m-2.NA RNA None 2835 None Fasta, JSON
IRAKf_m-2.kin_dom Protein Kinase Domain None 193 None Fasta, JSON

Protein domain

Protein domains of IRAKf_m-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKf_m-2.AA LRRNT_2 1-38 40 2.2e-12 43.16 Pfam 5-46 (46) Show / Hide 
Range on Protein: 1-38
Range on HMM: 5-46/46
Sequence Identity: 40% (17 aa)

GAVLLEIKKSFSN-AG--NALYDWDGSA-DHDPCFWRGVTCD
|. ||..|.|...  .  ..| .|. |. | |.| |.|||||
GQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 IRAKf_m-2.AA LRR_1 43-65 29 17.021935 2.38 Pfam 1-26 (26) Show / Hide 
Range on Protein: 43-65
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SVTGLNLTQ-L--SLSGVISPS-VGKL
. . |.|      .|.| |.||   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 67-89 33 0.001171 17.14 Pfam 1-26 (26) Show / Hide 
Range on Protein: 67-89
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLQYLDLRE-N--SIGGQIPDE-IGDC
.||.|||.  |  .. |.||.. .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 91-113 40 0.016461 13.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 91-113
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

VLKYIDLSF-N--ALVGDIPFS-VSQL
 |...|||  |   |.|.|| |   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 115-137 37 0.003442 15.48 Pfam 1-26 (26) Show / Hide 
Range on Protein: 115-137
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

QLETLILKS-N--QLTGPIPST-LSQL
.|..| | . |  .||| ||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 139-160 40 0.004075 15.22 Pfam 1-26 (26) Show / Hide 
Range on Protein: 139-160
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLKTLDLAQ-N--QLTGEIPT--LLYW
||..|||   |  .|||.||   .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 163-185 29 0.163994 9.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 163-185
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

VLQYLGLRD-N--SLSGTLSSD-MCRL
 ||.| |.. |  .|.|.....    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 187-209 29 0.015128 13.2 Pfam 1-26 (26) Show / Hide 
Range on Protein: 187-209
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

GLWYFDVRS-N--NISGIIPDN-IGNC
 | . |... |  |..| ||.. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 211-233 33 0.013372 13.39 Pfam 1-26 (26) Show / Hide 
Range on Protein: 211-233
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SFEILDLAY-N--RLNGEIPYN-IGFL
. ..||| . |  .| |.|| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 234-255 29 0.14402 9.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 234-255
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

QVATLSLQG-N--QFSGKIPE--VIGL
.  .|.|.| |  ...|.||.    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 258-280 44 0.000434 18.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 258-280
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

ALAVLDLSD-N--RLVGDIPAL-LGNL
 | .||||. |  .|.|.||   . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 285-304 45 0.101421 10.27 Pfam 4-26 (26) Show / Hide 
Range on Protein: 285-304
Range on HMM: 4-26/26
Sequence Identity: 45% (11 aa)

KLYLHG-N--LLTGTIPPE-LGNM
.|.| | |   |||.|||. . |.
HLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 306-328 37 0.000371 18.91 Pfam 1-26 (26) Show / Hide 
Range on Protein: 306-328
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLSYLQLND-N--QLTGEIPSE-LGSL
.| .| |.. |  .|||.||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 330-352 29 0.016568 13.06 Pfam 1-26 (26) Show / Hide 
Range on Protein: 330-352
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ELFELNLAN-N--QLYGRIPEN-ISSC
 | .|.| . |  .| | ||.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 354-376 37 0.002156 16.2 Pfam 1-26 (26) Show / Hide 
Range on Protein: 354-376
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALNYLNVHG-N--RLNGSIPPQ-LKKL
 | .|.. | |  .| |.|||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 378-400 33 0.00013 20.52 Pfam 1-26 (26) Show / Hide 
Range on Protein: 378-400
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLTYLNLSS-N--LFSGSIPDD-FGHI
.|..|.||. |   ..|.||.. | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 402-424 40 0.001798 16.48 Pfam 1-26 (26) Show / Hide 
Range on Protein: 402-424
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLDTLDVSD-N--YISGSIPSS-VGDL
|| .||.|. |   ..|.||.|    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 426-448 37 0.000503 18.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 426-448
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

