Gene IRAK-Un_ag (S.moellendorffii)
IRAK-Un_ag
Species: S.moellendorffii
Alias: IRAK-Un_ag
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| IRAK-Un_ag.AA | Protein | None | 422 | None | Fasta, JSON |
| IRAK-Un_ag.NA | RNA | None | 1269 | None | Fasta, JSON |
| IRAK-Un_ag.kin_dom | Protein Kinase Domain | None | 376 | None | Fasta, JSON |
Protein domains of IRAK-Un_ag.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | IRAK-Un_ag.AA | CMGC | 30-405 | 18 | 1.9e-101 | 334.2 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 30-405
Range on HMM: 1-513/513
Sequence Identity: 18% (110 aa)
YAVLDPIGSGAYSDVYHGKR--------------RDDGLHVALK------EVHDGK----------SSSRELAALQLL----------------TNSSHV
| ....||.|.|. || .. .... .||.| . ...| .. ||. |. | . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI
VQLLDHVWLHP-----------------GVLLVLEFLPGSLAEVIEERK-------EIPFQEFE------------ARNWM------EQILKAVA--ECH
|.|.|.. . . || |... .|...|.. . .|. | . .. | |||.... ||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH
SAG--ILHRDLKPSNLLISSD--------------------GVLKVADFGTALVLPVE-------------NVEEALKSAATSSEQQPETMVPAQIRGSK
|.. |.||||||.|.||... |.||..||| | . .. ||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNK-------------------------
SYDRLEIEDSGTEVSPRVSDAEEEEDGARSRNDRYSDGEWEKTSNKDSDWYKSSKMWWCSSQVGNDDFRGEMTDCVGTRWYKAPELLYGS---------T
.|. . .|. | ||||.|||.| |. .
----------------------------------------------------------------DDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSM
SYNFAVDLWAVGCILGELIQG--------EPLFPGASD-----------IDQLSRVVRVLGVPN---------------ETIWPGISSLPDYDK------
|. ..| |.||||..|...| .||||| |. |||| . ..||| |. | .||....||.|.|
HYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWN
-------ICF-----------NDDRPPVTLARILPR-----------------------------------ASGEALRLIEKLLVYDPASRLSASQALSH
.. .|| .. .. |. .. .|. |..|.|.|||. |..|.|||.|
WQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQH
EFF
..|
PYF
|
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| Kinase | IRAK-Un_ag.AA | S_TKc | 30-405 | 22 | 3.8e-83 | 283.47 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 30-405
Range on HMM: 1-231/231
Sequence Identity: 22% (87 aa)
YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDGKSSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPG---SLAEVIEERKE----IPFQEF
| .|..||.||.. || .. ...| .||.|... .. ||.. |. . ..|.|.|. . .|.|...| .| ..|..|. || |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-
EARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALVLPVENVEEALKSAATSSEQQPETMVPAQIRGSKSYDRLEIEDSGTEVSPRV
.|| .| ||..|.. ||| ||.||||||.|.|... ..|..||| | .|
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------------------------------
SDAEEEEDGARSRNDRYSDGEWEKTSNKDSDWYKSSKMWWCSSQVGNDDFRGEMTDCVGTRWYKAPELLYGSTSYNF-AVDLWAVGCILGELIQGEPLFP
| ..||.|| |||.| .|.. ..| |..|||| |.. |.|.||
------------------------------------------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP
GASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLARILPRASGEALRLIEKLLVYDPASRLSASQALS-------HEFF
..... .... | ||. .|.|.|..||. |..| .|| |..|
---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | IRAK-Un_ag.AA | MAPK | 130-405 | 25 | 1.2e-64 | 221.14 | In-house | 123-328 (328) | Show / Hide |
Range on Protein: 130-405
Range on HMM: 123-328/328
Sequence Identity: 25% (74 aa)
QILKA--VAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALVLPV-ENVEEALKSAATSSEQQPETMVPAQIRGSKSYDRLEIEDSGTEVSPRVSDAE
|||.. . |||...||||||||.|. ... ||..||| | .. .. .. . . .. |
QILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-F-Q-----------------------------------
EEEDGARSRNDRYSDGEWEKTSNKDSDWYKSSKMWWCSSQVGNDDFRGEMTDCVGTRWYKAPELLYG--STSYNFAVDLWAVGCILGELIQ-GEPLFPGA
.. ||. | |||| |||.. . .. |. ||| |.||||..|... . |||||
----------------------------------------------KMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGK
SDIDQLSRVVRVLGVPNETIWPGIS-S-LP-DYDKIC-FNDDRPPVTLARILPR----ASGEALRLIEKLLVYDPASRLSASQALSHEFF
. |||. ... ||| | | . |. | . .| . . .. .|..... ..| |. .|. |.||.|| || |... .||.|..|
DYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
|
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| Kinase | IRAK-Un_ag.AA | CDK | 275-405 | 40 | 5.7e-62 | 196.98 | In-house | 175-284 (284) | Show / Hide |
Range on Protein: 275-405
Range on HMM: 175-284/284
Sequence Identity: 40% (55 aa)
EMTDCVGTRWYKAPELLYGSTSYN--FAVDLWAVGCILGELIQ---GEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLAR
..| | |.|| ||||| ||. |. ..|.|.||||..|... ..||||| |.|||| .. |..| |.| .|||...||||
TYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------
ILPRASGEALRLIEKLLVYDPASRLSASQALSHEFF
|..|.|.|||. |.||.|||.|..|
----------DLLNKMLCYDPKKRISAEQALQHPYF
|
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| Kinase | IRAK-Un_ag.AA | CDK7 | 277-405 | 41 | 1.5e-60 | 159.77 | In-house | 160-288 (288) | Show / Hide |
Range on Protein: 277-405 Range on HMM: 160-288/288 Sequence Identity: 41% (54 aa) TDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPP--VTLARILPRA | | |||| |||||.| .| .||.|.||||. ||. | .|| ||||||.|. . || |.| ||......|| | | | .. . | | | THQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY--IKFKDFPGYSRTPLRHIFTAA SGEALRLIEKLLVYDPASRLSASQALSHEFF | ..| |..... .| |....|.|....| SDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF |
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| Kinase | IRAK-Un_ag.AA | CCRK | 280-405 | 53 | 3.6e-57 | 196.1 | In-house | 161-285 (285) | Show / Hide |
Range on Protein: 280-405 Range on HMM: 161-285/285 Sequence Identity: 53% (68 aa) VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLARILPRASGEAL | ||||.||||||| | |||||||||.|||. . |.||| ||.|| |.|.|| |.. .||.. |||| || | .. ||. | ...| || .|| VATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNNSPIFPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQ-PPMPLEQVVPDASPQAL RLIEKLLVYDPASRLSASQALSHEFF |... ||| | |..||||| |..| DLLKQFLVYPPRQRIAASQALLHQYF |
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| Kinase | IRAK-Un_ag.AA | CDC2 | 280-405 | 40 | 6.6e-53 | 160.67 | In-house | 166-301 (301) | Show / Hide |
Range on Protein: 280-405
Range on HMM: 166-301/301
Sequence Identity: 40% (56 aa)
VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGEL---IQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKI--CFNDDRPPVTLARILPR-
| |.|| |||.| |. |...||.|..|||. |. .. .|||.| | |||| .. |.|| ||| .|||...|||| ... | | .|.|.
VVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWK----PQDLSKICPNN
--------ASGEALRLIEKLLVYDPASRLSASQALSHEFF
. |.. |....|.|||. |.|| .||.| .|
QKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
|
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| Kinase | IRAK-Un_ag.AA | CDK5 | 280-405 | 37 | 7.9e-49 | 152.15 | In-house | 159-287 (287) | Show / Hide |
Range on Protein: 280-405 Range on HMM: 159-287/287 Sequence Identity: 37% (49 aa) VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELI-QGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYD-KICFNDDRPPVT-LARILPRASG | | || .| | || |. .|.| .|||. |.. | |||||... ||| |. ...| |.| ||.|. |||| .. . .|. . .. | |. .. VVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDE EALRLIEKLLVYDPASRLSASQALSHEFF . . | .|.|...|. |.|| .|| | .| KGMDLLQKMLQCNPNQRISAKAALHHPYF |
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| Kinase | IRAK-Un_ag.AA | PITSLRE | 277-405 | 40 | 6.2e-48 | 165.57 | In-house | 164-295 (295) | Show / Hide |
Range on Protein: 277-405 Range on HMM: 164-295/295 Sequence Identity: 40% (54 aa) TDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKIC-FNDDRPPVTLARILP--- | || | || ||||| |. | .||.| ||||..|.|...|||.| |.|||. .. .| |.| ||||...|| .. | . . .| .. | TPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYP-YNNLRKRFPAEN RASGEALRLIEKLLVYDPASRLSASQALSHEFF . | .. | ..| |.|. |..||.|| |..| HISDTGFDLLNQMLTYNPKNRITASDALKHPWF |
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| Kinase | IRAK-Un_ag.AA | CDK-Unclassified | 280-405 | 36 | 4e-46 | 149.65 | In-house | 199-324 (324) | Show / Hide |
Range on Protein: 280-405 Range on HMM: 199-324/324 Sequence Identity: 36% (47 aa) VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPV--TLARILPRASGE | ||||.||||| || |. .|| |..|||. |..|| |.|.| ..|.|.. . ..|| |.| || ....||| || |. . .. ||. VSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASE- ALRLIEKLLVYDPASRLSASQALSHEFF . .. ...|.| |......|.|. | -NNCEFQMVMYQPYNRWKCMEILQHPWF |
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| Kinase | IRAK-Un_ag.AA | RCK | 277-405 | 43 | 7.4e-45 | 140.08 | In-house | 171-298 (298) | Show / Hide |
Range on Protein: 277-405 Range on HMM: 171-298/298 Sequence Identity: 43% (56 aa) TDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLARILPRASG || |.|||| |||.| .| || .|.|||||| || |||||.| |||. . |.| || ..|| . | . | . .. | ..|..| TDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCK-GMPLKQLIPNCSQ EALRLIEKLLVYDPASRLSASQALSHEFF ... |.||.| .|| | .|.||| | .| DCIELMEKMLQWDPQKRITAQQALQHPYF |
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| Kinase | IRAK-Un_ag.AA | Pkinase | 30-167 | 31 | 2.3e-40 | 143.78 | Pfam | 1-157 (293) | Show / Hide |
Range on Protein: 30-167 Range on HMM: 1-157/293 Sequence Identity: 31% (49 aa) YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDGKSSS---------RELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPG-----SLAEVIEERK | .. .||||... ||.......| ||.|.. . .| .|.. .. | |. ..|.|.| . .. . .|.|...| .|...|. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR EIPF--QEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVL----KVADFG . .| .| |....| |||.... ||| ||.||||||.|.||...|.. |..||| HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG |
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| Kinase | IRAK-Un_ag.AA | CDK | 30-169 | 27 | 4.8e-39 | 122.46 | In-house | 1-160 (284) | Show / Hide |
Range on Protein: 30-169 Range on HMM: 1-160/284 Sequence Identity: 27% (47 aa) YAVLDPIGSGAYSDVYHGKRRDDG-----LHVALKEV---------HDGKSSS---RELAALQLLTNSSHVVQLLDHVWLH-----------PGVLLVLE | |. || |.| || .. ...| ||||.. .. .. || . |. | ..|.|.| . . . .| | YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE FLPGSLAEVIEERKEIPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGV-----LKVADFGTA ... |..... ...| |.|.... ||| .|.||||||.|.||...|. ||.|||| | YMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLA |
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| Kinase | IRAK-Un_ag.AA | CDK7 | 30-169 | 33 | 1.6e-32 | 83.57 | In-house | 1-149 (288) | Show / Hide |
Range on Protein: 30-169 Range on HMM: 1-149/288 Sequence Identity: 33% (51 aa) YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVH---------DG--KSSSRELAALQLLTNSSH--VVQLLDHVWLHPGVLLVLEFLPGSLAEVIEERKE |. .. || | . || . | || |.. || . || || . .| |. |.| . ||..|.. | .||. |. YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEM---QHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKD-KS IPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTA | . . ..| ..|. . || |||||||| |||....|.||.|||| | IILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLA |
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| Kinase | IRAK-Un_ag.AA | Pkinase | 274-405 | 32 | 3.6e-32 | 114.81 | Pfam | 167-293 (293) | Show / Hide |
Range on Protein: 274-405 Range on HMM: 167-293/293 Sequence Identity: 32% (44 aa) GEMTDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGA----SDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLAR . ||. .||.|| |||.. |.. | .|| |..|||| |.. |.|.|||. . .||. ...|..| |.. || .| ... . . . . . . S-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWT ILPRASGEALRLIEKLLVYDPASRLSASQALSHEFF ...| |.. .|...| .||..|..| |.| |..| F-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | IRAK-Un_ag.AA | CCRK | 30-171 | 44 | 4.7e-30 | 100.87 | In-house | 1-148 (285) | Show / Hide |
Range on Protein: 30-171 Range on HMM: 1-148/285 Sequence Identity: 44% (66 aa) YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEV-----HDG--KSSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPGSLAEVIEERKEIPFQEF |..|| || || |. | . | |||| | || ||. ||| . .. |||| | | || ||. ||||. . . | | YCILDRIGEGAHGIVFKAKHVETGEIVALKKVALRRLDDGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQR-PLAEA EARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALV . .| .|| || || |.|||||| ||||| | ||.|||| | | QVKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARV |
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| Kinase | IRAK-Un_ag.AA | CDC2 | 30-167 | 32 | 5.1e-28 | 82.77 | In-house | 1-148 (301) | Show / Hide |
Range on Protein: 30-167 Range on HMM: 1-148/301 Sequence Identity: 32% (48 aa) YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEV-----HDG----KSSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPGSLAEVIE--ERKEIP | . || | | || .| .... |||| . .| .. ||. |. | . .|.| | . . .| |.| | . . . |. . YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH FQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFG ... .. | |||..|. ||. .|.||||||.|.||...|..|.|||| MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFG |
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| Kinase | IRAK-Un_ag.AA | CDK5 | 30-169 | 34 | 1.2e-25 | 77.61 | In-house | 1-145 (287) | Show / Hide |
Range on Protein: 30-169 Range on HMM: 1-145/287 Sequence Identity: 34% (51 aa) YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVH-DGK------SSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPGSLAEVIEERKEIPFQEF | .. || | | || .. .. . ||||.| | . || . |. | .| | | . || ||. | ...... . YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKH-KNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG-EMDMH EARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTA .. | | || .| ||. .||||||| ||||. | || |||| | IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLA |
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| Kinase | IRAK-Un_ag.AA | CDK-Unclassified | 92-169 | 33 | 1.6e-18 | 57.39 | In-house | 92-173 (324) | Show / Hide |
Range on Protein: 92-169 Range on HMM: 92-173/324 Sequence Identity: 33% (28 aa) LHPGVLLVLEFLPGSLAEVIEERKEIPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDG-----VLKVADFGTA ||| . .|.| | . . . .. . || | |.|. | |...| |||.||.|..|.. . .||.|||| | LHPSFYMVMEYMPYTWYNQLHNNR-YNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQA |
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| Kinase | IRAK-Un_ag.AA | RCK | 118-169 | 33 | 1.8e-17 | 51.74 | In-house | 99-161 (298) | Show / Hide |
Range on Protein: 118-169 Range on HMM: 99-161/298 Sequence Identity: 33% (21 aa) PFQEFE--ARNWMEQILKAVAECHSAGILHRDLKPSNLLISS---------DGVLKVADFGTA ...|.. .| | |||.. | .|. |. |||||| |..... ....|.|||| . YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLC |
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| Kinase | IRAK-Un_ag.AA | PITSLRE | 98-167 | 41 | 3.1e-16 | 55.76 | In-house | 80-151 (295) | Show / Hide |
Range on Protein: 98-167 Range on HMM: 80-151/295 Sequence Identity: 41% (30 aa) LVLEFLPGSLAEVIEERK--EIPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFG .|.|.. |. ..| | . ||.. | | | |..|. |. |.||||| ||||.| |.||..||| MVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFG |
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| Kinase | IRAK-Un_ag.AA | TyrKc | 30-405 | 11 | 8.4e-10 | -64.21 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 30-405
Range on HMM: 1-280/280
Sequence Identity: 11% (49 aa)
YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDGKSSS---RELAALQLL-TNSSHVVQLLDHVWLH-------PGVLLVLEFLP-GSLAEVIEERKEI
.. .|.||. ||.|. . . || | ..... ||. . | . ..|.|. . . . ...|.|. | |.| . . ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK
PFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALVLPVE----------------NVE----------EALKSA-------
.. . ... || . . || .. |||| | |...... |..||| . . . . |...
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD
-----------ATSSEQQPET-----MVPAQIRGS-KSYDRLEIEDSGTEVSPRVSDAEEEEDGARSRNDRYSDGEWEKTSNKDSDWYKSSKMWWCSSQV
| .| .. | ..... |. .|... ... | .|
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MS--------------------------------------------
GNDDFRGEMTDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTL
----------------------------------------------------------------------------------------------------
ARILPRASGEALRLIEKLLVYDPASRLSASQALSHEFF
.... | ..... .||..| . |. ||.|
--F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | IRAK-Un_ag.AA | RCK | 30-59 | 30 | 1.4e-05 | 13.33 | In-house | 1-30 (298) | Show / Hide |
Range on Protein: 30-59 Range on HMM: 1-30/298 Sequence Identity: 30% (9 aa) YAVLDPIGSGAYSDVYHGKRRDDGLHVALK | ... .| |.|..| ... ..| || | YQIIKQLGDGTYGCVMKAQNKETGEIVAIK |
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| Kinase | IRAK-Un_ag.AA | MAPK | 30-59 | 36 | 0.000559 | 9.39 | In-house | 1-36 (328) | Show / Hide |
Range on Protein: 30-59 Range on HMM: 1-36/328 Sequence Identity: 36% (13 aa) YAVLDPIGSGAYSDVYHGKRRD------DGLHVALK | | |||.||| | . . .| .||.| YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIK |
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| Kinase | IRAK-Un_ag.AA | Pkinase_Tyr | 30-87 | 21 | 0.002799 | 11.73 | Pfam | 1-70 (270) | Show / Hide |
Range on Protein: 30-87 Range on HMM: 1-70/270 Sequence Identity: 21% (15 aa) YAVLDPIGSGAYSDVYHGKRR----DDGLHVALKEVHDGKSSS--------RELAALQLLTNSSHVVQLL . .|.||. .||.|. . .....|| | . .| ... ||.. . | . ..|.|. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY |
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| Kinase | IRAK-Un_ag.AA | APH | 32-141 | 16 | 0.003213 | 11.86 | Pfam | 1-113 (248) | Show / Hide |
Range on Protein: 32-141 Range on HMM: 1-113/248 Sequence Identity: 16% (21 aa) VLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDG---KSSSRELAALQLLTNS-S--HVVQLLD-------HVWLHPGVLLVLEFLPGSLAEVIEERKEIP . ||..|. ...|. | . . |. ... . ||...|..| . .| ..|. | | . ...|.||| .. . WWRPISGGWSNRTYYRTTDD-RPRYVLRRYPPPWWAEELHREHRWLRHLAAHGIPVPVPRVLWGCTDDEFHGW----PWYLMEWLPGEDLWRW------H -FQEFEARNWMEQILKAVAECHSA .. ..... |.. .. |. |.. ALHCAQRPALLEALARFLARLHQV |
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| Kinase | IRAK-Un_ag.AA | PITSLRE | 30-59 | 36 | 0.113669 | 2.12 | In-house | 1-30 (295) | Show / Hide |
Range on Protein: 30-59 Range on HMM: 1-30/295 Sequence Identity: 36% (11 aa) YAVLDPIGSGAYSDVYHGKRRDDGLHVALK . |. |. |.| || .| . . |||| FQCLNRIHEGTYGVVYRAKDKRTDEIVALK |
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| Kinase | IRAK-Un_ag.AA | Pkinase_Tyr | 152-167 | 43 | 0.335541 | 4.69 | Pfam | 141-156 (270) | Show / Hide |
Range on Protein: 152-167 Range on HMM: 141-156/270 Sequence Identity: 43% (7 aa) NLLISSDGVLKVADFG | |.....| |..||| NCLVTENNVVKICDFG |
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| Kinase | IRAK-Un_ag.AA | APH | 142-169 | 28 | 0.539839 | 4.27 | Pfam | 171-202 (248) | Show / Hide |
Range on Protein: 142-169 Range on HMM: 171-202/248 Sequence Identity: 28% (9 aa) GILHRDLKPSNLLIS--SDGVLK--VADFGTA ...|.|..| |.... .|| | |...| CWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDA |
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