Gene IRAKb_d (S.moellendorffii)
IRAKb_d
Species: S.moellendorffii
Alias: IRAKb_d
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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IRAKb_d.AA | Protein | None | 319 | None | Fasta, JSON |
IRAKb_d.NA | RNA | None | 960 | None | Fasta, JSON |
IRAKb_d.kin_dom | Protein Kinase Domain | None | 199 | None | Fasta, JSON |
Protein domains of IRAKb_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | IRAKb_d.AA | IRAK | 48-250 | 36 | 2e-58 | 200.41 | In-house | 1-225 (317) | Show / Hide |
Range on Protein: 48-250 Range on HMM: 1-225/317 Sequence Identity: 36% (82 aa) FSQANFLSEGGFGNVFKGILLEQGLE--VAVK----RHKLKSTQGDKEFFA---EIKVLSHTNHDNVVSLVGYCTENGQRILVYEYVCNGTLAWHLSAKN |...| ..||||| |..| . .... .||| ... .. ...| . |.||.. |.|.|.| |||||... |||.| ||.| |.. . FHKDNRIGEGGFGCVYRGQW--KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQD -STV---LSWPARHSIAVGIAKALRYLHHECTQGRVIHRDIRPHNILLRHDFTPVVGDFGLAKWE-NDSAAPETTL--------VAATGYVAPEYGA--T .. |||. |.||. |.|.....|| .||.|| . |||| .||| .||||. |. .|. .. | | .||. . GQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ GVATEKADVYSFGIVLLEIITGRRAID | | | |||||||||||..||.|| . GQLTKKTDVYSFGIVLLEVLTGCRAVY |
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Kinase | IRAKb_d.AA | TKL | 54-316 | 20 | 8.6e-53 | 181.71 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 54-316 Range on HMM: 1-364/364 Sequence Identity: 20% (79 aa) LSEGGFGNVFKGILLEQG--------LEVAVKRHKLKSTQGD---------------------------KEFFAEIKVLSHTNHDNVVSLVGYCTENGQ- . .|||| |.||.. .| .||||. | .. . . ... ||...| ..|.|.|...|||..... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------RILVYEYVCNGT-LAWHLSAKNSTVLSWPARHSIAVGIAKALRYLHH----ECTQGR--VIHRDIRPHNILLRHDFT----------- .|.||. .|. | .. |. |...| .||... ||| || .||||. ..|||. ..| CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNA ---PVVGDFGLAKWENDSAAPETT-------------------LVAATGYVAPEY--GAT--------------GVATEKADVYSFGIVLLEIITGRRAI . ..||||... . | . | . ... ||| |.. . ..||.||||||||| ||.|..| DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY D-LSCEQTSLV---EWARPKLEVRDAKSLLDP----RLGTDVDEYQIQC---MIHAAAFCLQEDPSRRLRIKQVSKNI . . ... . |. . .. . ...| .. . .| |. . | ..||. |. ... | . YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | IRAKb_d.AA | Pkinase | 48-246 | 27 | 1.4e-36 | 130.4 | Pfam | 1-209 (293) | Show / Hide |
Range on Protein: 48-246 Range on HMM: 1-209/293 Sequence Identity: 27% (60 aa) FSQANFLSEGGFGNVFKGILLEQGLEVAVKRHKLKSTQGDKE--FFA--EIKVLSHTNHDNVVSLVGYCTENGQRILVYEYVCNG----TLAWHLSAKNS . . .|.|| |.|.. | .||||. |.... .|. . ||... . ||.|.| | ....... .| ||. .| |. ..|.... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH TVL--SWPARHSIAVGIAKALRYLHHECTQGRVIHRDIRPHNILLRHDFTP----VVGDFGLAK---WENDSAAPETTLVAATGYVAPEYGA-TGVATEK ... |. ... |...| |.| . ..||||. | |||. .. .. ..|||||| . |.| . ||.. .|.||| . | GCFYFSEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-M--TTFCGTPWYMAPEVIRGGQYYGPK ADVYSFGIVLLEIITGR .|..|.|..| | ..|| VDMWSCGCILYEMLCGR |
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Kinase | IRAKb_d.AA | TK | 48-244 | 16 | 2.3e-35 | 115.43 | In-house | 1-389 (486) | Show / Hide |
