Gene IRAK-Un_dq (S.moellendorffii)

IRAK-Un_dq

Species: S.moellendorffii
Alias: IRAK-Un_dq
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_dq.AA Protein None 446 None Fasta, JSON
IRAK-Un_dq.NA RNA None 1341 None Fasta, JSON
IRAK-Un_dq.kin_dom Protein Kinase Domain None 399 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_dq.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_dq.AA CMGC 31-429 17 5.1e-101 332.74 In-house 1-513 (513) Show / Hide 
Range on Protein: 31-429
Range on HMM: 1-513/513
Sequence Identity: 17% (110 aa)

YAVLDPIGSGAYSDVYHGKR--------------RDDGLHVALK------EVHDGK----------SSSRELAALQLL----------------TNSSHV
| ....||.|.|. || ..               .... .||.|      . ...|          .. ||.  |. |                 .  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQLLDHVWLHP-----------------GVLLVLEFLPGSLAEVIEERK-------EIPFQEFE------------ARNWM------EQILKAVA--ECH
|.|.|..  .                   . || |... .|...|.. .        .|. | .             .. |       |||....   ||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SAG--ILHRDLKPSNLLISSD--------------------GVLKVADFGTALVLPVE-------------NVEEAVKDSSSGKKKLKGGAEFDRFGSGK
|..  |.||||||.|.||...                    |.||..||| |  . ..             ||                           
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNK-------------------------

KLDSEEIEAWLQGGSFKLKSAATSSEQQPETMVPAQIRGSKSYDRLEIEDSGTEVSPRVSDAEEEEDVLSFSLSQSSKMWWCSSQVGNDDFRGEMTDCVG
                                                                                       .|. .  .|. | 
---------------------------------------------------------------------------------------DDKPNRPYTHYVV

TRWYKAPELLYGS---------TSYNFAVDLWAVGCILGELIQG--------EPLFPGASD-----------IDQLSRVVRVLGVPN-------------
||||.|||.| |.         . |. ..| |.||||..|...|        .||||| |.           |||| . ..||| |.             
TRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFC

--ETIWPGISSLPDYDK-------------ICF-----------NDDRPPVTLARILPR-----------------------------------ASGEAL
  | .||....||.|.|             ..               .|| .. .. |.                                   .. .|.
KHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAI

RLIEKLLVYDPASRLSASQALSHEFF
 |..|.|.|||. |..|.|||.|..|
DLLKKMLQYDPDKRITAEQALQHPYF
Kinase IRAK-Un_dq.AA S_TKc 31-429 21 2.2e-81 277.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 31-429
Range on HMM: 1-231/231
Sequence Identity: 21% (87 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDGKSSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPG---SLAEVIEERKE----IPFQEF
| .|..||.||.. || .. ...| .||.|...  ..  ||.. |.   .  ..|.|.|.      . .|.|...|   .| ..|..|.      || | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

EARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALVLPVENVEEAVKDSSSGKKKLKGGAEFDRFGSGKKLDSEEIEAWLQGGSFKL
.|| .| ||..|.. ||| ||.||||||.|.|...  ..|..||| | .|                                                  
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------------------------------

KSAATSSEQQPETMVPAQIRGSKSYDRLEIEDSGTEVSPRVSDAEEEEDVLSFSLSQSSKMWWCSSQVGNDDFRGEMTDCVGTRWYKAPELLYGSTSYNF
                                                                             | ..||.|| |||.|    .|..
-----------------------------------------------------------------------------TTFCGTPWYMAPEVL----GYGK

-AVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLARILPRASGEALRLIEKLLVYDPASRLSASQ
 ..| |..|||| |.. |.|.||   ..... ....                                        | ||. .|.|.|..||. |..| .
CKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-E

ALS-------HEFF
||        |..|
ALQDEWDIKCHPWF
Kinase IRAK-Un_dq.AA MAPK 131-429 23 1.2e-63 217.73 In-house 123-328 (328) Show / Hide 
Range on Protein: 131-429
Range on HMM: 123-328/328
Sequence Identity: 23% (74 aa)

QILKA--VAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALVLPV-ENVEEAVKDSSSGKKKLKGGAEFDRFGSGKKLDSEEIEAWLQGGSFKLKSAA
|||..  .   |||...||||||||.|. ... ||..||| | ..   .. ..  .|   .   .                                   
QILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-F-Q-----------------------------------

