Gene IRAKb_b-2 (S.moellendorffii)

IRAKb_b-2

Species: S.moellendorffii
Alias: IRAKb_b-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKb

Sequence

Name Sequence Type Origin Length Description Download
IRAKb_b-2.AA Protein None 379 None Fasta, JSON
IRAKb_b-2.NA RNA None 1140 None Fasta, JSON
IRAKb_b-2.kin_dom Protein Kinase Domain None 198 None Fasta, JSON

Protein domain

Protein domains of IRAKb_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKb_b-2.AA TKL 109-301 23 1e-51 178.11 In-house 1-287 (364) Show / Hide 
Range on Protein: 109-301
Range on HMM: 1-287/364
Sequence Identity: 23% (71 aa)

LAEGGFGFVYKGVLKG---------GQHIAVKQHKLASTQGG---------------------------REFCAEVKVLSGAQHRNLVTLLG--------
. .|||| ||||...|         |. .|||. |  . .                              ..  |....|  .| |.| ..|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-FCVE----DGKRMLVYEFVCNKS-LDYHLFDKNTVLPWCARQGIALGAARAMRYLHE----ECRVGT--IIHRDLRPHNILLTHDYA------------
 .|..    .|. ..|.|.. . | |.|..        |  |  .||..||.| |||      |.  .  |||||| ..|||.  ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PMVGDFGLARWNTSSQPAVETK------------------VVGTLGYLAPEYAS----------------SGQVTEKADVYSFGVILLEMVTGRR
  . ..||||.|... |.    |.                  ..||....|||                   ... .||.||||||..| |..|..|
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR
Kinase IRAKb_b-2.AA IRAK 103-301 34 1.6e-49 170.88 In-house 1-222 (317) Show / Hide 
Range on Protein: 103-301
Range on HMM: 1-222/317
Sequence Identity: 34% (77 aa)

FSHANFLAEGGFGFVYKGVLKGGQ-HIAVK----QHKLASTQGGREFCA---EVKVLSGAQHRNLVTLLGFCVEDGKRMLVYEFVCNKSLDYHLFDKNT-
|. .| . ||||| ||.|..|.     |||      ..  ..  ..| .   |.||..  .| |.| |.|.| | ..  |||..  | || . |   .. 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-V---LPWCARQGIALGAARAMRYLHEECRVGTIIHRDLRPHNILLTHDYAPMVGDFGLARWN--TSSQPAVET------KVVGTLGYLAPEYAS--SGQ
     |.|  |  |..|.|.. ..||.      |||.|  . ||||  .  |  .||||.|    .|.  . .       .|.||. |..||.    .||
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VTEKADVYSFGVILLEMVTGRR
 | | ||||||. ||| .||.|
LTKKTDVYSFGIVLLEVLTGCR
Kinase IRAKb_b-2.AA Pkinase 109-300 26 6.9e-35 124.43 Pfam 7-209 (293) Show / Hide 
Range on Protein: 109-300
Range on HMM: 7-209/293
Sequence Identity: 26% (56 aa)

LAEGGFGFVYKGVLKGGQH-IAVKQHKLASTQGGRE--FCA--EVKVLSGAQHRNLVTLLGFCVEDGKRMLVYEFVCNK----SLDYHLF-DKNTVL--P
. .|.|| |||.. || ..  |||. |. ..  . .       |....   .| | |.|.... ....  .| |.. .     .|  ..  ......  .
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS

WCARQGIALGAARAMRYLHEECRVGTIIHRDLRPHNILLTHDYAP----MVGDFGLAR---WNTSSQPAVETKVVGTLGYLAPEYAS-SGQVTEKADVYS
.   . ...  .|.. |.|..     |||||| | |||. ... .     ..|||||.   .  .| .   | ..||..|.|||    .   . |.|..|
EWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-M---TTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGVILLEMVTGR
.|.|| ||..||
CGCILYEMLCGR
Kinase IRAKb_b-2.AA LRRK 103-301 25 1.9e-34 119.28 In-house 1-281 (351) Show / Hide 
Range on Protein: 103-301
Range on HMM: 1-281/351
Sequence Identity: 25% (72 aa)

FSHANFLAEGGFG-FVYKGVLKG---------------------------GQHIAVKQHKLA----------------------------------STQG
. . . . .|||| |||.. ..|                           .| .|.|. ..                                   ..  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

GREFCAEVKVLSGAQHRNLVTLLGFCVEDGKRMLVYEFVCNKSLDYHLFDKN--------TVLPWCARQGIALGAARAMRYLHEECRVGT--IIHRDLRP
 |||  || ..|. .| |.| |.||| .   ...| |.. . .|. .|..|         ....|  .. |||  |..|.|||      .  ||||||..
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH----NPPIIHRDLKS

HNILL-THD--Y------APM---VGDFGLAR-WNTSSQPAVETKVVGTLGYLAPEYASSG---QVTEKADVYSFGVILLEMVTGR-R
.|||| ...  .      |..   ..|||. | . .. ...|  ..||. |..|||    .   . |||.|.||||.|| | .|.. .
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHH
Kinase IRAKb_b-2.AA TKL-Unique 105-299 28 4.1e-32 110.61 In-house 1-224 (290) Show / Hide 
Range on Protein: 105-299
Range on HMM: 1-224/290
Sequence Identity: 28% (65 aa)

HANFLAEGGFGFVYKGVLKGGQHIAVKQHK-LASTQGG--REFCAEVKVLSGAQ-HRNLVTLLGFCV----EDGKRMLVYEFVCNKSLDYHLF-------
  | . |||.| ||||. . |  .|.|| . ...      .||  ||....  . | |.|.. |.|.      ... .| |..   ||. .|        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--DKNTVLPWCARQGIALGAARAMRYLHEECRVGTIIHRDLRPHNILLTHD-----YAPMVGDFGLARWNT-SSQPAVETK-------VVGTLGYLAPEY
   .|. |..  |  .|. .|..| ||| .   ..||||||.. |.|.. .     .   . ||||.. |. ...  . ..       ..|.. ..||| 
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE--PPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

ASS--GQVTEKADVYSFGVILLEMVTG
 ..   | .||.||||||..| |..|.
LRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKb_b-2.AA MLK 103-300 25 1e-31 107.39 In-house 1-233 (291) Show / Hide 
Range on Protein: 103-300
Range on HMM: 1-233/291
Sequence Identity: 25% (61 aa)

FSHANFLAEGGFGFVYKGVLKGGQ----HIAVKQHK-------LASTQGGREFCAEVKVLSGAQHRN----LVTLLGFCVEDGK-RMLVYEFVCNKSLDY
.    .. .|.|| |.||. ..       .|||...        ....  ..|  |.. |.  .|.|     . ..| | ....   .| |.. . ||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCE-QWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HLFDKNT-------------VLPWCARQGIALGAARAMRYLHEECRVGTIIHRDLRPHNILLTH------DYAPMVGDFGLAR-WNTSSQPAVETKVVGT
 | ....             | .      .||  ||.| |||.. .. .|||||| .||||...      .    . |||..| |...   .  ..  ||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPK-PIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGT

LGYLAPEY---ASSGQVTEKADVYSFGVILLEMVTGR
. . |||    . .....||.||.|.||.| ||.|..
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAKb_b-2.AA S_TKc 103-375 21 7.5e-31 109.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 103-375
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

FSHANFLAEGGFGFVYKGVLKG-GQHIAVKQHKLASTQGGREFCAEVKVLSGAQHRNLVTLLGFCVEDGKRMLVYEFVCN--KSLDYHLFDKNTV-----
.   . . .|.|| |||.. |. |.. |.|. |       . .. |...|.  .| |.|.|...... ..  .| |.. .   .|  .. ....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LPWCARQGIALGAARAMRYLHEECRVGTIIHRDLRPHNILLTHDYAPMVGDFGLARWNTSSQPAVETKVVGTLGYLAPEYASSGQVTE-KADVYSFGVIL
.|    . ..   ..|. |.|.      |||||| | ||||..    ...||||||          | ..||. |.|||     . .  |.|..|.|.||
FPE-HARFYMYQICCALEYCHSHG----IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LEMVTGRRSLDISLPHAEQCLTEWARPKLDVRDADSLLDPRLVKDLLQESQLYEIQAMVHAAAF-----CLRREPSQRPRMSQVDT----------Y
 ||..|.   .      .| . .  .                                    |      ||...|..||   .. .           
YEMLCGYPPFP-----QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKb_b-2.AA LISK 108-301 27 1.4e-30 96.46 In-house 1-237 (296) Show / Hide 
Range on Protein: 108-301
Range on HMM: 1-237/296
Sequence Identity: 27% (66 aa)

