Gene IRAK-0_e-1 (S.moellendorffii)

IRAK-0_e-1

Species: S.moellendorffii
Alias: IRAK-0_e-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_e-1.AA Protein None 587 None Fasta, JSON
IRAK-0_e-1.NA RNA None 1764 None Fasta, JSON
IRAK-0_e-1.kin_dom Protein Kinase Domain None 198 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_e-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF26 IRAK-0_e-1.AA DUF26 108-151 20 9e-07 22.53 Pfam 12-55 (55) Show / Hide 
Range on Protein: 108-151
Range on HMM: 12-55/55
Sequence Identity: 20% (10 aa)

DQPSCSSCIQQTYANV-RTRFP--IGARFWRNSTAQRCNMRFE-NSNF
.  .|..|...  ... ....|  .|.|.|. .    |..|.. ..||
SPSDCRDCLATAVRQMLPQCCPNRQGGRIWYDW----CYLRYSDYPNF
SKG6 IRAK-0_e-1.AA SKG6 188-224 32 0.00033 18.1 Pfam 1-40 (40) Show / Hide 
Range on Protein: 188-224
Range on HMM: 1-40/40
Sequence Identity: 32% (13 aa)

GSGGSGN--TAAIVAGVVVPVFLI-LGVAGLLLVKRRRSR
 . .. .  |.||..|||.||  | |.. ..|.. .||..
KPTDKHWKTTVAIACGVVIPVGVIILVLICFLFCWWRRKK
Kinase IRAK-0_e-1.AA IRAK 266-468 33 1.3e-58 201.0 In-house 1-226 (317) Show / Hide 
Range on Protein: 266-468
Range on HMM: 1-226/317
Sequence Identity: 33% (75 aa)

FSDRNKLGQGGFGTVYKAAFFGDGTVFAVKRL----SVESQQGKREFVN---EIDIITGIRHKNLVMLEGYCCEGNHRLIVYEFLEKGSLDQTLFGKSL-
|.  |..|.||||.||.. . . . ..|||.|    ...  . ...|     |. . . .||.|.| | ||| |.     ||...  |||   | .    
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

--L--LDWPARFQIIVGVAKGLAYLHEES-HEQVIHRDIKASNILLDKMLQPKISDFGISK---LAG--VDREN---TTTRLAGTVGYMAPEYVL--RGR
  .  | |. |. |  | |.|. .||. .    .||.||| .|||||. ..|||.|||       |.   . .     | .. ||  ||.||.     |.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LSSKADVFSFGVLVLEIISGRKCMDD
|. | ||.|||. .||...|.. ..|
LTKKTDVYSFGIVLLEVLTGCRAVYD
Kinase IRAK-0_e-1.AA TKL 272-464 23 3.8e-58 199.48 In-house 1-287 (364) Show / Hide 
Range on Protein: 272-464
Range on HMM: 1-287/364
Sequence Identity: 23% (69 aa)

LGQGGFGTVYKAAFFG--------DGTVFAVKRLSV---------------------------ESQQGKREFVNEIDIITGIRHKNLVMLEGYCCEGNH-
.|.||||.|||. . |        .|.. |||....                           |... . ....|| ..  .|| |.| . ||||.... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLIVYEFLEKGS-LDQTLFGKSLLLDWPARFQIIVGVAKGLAYLHEESH-----EQVIHRDIKASNILLDKMLQ--------------
              ||.|. ..|| |.. .        |. |.... ..|.|..||| .        ..||||.| .|||.|. ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

PKISDFGISKLA-------------------GVDRENTTTRLAGTVGYMAPEYVL----------------RGRLSSKADVFSFGVLVLEIISGRK
.||.|||.|.                       ....|| .  || ..||||                    .  | |.||.|||..  ||.....
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR
Kinase IRAK-0_e-1.AA Pkinase 266-463 27 6.4e-44 156.37 Pfam 1-209 (293) Show / Hide 
Range on Protein: 266-463
Range on HMM: 1-209/293
Sequence Identity: 27% (60 aa)

FSDRNKLGQGGFGTVYKAAFFGDGTVFAVKRLSVESQQG--KREFVN--EIDIITGIRHKNLVMLEGYCCEGNHRLIVYEFLEKG----SLDQTLF---G
.    |.|.|.||.|||.   |.| ..|||.......    ... ..  || |   ..|.| | | ... ...|  .| |..|.|    .|   .    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KSLLLDWPARFQIIVGVAKGLAYLHEESHEQVIHRDIKASNILLDKMLQP----KISDFGISKLA-GVDRENTTTRLAGTVGYMAPEYVL-RGRLSSKAD
.......     ..  ...||.|.|..    .||||.| .|||.|.  ..    ||.|||..|..     .  .| ..|| .||||| .. .   ..|.|
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVD

VFSFGVLVLEIISGR
..|.|... | ..||
MWSCGCILYEMLCGR
Kinase IRAK-0_e-1.AA TKL-Unique 268-462 31 1.2e-42 148.01 In-house 1-224 (290) Show / Hide 
Range on Protein: 268-462
Range on HMM: 1-224/290
Sequence Identity: 31% (71 aa)

DRNKLGQGGFGTVYKAAFFGDGTVFAVKRLSV-ESQQGK--REFVNEIDIITGIR-HKNLVMLEGYCC----EGNHRLIVYEFLEKGSLDQTLF------
. ||.|.||.|.|||. .   |.  |.|.... |..  .  .|| ||. ..  .. |.|.| . |||       ... || |... |||.  |       
FWNKIGEGGYGQVYKGKW--RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---GKSLLLDWPARFQIIVGVAKGLAYLHEESHEQVIHRDIKASNILLDKM-----LQPKISDFGISKLAGVDRENTTTRL--------AGTVGYMAPEY
    ... |..  | ...  .|.|. ||| ..   .||||.| ||.|.|       .. ||.|||.||..  . ..|....         |.  .|||| 
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE-

VLRG---RLSSKADVFSFGVLVLEIISG
|||.     | |.||.|||. . ||...
VLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_e-1.AA TK 266-461 17 1.2e-38 126.71 In-house 1-389 (486) Show / Hide 
Range on Protein: 266-461
Range on HMM: 1-389/486
Sequence Identity: 17% (68 aa)

FSDRNKLGQGGFG---TVYKAAFFGDG-------------------------TVFAVKRLSVESQQGKREFVN--------------EIDIITGIR----
    .|||.| ||   .|||.  .|..                         |  ||| |  .. . ..||                |  ..   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLVMLEGYCCEG------------NHRLIVYEFLEKGS----LDQTLFGKSLL--------------------------------------------
 |.|.| | |.|..|             . .|| |. ..|.    |.. |  ..                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWPARFQIIVGVAKGLAYLHEESHE---QVIHRDIKASNILLDKMLQ-----------PKISDFGISK
                               |. . .  . . .|.|..|||.   |   ...|||. | |.|... ..            ||.||| |.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAGVDRENTTTRLAGTVG----------------------------YMAPEYVL---------RGRLSSKADVFSFGVLVLEIIS
     ||  . ...  . ... |                            .|||| ..          |. ..| ||.|||||. || .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_e-1.AA STE 266-463 22 5.9e-38 131.62 In-house 1-265 (359) Show / Hide 
Range on Protein: 266-463
Range on HMM: 1-265/359
Sequence Identity: 22% (63 aa)

FSDRNKLGQGGFGTVYKAAFFG---------------DGTVFAVKRLSVESQQG-----------------KREFVNEIDIITGIR--HKNLVMLEGYCC
. .  |.|.|.|||||||.                   |...|.|....|...                  . .. .||.|    .  |.| |   |.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------NHRLIVYEFLEKGSLDQTLF---GKSLLLD----------WPARFQIIVGVAKG-LAYLHEESHEQVIHRDIKASNILLDKMLQPKISDFG
 .       ..  |. |... ||||. .    |.   |.           .    |.. . || |.|||.     .||||||..||||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

ISK-LAGV--------------DRENTTTRLAGTVGYMAPEYVLRGR------LSSKADVFSFGVLVLEIISGR
... |.                ..   .. ..||  .|||| .....       . |.|. |.| ...| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_e-1.AA MLK 266-463 25 1.1e-36 124.77 In-house 1-233 (291) Show / Hide 
Range on Protein: 266-463
Range on HMM: 1-233/291
Sequence Identity: 25% (60 aa)

FSDRNKLGQGGFGTVYKAAFFGDG---TVFAVKRLS------VESQQGKREFVNEIDIITGIRHKN-----LVMLEGYCCEGNHRLIVYEFLEKGSLDQT
.    ..| |.|| |.|. . .      . ||||        ...   ...|  |. .   ..|.|      . . .  ....| .|| |..|.|||   
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFGKS-------------LLLDWPARFQIIVGVAKGLAYLHEESHEQVIHRDIKASNILLD------KMLQPKISDFGISKLAGVDRENTTTRLAGTVGY
| |..                |    ... . .|.|..|||..   ..||||.| .|||.|      . .. ||.|||.|.        . .  |||. .
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