Range on Protein: 48-244 Range on HMM: 1-389/486 Sequence Identity: 16% (65 aa) FSQANFLSEGGFG---NVFKGILLEQG-------------------------LEVAVKRHKLKSTQGDKEFFA-----------------EIKVLSH--T . | || || |.||.. ... .|||| |..... ..|||. |.|...| ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG NHDNVVSLVGYCTEN------------GQRILVYEYVCNGT----LAWHLS--AKNSTV----------------------------------------- .|.|.|.|.|.||.. . ..| ||...| | .| .. . HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY -------------------------------LSWPARHSIAVGIAKALRYLHHE-CTQG--RVIHRDIRPHNILLRHDFT-----------PVVGDFG-- |. . .. ... ||....||| |. . ...|||. .|.|. .. . ..||| DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS ------LAKWENDSAAPETTLVAATGY--------------------------VAPEYGA---------TGVATEKADVYSFGIVLLEIIT ||. ... .. || ||| . .|. |.| ||.|||... || | RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT |
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Kinase | IRAKb_d.AA | TKL-Unique | 50-245 | 29 | 7.4e-35 | 120.4 | In-house | 1-224 (290) | Show / Hide |
Range on Protein: 50-245 Range on HMM: 1-224/290 Sequence Identity: 29% (67 aa) QANFLSEGGFGNVFKGILLEQGLEVAVKRHKLKSTQG-D--KEFFAEIKVLSHTN-HDNVVSLVGYCT----ENGQRILVYEYVCNGTLAWHLSA----- | . |||.|.|.||. | .||.|. .... . . .|| |..... . |.|.| ..|||. ......| ||. |.| .|. FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN ---KNSTVLSWPARHSIAVGIAKALRYLHHECTQGRVIHRDIRPHNILLRHD-----FTPVVGDFGLAKWENDS---AAPET------TLVAATGYVAPE .|.. |.. | ..| ||... ||||. . .||||... |.|. . . . ||||.| . . . | | .. . ..||| NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP--IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE YGAT--GVATEKADVYSFGIVLLEIITG .||.||||||||| ||.|. VLRMNFCQYSEKSDVYSFGIVLWEIATR |
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Kinase | IRAKb_d.AA | TK-Unique | 48-244 | 24 | 4.3e-33 | 111.5 | In-house | 1-234 (294) | Show / Hide |
Range on Protein: 48-244 Range on HMM: 1-234/294 Sequence Identity: 24% (60 aa) FSQANFLSEGGFGNVFKGILL------EQGLEVAVKRHKLKSTQGD-KEFFAEIKVLSHTN-HDNVVSLVGYCTENG-QRILVYEYVCNGTLAWHLS--- . . . || || |..| . .. |||| .| ..|. | ..|. ||..... | |.|...|.||... . ...||. .|.| .| LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR --------------------AKNSTV-LSWPARHSIAVGIAKALRYLHH---ECTQGRVIHRDIRPHNILLRHDFTPVVGDFGLAK-----WENDSAAPE .|..| .| ..|..||... ||. .. .|||. .|.|| .|.. ..|||.|. .... . PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI-----VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQ TTLVAATGYVAPEYGA--TGVA-TEKADVYSFGIVLLEIIT .. . . |||. .|.. |.| ||.|||... || | GRIPIR--WMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT |
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Kinase | IRAKb_d.AA | S_TKc | 48-318 | 21 | 2.6e-32 | 114.57 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 48-318 Range on HMM: 1-231/231 Sequence Identity: 21% (62 aa) FSQANFLSEGGFGNVFKGILLEQGLEVAVKRHKLKSTQGDKEFFAEIKVLSHTNHDNVVSLVGYCTENGQRILVYEYVCN--GTLAWHLSAKNS----TV . . . .|.|| |.|.. . | .||.|. | . . ||..|.. .|.|.| | ... . . .| ||. . |.| ... ... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LSWPARHSIAVGIAKALRYLHHECTQGRVIHRDIRPHNILLRHDFTPVVGDFGLAKWENDSAAPETTLVAATGYVAPEYGATGVATEKADVYSFGIVLLE .. ... |..|| |.| . ..||||. | |||| . . ..|||||. ||.. |.||| | ..|.|..|.|..| | FPE-HARFYMYQICCALEYCHS---H-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYE IITGRRAIDLSCEQTSLVEWARPKLEVRDAKSLLDPRLGTDVDEYQIQCMIHAAAF-----CLQEDPSRRLRIKQVSK-------NIKT ..|. . .. . . . | ||| ||..|. . .. . MLCGYPPFP---QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | IRAKb_d.AA | LRRK | 56-250 | 24 | 7e-30 | 102.88 | In-house | 9-284 (351) | Show / Hide |