FLAEGGFGFVYKGVLK-GGQHIAVKQHKL-----ASTQGGREFCAEVKVLSGAQHRNLVTLLGFCVE-DGKRMLVYEFVCNKSLDYHLFDKNT---VLPW
 . .|.|| |||| ..  || .|.|. .            . .  ||...   .|.| |   | |.. ||. ..| |..    | . |.|..    .|||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

CARQGIALGAARAMRYLHEECRVGTIIHRDLRPHNILLT----HDYAPMVGDFGLARWNTSSQ-----------------------------PAVETK--
  |  |||. |..|.|||. .    ||||||  .|.|.      ..   |.|||.||  . ..                             ..   |  
PQRVKIALDIACGMSYLHSMN----IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRR

--VVGTLGYLAPEYASSGQVTEKADVYSFGVILLEMVTGRR
  ..||    |||     . .|..||.|||..|.|..|...
MTICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKb_b-2.AA TK 103-298 16 9e-30 96.37 In-house 1-389 (486) Show / Hide 
Range on Protein: 103-298
Range on HMM: 1-389/486
Sequence Identity: 16% (63 aa)

FSHANFLAEGGFG---FVYKGVLKGG--------------------------QHIAVKQHKLASTQGGRE-----------------FCAEVKVLSG--A
    . | || ||    |||| ..|.                          .  |||. |. ...  .|                 ...| |...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHRNLVTLLGFCVED------------GKRMLVYEFVCNKS----LDYHLFDK-----------------------------------------------
.| |.| |.| |...            .  |.| |.... .    |. .| ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------NTVLPWCARQGIALGAARAMRYLHEE-CRVG--TIIHRDLRPHNILLTHDYA-----------PMVGDFG--
                            .  |.   .  ... .|..|.|||.  |. .   ..||||  .|.|.....              ..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARWNTSSQPAVETKVVGTLG-------------------------YLAPEYASSGQ---------VTEKADVYSFGVILLEMVT
      |||   |..  . ..  || .                         ..|||   ...          |.| ||.|||| . |..|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKb_b-2.AA TK-Unique 103-298 24 3.8e-28 94.22 In-house 1-234 (294) Show / Hide 
Range on Protein: 103-298
Range on HMM: 1-234/294
Sequence Identity: 24% (58 aa)

FSHANFLAEGGFGFVYKGVLKG-------GQHIAVKQHKLASTQG-GREFCAEVKVLSGAQ-HRNLVTLLGFCVEDG-KRMLVYEFVCNKSLDYHLFDKN
.   . . || ||.|..| ..|        ...|||..|  .|.   ..|  | ....    | |.|..|| |....   |...|.. . .|. .|  . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

TV-------------------------LPWCARQGIALGAARAMRYLHE-ECRVGTIIHRDLRPHNILLTHDYAPMVGDFGLAR-WNTSSQPAVE-TKVV
 .                         .  .    .| . |..| ||..  ...   .||||  .|.|||.|.   ..|||.||  .|  . . . ..  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI---VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

GTLGYLAPEYAS--SGQV-TEKADVYSFGVILLEMVT
  . ..|||. .   |.  |.| ||.||||.. |..|
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAKb_b-2.AA Dicty4 103-299 31 1.2e-25 82.7 In-house 1-213 (277) Show / Hide 
Range on Protein: 103-299
Range on HMM: 1-213/277
Sequence Identity: 31% (69 aa)

FSHANFLAEGGFGFVYKGVLKGGQHIAVKQHKLASTQGG------REFCAEVKVLSGAQHRNLVTLLGFCV----EDGKRMLVYEFVCNKSLDYHLFD--
    ... .|.|| ||||  . |.  |||  || ... .       || .||. ..  .| |.....| |     . || . | |..   .|   | |  
INIEQRIGKGSFGEVYKGTWR-GKEVAVK--KLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

