Gene IRAK-0_a-2 (S.moellendorffii)

IRAK-0_a-2

Species: S.moellendorffii
Alias: IRAK-0_a-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_a-2.AA Protein None 787 None Fasta, JSON
IRAK-0_a-2.NA RNA None 2364 None Fasta, JSON
IRAK-0_a-2.kin_dom Protein Kinase Domain None 197 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAK-0_a-2.AA B_lectin 119-223 32 1.3e-28 99.9 Pfam 1-137 (137) Show / Hide 
Range on Protein: 119-223
Range on HMM: 1-137/137
Sequence Identity: 32% (45 aa)

HTSAVWKANNG---RPV-----PLGASLKLQV-DGNLVLYNPD-G-TE--SWST--KTSGLG---VAGMRLNQTGNLVLY-RED--DQVVWQS--FDHPT
 .  || ||     .||     . ...|..|  |||||||... | ..   |||   ||| |    . ...  .||||||  ..  . |.|||  |||||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DTLVPHQLIKT------GMK----LVSSSPGGTGEGY--F
||. | . . .      .|.    |.|.. ..    |   
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTN---YDPS
B_lectin IRAK-0_a-2.AA B_lectin 73-194 29 3.3e-22 81.0 SMART 1-126 (126) Show / Hide 
Range on Protein: 73-194
Range on HMM: 1-126/126
Sequence Identity: 29% (39 aa)

NWTLNGDLHPFLCQNLSKRAFAAGFTSSKTGLFYLAVYYVKAGGENHTSAVWKA--NNGRPVPLG---ASLKLQVDGNLVLYNPDGTESWSTKTS-GLGV
. ||... .    . | .  |..|| .     ... . | .  .. .   || |  | ..||  |   . |..| |||||.|.  ..  ||..|. . |.
DNTLSSGQTLVSGNSLFE--FYLGFFTFIMQ-WCNGIWYKNISNK-QRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNNGN

AGMRLNQTGNLVLYRED----DQVVWQSFDHP
  ..| ..||.|.|..|    . ..|||||||
YVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
PAN_AP IRAK-0_a-2.AA PAN_AP 368-447 16 0.000356 19.51 SMART 1-85 (85) Show / Hide 
Range on Protein: 368-447
Range on HMM: 1-85/85
Sequence Identity: 16% (15 aa)

DLAMEYRLVAGDKFYDYLPLKFMQG-----AI-LSQADCLETCLTNSSCKAVLFEDNNRTCFHLTEVYTLNVTR-------APAFSAFIKVKT
.    .... . |        | .       |  |  .|.. || |.||... . .  ..| . ..   |. .|        |... ..  |.
CCDDCFVRMPNMKL-------FSPIVNWVDVIVMSLEECMQKCLNNCSCRSFMYYN-TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAK-0_a-2.AA TKL 532-785 22 1.8e-65 223.79 In-house 1-364 (364) Show / Hide 
Range on Protein: 532-785
Range on HMM: 1-364/364
Sequence Identity: 22% (85 aa)

IGSGGFGTVFEGSLSD---------GSRIAVKLLDDSN-QGE---------------------------KQFKAEVRAICNIHHRNLVTLRGYCSQKPH-
|||||||.|. | .           |  .||| .   | . .                           .... |.. . ...| |.| . ||| . |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------HFLVYDYVHNGSLDRWLFDSSKAKSLDWNRRFSIVQDIARGLAYLHE----ECSST--VLHLDIKPQNVLLDESFT------------
            ...|..|...|||   |          |..|.....|||||..|||      |  .  ..| |.|..|.|.|| .|            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKISDFGLSRILGGDG----------------RTDNAVTAIKGTPGYMAPEWLTQT----------------KVTKALDVYSFGIVVLEIITGLSAVD
  .||.|||||| . ..|                .....   . |||..|||| | ..                . ... ||||||||  ||.|.    .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

ERMSRKNV-----SSTLEVVIDQGMDRTKR------------SKI-ERLIQIGLWCTKVEQSQRPSMVEVVKVL
. ...  .        ...|.| |.  .              . . ......  .| . . ..|||. |..| |
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_a-2.AA IRAK 527-731 38 1.4e-54 187.64 In-house 2-228 (317) Show / Hide 
Range on Protein: 527-731
Range on HMM: 2-228/317
Sequence Identity: 38% (87 aa)

NFSKRIGSGGFGTVFEGSLSDGS-RIAVKLLDDS-----NQGEKQFKA---EVRAICNIHHRNLVTLRGYCSQKPHHFLVYDYVHNGSL-DR-WLFDSSK
. . |||.||||.|. | ..      |||.|        |. ...| .   |... | ..| |.| | |||.. . | |||.|  |||| || |  | . 
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

A-KSLDWNRRFSIVQDIARGLAYLHEECSS-TVLHLDIKPQNVLLDESFTAKISDFGLSRIL---GGDGRTDN---AVTAIKGTPGYMAPEWLT--QTKV
. | | | .|.|| . .|.|. .||.  .   . | |||. |.|||. ||.||.|||| |     ..  ..      .  ..||  ||.|| ..  | . 
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

TKALDVYSFGIVVLEIITGL-SAVDER
|| .||||||||.||..||.  ..|.|
TKKTDVYSFGIVLLEVLTGCRAVYDDR
Pkinase IRAK-0_a-2.AA Pkinase 526-724 25 1.6e-46 165.6 Pfam 1-208 (293) Show / Hide 
Range on Protein: 526-724
Range on HMM: 1-208/293
Sequence Identity: 25% (54 aa)

RNFSKRIGSGGFGTVFEGSLSDGSR-IAVKLLDDSNQGEKQFKA-----EVRAICNIHHRNLVTLRGYCSQKPHHFLVYDYVHNG----SLDRWLFDSSK
  . ..||||.||.|...   . ..  ||| .. ... ... ..     |..   ...| | |.|....  |.|  .| .|. .|    .| ...   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

AKSL--DWNRRFSIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTA----KISDFGLSRILGGDGRTDNAVTAIKGTPGYMAPEWLT-QTKVTKA
 ...  ...   ...  |.|||.|.|..    ..| |.||.|.|.|.  .     ||.||||.. .      .   | . |||.|||||..  ... ...
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

LDVYSFGIVVLEIITG
 |..|.|... | ..|
VDMWSCGCILYEMLCG
Kinase IRAK-0_a-2.AA TKL-Unique 528-724 30 5.4e-45 155.8 In-house 1-224 (290) Show / Hide 
Range on Protein: 528-724
Range on HMM: 1-224/290
Sequence Identity: 30% (70 aa)

FSKRIGSGGFGTVFEGSLSDGSRIAVKLLD---DSNQGEKQ-FKAEVRAICNIH-HRNLVTLRGYCS----QKPHHFLVYDYVHNGSLDRWLFD----S-
|.. ||.||.|.|. |    |. .|.| .    ||.  ..| |. ||. . ..| | |.|.. |||     . |. ..| .|.  |||.  | .    . 
FWNKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--SKAKSLDWNRRFSIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDES-----FTAKISDFGLSRILGGDGRTDNAVTAI--------KGTPGYMAPE
  .. . |....| ....|||.|. ||| .    ..|.|.|..|.|.|.      . .||.|||||...  . .... .. .        .|.. .||||
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFN--SKINKMTNNEHKGTRNQTRCGSFRWMAPE

WLTQ--TKVTKALDVYSFGIVVLEIITG
 |..  .. ..  ||||||||. ||.|.
VLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_a-2.AA Dicty4 527-724 35 1.8e-44 146.36 In-house 2-213 (277) Show / Hide 
Range on Protein: 527-724
Range on HMM: 2-213/277
Sequence Identity: 35% (76 aa)

NFSKRIGSGGFGTVFEGSLSDGSRIAVKLLDDSNQG--E---KQFKAEVRAICNIHHRNLVTLRGYCS----QKPHHFLVYDYVHNGSLDRWLFD----S
|. .|||.|.||.|. |.   |.  |||.|   ||.  |   . |..||   |.| | |.... |.|     ...    |  |.. |.| . | |     
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

SKAKSLDWNRRFS---IVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFGLSR-ILGGDGRTDNAVTAIKGTPGYMAPEWLTQTKVTKAL
 . ..||| .. .   .  |.|||...||. | . ..|.|.|. | | |.....|..|||||. .  .   .||. || .|||..|||| .     . . 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWMAPEVMMHQPYNEKA

DVYSFGIVVLEIITG
||||||||  || |.
DVYSFGIVLWEILTR
S_TKc IRAK-0_a-2.AA S_TKc 526-785 22 4.9e-38 133.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 526-785
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

RNFSKRIGSGGFGTVFEGSLSD-GSRIAVKLLDDSNQGEKQFKAEVRAICNIHHRNLVTLRGYCSQKPHHFLVYDYVHN--GSLDRWLFDSSKAKS---L
  . . ||.|.||.|. .   . | . |.| ..      .... |..   . || |.|.| ...    | ..| .|. .  |.| . . .  . .    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DWNRRFSIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFGLSRILGGDGRTDNAVTAIKGTPGYMAPEWLTQTKVTK-ALDVYSFGIVV
.  .  .... |...|.|.|.     ..| |.||.|.||||  . ||.||||.|.|          | . ||| ||||| |   . .| . |..|.|...
PE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LEIITGLSAVDERMSRKNVSSTLEVVIDQGMDRTKRSKIERLIQIGLWCTKVEQSQRPSMVEVVK---------VL
 | ..|    .          ........ .        . ....   | ... ..||.  |. .          .
YEMLCGYPPFP----------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_a-2.AA MLK 526-724 27 5.6e-36 122.33 In-house 1-232 (291) Show / Hide 
Range on Protein: 526-724
Range on HMM: 1-232/291
Sequence Identity: 27% (66 aa)

RNFSKRIGSGGFGTVFEGSLSDGSR-----IAVKLLD-------DSNQGEKQFKAEVRAICNIHHRN----LVTLRGYCSQKPHH-FLVYDYVHNGSLDR
 .|.. ||||.|| |. |    . .     .|||  .       |.    ..|. |.|    . |.|     . ..| |.| |.| ..|  |. .||| .
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WLFDSSKAKS-----------LDWNRRFSIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDE------SFTAKISDFGLSRILGGDGRTDN-A-VTAIK
 | . ..  .            |    ...  ..|||..|||..   .. | |.|..|.|.||        |.||.|||.|| .     ... .  .  .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW-----HQMCTNMMSNA

GTPGYMAPEWLTQ---TKVTKALDVYSFGIVVLEIITG
||. .|||| ..|   .|.... ||.|.|.|  |..|.
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAK-0_a-2.AA LISK 531-727 28 6.9e-35 110.65 In-house 1-238 (296) Show / Hide 
Range on Protein: 531-727
Range on HMM: 1-238/296
Sequence Identity: 28% (68 aa)

RIGSGGFGTVFEGSLS-DGSRIAVKLLD------DSNQGEKQFKAEVRAICNIHHRNLVTLRGYCSQ-KPHHFLVYDYVHNGSLDRWLFDSS-KAKSLDW
 ||.|.|| |. |..  .|. .|.| .       . .  .| .. ||  . |. |.| |   | | . . . ..|  |.  | | . |.|.. . . | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

NRRFSIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDES----FTAKISDFGLSRILGGDG-------------------------------RTDNAVT
  | .|  |||.|..|||. .   ..| | | .|.|..|.    ...|. |||. |..  .                                .. .   
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

AIKGTPGYMAPEWLTQTKVTKALDVYSFGIVVLEIITGLSA
.| |||  |||| |.. . . . ||.|||||..||||.  |
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase IRAK-0_a-2.AA DRK 527-723 34 2.3e-33 110.35 In-house 2-197 (258) Show / Hide 
Range on Protein: 527-723
Range on HMM: 2-197/258
Sequence Identity: 34% (71 aa)

NFSKRIGSGGFGTVFEGSLSDGSRIAVKLLDDSNQG-E---KQFKAEVRAICNIHHRNLVTLRGYCSQKPHHFLVYDYVHNGSLDRWLFDSSKAKSLDWN
    ||| |..| || |.   |. .||| |   |   |   . |. |.  .|.  | | .   | |   |    .  |   ||| . | | |   ..|| 
KIGNRIGRGNYGEVFRGTWR-GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDES--IEMDWP

RRFSIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFGLSR----ILGGDGRTDNAVTAIKGTPGYMAPEWLTQTKVTKALDVYSFGIVV
.. ..  |.|.|. |||  |   ..| | |  | | ||..  |..|||||     ..        | |.. |||.  ||| |     |   |||||.|| 
LMKQMMFDCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHK----QHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVL

LEIIT
 |..|
WECVT
Kinase IRAK-0_a-2.AA TK 526-723 15 2.1e-32 105.37 In-house 1-389 (486) Show / Hide 
Range on Protein: 526-723
Range on HMM: 1-389/486
Sequence Identity: 15% (61 aa)

RNFSKRIGSGGFG---TVFEGSLSDGS--------------------------RIAVKLLDD-SNQGEKQFKA--------------EVRAICNIH----
  . | .|.| ||   .|..| . ...                          . ||| | . ... ...|..              |.....  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVTLRGYCSQK------------PHHFLVYDYVHNGS----LDRWLFDSSKAKS------------------------------------------
 | |.| | |.|.|.            ..  .|  |...|.    |. .| .... ..                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWNRRFSIVQDIARGLAYLHEE-CSST---VLHLDIKPQNVLLDESFT-----------AKISDFG--
                               |.  ..  . ..||.|..|||.  |.     . | |.   |.|..|. .           .||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LSRILG--GDGRTDNAVTAIKGTPG----------------------YMAPEWLT---------QTKVTKALDVYSFGIVVLEIIT
      |.| ..  .| ....  .. ..                         .|||| |.           | | . ||.|||... || |
RQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_a-2.AA RIPK 532-724 27 1.5e-31 104.74 In-house 1-224 (290) Show / Hide 
Range on Protein: 532-724
Range on HMM: 1-224/290
Sequence Identity: 27% (62 aa)

IGSGGFGTVFEGS-LSDGSRIAVKL-----LDDS--NQGEKQFKAEVRAICNIHHRNLVTLRGYCSQK-----PH-HFLVYDYVHNGSLDRWLFDSS--K
.|.||||.||     . | ..|.|       .     | ... | |. .  .. ... | . | | ..     .    .|  |  ||||   |   .   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

AKSLDWNRRFSIVQDIARGLAYLHEECSST--VLHLDIKPQNVLLDESFTAKISDFGLSRILGGDGRTD--------NAVTAIK--GTPGYMAPEWLT--
 . . |  |. ... |..|  |||   | .  ..|.| ||.|.|.|  | .||.||||.  ...  ...           .  .  ||  ||.|| .   
HHPDPWPLRCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

QTKV----TKALDVYSFGIVVLEIITG
. |     |.. |||||.||. |. |.
NKKPIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAK-0_a-2.AA STE 526-724 21 1.7e-31 108.54 In-house 1-264 (359) Show / Hide 
Range on Protein: 526-724
Range on HMM: 1-264/359
Sequence Identity: 21% (59 aa)

RNFSKRIGSGGFGTVFEGSLSD----------------GSRIAVKLLDDSNQG------------------EKQFKAEVRAICNIH--HRNLVTLRGYCS
  . ..||.|.||||. .   .                | ..|.| .. .|.                   ..|.. |..   . .  | | |.  |.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QK-------PHHFLVYDYVHNGSLDRWLF-DSSKAKSLD----------WNRRFSIVQDIARG-LAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFG
..        . ...  |. .||||  .    .. |.|.           .    |...| .| |.|||.     . | ||||.|.||     .|..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LSRILGGDGR------------TDNAVT-AIKGTPGYMAPEWLTQ------TKVTKALDVYSFGIVVLEIITG
.. .|  ...            |    .  . ||| .|||| ..|       . .   |..|.|....| .||
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG
Kinase IRAK-0_a-2.AA Pkinase_Tyr 527-723 28 7.2e-30 101.79 Pfam 2-209 (270) Show / Hide 
Range on Protein: 527-723
Range on HMM: 2-209/270
Sequence Identity: 28% (61 aa)

NFSKRIGSGGFGTVFEGSLS-----DGSRIAVKLL-DDSNQGE---KQFKAEVRAICNI-HHRNLVTLRGYCS-QKPH--HFLVYDYVHNGSLDRWLFDS
 | | .|.| ||.|..| .      ..   ||| | ... . .   . | .|..  ... || |.| | | |. |. .  ...|  |. .|.|.  | . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

-SKAKSLDWNRRFSIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFGLSRILGGDGRT----DNAVTAIKGTPGYMAPEWLTQTKVTKA
 .  ..|.  .  .. ..||.|..||..       | |.   |.|..|....||.||||.| .  |.      ...   || .    ||| .   | | .
REDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTK

LDVYSFGIVVLEIIT
 ||.|||..  ||.|
SDVWSFGVLMWEIFT
Kinase IRAK-0_a-2.AA TyrKc 526-785 26 2e-25 91.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 526-785
Range on HMM: 1-280/280
Sequence Identity: 26% (78 aa)

RNFSKRIGSGGFGTVFEGSLSDGSRIAVKLLDDSNQGEKQFKAEVRAICNI--HHRNLVTLRGYCSQK-------PHHFLVYDYVHNGSLDRWLFDSSKA
  . | .|.| ||.|..| ..     ||| | ..   .. |  | |  |..  || |.| | |.|.|.       . ...|  |. .|.|.  | .. . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KSLDWNRRFSIVQDIARGLAYLHEECSSTVLHLDIKPQNVLLDESFTAKISDFGLSRILGGD---GRTDNAVTAIK---GTPG-----YMAPEWLTQTKV
  | .    |.  .||.| .|||.     . | |.   |.|..| .|.||||||||| .. |   |     .   |   |. .      |||| .   | 
--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TKALDVYSFGIVVLEIITGLSAVDERMSR--KNVSSTLEVVIDQGMDRTKRS--------KIERLIQIGLWCTKVEQSQRPSMVEVVKVL
| . ||.|||..  || |      . |    .. .  .| | . .. .   .          . . || ..| . . ..||.. |... .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_a-2.AA DRK 773-787 46 0.000655 9.17 In-house 244-258 (258) Show / Hide 
Range on Protein: 773-787
Range on HMM: 244-258/258
Sequence Identity: 46% (7 aa)

SQRPSMVEVVKVLEI
..|||| |... || 
QHRPSMQECLERLEA
Kinase IRAK-0_a-2.AA LISK 758-785 28 0.001376 7.3 In-house 269-296 (296) Show / Hide 
Range on Protein: 758-785
Range on HMM: 269-296/296
Sequence Identity: 28% (8 aa)

ERLIQIGLWCTKVEQSQRPSMVEVVKVL
. .... ..|.|.. . |||  |.|..|
PPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAK-0_a-2.AA Dicty4 773-787 35 0.011667 4.89 In-house 261-277 (277) Show / Hide 
Range on Protein: 773-787
Range on HMM: 261-277/277
Sequence Identity: 35% (6 aa)

SQRPSMVEVVKV--LEI
..|||. |...   || 
QHRPSFEEIIQRRILEH
Kinase IRAK-0_a-2.AA TK 765-785 19 0.014382 3.57 In-house 466-486 (486) Show / Hide 
Range on Protein: 765-785
Range on HMM: 466-486/486
Sequence Identity: 19% (4 aa)

LWCTKVEQSQRPSMVEVVKVL
. | . . ..||.. .... |
QQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_a-2.AA MLK 773-785 38 0.160763 1.2 In-house 279-291 (291) Show / Hide 
Range on Protein: 773-785
Range on HMM: 279-291/291
Sequence Identity: 38% (5 aa)

SQRPSMVEVVKVL
..|||. ..|. |
HKRPSFRQIVQHL
Kinase IRAK-0_a-2.AA Pkinase_Tyr 773-785 30 5.301997 0.63 Pfam 258-270 (270) Show / Hide 
Range on Protein: 773-785
Range on HMM: 258-270/270
Sequence Identity: 30% (4 aa)

SQRPSMVEVVKVL
..||.. |..  |
EDRPTFSEIHEQL