Range on Protein: 56-250 Range on HMM: 9-284/351 Sequence Identity: 24% (69 aa) EGGFG-NVFKGILLEQ--------------------------GLEVAVKRHKLK---STQGD--------------------------------KEFFAE .|||| .|..... | . .||.| .. .. | || | RGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTID-NDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAFREFRHE IKVLSHTNHDNVVSLVGYCTENGQRILVYEYVCNGTLAWHLSAKNST-------VLSWPARHSIAVGIAKALRYLHHECTQGR--VIHRDIRPHNILL-R . ..|| ||.|.|||.|.| . ...| ||. .|.| .|..| .. ..|| .. ||. |||...||| . .|||| ...|||| . VWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH----NPPIIHRDLKSPNILLWS HD--F------TPV---VGDFGLAKWENDSAAPET---TLVAATGYVAPEYGATG---VATEKADVYSFGIVLLEIITGR-RAID .. . ..| ..|||. .. ... ..| |..||| . . |||.|.||||..| |..|.. .. | SPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD |
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Kinase | IRAKb_d.AA | Pkinase_Tyr | 56-197 | 29 | 1.2e-28 | 97.68 | Pfam | 9-159 (270) | Show / Hide |
Range on Protein: 56-197 Range on HMM: 9-159/270 Sequence Identity: 29% (45 aa) EGGFGNVFKGILL----EQGLEVAVKRHKLKSTQGD---KEFFAEIKVLSHT-NHDNVVSLVGYCT-ENGQ--RILVYEYVCNGTLAWHLSAK--NSTVL || ||.|.||.. .....|||| | .... . ..|..|.|.... .|.|.|.|.| || . .. ..| ||...| | .| .. . | EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPL SWPARHSIAVGIAKALRYLHHECTQGRVIHRDIRPHNILLRHDFTPVVGDFGLAK . . .... |||.. ||. ||||.. |.|. .... ..|||||. TMKDLLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLAR |
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Kinase | IRAKb_d.AA | MLK | 48-246 | 24 | 1.9e-28 | 95.87 | In-house | 1-233 (291) | Show / Hide |
Range on Protein: 48-246 Range on HMM: 1-233/291 Sequence Identity: 24% (57 aa) FSQANFLSEGGFGNVFKGILLEQGLE-----VAVKRHKL------KSTQGDKEFFAEIKVLSHTNHDN----VVSLVGYCTENGQ-RILVYEYVCNGTLA . .. .|.|| |.|| .. . |||||.. .. ...| |.. |.. .| | .. ..| |..... .| ||. .| |. IQFHEWIGSGSFGKVWKGRW--RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY WHLSAKNS------------TVLSWPARHSIAVGIAKALRYLHHECTQGRVIHRDIRPHNILLRH------DFTPVVGDFGLAK-WENDSAAPETTLVAA | ...| | . ..|. .|... ||| . . .||||. .||||. . . | .. |||... | . . . NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPK-PIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGT TGYVAPEY---GATGVATEKADVYSFGIVLLEIITGR . ||| . .||.||.|.|.|| |..|.. YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE |
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Kinase | IRAKb_d.AA | LISK | 53-197 | 30 | 2.2e-27 | 85.85 | In-house | 1-153 (296) | Show / Hide |
Range on Protein: 53-197 Range on HMM: 1-153/296 Sequence Identity: 30% (48 aa) FLSEGGFGNVFKGILLEQGLEVAVKRHK-------LKSTQGDKEFFAEIKVLSHTNHDNVVSLVGYCTE-NGQRILVYEYVCNGTLAWHLSAKN--STVL ...|.|| |.|| ... | ..|.| . ....| | . |.... | |.| .| | . .|| .| ||. |.| . |.... . .| EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQ--KFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPL SWPARHSIAVGIAKALRYLHHECTQGRVIHRDIRPHNILLR----HDFTPVVGDFGLAK .|| | .||..||....||| . .|||| .|.|.| ... .|.|||.|. PWPQRVKIALDIACGMSYLHSMN----IIHRDLKSKNCLVRENDNNQWRIKVCDFGFAR |