----KNTVLPWCARQG---IALGAARAMRYLHE-ECRVGTIIHRDLRPHNILLTHDYAPMVGDFGLAR--WNTSSQPA-VETKVVGTLGYLAPEYASSGQ
    ... |.|  .     .|. ||| | .||.  ..   |||||| .||.|   ..   |.||||..     ... .   | ..|| .. |||   .  
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV---IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT-ACGTPCWMAPEVMMHQP

VTEKADVYSFGVILLEMVTG
 .||||||||| .| |..|.
YNEKADVYSFGIVLWEILTR
Kinase IRAKb_b-2.AA CZAK 103-300 32 8.5e-24 83.38 In-house 1-219 (279) Show / Hide 
Range on Protein: 103-300
Range on HMM: 1-219/279
Sequence Identity: 32% (72 aa)

FSHANFLAEGGFGFVYKGVLKGGQHIAVKQHKLASTQGGRE------FCAEVKVLSGAQHRNLVTLLGFCVEDG--KRMLVYEFVCNKSLDYHLFDK-NT
.       .| || |||.. . |  .|.|   . .     |      |  || ..|   | | |  || | |||   .  | |.    ||.  | |. . 
LKFGQTIGQGFFGEVYKAYWR-GKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFY

VLP-WCARQGIALGAARAMRYLHEECRVGTIIHRDLRPHNILLTHDYA-------------PMVGDFGLARWNTSSQPAVETKVVGTLGYLAPEYASSGQ
...    .  .|.  || | |||   . . |.||||   |||| | |                . |||| |     ||   |  .| | . |||      
HKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSR-EMMEQPFEMTQTMGCLCWMAPECFKGEN

VTEKADVYSFGVILLEMVTGR
 |||.|||||| || ...|..
YTEKVDVYSFGMILWCIITCD
Kinase IRAKb_b-2.AA Pkinase_Tyr 109-250 29 5.1e-20 68.42 Pfam 7-159 (270) Show / Hide 
Range on Protein: 109-250
Range on HMM: 7-159/270
Sequence Identity: 29% (46 aa)

LAEGGFGFVYKGVLK-----GGQHIAVKQHKLASTQGG---REFCAEVKVLSGA-QHRNLVTLLGFCV-EDGK--RMLVYEFVCNKSLDYHLFDK---NT
| || || ||||..|     .... |||  |  ...     ..| .|.|...   .| |.| |.| |. ...    ..| |.... .|. .| ..   . 
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

VLPWCARQGIALGAARAMRYLHEECRVGTIIHRDLRPHNILLTHDYAPMVGDFGLAR
 |.     ....  |..| ||..      .|||||.  |.|.|..    ..||||||
PLTMKDLLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase IRAKb_b-2.AA TyrKc 103-378 22 8.8e-17 48.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 103-378
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

FSHANFLAEGGFGFVYKGVLKGGQHIAVKQHKLASTQGGREFCAEVKVLSGA--QHRNLVTLLGFCVED-------GKRMLVYEFVCNKSLDYHLFDKNT
 .    | || || ||||..|  .  |||  |  .    ..|. | ....    .| |.| |.| |...       .  |.| |.... .|. .| ..  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

VLPWCARQGIALGAARAMRYLHEECRVGTIIHRDLRPHNILLTHDYAPMVGDFGLARWNTSS--------QPAV----ETKVVGTLGYLAPEYASSGQVT
 |..     ... .|. |.|||.      .|||||   |.|.....   ..||||.|  ..            .     .| .  .  .|||    |  |
KLCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKADVYSFGVILLEMVTGRRSLDISLPHAEQ----CLTEWARPKLDVRDADSLLDPRLVKDLLQESQLYEI------QAMVHAAAFCLRREPSQRPRMSQ
.| ||.|||| . |. |     .   |. ..    .  . .. ... ..     .  .           ..      ..|      | ...|..||..|.
TKSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-----------PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

VDTYEEK
.  .|. 
I--HECF
Kinase IRAKb_b-2.AA Pkinase_Tyr 270-298 48 0.012925 9.48 Pfam 181-209 (270) Show / Hide 
Range on Protein: 270-298
Range on HMM: 181-209/270
Sequence Identity: 48% (14 aa)

LAPEYASSGQVTEKADVYSFGVILLEMVT
.|||  . |  |.| ||.|||| . |..|
MAPECINYGKFTTKSDVWSFGVLMWEIFT