MAPEYVLR---GRLSSKADVFSFGVLVLEIISGR
||||   .   .. | |.||.|.||.  |.....
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_e-1.AA S_TKc 266-521 24 1.3e-34 122.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 266-521
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

FSDRNKLGQGGFGTVYKAAFFGDGTVFAVKRLSVESQQGKREFVNEIDIITGIRHKNLVMLEGYCCEGNHRLIVYEFLEK--GSLDQTLFGKSL------
.   .|.|.|.||.|||.   ..| ..|.|...       . . .||.|    .|.|.| | ... . .|  .| |...   |.| . .  .        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LLDWPARFQIIVGVAKGLAYLHEESHEQVIHRDIKASNILLDKMLQPKISDFGISKLAGVDRENTTTRLAGTVGYMAPEYVLRGRLSS-KADVFSFGVLV
.    ||| ..  ....|.|.|  || ..||||.| .|||||.  . ||.|||....         | . ||  ||||| .     .  |.|. |.|...
FPE-HARF-YMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LEIISGRKCMDDTLPVEEEILAQWAWSLFGAGKLEELIDPRLEKFYIAEEAHRATHVALLC-------SREF
 | ..|.   . .. .  ...             .|..|  ..|    . ..| |   .|           |
YEMLCGYPPFP-QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_e-1.AA Pkinase_Tyr 266-464 30 2.7e-32 110.01 Pfam 1-213 (270) Show / Hide 
Range on Protein: 266-464
Range on HMM: 1-213/270
Sequence Identity: 30% (65 aa)

FSDRNKLGQGGFGTVYKAAFF----GDGTVFAVKRLSVESQQG---KREFVNEIDIITGI-RHKNLVMLEGYCC-EGNH--RLIVYEFLEKGSLDQTLFG
 .   |||.| ||.|||.  .    ....  ||| |   . .    ...| .|. | . . .|.|.| | | |  .| .   .|| |. ..|.|.  |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K---SLLLDWPARFQIIVGVAKGLAYLHEESHEQVIHRDIKASNILLDKMLQPKISDFGISKLA-GVDRE-NTTTRLAGTVGYMAPEYVLRGRLSSKADV
.      |. .   |. . .|||..||..      ||||. | |.|... .. ||.||| ...    |    ...     .  ||||    |. ..| ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

FSFGVLVLEIIS-GRK
 |||||  ||.. |..
WSFGVLMWEIFTYGEQ
Kinase IRAK-0_e-1.AA RIPK 272-464 26 7e-32 105.91 In-house 1-226 (290) Show / Hide 
Range on Protein: 272-464
Range on HMM: 1-226/290
Sequence Identity: 26% (60 aa)

LGQGGFGTVYKAAFFGDGTVFAVKR---LSVE---SQQGKREFVNEIDIITGIRHKNLVMLEGYCCEGNH------RLIVYEFLEKGSLDQTLFGKSLL-
.| ||||.|.||     |.. |.|    . ..    .| . .   |  .   .|... | ..| | . .         || |. |.|||  .|  |.   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LDWPARFQIIVGVAKGLAYLHEESHEQ--VIHRDIKASNILLDKMLQPKISDFGISKLAGVDRENT-----------TTRLA-GTVGYMAPEYVLRG
   . || |. .|. .. |  |||     .  .|||| | .|||.|  .  ||.||| ..  .    ..           . ..  ||  ||.||  . .
HHPDPWPLRCRMIHEISCGMCYLHS---MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

RLSS------KADVFSFGVLVLEIISGRK
  ..      | || ||.... |. ....
NKKPIKVVTPKYDVYSFAIVMWEVLTQKH
Kinase IRAK-0_e-1.AA LRRK 266-463 23 4.4e-31 107.18 In-house 1-279 (351) Show / Hide 
Range on Protein: 266-463
Range on HMM: 1-279/351
Sequence Identity: 23% (67 aa)

FSDRNKLGQGGFG-TVYKAAFFGD--------------------------GTVFAVKRLSVE----------------------------------SQQG
.   ...|.|||| .||.| . |                           ..  |.| . ..                                  .   
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

KREFVNEIDIITGIRHKNLVMLEGYCCEGNHRLIVYEFLEKGSLDQTLF---GKSL-----LLDWPARFQIIVGVAKGLAYLHEESHE-QVIHRDIKASN
 ||| .|. |. . .| |.| | |.|   ... .| |..  |.|.. |.     ..      ..|  . .| . .|||..|||  ||   .|||| |  |
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH--SHNPPIIHRDLKSPN