TSSEQQPETMVPAQIRGSKSYDRLEIEDSGTEVSPRVSDAEEEEDVLSFSLSQSSKMWWCSSQVGNDDFRGEMTDCVGTRWYKAPELLYG--STSYNFAV
                                                                     .. ||. | |||| |||.. .  .. |. ||
---------------------------------------------------------------------KMHMTEYVATRWYRAPEIMLNWIWMHYTKAV

DLWAVGCILGELIQ-GEPLFPGASDIDQLSRVVRVLGVPNETIWPGIS-S-LP-DYDKIC-FNDDRPPVTLARILPR----ASGEALRLIEKLLVYDPAS
| |.||||..|... . ||||| . |||. ... ||| | |  .  |. |  . .| . . ..  .|..... ..|     |. .|. |.||.|| ||  
DMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDK

RLSASQALSHEFF
|... .||.|..|
RITVEEALQHPYF
Kinase IRAK-Un_dq.AA CDK 299-429 40 5.7e-62 196.98 In-house 175-284 (284) Show / Hide 
Range on Protein: 299-429
Range on HMM: 175-284/284
Sequence Identity: 40% (55 aa)

EMTDCVGTRWYKAPELLYGSTSYN--FAVDLWAVGCILGELIQ---GEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLAR
..|  | |.|| ||||| ||. |.   ..|.|.||||..|...   ..||||| |.|||| .. |..| |.| .|||...||||                
TYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------

ILPRASGEALRLIEKLLVYDPASRLSASQALSHEFF
           |..|.|.|||. |.||.|||.|..|
----------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase IRAK-Un_dq.AA CDK7 301-429 41 1.5e-60 159.77 In-house 160-288 (288) Show / Hide 
Range on Protein: 301-429
Range on HMM: 160-288/288
Sequence Identity: 41% (54 aa)

TDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPP--VTLARILPRA
|  | |||| |||||.|  .|  .||.|.||||. ||.   | .|| ||||||.|. . || |.|  ||......||  | | |  ..  . |  |   |
THQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY--IKFKDFPGYSRTPLRHIFTAA

SGEALRLIEKLLVYDPASRLSASQALSHEFF
| ..| |.....  .|  |....|.|....|
SDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase IRAK-Un_dq.AA CCRK 304-429 53 3.6e-57 196.1 In-house 161-285 (285) Show / Hide 
Range on Protein: 304-429
Range on HMM: 161-285/285
Sequence Identity: 53% (68 aa)

VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLARILPRASGEAL
| ||||.|||||||   |   |||||||||.|||. . |.|||  ||.||  |.|.|| |.. .||..  |||| || | .. ||. | ...| || .||
VATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNNSPIFPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQ-PPMPLEQVVPDASPQAL

RLIEKLLVYDPASRLSASQALSHEFF
 |... ||| |  |..||||| |..|
DLLKQFLVYPPRQRIAASQALLHQYF
Kinase IRAK-Un_dq.AA CDC2 304-429 40 6.6e-53 160.67 In-house 166-301 (301) Show / Hide 
Range on Protein: 304-429
Range on HMM: 166-301/301
Sequence Identity: 40% (56 aa)

VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGEL---IQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKI--CFNDDRPPVTLARILPR-
| |.|| |||.| |.  |...||.|..|||. |.   .. .|||.| | |||| .. |.|| ||| .|||...||||     ...    |  | .|.|. 
VVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWK----PQDLSKICPNN

--------ASGEALRLIEKLLVYDPASRLSASQALSHEFF
        .  |.. |....|.|||. |.|| .||.| .|
QKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase IRAK-Un_dq.AA CDK5 304-429 37 7.9e-49 152.15 In-house 159-287 (287) Show / Hide 
Range on Protein: 304-429
Range on HMM: 159-287/287
Sequence Identity: 37% (49 aa)

VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELI-QGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYD-KICFNDDRPPVT-LARILPRASG
| | || .|  | ||  |.  .|.| .|||. |..  | |||||... ||| |. ...| |.|  ||.|. ||||  ..   . .|. . .. | |. ..
VVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDE

EALRLIEKLLVYDPASRLSASQALSHEFF
. . | .|.|...|. |.|| .|| | .|
KGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase IRAK-Un_dq.AA PITSLRE 301-429 40 6.2e-48 165.57 In-house 164-295 (295) Show / Hide 
Range on Protein: 301-429
Range on HMM: 164-295/295
Sequence Identity: 40% (54 aa)

TDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKIC-FNDDRPPVTLARILP---
| || | || ||||| |.  |  .||.| ||||..|.|...|||.| |.|||. ..   .| |.| ||||...||   ..  | .   . .| .. |   
TPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYP-YNNLRKRFPAEN

RASGEALRLIEKLLVYDPASRLSASQALSHEFF
. |  .. |  ..| |.|. |..||.|| |..|
HISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase IRAK-Un_dq.AA CDK-Unclassified 304-429 36 4e-46 149.65 In-house 199-324 (324) Show / Hide 
Range on Protein: 304-429
Range on HMM: 199-324/324
Sequence Identity: 36% (47 aa)

VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPV--TLARILPRASGE
| ||||.||||| ||  |. .|| |..|||. |..|| |.|.| ..|.|.. . ..|| |.|  || ....||| || |.   .    ..      ||. 
VSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASE-

ALRLIEKLLVYDPASRLSASQALSHEFF
 . ..  ...|.|  |......|.|. |
-NNCEFQMVMYQPYNRWKCMEILQHPWF
Kinase IRAK-Un_dq.AA RCK 301-429 43 7.4e-45 140.08 In-house 171-298 (298) Show / Hide 
Range on Protein: 301-429
Range on HMM: 171-298/298
Sequence Identity: 43% (56 aa)

TDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLARILPRASG
|| |.|||| |||.|  .| ||  .|.||||||  ||    |||||.| |||.   . |.| || ..||  . |     . | .   .. |  ..|..| 
TDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCK-GMPLKQLIPNCSQ

EALRLIEKLLVYDPASRLSASQALSHEFF
... |.||.| .||  | .|.||| | .|
DCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase IRAK-Un_dq.AA Pkinase 31-168 31 2.3e-40 143.78 Pfam 1-157 (293) Show / Hide 
Range on Protein: 31-168
Range on HMM: 1-157/293
Sequence Identity: 31% (49 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDGKSSS---------RELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPG-----SLAEVIEERK
| .. .||||... ||.......|  ||.|..   . .|         .|.. .. | |. ..|.|.| .  .. . .|.|...|     .|...|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

EIPF--QEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVL----KVADFG
. .|  .| |....| |||.... ||| ||.||||||.|.||...|..    |..|||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG
Kinase IRAK-Un_dq.AA CDK 31-170 27 4.8e-39 122.46 In-house 1-160 (284) Show / Hide 
Range on Protein: 31-170
Range on HMM: 1-160/284
Sequence Identity: 27% (47 aa)

YAVLDPIGSGAYSDVYHGKRRDDG-----LHVALKEV---------HDGKSSS---RELAALQLLTNSSHVVQLLDHVWLH-----------PGVLLVLE
|  |. || |.|  || .. ...|       ||||..         ..   ..   || . |. |    ..|.|.| .  .             . .| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FLPGSLAEVIEERKEIPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGV-----LKVADFGTA
...  |.....            ...| |.|.... ||| .|.||||||.|.||...|.     ||.|||| |
YMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLA
Kinase IRAK-Un_dq.AA CDK7 31-170 33 1.6e-32 83.57 In-house 1-149 (288) Show / Hide 
Range on Protein: 31-170
Range on HMM: 1-149/288
Sequence Identity: 33% (51 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVH---------DG--KSSSRELAALQLLTNSSH--VVQLLDHVWLHPGVLLVLEFLPGSLAEVIEERKE
|. .. || | .  || .     |  || |..          ||   .  ||   || .   .|  |. |.|       . ||..|..  | .||.  |.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEM---QHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKD-KS

IPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTA
| .   .  ..| ..|. .  ||   |||||||| |||....|.||.|||| |
IILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLA
Kinase IRAK-Un_dq.AA Pkinase 298-429 32 3.6e-32 114.81 Pfam 167-293 (293) Show / Hide 
Range on Protein: 298-429
Range on HMM: 167-293/293
Sequence Identity: 32% (44 aa)

GEMTDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGA----SDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLAR
. ||. .||.|| |||.. |.. |  .|| |..|||| |.. |.|.|||.    . .||. ...|..| |..  ||  .| ...  . . . .    . .
S-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWT

ILPRASGEALRLIEKLLVYDPASRLSASQALSHEFF
  ...| |.. .|...| .||..|..| |.| |..|
F-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase IRAK-Un_dq.AA CCRK 31-172 44 4.7e-30 100.87 In-house 1-148 (285) Show / Hide 
Range on Protein: 31-172
Range on HMM: 1-148/285
Sequence Identity: 44% (66 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEV-----HDG--KSSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPGSLAEVIEERKEIPFQEF
|..|| || ||   |.  |  . |  |||| |      ||      ||. ||| . ..  |||| |      |  || ||.   ||||. . .  |  | 
YCILDRIGEGAHGIVFKAKHVETGEIVALKKVALRRLDDGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQR-PLAEA

EARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALV
  . .|  .|| || ||   |.|||||| |||||  | ||.|||| | |
QVKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARV
Kinase IRAK-Un_dq.AA CDC2 31-168 32 5.1e-28 82.77 In-house 1-148 (301) Show / Hide 
Range on Protein: 31-168
Range on HMM: 1-148/301
Sequence Identity: 32% (48 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEV-----HDG----KSSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPGSLAEVIE--ERKEIP
|  .  || | |  || .| ....  |||| .      .|     .. ||.  |. | .   .|.| | .     . .| |.|   | .  .  . |. .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

FQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFG
...   .. | |||..|. ||. .|.||||||.|.||...|..|.||||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFG
Kinase IRAK-Un_dq.AA CDK5 31-170 34 1.2e-25 77.61 In-house 1-145 (287) Show / Hide 
Range on Protein: 31-170
Range on HMM: 1-145/287
Sequence Identity: 34% (51 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVH-DGK------SSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPGSLAEVIEERKEIPFQEF
|  .. || | |  || .. .. .  ||||.|  |        .  || . |. |     .| | | .       || ||.   |   ......   .  
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKH-KNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG-EMDMH

EARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTA
 ..  | | || .| ||.  .||||||| ||||.  | || |||| |
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLA
Kinase IRAK-Un_dq.AA CDK-Unclassified 93-170 33 1.6e-18 57.39 In-house 92-173 (324) Show / Hide 
Range on Protein: 93-170
Range on HMM: 92-173/324
Sequence Identity: 33% (28 aa)

LHPGVLLVLEFLPGSLAEVIEERKEIPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDG-----VLKVADFGTA
||| . .|.|  |  .  . .    ..    . || | |.|.  |  |...| |||.||.|..|.. .     .||.|||| |
LHPSFYMVMEYMPYTWYNQLHNNR-YNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQA
Kinase IRAK-Un_dq.AA RCK 119-170 33 1.8e-17 51.74 In-house 99-161 (298) Show / Hide 
Range on Protein: 119-170
Range on HMM: 99-161/298
Sequence Identity: 33% (21 aa)

PFQEFE--ARNWMEQILKAVAECHSAGILHRDLKPSNLLISS---------DGVLKVADFGTA
...|..   .| | |||.. | .|. |. |||||| |.....         ....|.|||| .
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLC
Kinase IRAK-Un_dq.AA PITSLRE 99-168 41 3.1e-16 55.76 In-house 80-151 (295) Show / Hide 
Range on Protein: 99-168
Range on HMM: 80-151/295
Sequence Identity: 41% (30 aa)

LVLEFLPGSLAEVIEERK--EIPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFG
.|.|..   |. ..|  |  . ||.. |    | | |..|.  |.  |.||||| ||||.|  |.||..|||
MVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFG
Kinase IRAK-Un_dq.AA TyrKc 31-429 10 4.3e-09 -75.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 31-429
Range on HMM: 1-280/280
Sequence Identity: 10% (47 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDGKSSS---RELAALQLL-TNSSHVVQLLDHVWLH-------PGVLLVLEFLP-GSLAEVIEERKEI
   .. .|.||.  ||.|. .   . || | .....      ||.  .  |  .  ..|.|.  .  .       . ...|.|. | |.| . . .... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

PFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALVLPVE---NVEEAVKDSSS--GKKK-----------LKGG-------
 ..  .  ... || .  .  || .. ||||   | |...... |..||| .  .  .    ... ......  |.|            .. |       
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

--------------AEFDRFG---SGKKLDSEEIEAWLQGGSFKLKSAA----TSSEQQPETMVPAQIRGSKSYDRLEIEDSGTEVSPRVSDAEEEEDVL
               .    |      ... .|. .... |    . .                                                    
VWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------------------

SFSLSQSSKMWWCSSQVGNDDFRGEMTDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSL
                                                                                                    
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PDYDKICFNDDRPPVTLARILPRASGEALRLIEKLLVYDPASRLSASQALSHEFF
                     .... |  .....   .||..| . |.   ||.|
-------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase IRAK-Un_dq.AA RCK 31-60 30 1.4e-05 13.33 In-house 1-30 (298) Show / Hide 
Range on Protein: 31-60
Range on HMM: 1-30/298
Sequence Identity: 30% (9 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALK
| ... .| |.|..|  ... ..|  || |
YQIIKQLGDGTYGCVMKAQNKETGEIVAIK
Kinase IRAK-Un_dq.AA MAPK 31-60 36 0.000559 9.39 In-house 1-36 (328) Show / Hide 
Range on Protein: 31-60
Range on HMM: 1-36/328
Sequence Identity: 36% (13 aa)

YAVLDPIGSGAYSDVYHGKRRD------DGLHVALK
|  | |||.|||  |   . .       .| .||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIK
Kinase IRAK-Un_dq.AA Pkinase_Tyr 31-88 21 0.002799 11.73 Pfam 1-70 (270) Show / Hide 
Range on Protein: 31-88
Range on HMM: 1-70/270
Sequence Identity: 21% (15 aa)

YAVLDPIGSGAYSDVYHGKRR----DDGLHVALKEVHDGKSSS--------RELAALQLLTNSSHVVQLL
   .  .|.||. .||.|. .    .....|| | . .| ...        ||.. .  | .  ..|.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase IRAK-Un_dq.AA APH 33-142 16 0.003213 11.86 Pfam 1-113 (248) Show / Hide 
Range on Protein: 33-142
Range on HMM: 1-113/248
Sequence Identity: 16% (21 aa)

VLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDG---KSSSRELAALQLLTNS-S--HVVQLLD-------HVWLHPGVLLVLEFLPGSLAEVIEERKEIP
 . ||..|. ...|.    | .  . |.  ...    .  ||...|..| .     .| ..|.       | |    . ...|.|||  ..        .
WWRPISGGWSNRTYYRTTDD-RPRYVLRRYPPPWWAEELHREHRWLRHLAAHGIPVPVPRVLWGCTDDEFHGW----PWYLMEWLPGEDLWRW------H

-FQEFEARNWMEQILKAVAECHSA
  .. ..... |.. .. |. |..
ALHCAQRPALLEALARFLARLHQV
Kinase IRAK-Un_dq.AA PITSLRE 31-60 36 0.113669 2.12 In-house 1-30 (295) Show / Hide 
Range on Protein: 31-60
Range on HMM: 1-30/295
Sequence Identity: 36% (11 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALK
.  |. |. |.|  || .| .  .  ||||
FQCLNRIHEGTYGVVYRAKDKRTDEIVALK
Kinase IRAK-Un_dq.AA Pkinase_Tyr 153-168 43 0.335541 4.69 Pfam 141-156 (270) Show / Hide 
Range on Protein: 153-168
Range on HMM: 141-156/270
Sequence Identity: 43% (7 aa)

NLLISSDGVLKVADFG
| |.....| |..|||
NCLVTENNVVKICDFG
Kinase IRAK-Un_dq.AA APH 143-170 28 0.539839 4.27 Pfam 171-202 (248) Show / Hide 
Range on Protein: 143-170
Range on HMM: 171-202/248
Sequence Identity: 28% (9 aa)

GILHRDLKPSNLLIS--SDGVLK--VADFGTA
...|.|..| |....  .||     | |...|
CWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDA