Gene IRAKb_j (S.moellendorffii)

IRAKb_j

Species: S.moellendorffii
Alias: IRAKb_j
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKb

Sequence

Name Sequence Type Origin Length Description Download
IRAKb_j.AA Protein None 369 None Fasta, JSON
IRAKb_j.NA RNA None 1110 None Fasta, JSON
IRAKb_j.kin_dom Protein Kinase Domain None 228 None Fasta, JSON

Protein domain

Protein domains of IRAKb_j.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKb_j.AA TKL 96-219 20 6e-27 94.07 In-house 9-196 (364) Show / Hide 
Range on Protein: 96-219
Range on HMM: 9-196/364
Sequence Identity: 20% (41 aa)

VFRGVLEG---------GEVVAVRVISDASV------------------------------FQSRKQLL--GRIRSPNIVRLVGYCDEGDDR--------
|..|.. |         |..||| ...  ..                              |. .....   |.| ||||...||| .....        
VYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVG

----KFLVYDFICNGS-LEWHLTVLTRNAMGWSIRKSIAVGIAKGLLYLHSYS--------IVHRNLRSRNVLLTHDYT-----------PVVSKLC
     ..|.... .|| |. ..         |. | ..| .||.|. ||||          |.||.| |.|.|.  ..|           ... |.|
PWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC
Kinase IRAKb_j.AA IRAK 94-207 31 2.5e-18 61.68 In-house 13-146 (317) Show / Hide 
Range on Protein: 94-207
Range on HMM: 13-146/317
Sequence Identity: 31% (43 aa)

GHVFRGVLEGGE-VVAVR---VISDASVFQSRKQLLG---------RIRSPNIVRLVGYCDEGDDRKFLVYDFICNGSLEWHLTVLT-RNA---MGWSIR
| |.||.. . . ..||.      | |  .......          |.| |||| | ||| |...   |||... |||||  |  ..  ..     | .|
GCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCH-CLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQR

KSIAVGIAKGLLYLHSYS----IVHRNLRSRNVLL
.||. |.|.|. .||. .    | |..  | |.||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL
Kinase IRAKb_j.AA TK-Unique 94-212 25 5.2e-17 55.31 In-house 13-171 (294) Show / Hide 
Range on Protein: 94-212
Range on HMM: 13-171/294
Sequence Identity: 25% (41 aa)

GHVFRGVLEGGE-------VVAVRVISDASVFQSRKQLLGRIRS-------PNIVRLVGYCDEGDDRKFLVYDFICNGSLEWHLTVLTRNAMGW------
|.|.|| ..|.        .|||    | . .......| .|.        ||||...|.| . |.. .... .. .|.|. .|    ... .       
GQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNL

--------------SIR----KSIAVGIAKGLLYLHS--YSIVHRNLRSRNVLLTHDYT
              .|      ..|..||.|. ||.|  . ||||.| .||||||.|..
KFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKV
Kinase IRAKb_j.AA TK 94-215 12 1.7e-15 47.69 In-house 13-290 (486) Show / Hide 
Range on Protein: 94-215
Range on HMM: 13-290/486
Sequence Identity: 12% (36 aa)

G---HVFRGVLEGG--------------------------EVVAVRVISDASVFQSRKQLL-------------------GRIR-----SPNIVRLVGYC
|    |..| ..|.                          . ||| .. . .  ... ...                      .      ||||||.|.|
GSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVC

DEGD-----------DRKFLVYDFICNGS----LEWHLT--VLTRNA-----------------------------------------------------
 .|.               .|  . ..|.    |  .|     ...                                                      
TQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPL

-------------------MGWSIRKSIAVGIAKGLLYLHSY------SIVHRNLRSRNVLLTHDYT---------PVV
                   .    .  ... ||.|. ||||        .|||.|  ||.|......         ||.
TTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVC
Kinase IRAKb_j.AA TKL-Unique 118-211 25 1e-14 48.5 In-house 42-154 (290) Show / Hide 
Range on Protein: 118-211
Range on HMM: 42-154/290
Sequence Identity: 25% (29 aa)

FQSRKQLLGRIR-SPNIVRLVGYC-DEGDDRK--FLVYDFICNGSLEWHLTV--------LTRNAMGWSIRKSIAVGIAKGLLYLHSYS--IVHRNLRSR
| . . .. ... .||||...||| |.  . .  ..| ...  |||  .|.            . . .. | ..|  ||.|. |||...  | ||.|.|.
FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSS

NVLLTHD-----Y
|.|.. .     .
NFLVDNNSNIAEW
Kinase IRAKb_j.AA Pkinase_Tyr 123-212 27 8.8e-14 47.3 Pfam 55-149 (270) Show / Hide 
Range on Protein: 123-212
Range on HMM: 55-149/270
Sequence Identity: 27% (26 aa)

QLLGRI-RSPNIVRLVGYCDEGDDR--KFLVYDFICNGSLEWHLTVL--TRNAMGWSIRKSIAVGIAKGLLYLHSYSIVHRNLRSRNVLLTHDYT
...  . . ||||||.| | . ..    ..|  . ..|.|  .|      ...   .   .... ||||. ||.|  ..|| |. ||.|.|.. .
KIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNV
Kinase IRAKb_j.AA LRRK 131-219 29 2e-13 43.82 In-house 117-220 (351) Show / Hide 
Range on Protein: 131-219
Range on HMM: 117-220/351
Sequence Identity: 29% (32 aa)

PNIVRLVGYCDEGDDRKFLVYDFICNGSLEWHLTVLTRNA-------MGWSIRKSIAVGIAKGLLYLHSYS--IVHRNLRSRNVLL-THD--Y------T
|||| |.|.| .      .| ... .|.|  .|    ...       ..|...  ||. ||||. |||| .  |.||.|.| |.|| ...  .      .
PNIVSLKGFCIHP---LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNA

PVVSKLC
.|. |..
HVCAKIA
Kinase IRAKb_j.AA TESK 123-206 32 2.4e-12 34.85 In-house 45-126 (292) Show / Hide 
Range on Protein: 123-206
Range on HMM: 45-126/292
Sequence Identity: 32% (28 aa)

QLLGRIRSPNIVRLVGYCDEGDDRKFLVYDFICNGSLEWHLTVLT--RNAMGWSIRKSIAVGIAKGLLYLHSYSIVHRNLRSRNVL
||. . . |||.|  | |   . .   .  .|  |.||    .|     .. |  .   |..||.|. ||||  . || | |.|.|
QLMNKLQHPNILRFMGVCVH-QGQLHALTEYINGGCLE---QLLADSELHLSWTQKIHLAYDIARGMSYLHSKGVFHRDLTSKNCL
S_TKc IRAKb_j.AA S_TKc 82-352 17 2.9e-12 2.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 82-352
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)

FGFCNYMADAEGGHVFRGVLEG-GEVVAVRVISDASVFQSRKQLLGRIRSPNIVRLVGYCDEGDDRKFLVYDFICN--GSLEWHLTVLTRNA----MGWS
. . .       | |....  . |..||. .|.    ...  |.| . . ||||.| .....  |. ..| ... .  |.| ...    |.     .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

IRKSIAVGIAKGLLYLHSYSIVHRNLRSRNVLLTHDYTPVVSKLCFFSKSSLCHWVSFVFISDAIAHFHVDS------YSAPEHFRGHAVDE-KNDIFSY
  ....  |...| |.||  |.|| |   |.||..     . |.| |  . .                  ..      | ||| .     .  | |. | 
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVILLELITSRKAMEDSSQRLLTEWASPLLRDFDRQKLVDPELGCDDNNTYELVTMMSIASLCLNEDPLERPSASKVNVRE-----LECL
|.|| |... .   .   . .. .                               . .. . ||. || .||.| ..  .|      . .
GCILYEMLCGYPPFP--QMQMMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKb_j.AA Dicty5 178-212 40 5.8e-12 37.46 In-house 108-142 (260) Show / Hide 
Range on Protein: 178-212
Range on HMM: 108-142/260
Sequence Identity: 40% (14 aa)

SIAVGIAKGLLYLHSYSIVHRNLRSRNVLLTHDYT
..|..||... .||| .|.|| | | |.|.| ...
HMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWK
Kinase IRAKb_j.AA TyrKc 94-349 20 1e-11 -33.35 SMART 13-280 (280) Show / Hide 
Range on Protein: 94-349
Range on HMM: 13-280/280
Sequence Identity: 20% (61 aa)

GHVFRGVLEGGEVVAVRVISDASVFQSRK------QLLGRI--RSPNIVRLVGYCDEG------DDRKFLVYDFICNGSLEWHLTVLTRNAMGWSIRKSI
| |..|..   . ||| .. . .    |.      ... ..  . ||||||.|.| ..      ..  ..|  . ..|.|  .|    ..   ..   |.
GEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCMKDLLSF

AVGIAKGLLYLHSYSIVHRNLRSRNVLLTHDYTPVVSKLCFFSKSSLCHWVSFVFISD---AIAHFHV-------DSYS----------------APEHF
.. ||.|  ||||  ..|| |  ||.|.....                     | |||   . .. .        | |.                ||| .
CWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

RGHAVDEKNDIFSYGVILLELITSRKAMEDSSQR----LLTEWASPLLRDFDRQKLVDPEL-----GCDDNNTYELVTMMSIASLCLNEDPLERPSASKV
. .   .| |..|.|| . |. |    ..  .      .  . .  .... .| .  .  .     .| |        | .| . | .||| .||. | .
NYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDE-------MYQIMKQCWHEDPEDRPTFSEI

NVREL
 ....
-HECF
Kinase IRAKb_j.AA LISK 131-207 37 1.5e-10 30.3 In-house 56-134 (296) Show / Hide 
Range on Protein: 131-207
Range on HMM: 56-134/296
Sequence Identity: 37% (30 aa)

PNIVRLVGYCDEGDDRKFLVYDFICNGSLEWHLTVL--TRNAMGWSIRKSIAVGIAKGLLYLHSYSIVHRNLRSRNVLL
||||. .| | . |.. ..|  .|  | |.. |           |. | .||..||.|. ||||  |.|| | | |.|.
PNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLV
Kinase IRAKb_j.AA CZAK 174-216 46 2.1e-10 34.14 In-house 105-154 (279) Show / Hide 
Range on Protein: 174-216
Range on HMM: 105-154/279
Sequence Identity: 46% (23 aa)

SIRKSIAVGIAKGLLYLHS----YSIVHRNLRSRNVLLTHDYT---PVVS
... ..|. ||.|  |||       |.|| | |||.|| | ||   ||||
HLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVS
Kinase IRAKb_j.AA TKL 247-348 16 2.9e-10 33.18 In-house 239-364 (364) Show / Hide 
Range on Protein: 247-348
Range on HMM: 239-364/364
Sequence Identity: 16% (24 aa)

YSAPEHFRGH----------------AVDEKNDIFSYGVILLELITSRKAMEDSSQRLLTEWASPLLRDFDRQKLVDP-------ELGCDDN--------
. ||| .||.                  .|| |..|.|..| |..| ..                  .|..    .         .. ||..        
WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPI

---------NTYELVTMMSIASLCLNEDPLERPSASKVNVRE
         ... .  | ...  | ..|| .|||....  | 
WQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKb_j.AA Pkinase 123-198 25 5.6e-09 32.82 Pfam 52-132 (293) Show / Hide 
Range on Protein: 123-198
Range on HMM: 52-132/293
Sequence Identity: 25% (22 aa)

QLLGRIRSPNIVRLVGYCDEGDDRKFLVYDFICNG----SLEWHLTVLT---RNAM--GWSIRKSIAVGIAKGLLYLHSYSIVHR
|.. |...|||||| ... . .|.  .| ..  .|    .|    ....   ....   .   |...  |..|| |.|| .|.||
QIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLF---DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR
Kinase IRAKb_j.AA LISK 249-283 48 8.1e-08 21.26 In-house 207-241 (296) Show / Hide 
Range on Protein: 249-283
Range on HMM: 207-241/296
Sequence Identity: 48% (17 aa)

APEHFRGHAVDEKNDIFSYGVILLELITSRKAMED
|||  .|   ||. |.||.|..|.|.|| .|| .|
APEMLLGQSYDESCDVFSFGIVLCEIITRVKADPD
Kinase IRAKb_j.AA CZAK 247-278 43 4.5e-07 21.91 In-house 188-219 (279) Show / Hide 
Range on Protein: 247-278
Range on HMM: 188-219/279
Sequence Identity: 43% (14 aa)

YSAPEHFRGHAVDEKNDIFSYGVILLELITSR
. ||| | |    || |..|.| || ..||..
WMAPECFKGENYTEKVDVYSFGMILWCIITCD
Kinase IRAKb_j.AA Dicty5 247-276 36 9.8e-07 19.21 In-house 169-198 (260) Show / Hide 
Range on Protein: 247-276
Range on HMM: 169-198/260
Sequence Identity: 36% (11 aa)

YSAPEHFRGHAVDEKNDIFSYGVILLELIT
. |.| | |   ..| |..|.|..| |..|
WMACELFNGQPYHQKCDVYSFGIVLWEMFT
Kinase IRAKb_j.AA TESK 249-275 55 2e-06 15.93 In-house 204-230 (292) Show / Hide 
Range on Protein: 249-275
Range on HMM: 204-230/292
Sequence Identity: 55% (15 aa)

APEHFRGHAVDEKNDIFSYGVILLELI
|||  ||   ||| |.||.|..| |.|
APEVLRGEWYDEKADVFSFGIVLCEII
Kinase IRAKb_j.AA TKL-Unique 247-277 36 3e-05 14.68 In-house 192-224 (290) Show / Hide 
Range on Protein: 247-277
Range on HMM: 192-224/290
Sequence Identity: 36% (12 aa)

YSAPEHFRG--HAVDEKNDIFSYGVILLELITS
..||| .|.     .|| |..|.|..| |..|.
WMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKb_j.AA LRRK 259-276 55 0.001739 8.18 In-house 260-277 (351) Show / Hide 
Range on Protein: 259-276
Range on HMM: 260-277/351
Sequence Identity: 55% (10 aa)

DEKNDIFSYGVILLELIT
.|| |..|.|.|| ||.|
TEKVDCYSFGMILWELLT
Kinase IRAKb_j.AA IRAK 261-283 43 0.001995 8.2 In-house 204-226 (317) Show / Hide 
Range on Protein: 261-283
Range on HMM: 204-226/317
Sequence Identity: 43% (10 aa)

KNDIFSYGVILLELITSRKAMED
| |..| |. |||..| ..|. |
KTDVYSFGIVLLEVLTGCRAVYD
Kinase IRAKb_j.AA TK-Unique 247-276 30 0.007749 5.76 In-house 202-234 (294) Show / Hide 
Range on Protein: 247-276
Range on HMM: 202-234/294
Sequence Identity: 30% (10 aa)

YSAPEHFR--GHAV-DEKNDIFSYGVILLELIT
. ||| ..  ..    .|.|. |.||.. |. |
WMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAKb_j.AA LRRK 329-344 37 0.04276 3.19 In-house 330-345 (351) Show / Hide 
Range on Protein: 329-344
Range on HMM: 330-345/351
Sequence Identity: 37% (6 aa)

LCLNEDPLERPSASKV
.| ..||..||..|..
HCWQHDPKKRPHFSQI
Kinase IRAKb_j.AA Pkinase 247-278 42 0.05772 8.03 Pfam 177-209 (293) Show / Hide 
Range on Protein: 247-278
Range on HMM: 177-209/293
Sequence Identity: 42% (14 aa)

YSAPEHFR-GHAVDEKNDIFSYGVILLELITSR
| |||  | |   . | |..|.|.|| |... |
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAKb_j.AA Pkinase_Tyr 329-349 33 3.574506 1.21 Pfam 251-270 (270) Show / Hide 
Range on Protein: 329-349
Range on HMM: 251-270/270
Sequence Identity: 33% (7 aa)

LCLNEDPLERPSASKVNVREL
.| ..|| .||. | . ...|
QCWHYDPEDRPTFSEI-HEQL