HLLTLILRN-N--DISGKIPSE-FGNL
.| .| |.. |   ..|.||.. | ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 450-472 40 0.00432 15.13 Pfam 1-26 (26) Show / Hide 
Range on Protein: 450-472
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SIDLLDLSQ-N--KLSGNIPPE-LGQL
..  ||||  |  .|.|.|||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 474-496 33 0.018744 12.87 Pfam 1-26 (26) Show / Hide 
Range on Protein: 474-496
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

TLNTLFLQH-N--KLSGAIPVQ-LTNC
.| .| |.. |  .|.| ||   . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_m-2.AA LRR_1 498-522 32 0.009235 13.96 Pfam 1-26 (26) Show / Hide 
Range on Protein: 498-522
Range on HMM: 1-26/26
Sequence Identity: 32% (9 aa)

SLNILNVSY-N--NLSGEVPSGTIFSKF
.| .|..|. |  ||.|..|.. .| ..
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase IRAKf_m-2.AA TKL 626-886 21 9.2e-64 218.15 In-house 1-364 (364) Show / Hide 
Range on Protein: 626-886
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

IGRGASSTVYKCSLKN---------GKTVAIKKLYNH--FPQNI-------------------------HEFETELETLGHIKHRNLVGLHGYSLSPAG-
||.|....|||  ...         ||.||.||.  |     ..                          ..| |.  .  ..| |.| . ||...| . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------NLLFYDYLENGSLWDVLHGPVRKVKLDWDTRLKIALGAAQGLAYLHHDCS-----PRIIHRDVKSSNILLDENFD-------------
              . ..| ..|||...||         |. |...||..|.|..||| .       | ||||| ||.|||.|||.              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-AHISDFGIAKSICPTKTHTSTF------------------VLGTIGYIDPEYARTS----------------RLNEKSDVYSYGIVLLELITGLKAVDD
 . |.|||.........  . |                   . ||...  ||  | .                  .||.||||.|||| |..|. . . .
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYY

ERNLHQWVLS----HVNNNTVMEVIDAEIKDTCQD-------IGTVQKMIRLALLCAQKQAAQRPAMHDVANVL
. .  .....          . .    .|....|.         . . |..|.  | .  . .|| . ..   |
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKf_m-2.AA IRAK 621-886 28 2.8e-55 189.97 In-house 2-317 (317) Show / Hide 
Range on Protein: 621-886
Range on HMM: 2-317/317
Sequence Identity: 28% (90 aa)

NERFIIGRGASSTVYKCSLKNGK-TVAIKKLYNHFPQNIHE----FET---ELETLGHIKHRNLVGLHGYSLSPAGNLLFYDYLENGSLWDVLHGPVRKV
.. . || |.  .||.  .||   ..|.||| ..   .. |    | .   ||...  . | |.| | ||.. .    | |.|. |||| | |..    .
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

K---LDWDTRLKIALGAAQGLAYLHHDCSP-RIIHRDVKSSNILLDENFDAHISDFGIAK------SICPTKT---HTSTFVLGTIGYIDPEYAR--TSR
    | | .|..|..|.| |. .|| . .   |||.|.||.|||||..| . |.||| .       .   ..    .||... ||  |  ||. |  . .
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVR-GTTWYMPPEFIRDPQGQ

LNEKSDVYSYGIVLLELITGLKAVDDE-RN--LHQWVLSHVNNNTV-----------------------MEVIDAEIKDTCQDIG--TVQKMIRLALLCA
|  |.|||| ||||||..||..||.|. .   .    .. . . .                        | ..   |.    . .   ...|  .|. |.
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

QKQAAQRPAMHDVANVL
   |. |..|  | . |
HHRANRRCDMAWVMQQL
Kinase IRAKf_m-2.AA Dicty4-Unclassified 620-817 37 8.8e-45 151.29 In-house 1-204 (263) Show / Hide 
Range on Protein: 620-817
Range on HMM: 1-204/263
Sequence Identity: 37% (79 aa)