ILLDKMLQP------------KISDFGISK-LAGVDRENTTTRLAGTVGYMAPEYVLRG----RLSSKADVFSFGVLVLEIISGR
||| .. |.            ||.|||||     ....  . .. |. |.|||| ..|.      . |.|..|||..  |.....
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPE-IMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAK-0_e-1.AA Ciliate-E2-Unclassified 266-463 22 5.6e-31 104.7 In-house 1-267 (352) Show / Hide 
Range on Protein: 266-463
Range on HMM: 1-267/352
Sequence Identity: 22% (62 aa)

FSDRNKLGQGGFGTVYKAAFFGDGTVFAVKRLS-------VESQQGKREFVNEIDIITGIR-----------------HKNLVMLEGYCCEG--NHRLIV
.    ..||||||.|||.    .. ..| | ..          .. . |..||....  .                  |.... .  . |.   ..  ||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

YEFLEKGSLDQTL----------------------FGKSLLL---DWPARFQIIVGVAKGLAYLHEESHEQVIHRDIKASNILLDKML---QPKISDFGI
.|..| |.| | .                      |     .         ...  . .|| |||..    .|||||| .|||.|.     ..||.||||
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA----KFYFAQILQGLEYLHHKN--NIIHRDIKPENILFDNNGKNYYIKIIDFGI

SKLAGVDRENTTTRL---------------AGTVGYM----APEYVLRGRLS----SKADVFSFGVLVLEIISGR
||  . ..... |.                .|| .||    |||.  .   .     |.|..|.||.  |.. |.
SKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY
Kinase IRAK-0_e-1.AA CZAK 266-463 29 7.4e-30 105.51 In-house 1-219 (279) Show / Hide 
Range on Protein: 266-463
Range on HMM: 1-219/279
Sequence Identity: 29% (66 aa)

FSDRNKLGQGGFGTVYKAAFFGDGTVFAVKRLSVESQQGKRE------FVNEIDIITGIRHKNLVMLEGYCCEGN--HRLIVYEFLEKGSLDQTLFGKSL
.      ||| || ||||     |.. |.| .  ..   | |      | .|. |.   .| | |.  | | |..  |. || |. . |||.. |  .. 
LKFGQTIGQGFFGEVYKAYW--RGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYF

LLDW-PA-RFQIIVGVAKGLAYLHEESHE-QVIHRDIKASNILLDKMLQ-------------PKISDFGISKLAGVDRENTT--TRLAGTVGYMAPEYVL
..   |  . .. . .|.|  |||    .  ..|||   .|||||  .               ||.||| |..    .|  .  |   | . .||||   
YHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREM---MEQPFEMTQTMGCLCWMAPECFK

RGRLSSKADVFSFGVLVLEIISGR
    . |.||.||| .. .|| ..
GENYTEKVDVYSFGMILWCIITCD
Kinase IRAK-0_e-1.AA TyrKc 266-535 23 4.9e-27 97.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 266-535
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)

FSDRNKLGQGGFGTVYKAAFFGDGTVFAVKRLSVESQQGKREFVNEIDIITGI--RHKNLVMLEGYCCEG-------NHRLIVYEFLEKGSLDQTLFGKS
 .   ||| | ||.|||.      .  ||| |  ..   ...| .|. | . .  .|.|.| | |.| ..          .|| |. ..|.|.. |  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

LLLDWPARFQIIVGVAKGLAYLHEESHEQVIHRDIKASNILLDKMLQPKISDFGISKLAGVD-------RENTT-----TRLAGTVGYMAPEYVLRGRLS
  | ..   .. . .|.| .|||.    ..||||. | |.|... .. |||||| |.  . |          ..     ..    .  ||||    |. .
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

SKADVFSFGVLVLEIISGRKCMDDTLPVEE-EILAQWAWSLFGAGKLEELIDPRLEKFYIAE------EAHRATHVALLCSREFEGSRPTMSAVVAML
.| ||.||||.  || .   ..     ...  . .| .  .  .|.  .  .  .      .       .   . . . | .|   .|||.|...  .
TKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY------PMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_e-1.AA TK 525-535 45 0.132476 0.28 In-house 476-486 (486) Show / Hide 
Range on Protein: 525-535
Range on HMM: 476-486/486
Sequence Identity: 45% (5 aa)

RPTMSAVVAML
|||.|... .|
RPTFSQLHEQL
Kinase IRAK-0_e-1.AA Pkinase_Tyr 525-535 45 4.820708 0.77 Pfam 260-270 (270) Show / Hide 
Range on Protein: 525-535
Range on HMM: 260-270/270
Sequence Identity: 45% (5 aa)

RPTMSAVVAML
|||.|... .|
RPTFSEIHEQL