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Kinase | IRAKb_d.AA | DRK | 57-244 | 32 | 3.1e-26 | 85.87 | In-house | 10-197 (258) | Show / Hide |
Range on Protein: 57-244 Range on HMM: 10-197/258 Sequence Identity: 32% (64 aa) GGFGNVFKGILLEQGLEVAVKRHKLKSTQGD-----KEFFAEIKVLSHTNHDNVVSLVGYCTENGQRILVYEYVCNGTLAWHLSAKNSTVLSWPARHSIA |..| || | | .|||| .|. . .|| || ... | |.. | |.. . || | |. | | ..|| . ... GNYGEVFRGTW--RGTQVAVK--MLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNIL-HDESIEMDWPLMKQMM VGIAKALRYLHHECTQGRVIHRDIRPHNILLRHDFTPVVGDFGLAK----WENDSAAPETTLVAATGYVAPEYGATGVATEKADVYSFGIVLLEIIT .|| . ||| | .|||| || | . | ||||. . .| | . .. .||| . |||||||||.||| |..| FDCAKGMIYLH--CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFA--MTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT |
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Kinase | IRAKb_d.AA | Dicty4 | 48-245 | 31 | 3e-25 | 81.29 | In-house | 1-213 (277) | Show / Hide |
Range on Protein: 48-245 Range on HMM: 1-213/277 Sequence Identity: 31% (69 aa) FSQANFLSEGGFGNVFKGILLEQGLEVAVKRHKLKSTQGD------KEFFAEIKVLSHTNHDNVVSLVGYCT----ENGQRILVYEYVCNGTLAWHLSA- ... .|.|| |.||. | ||||| ||.... . .|| .|.. .. | |.. . |.|| . | | ||. |.|. | . INIEQRIGKGSFGEVYKGTW--RGKEVAVK--KLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDK ----KNSTVLSWPARHS---IAVGIAKALRYLHH-ECTQGRVIHRDIRPHNILLRHDFTPVVGDFGLAK----WENDSA-APETTLVAATGYVAPEYGAT . |. |.|| . . .| .|. . .|| . ..||||. .||.| ... |.||||.. |. .. . .| . ....||| . PSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP---VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQ--MTACGTPCWMAPEVMMH GVATEKADVYSFGIVLLEIITG .|||||||||||| || |. QPYNEKADVYSFGIVLWEILTR |
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Kinase | IRAKb_d.AA | TyrKc | 48-316 | 23 | 6.4e-18 | 66.78 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 48-316 Range on HMM: 1-280/280 Sequence Identity: 23% (70 aa) FSQANFLSEGGFGNVFKGILLEQGLEVAVKRHKLKSTQGDKEFFAEIKVLSHT--NHDNVVSLVGYCTEN-------GQRILVYEYVCNGTLAWHLSAKN . | || || |.||.. ..|||| | . ..| |...... .|.|.| |.|.||. .. .| ||...| | .| .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR STVLSWPARHSIAVGIAKALRYLHHECTQGRVIHRDIRPHNILLRHDFTPVVGDFGLAKWENDS----AAPETTLV----AATG-----YVAPEYGATGV . |... .|... ||. .|||. ..||||. |.|. ...| ..||||.. | .. .. . . . ||| .|. PK-LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK ATEKADVYSFGIVLLEIITGRRAIDLSCE---QTSLVEWARPKLEVRDAKSLLDPRL--------GTDVDEYQIQCMIHAAAFCLQEDPSRRLRIKQVSK |.| ||.|||... || | . . | ..... |.. . . | .| ... | .|||. | . ... . FTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQ-------CWHEDPEDRPTFSEIHE NI . CF |
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Kinase | IRAKb_d.AA | LISK | 227-248 | 63 | 6.1e-10 | 28.28 | In-house | 217-238 (296) | Show / Hide |
Range on Protein: 227-248 Range on HMM: 217-238/296 Sequence Identity: 63% (14 aa) TEKADVYSFGIVLLEIITGRRA .|..||.||||||.||||...| DESCDVFSFGIVLCEIITRVKA |
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Kinase | IRAKb_d.AA | Pkinase_Tyr | 227-244 | 55 | 0.004014 | 11.2 | Pfam | 192-209 (270) | Show / Hide |
Range on Protein: 227-244 Range on HMM: 192-209/270 Sequence Identity: 55% (10 aa) TEKADVYSFGIVLLEIIT |.| ||.|||... ||.| TTKSDVWSFGVLMWEIFT |