LNERFIIGRGASSTVYKCSLKNGKTVAIKKL-YNHFPQN---IHEFETELETLGHIKHRNLVGLHGYSLSP----AGNLLFYDYLENGSLWDVLH----G
.     ||.|. | |.|   | || ||.||.  | |      | .|  | | || | | ||| . ||.. |    .        .  | |  | |     
IQIDQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

PVRKVKLDWDTRLKIALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPTKTHTSTFVLGTIGYIDPEYARTSRLNEKSDVYSY
  . .|||    .|.|.  |||...||   .  .||||.||||||.| .| . | ||||.  |    . . | . ||     ||  .    | |||||||
QQQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY

GIVLLELITG
...| ||.||
AMMLYELATG
Kinase IRAKf_m-2.AA Dicty4 620-817 33 6.4e-42 137.69 In-house 1-213 (277) Show / Hide 
Range on Protein: 620-817
Range on HMM: 1-213/277
Sequence Identity: 33% (72 aa)

LNERFIIGRGASSTVYKCSLKNGKTVAIKKL----YNHFPQNIHEFETELETLGHIKHRNLVGLHGYSL----SPAGNLLFYDYLENGSLWDVLHG----
.|   .||.|. ..||| . . || ||.|||     | .   . ||  | . .. | | |.. . |...     |   .    |.  |.|  .||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

PVRKVKLDWDTRLK---IALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPTKTHTS--TFVLGTIGYIDPEYARTSRLNEKS
   ..|||| ....   .|. ||.|...||  | |.||||| ||.|.| |.|. . ..|||... . . ..|.   . . || ..  ||  .  . |||.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSYGIVLLELITG
||||.|||| |. |.
DVYSFGIVLWEILTR
Kinase IRAKf_m-2.AA LRRK 620-823 24 1.2e-39 137.99 In-house 1-285 (351) Show / Hide 
Range on Protein: 620-823
Range on HMM: 1-285/351
Sequence Identity: 24% (72 aa)

LNERFIIGRGASS-TVYKCSLKN---------------------------GKTVAIKKLYNH----------------------------------FPQN
| .   ||||..  .||.  ...                           ...|||||.  .                                  .. .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IHEFETELETLGHIKHRNLVGLHGYSLSPAGNLLFYDYLENGSLWDVLHGPVRKV------KLDWDTRLKIALGAAQGLAYLHHDCSPRIIHRDVKSSNI
 .||  |.  . | .| |.| | |....|    .  .|. .|.| ..|| . .        ...| ..|||||  | |..|| |...| ||||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LL---D---------ENFDAHISDFGIAK--SICPTKTHT-STFVLGTIGYIDPEYAR---TSRLNEKSDVYSYGIVLLELITGL-KAVDD
||   .         ..  |.|.||||    ....   ..   ...|..|.  ||  |   ..  .||.|.||.|..| ||.|..  . |.
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFH---MGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase IRAKf_m-2.AA TKL-Unique 625-817 35 2.2e-39 136.55 In-house 4-224 (290) Show / Hide 
Range on Protein: 625-817
Range on HMM: 4-224/290
Sequence Identity: 35% (79 aa)

IIGRGASSTVYKCSLKNGKTVAIKKLY-NHFPQNI--HEFETELETLGHIK-HRNLVGLHGYSL----SPAGNLLFYDYLENGSLWDVLH-------GPV
 ||.|....|||    .|. ||||..  |  . |.   ||| |. ..  .. | |.| . ||.     .|.   .. .|.. ||| ||||          
KIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

RKVKLDWDTRLKIALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDEN-----FDAHISDFGIAKSICPTKTHTST--------FVLGTIGYIDPEYART-
.. ||..  |.|.|. .|||. ||||   | ||||| ||||.|.|.|     . . |.|||..|.     . |..         ..|.. .. ||  |  
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-SRLNEKSDVYSYGIVLLELITG
 .  .|||||||.|||| |..|.
FCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKf_m-2.AA MLK 620-817 28 1.4e-38 131.5 In-house 1-232 (291) Show / Hide 
Range on Protein: 620-817
Range on HMM: 1-232/291
Sequence Identity: 28% (66 aa)

LNERFIIGRGASSTVYKCSLKNGK----TVAIKKLYNHFPQNIHE-------FETELETLGHIKHRN-----LVGLHGYSLSPAGNLLFYDYLENGSLWD
...  .|| |..  |.|   .|      .||.|.    .   . .       ||.| . | ...|.|      . ... . .| . ..   |.|.||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLHG-PV----------RKVKLDWDTRLKIALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDE------NFDAHISDFGIAKSICPT-KTHTSTFVLGTI
|||| .           . .  | |  ...||  |.|..||| .  . ||||| ||.|||.||      . .. |.|||...... . ....|.   || 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNA--GTY

GYIDPEY---ARTSRLNEKSDVYSYGIVLLELITG
 .  ||    .| .. .||.||.|.|.|| |..|.
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAKf_m-2.AA Pkinase 625-817 28 2.2e-36 129.75 Pfam 6-208 (293) Show / Hide 
Range on Protein: 625-817
Range on HMM: 6-208/293
Sequence Identity: 28% (59 aa)

IIGRGASSTVYKCSLKNG-KTVAIKKLYNHFPQNIHEFET-----ELETLGHIKHRNLVGLHGYSLSPAGNLLFYDYLENG----SLWDVLHGPVRKVKL
.||.|....||||  |.  |.||.|..  .  ..  . .|     |.. . ...| | | |...  ..    .  .|.|.|    .|.|....  |. ..
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCF

--DWDTRLKIALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDENFDA----HISDFGIAKSICPTKTHTSTFVLGTIGYIDPEYAR-TSRLNEKSDVYSY
  ....  ....  ..||.|.|     .|||||.|..|||.|.| .     .|.|||.|| .   . .  | . ||..|. ||  |  .    |.|..|.
YFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIVLLELITG
|..| |...|
GCILYEMLCG
Kinase IRAKf_m-2.AA DRK 626-816 33 5.1e-33 109.18 In-house 7-197 (258) Show / Hide 
Range on Protein: 626-816
Range on HMM: 7-197/258
Sequence Identity: 33% (66 aa)

IGRGASSTVYKCSLKNGKTVAIKKLYNHFPQ---NIHEFETELETLGHIKHRNLVGLHGYSLSPAGNLLFYDYLENGSLWDVLHGPVRKVKLDWDTRLKI
||||    |.  .   |  ||.|.| ||       . ||  | . .    | | .   |  . |   .    |.  |||  .|| .  ....||  ....
IGRGNYGEVFRGTWR-GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDE--SIEMDWPLMKQM

ALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAK--SICPTKTHTSTFVLGTIGYIDPEYARTSRLNEKSDVYSYGIVLLELIT
.. .| |. |||  | | ||||| || | | ||..   ..||| .        .. . | . || . . ||  |  |  || ||||..||| |..|
MFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase IRAKf_m-2.AA RIPK 626-833 25 8.3e-32 105.65 In-house 1-240 (290) Show / Hide 
Range on Protein: 626-833
Range on HMM: 1-240/290
Sequence Identity: 25% (62 aa)

IGRGASSTVYKCSLKNGKTVAIKKLYN----HFP---QNIHEFETELETLGHIKHRNLVGLHGYSLSP-----AG-NLLFYDYLENGSLWDVLHGPV--R
.|.|....|.|.  .  .....|| ..    | .   |   .   | . .  ..... | . |    .      .   .   | ||||||..||      
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

KVKLDWDTRLKIALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPTKTHT------------STFVLGTIGYIDPEYAR---T
.  . |. |  .    . |  || |.  | ||||| | .|||.| || . |.||| |.     . |.            | .  ||. |..||  |    
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

SR---LNEKSDVYSYGIVLLELITGLKAVDDERNLHQWVLS
..    ..|.||||..||. |. |. ..  |. .  . ...
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMC
Kinase IRAKf_m-2.AA STE 621-817 20 1.1e-31 109.18 In-house 1-264 (359) Show / Hide 
Range on Protein: 621-817
Range on HMM: 1-264/359
Sequence Identity: 20% (55 aa)

NER-FIIGRGASSTVYKCSLKN----------------GKTVAIKKLYNHFP-----------------QNIHEFETELETLGHIK--HRNLVGLHGYSL
 |.  .||.||. ||||.  ..                |. .|||..                      ... ... |.... . .  | | |  .|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----SPAGN--LLFYDYLENGSLWDVLH---GPVRK--------VKLDWDTRLKIALGAAQG-LAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFG
     . ...   ..  |...||| |...   |. .          ... .   .|.    .| |.|||      |||||.|..||||     . ..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

IAKSICP---------------TKTHTSTFVLGTIGYIDPEYARTSR------LNEKSDVYSYGIVLLELITG
..... .               |    .. . ||  .  ||  .  .       ..|.|..| |....|..||
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG
Kinase IRAKf_m-2.AA S_TKc 620-887 23 3.3e-24 87.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 620-887
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

LNERFIIGRGASSTVYKCSLKN-GKTVAIKKLYNHFPQNIHEFETELETLGHIKHRNLVGLHGYSLSPAGNLLFYDYLEN--GSLWDVLHGPVRKVK---
     .||.|| ..||||  |. |. ||||..          .. |.. | . .| |.| |...  .     .. .|...  |.| |...   |. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWDTRLKIALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPTKTHTSTFVLGTIGYIDPEYARTSRLNE-KSDVYSYGIVLL
..  .  ...   ...|.|.|   | .|||||.| .||||||     |.|||.|. .        | . ||  |. ||       .  |.|..| |..| 
FPE-HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELITGLKAVDDERNLHQWVLSHVNNNTVMEVIDAEIKDTCQDIGTVQKMIRLALLCAQKQAAQRPAMHDVAN--------VLF
|...|    .             . ......|              . .. .   | ||  ..||   .. .          |
EMLCGYPPFP-------------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKf_m-2.AA Pkinase_Tyr 620-770 26 5.2e-22 75.16 Pfam 1-161 (270) Show / Hide 
Range on Protein: 620-770
Range on HMM: 1-161/270
Sequence Identity: 26% (44 aa)

LNERFIIGRGASSTVYKCSLK-----NGKTVAIKKLYNHFPQN---IHEFETELETLGHI-KHRNLVGLHGYSLSPAGN---LLFYDYLENGSLWDVLHG
.     .|.||  .|||. .|     .. .||.|.| ..  .    . .|  |.... .. .| |.| |.|  ..  .    ..   | ..|.| | |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P-VRKVKLDWDTRLKIALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAKSI
.   | .|.  . |....  |.|..||.      .||||.   |.|..||. . |.||| |. |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase IRAKf_m-2.AA TyrKc 620-886 21 2.2e-18 68.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 620-886
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

LNERFIIGRGASSTVYKCSLKNGKTVAIKKLYNHFPQNIHEFETELETLGHI--KHRNLVGLHGYSLSP-------AGNLLFYDYLENGSLWDVLHGPVR
.    ..|.||  .|||. .|   .||.|.| ..    . .|  |.. . ..  .| |.| |.|. ...          ..   | ..|.| | |. . .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KVKLDWDTRLKIALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPT-------KTHTSTF--VL---GTIGYIDPEYARTSRL
|  | ... |.... .|.| .|||.    ..||||    |.|..||. . ||||| .. |          .. ...          |    ||  .... 
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NEKSDVYSYGIVLLELITGLKAVDDERNLHQW-VLSHVNNNTVMEVIDAEIKDTCQDIG-------TVQKMIRLALLCAQKQAAQRPAMHDVANVL
..||||.|.|... |. |      .    .   ..  ..|  |.| ...     . . .         ..| .. . | . ....|| . ..   .
TTKSDVWSFGVCMWEIFT------YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKf_m-2.AA Pkinase_Tyr 790-816 37 0.000649 13.88 Pfam 183-209 (270) Show / Hide 
Range on Protein: 790-816
Range on HMM: 183-209/270
Sequence Identity: 37% (10 aa)

PEYARTSRLNEKSDVYSYGIVLLELIT
||  .... ..||||.|.|... |..|
PECINYGKFTTKSDVWSFGVLMWEIFT