CLUSTAL W (1.83) multiple sequence alignment Haspin_Hsap MAASLPGPGS-RLFRTYGAADGR-RQRRPGREAAQWFPPQDR------------------ Haspin_Dmel MLSISKTK--MDFLEE--G---------------RWKDPFDELLDSRTKLSK-------- Haspin_Mmus MAQAHPRSGT-RLFRTYAARGVRGSQRQPGGLAEQWFQPPNL------------------ K08B4.5_Cele MDKLAMRYLKMSI-R----G--------------------------------IQMD---- H12I13.1_Cele MPNAECRHNAGFW-S----AAY-------------------------------------- F22H10.5_Cele MPTLEIQFSNSNVYG-------------------------------------VHQ----- C50H2.7_Cele MGRIKQ------------------------------------------------------ C04G2.10_Cele MSTKELEERKVCF------F---------------------------------------- C01H6.9_Cele MPPKPRIK--VPISPG--K------------KARNNF----ARRNR--QLSSVII----- aSWK213_Cele MSWMRFTK--TAVVT--------------------------------------------- T05E8.2_Cele MGSEKCSILSWFF-I----F---------------------------------------- Y40A1A.1_Cele MVISILCK--NHIQQ-------------------------------------L------- Y48B6A.10_Cele MWMGKKLVQQRLY-R----L--------------------------------EHL----- Y73B6A.1_Cele MVKNGSRKTGKSI----------------------------------------------- ZK177.2_Cele MIFAVVDILEISI-Q--------------------------------------------- DDB0231182_Ddis MTLRLDTSLKRGA-S--------------------------------------------- ALK1_Scer MLLHFDIVIQLLS-S----HTLKS----------------------------H------- YBL009W_Scer MNFDAVADQQMT------------------------------------------------ Haspin_Spur MAFDGRVVKT------YGRLKQKT------IKQDNWISSPHL------------------ aSWK457_Cele MIKILQMYSKQHI-P----SFI------------------------------EHF----- CC1G_01353_Ccin MLSAQTKQVNAYG-K----RARRV----------------------------VNVTASSS AqueK156_Aque MRFFYRLKAT-TL-ALFFLHT--------------------------------------- Haspin_Smoe D----------------------------------------------------------- Haspin_Hsap ---------------R----------------RFFNSSGSSDAS---------------- Haspin_Dmel -------------MNI-------------------------------------------- Haspin_Mmus ---------------K----------------RAFSSSLSDSNE---------------- K08B4.5_Cele -----------A------PEMMALIISWIENGI-------------PIEARLQLQDIFMG H12I13.1_Cele -----------A------------------------------------------------ F22H10.5_Cele -----------QKENASK------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele -----------C------------------------------------------------ C01H6.9_Cele -----------TECPIDFPEY-----EFSKNPALFKS-FNDNPEFKPSKKKNKPKPVFPP aSWK213_Cele -------------TTV-------------------------------------------- T05E8.2_Cele -----------A------------------------------------------------ Y40A1A.1_Cele --------------PIKY------------------------------------------ Y48B6A.10_Cele --------------------------QFIQSL--------------RHTVKCRSQNFFAA Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis -----------R------------------------------------------------ ALK1_Scer -----------Q------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ---------------A----A-----GRKIS-NVFSSPDNDSNA---------------- aSWK457_Cele --------------------------QFGNSS--------------GKKV---------- CC1G_01353_Ccin GPAPGGIISIFD------------------------------------------------ AqueK156_Aque ---------------I----------------IVFSCTY--------------------- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ---I-------GDPSQSDDPDDPDD----------------------------------- Haspin_Dmel ---------------VKQN----------------------------------------- Haspin_Mmus ---S--------PAVASDD---PDD----------------------------------- K08B4.5_Cele RPNHRFQLQSMVPNVIRLN---VTHLNLERSIEESGDWNMMSYDILPKVVFI-----EVM H12I13.1_Cele ----------EMP-ILKFT---AHAE------------SAVMP----------------- F22H10.5_Cele ---------------LDG-----KSE---------------------------------- C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ----------KILGFLSFP----------------------------------------- C01H6.9_Cele SPNV-------SDVEISSD---EEDA---------------------------------- aSWK213_Cele ---------------LALD---MTNE---------------------------------- T05E8.2_Cele ----------MIPPILRST---KSHA------------K--------------------- Y40A1A.1_Cele ---------------FQMS---FTNK---------------------------------- Y48B6A.10_Cele R-----LFRKKMPPCCRLG---KTNTLY-SSF----HKEYLSIGLQFSVLFYFISC-VCV Y73B6A.1_Cele ---------------KRR--------------------ANYKRN---------------- ZK177.2_Cele --------------------------------------------LL---------CILLF DDB0231182_Ddis ----------NIPPIPTFS---SVSN------------ENLSSS---------------- ALK1_Scer ----------VEPPM-DFE---TSFE------------EFVED----------------- YBL009W_Scer ------------------------------------------D----------------- Haspin_Spur ---S--------SDVLAIN---VSE----------------------------------- aSWK457_Cele -------------DILRIS-----------------------CKLI---------CSMLN CC1G_01353_Ccin ----------DLPPAPALM---PLAS--------------RMK----------------- AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------PDFPG------------------------------------- Haspin_Dmel -------------------------------------------------VRVTYNIDSSV Haspin_Mmus ------------------PDFPG------------------------------------- K08B4.5_Cele RTT--------------------------------------------VID---------- H12I13.1_Cele -------KRK----------M------------------------NGISA-----YAD-- F22H10.5_Cele --------RK-------------------------------------------------- C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------A--------------------IKIR------I---- C01H6.9_Cele --------GQFKVPDADADE---------EEKIKKIKEAFDSLDDVSLEVFNNDGIRVKI aSWK213_Cele --------RR-------------------------------------------------- T05E8.2_Cele ----RLTYKD----------M---I--------------------VEIK------VLNDP Y40A1A.1_Cele --------RK-------------------------------------------------- Y48B6A.10_Cele GMTRIPAFQA----------M---I--------------------LESLK-----KQMNP Y73B6A.1_Cele ----EKSYAE----------M---V--------------------LSVLE-----SSDSI ZK177.2_Cele GTT--------------------------------------------------------- DDB0231182_Ddis ----PYTSSS----------Y---Y--------------------SSNCE-----SLDSI ALK1_Scer --------KR----------F------------------------IAL-E-----VSDND YBL009W_Scer --------RR----------Y------------------------FAL-E-----VAESD Haspin_Spur ------------------KENILPTVTDEGKKPRRKAAK-KAT----------------- aSWK457_Cele GTT--------------------------------------------------------- CC1G_01353_Ccin -------KRE----------N------------------------IAPKP-----KSQ-- AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel EN--SSYI-EIKE----PN-H------------------------------KNEPLT--- Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele EH--ATK----------IH-DKFEFPFHIHMDNFLEDASEDSQQ-----T---------- H12I13.1_Cele -----------------------------------------MPKKI-FGGIC-------R F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------G-TPAN----------------TISR---------------- C01H6.9_Cele EN--GKHIIHDKQ----PE-E------------------------------AWRPEP--- aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele EG--ATRF-AILK---YID-EKWK----------------TITK-----AKA-------- Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele RG--VTRY-EIRK---YVK-GKWLDR-----RA-------GVNK-----A---------- Y73B6A.1_Cele NG--FSHH-AIKK---GVSQMMTR----------------TIGK-----GFS-------- ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis GD--ISID-SSVY---SSSE--IE----------------FVGN-----GDK-------K ALK1_Scer DDCDTDLT-ADTADELE---SSAILKMRESDASLNVTTGNNTSRKTTSNSKK-------R YBL009W_Scer D-ADSSLN-SSSM---G---SPA-----------------------VDVGRK-------V Haspin_Spur -------------------------------------------------------AVLEE aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin -----------------------------------------LSPKP-VG----------- AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap -------------SPVRRRRRRPGGRVPKDRPSLTVTPKRWKL--RARPSLT---VTPRR Haspin_Dmel -----------------------------------------------LEDC--------- Haspin_Mmus -------------SLVGQRRRRPRGS---------------GS--RNQRTLT---NTPRV K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele YAVMPKNSECRT----------------------------GDAKDRRWEK------MDDV F22H10.5_Cele -----------------------------------------------EEKLS-------- C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele -----------------------------------------------------------H C01H6.9_Cele ------AKKIDFAKKM------------------------------EQRQKKPVKQVPEM aSWK213_Cele ----------------------------------------------FQRQLK-------- T05E8.2_Cele ---------K---------------------------------DQPKDKG------AEKT Y40A1A.1_Cele ----------------------------------------------MLINLI-------- Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis KNFIN----N---------------------------------NNNNNG----------- ALK1_Scer WSLLSNHSAVSS-----------------------------SKSKKRWSV------LSSS YBL009W_Scer YKI--------T-----------------------------SHKGSAEDE------SQSF Haspin_Spur YVLKDNGGKAD--SSKGRKTRRN---------------KTGKG--RQFSKLS------RQ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ----------------------------------------GKQRKRRLSP------VLTP AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap LGL--RARP--------------------------------------------------- Haspin_Dmel ---SIKVYCP-------------------------------------------------- Haspin_Mmus QRL--RPRL--------------------------------------------------- K08B4.5_Cele L------------HKY---------------------NLHA------------------- H12I13.1_Cele -------------------------------------HV--------------------- F22H10.5_Cele ------------------------------------K----------------------- C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele L------------TG----------------------F-AS------------------- C01H6.9_Cele NSKANQVQCPTNYASFCGSILADHMRQNKKASLAAPSLFRVFGTPQRSKMIVPAKHVQCQ aSWK213_Cele ------------------------------------SHFRT------------------- T05E8.2_Cele I------------RT----------------------FYRT------------------- Y40A1A.1_Cele ------------------------------------K----------------------- Y48B6A.10_Cele Y------------EKQ---------------------CLAS------------------- Y73B6A.1_Cele --------------R----------------------YILS------------------- ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis -------------NK----------------------YDFS------------------- ALK1_Scer -------------------------------------FTSE------------------- YBL009W_Scer -------------------------------------FTSS------------------- Haspin_Spur YRKV-KNDD--------------------------------------------------- aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin -------------------------------------VK--------------------- AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ---------------------------------PQKC-STPCGPLR----LPP------- Haspin_Dmel ---------------------------------SDSI-STPCD----------------- Haspin_Mmus ---------------------------------PQKC-STPCSRLR----PPP------- K08B4.5_Cele --------------IIVHLG----EDGKGHF---------------------MTYRSI-- H12I13.1_Cele -------------------SDV-------------------------------------- F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele --------------YCIHL-----AVGV-------------------------------- C01H6.9_Cele DERLAIYSYTPIRVNKTAKQLDDTIGSIVFSPKTQNA-STPIEKQTAGRRPKS------- aSWK213_Cele --------VH-------------------------------------------------- T05E8.2_Cele --------------AIYDLR----KDGVIQY---------------------TTRETFAL Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele --------------AMWSLQ----NQGVIHV---------------------KSKDRYVL Y73B6A.1_Cele --------------ALQKLE----SQKIIFQ---------------------PRKQRFKL ZK177.2_Cele ---------------------------VINC---------------------V------- DDB0231182_Ddis --------------NL--LE----TPKLKFS---------------------PST----- ALK1_Scer --------------SHKDRE----SRNVLQQ---------------------KRKSLQSY YBL009W_Scer --------------DSPTSKTRP-VGK--------------------------------- Haspin_Spur ---------------------------------PEEE-EEDCDDVH----EN-------- aSWK457_Cele ---------------------------VLFF---------------------V------- CC1G_01353_Ccin -------------------KVPRVAQLIKES--------------R----TQP------- AqueK156_Aque ----------------------------------VFCSSYNCGG---------------- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------FPSR-DSGRLSPDL-------SVCGQP-----RDGDELGISA Haspin_Dmel -----------------------------------------------------KRLGGTT Haspin_Mmus ------------------FPNC-SPGCLGSDH-------SVCIQS-----RDSNELGTSA K08B4.5_Cele -----RNN---------------------------------------------------- H12I13.1_Cele ------------------------------------SWEEVERHSYGTGSDD-------T F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------FPVF-------------------------------D------ aSWK213_Cele --------------------AF-------------------------------E------ T05E8.2_Cele TTQDP-QNSPL------------------------------------------------- Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele GSDRAGAGGVILTGS--------------------------------------------- Y73B6A.1_Cele SSIRAQAGRGLFSAA--------------------------------------------- ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis --------------G--------------------------------------------- ALK1_Scer SSLDTVASNSSISASSSLKRSST-GLSLRQLFTKIGINDDI------------------- YBL009W_Scer -----TIENDDY----YGKRSST-GSSLKQLFNKININDTA------------------- Haspin_Spur ---------------------KMETGRI-LRG-------KAAAKP-----AD-------S aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------LDNKL-DGGVRQANAKVNLTTEAEASPF-----D-------A AqueK156_Aque ------------------------------------------------------RHG--- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap S-----------------L---FSSLASPC--------PGS------------------- Haspin_Dmel G-----------------L---FETDLSPI----------T------------------- Haspin_Mmus S-----------------L---FSSPASPG----------A------------------- K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele SSAVLIVYTKVKDATDDFT---YD--VTPNA--HVVDVPGISLPPARTSISMETLSANPL F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------VSLNDS----------C------------------- aSWK213_Cele ------------------------L----------------------------------- T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ------------------------------------------------------------ ALK1_Scer ------------------------------------SQPGIG------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur S-----------------FDLIFK------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin S-----------------S---FSSPRRPFSSFS-VNVPG-------------------- AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------------------------------PTPRDSVISIGTSACL-V Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------P------------DPL-Y K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele HGHVVDAPVFYHQQNHSSRTSISMESLNYPSPGDAHQTEEQLP------------ENQLT F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ------------------------------------------------------------ ALK1_Scer ---------------IP-------------------QGKENLP------------PTM-- YBL009W_Scer ---------------HS-------------------SNKENVS------------QSVLS Haspin_Spur ---------------------------------------------------------L-T aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin --------------------------------------SPALP------------ASLRA AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap -AA--------SAVP-----S---------------------------GLHLPEVSLDRA Haspin_Dmel --------------------------------------------------RLKLEGVEDS Haspin_Mmus -AD--------SAVP-----G---------------------------SFHLPAASLSEP K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele K-NRKTPGCYLNQCI-----KFLHTKSENVGKPFVRTTFYANFKNVVYYKGTA-TTLGRG F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele --------------------------------------------------ENITKKEEQI aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele --------------------------------------------------------KKSP Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ---------------------------------------------------------A-- Y73B6A.1_Cele --------------------------------------------------------APTP ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis --------------------------------------------------------RT-- ALK1_Scer --------------------------GKKNSSIAS--------------TSSE-NRLRTP YBL009W_Scer E-NKL------------------LSPSKRLSKQGL-------------TKVTN-SKFRTP Haspin_Spur EQK--------KTVTSSSSGD-------------------------------------SV aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin S-K--------SRVP-----S---------------------------AKSIP-FKLAKP AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap SLPCSQEEATG------------------GAKDTRMVHQTRASL---RSVL-FGLMNSGT Haspin_Dmel RDKCA--------------------------------DTNEADLYVNVEIL-FQNI---- Haspin_Mmus SVPCPQVAATG------------------DRYTGRAL-RAEASF---RSSL-FSLVNSGA K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele LQPLLHDAIISSEYKDFRKCQMLFVMSIQITN---------------------------- F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ---AHT------------------------------------------------------ C01H6.9_Cele AQKSA--------------------------------NSDQKETT----------IN--- aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele S-RAAA------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele VVPKTT------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis -KNNNN------------------------------------------------------ ALK1_Scer LKPLVN------------------------------------------------------ YBL009W_Scer LRPISN------------------------------------------------------ Haspin_Spur TSPVLSVEILE------------------------------------GLELGSGVVETST aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin SSPVVNMDIIV------------------LDD---------------------------- AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap PEDSEFRADGKNMRE--------------------------------------------- Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus TEENKFGTDGENVKE--------------------------------------------- K08B4.5_Cele --------------------------------------------------------CDVE H12I13.1_Cele --------QSFLYRLAKNS-FSITLDRFYRIEVCEYQSKKFSGVHKCPGLVKEIAIK-PT F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele --------------------------------------------------------R-PR Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ------------------------------------------------------------ ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur PYEAHQRSLGQSLDN--------------------------------------------- aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin --------DGQVVRKERRSSK--------------------TGVET----------N-PV AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap -------SCCKRKLVVGNGPEGPGLS-STGKR--RATG-------------QDSCQ--ER Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus -------SCCERRQQMGNRLTDPDLT-SPGKR--KAA-----------------CK--KV K08B4.5_Cele ----GLA-------------------------TQWVK-LDDA------------------ H12I13.1_Cele SDLQTGQ------------------------NLVAHPMSSRR------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ----RPE------------------------PEL-------------------------- C01H6.9_Cele -----------------NIP---IEEEYSGRV--H-----------------ESSLAG-- aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ----GGK------------------------DDI-------------------------- Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ----EGA------------------------VGKRLNKNERQ------------------ Y73B6A.1_Cele ----KGR------------------------NDVHLKNNARR------------------ ZK177.2_Cele -------------------------------------SKGR------------------- DDB0231182_Ddis ----NNN------------------------NNINNN--NYK------------------ ALK1_Scer ----HSK--------------------------RPTSQP--Q------------------ YBL009W_Scer ----QST--------------------------LSRDEP--V------------------ Haspin_Spur ------RGCITRRRAKRDVPFSPG---GHGRR--RTKRQRVVVPQILSFSDDDSCLFAPR aSWK457_Cele -------------------------------------SKLR------------------- CC1G_01353_Ccin KDVPKKR------------------------ARPSRAAASKA------------------ AqueK156_Aque --------GCENRLNRELMLQDPHKK-A-------------------------------- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap GL--------------QEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSK-------- Haspin_Dmel -------------------------NSS-PKK----------C--SNFGKK--------- