Gene IRAK-Un_ay-2 (S.moellendorffii)

IRAK-Un_ay-2

Species: S.moellendorffii
Alias: IRAK-Un_ay-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_ay-2.AA Protein None 307 None Fasta, JSON
IRAK-Un_ay-2.NA RNA None 924 None Fasta, JSON
IRAK-Un_ay-2.kin_dom Protein Kinase Domain None 190 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_ay-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_ay-2.AA TKL 23-278 18 1.8e-49 170.71 In-house 28-364 (364) Show / Hide 
Range on Protein: 23-278
Range on HMM: 28-364/364
Sequence Identity: 18% (65 aa)

VVAVKYLTS-------------------------SDLSEKARLDFENEVSTICLLQHKNVVRLFGFCSEKEH-------------KLIVCELVENGNLSD
.|||| . |                         .. ....|  .|.|.  .  |.| |.|.. |.| . ..               || |....|.| .
DVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLH

ALFELLTRVSSISVRNDLQLDWTARYNICVGVAQGLAYLHGETS----QVTIVHRDIKALNILLASDLK--------------PKISDFGLARLIQQSRS
 |                   |  | ... ..|.|..||| ..        |.|||.|  |||. ....              .||.||||.| ..|| .
YLH------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGN

YISTR------------------AAGTAGYLAPEYALYG----------------QLTVKADVYSFGILVLEIISGRKNMDFSEFFLLEWAWN----AFQ
   |                     || ...|||                     . . |.|||||||.  ||.....   ....   .. ..    ...
MNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PYYDYPYMPMIFQDPFEEMF

SGNLQEIIDKRLEVGERE-------IHEIKRVFTVALHCTQASQNKRPVMYKVVGML
... ..     .    ..        .  ...   . .| ..  .||| . ...  |
MMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_ay-2.AA TK 22-207 20 9.9e-36 116.7 In-house 53-389 (486) Show / Hide 
Range on Protein: 22-207
Range on HMM: 53-389/486
Sequence Identity: 20% (68 aa)

HVVAVKYLTS-SDLSEKARLD--------------FENEVSTIC--LLQHKNVVRLFGFCSEK------------EHKLIVCELVENGN----LSDALF-
. |||| |.. .. |.....|              . .| .  |  |..|.|.|||.| |...            |. .|| |....|.    | | |  
TPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRK

-ELLTRV--------------------------------------------------SSISVRNDLQ------------LDWTARYNICVGVAQGLAYLH
    ..                                                   .... .  ||            |.   .  .|. .|.|..|||
CRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH

GETSQVT---IVHRDIKALNILLASDLK-----------PKISDFG--------LARLIQQSRSYISTRAAGTAG-------------------------
    .     .||||. | |.|......            ||.|||        ||| |...  | ...  ||..                         
SKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIR

YLAPEYAL---------YGQLTVKADVYSFGILVLEIIS
..|||  .         ||  | | ||.|||.|. || .
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-Un_ay-2.AA IRAK 104-213 40 6.8e-34 117.55 In-house 106-225 (317) Show / Hide 
Range on Protein: 104-213
Range on HMM: 106-225/317
Sequence Identity: 40% (48 aa)

LDWTARYNICVGVAQGLAYLHGETSQVTIVHRDIKALNILLASDLKPKISDFGLARL-----IQQSRSY---ISTRAAGTAGYLAPEYAL--YGQLTVKA
| |  |  || | | |. .||   . . | |.|||  ||||  .. |||.||||.|         . .|   .  .  ||. |..||.     ||||.| 
LSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKT

DVYSFGILVLEIISGRKNMD
||||||| .||...|.. ..
DVYSFGIVLLEVLTGCRAVY
Kinase IRAK-Un_ay-2.AA TKL-Unique 24-208 29 7.6e-32 109.66 In-house 23-224 (290) Show / Hide 
Range on Protein: 24-208
Range on HMM: 23-224/290
Sequence Identity: 29% (61 aa)

VAVKYLT-SSDLSEKARLDFENEVSTICLLQ-HKNVVRLFGFCS----EKEHKLIVCELVENGNLSDALFELLTRVSSISVRNDLQLDWTARYNICVGVA
||.| .   .|.| . . .|||||...  |. |.|.|...|.|        .  ||.| .. |.| | |   .    .   .| . |..  |...   .|
VAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN--NNNNNNNCKLNMQQRVKMAIDIA

QGLAYLHGETSQVTIVHRDIKALNILLASD-----LKPKISDFGLARLIQQSRSYISTRA--------AGTAGYLAPEYALYG---QLTVKADVYSFGIL
||. |||  ... .| |||.| .|.|. ..     .. ||.||||...  ..   ....          |.. ..|||  | .   | . |.||||||| 
QGMYYLH--HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV-LRMNFCQYSEKSDVYSFGIV

VLEIISG
. ||...
LWEIATR
Pkinase IRAK-Un_ay-2.AA Pkinase 20-209 25 4.4e-31 110.99 Pfam 23-209 (293) Show / Hide 
Range on Protein: 20-209
Range on HMM: 23-209/293
Sequence Identity: 25% (53 aa)

DSHVVAVKYLTSSDLSEKAR-----LDFENEVSTICLLQHKNVVRLFGFCSEKEHKLIVCELVENG----NLSDALFELLTRVSSISVRNDLQL--DWTA
....|||| .  .. ... .     |   .|..    |.|.|.|||.... .| |  .| |..|.|     |.| .            ...  .  ..  
TGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----------WRHGCFYFSEWE

RYNICVGVAQGLAYLHGETSQVTIVHRDIKALNILLASDLKP----KISDFGLARLIQQSRSYISTRAAGTAGYLAPEYAL-YGQLTVKADVYSFGILVL
  ...  ...||.|.| .     |.|||.|  |||. ..  .    ||.|||||....  ..   |  .|| .|.|||  . .   . |.|..|.|... 
CKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILY

EIISGR
| ..||
EMLCGR
Kinase IRAK-Un_ay-2.AA Pkinase_Tyr 24-210 32 1.6e-30 103.99 Pfam 31-213 (270) Show / Hide 
Range on Protein: 24-210
Range on HMM: 31-213/270
Sequence Identity: 32% (65 aa)

VAVKYLTSSDLSEKA--RLDFENEVSTICLL-QHKNVVRLFGFCS-EKEH--KLIVCELVENGNLSDALFELLTRVSSISVRNDLQLDWTARYNICVGVA
|||| |   . ....  | || .|... . | .|.|.||| | |. ..|.   .|| |....|.| | | .           .. .|.     ..|. .|
VAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--------EDKQPLTMKDLLQMCWQIA

QGLAYLHGETSQVTIVHRDIKALNILLASDLKPKISDFGLARLIQQSRSYISTRAAGTAG----YLAPEYALYGQLTVKADVYSFGILVLEIIS-GRK
.|..||.       ..|||. | |.|...... ||.||||||.| .. .|  .|..| .      .|||   ||  |.| ||.|||.|  ||.. |..
KGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase IRAK-Un_ay-2.AA MLK 23-209 27 1.7e-29 99.55 In-house 29-233 (291) Show / Hide 
Range on Protein: 23-209
Range on HMM: 29-233/291
Sequence Identity: 27% (57 aa)

VVAVKYLTSSDLSEKAR-----LDFENEVSTICLLQHKN----VVRLFGFCSEKEH-KLIVCELVENGNLSDALFELLTRVS---SISVRNDLQLDWTAR
.||||  ...   .|..      ||| |.     |.|.|    .... | |.. ..  .|| | .|.| |.. | .  .  .        ||   |    
IVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK-NDRVYDHDHA

YNICVGVAQGLAYLHGETSQVTIVHRDIKALNILLAS------DLKPKISDFGLARLIQQSRSYISTRAAGTAGYLAPEY---ALYGQLTVKADVYSFGI
 |... .|.|..||| .  ...|.|||.|  |||..       ... ||.|||..| ..|.     . .|||. . |||    .  .. . |.||.|.|.
MNWALQCARGMHYLHSMA-PKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGV

LVLEIISGR
.  |.....
VLWEMLTRE
Kinase IRAK-Un_ay-2.AA Dicty4 24-201 30 2.8e-28 91.54 In-house 25-206 (277) Show / Hide 
Range on Protein: 24-201
Range on HMM: 25-206/277
Sequence Identity: 30% (57 aa)

VAVKYL--TSSDLSEKARLDFENEVSTICLLQHKNVVRLFGFCS----EKEHKLIVCELVENGNLSDALFELLTRVSSISVRNDLQLDWTARYN---ICV
|||| |  .  ...|.   .| .||.  | ..| |.. . | |     ...  .|| |..  ||    |..||    |       .|||. .     .. 
VAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGN----LYSLLHDKPS-EQQQSIKLDWPLIKRAMRMAF

GVAQGLAYLHGETSQVTIVHRDIKALNILLASDLKPKISDFGLARLIQQSRSYIS--TRAAGTAGYLAPEYALYGQLTVKADVYSFGIL
 .|.|...||.  . . |.|||.|. |.|   ... |..||||.....   .     . |.||... |||       . |||||||||.
DAARGMNWLHC--CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIV
Kinase IRAK-Un_ay-2.AA Dicty4-Unclassified 24-208 32 1e-25 85.05 In-house 25-204 (263) Show / Hide 
Range on Protein: 24-208
Range on HMM: 25-204/263
Sequence Identity: 32% (63 aa)

VAVKYLTSSDLSEKAR----LDFENEVSTICLLQHKNVVRLFGFC----SEKEHKLIVCELVENGNLSDALFELLTRVSSISVRNDLQLDWTARYNICVG
|||| . .   . |.|     ||  ||    ..|| | |.. | |    | |    || |.   ||    |||.     |      ..|| |    .   
VAVKKFNEN--KFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGN----LFEVIHSKPS-EQQQPIKLDDTLIIKYAFD

VAQGLAYLHGETSQVTIVHRDIKALNILLASDLKPKISDFGLARLIQQSRSYISTRAAGTAGYLAPEYALYGQLTVKADVYSFGILVLEIISG
.|||...||     . ..|||||. |||.  .   || |||..| |  .  .  |  |||    .||       . |.||||....  | . |
IAQGMQHLH----TRNFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAK-Un_ay-2.AA Src 24-209 34 2.1e-25 83.2 In-house 26-198 (255) Show / Hide 
Range on Protein: 24-209
Range on HMM: 26-198/255
Sequence Identity: 34% (65 aa)

VAVKYLTSSDLSEKARLDFENEVSTICLLQHKNVVRLFGFCSEKEHKLIVCELVENGNLSDALFELLTRVSSISVRNDLQLDWTARYNICVGVAQGLAYL
|||| | . ..| .|   |  |  .   |.|...|.|.  ||..|  .|| |. ..|.| | | .          .   .|  .    .   ||.| |||
VAVKTLKPGTMSPEA---FLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK---------DGEGRHLHLPQLIDMAAQVAEGMAYL

HGETSQVTIVHRDIKALNILLASDLKPKISDFGLARLIQ-QSRSY-ISTRAAGTAGYLAPEYALYGQLTVKADVYSFGILVLEIIS-GR
    ..  ..|||  | |.|   ..  |. ||||||||.     |  .. |       ||| ..||. |.|.|| |||||  ||.. ||
----ESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGR
Kinase IRAK-Un_ay-2.AA TK-Unique 110-207 34 2.9e-22 73.67 In-house 134-234 (294) Show / Hide 
Range on Protein: 110-207
Range on HMM: 134-234/294
Sequence Identity: 34% (36 aa)

YNICVGVAQGLAYLHGETSQVTIVHRDIKALNILLASDLKPKISDFGLARLIQQSRSYISTR--AAGTAGYLAPEYAL--YGQL-TVKADVYSFGILVLE
|......|.|..||..   ..  ||||. | |.||..|.. ||.|||.|| ..  . |....        ..|||. .  .|.  | | ||.|||.|  |
YHFAWQIACGMEYLASQRKKI--VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWE

IIS
| .
IFT
Kinase IRAK-Un_ay-2.AA STE 112-209 26 1.5e-21 72.96 In-house 156-265 (359) Show / Hide 
Range on Protein: 112-209
Range on HMM: 156-265/359
Sequence Identity: 26% (32 aa)

ICVGVAQG-LAYLHGETSQVTIVHRDIKALNILLASDLKPKISDFGLARLIQQ---------------SRSYISTRAAGTAGYLAPEYALY------GQL
||. . .| |.|||       |.|||||. ||||      |..|||..  ...               ...  ..  .||  . |||  .       .. 
ICRQILKGLLYYLHSHH----IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGY

TVKADVYSFGILVLEIISGR
..|.|..|.|....| . |.
DTKCDIWSLGCTIIEMATGK
TyrKc IRAK-Un_ay-2.AA TyrKc 10-278 22 1.3e-17 61.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-278
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

IVDTHT----------QGVIDSHVVAVKYLTSSDLSEKARLDFENEVSTICLL--QHKNVVRLFGFCSEK-------EHKLIVCELVENGNLSDALFELL
|.  ..          .|. .   |||| | ..      | || .| .  | |  .|.|.|||.| |...       |  .|| |....|.| | | .  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

TRVSSISVRNDLQLDWTARYNICVGVAQGLAYLHGETSQVTIVHRDIKALNILLASDLKPKISDFGLARLIQQS-------RSYI-----STRAAGTAGY
 .           | .    ..|. .|.| .|||       ..|||. | |.|.....  |||||||.| |            |      ....      
PK-----------LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

LAPEYALYGQLTVKADVYSFGILVLEIISGRKNMDFSE----FFLLEWAWNAFQSGNLQEIIDKRLEVGEREIHEI------KRVFTVALHCTQASQNKR
.|||   ||  | | ||.|||..  || .  . .  ..    .   . . .  ..|.  .. .  .        ..      . .... . | ..  ..|
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQ-QPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--------PMSFVCCPDEMYQIMKQCWHEDPEDR

PVMYKVVGML
| .  ..  .
PTFSEIHECF
S_TKc IRAK-Un_ay-2.AA S_TKc 3-254 19 6.8e-14 26.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 3-254
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

FLTEKN----------SIVDTHTQGVIDSHVVAVKYLTSSDLSEKARLDFENEVSTICLLQHKNVVRLFGFCSEKEHKLIVCELVEN--GNLSDALFELL
.   .             ....     . ..||.| .           ....|..     .|.|.|.|.... . .|  .| |....  |.| | . .  
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

TR-----VSSISVRNDLQLDWTARYNICVGVAQGLAYLHGETSQVTIVHRDIKALNILLASDLKPKISDFGLARLIQQSRSYISTRAAGTAGYLAPEYAL
..      .   .|            ..  ....|.|.|   |.  |.|||.|  |||| .    ||.||||||..        |   ||  |.|||   
RHGLRFPFPE-HAR-----------FYMYQICCALEYCH---SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-

YGQLTV-KADVYSFGILVLEIISGRKNMDFSEFFLLEWAWNAFQSGNLQEIIDKRLEV------GEREIHE------IKRVF
  . .  |.|..|.|... | ..|.   .  .. ...       |  . ..|.| |..      .  |. .      .   |
--GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-Un_ay-2.AA STE 23-86 13 1.7e-05 15.49 In-house 41-128 (359) Show / Hide 
Range on Protein: 23-86
Range on HMM: 41-128/359
Sequence Identity: 13% (12 aa)

VVAVKYLTSSDLS---------------EKARLDFENEVSTICLLQ--HKNVVRLFGFCSEK-------EHKLIVCELVENGNLSDAL
..|.| .  .. .               .. . ....|...   ..  |.|.|. .| .  .       ..  |. |....| |.| .
IMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDII
Kinase IRAK-Un_ay-2.AA TK-Unique 51-82 36 6.1e-05 13.11 In-house 60-92 (294) Show / Hide 
Range on Protein: 51-82
Range on HMM: 60-92/294
Sequence Identity: 36% (12 aa)

LLQHKNVVRLFGFCSEK-EHKLIVCELVENGNL
| .|.|.|...| | .. |  .|. | ...|||
LGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNL
Kinase IRAK-Un_ay-2.AA IRAK 44-84 36 0.000344 10.94 In-house 52-92 (317) Show / Hide 
Range on Protein: 44-84
Range on HMM: 52-92/317
Sequence Identity: 36% (15 aa)

NEVSTICLLQHKNVVRLFGFCSEKEHKLIVCELVENGNLSD
||. . |...|.|.| | |.|.| .    | ..  || | |
NELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLED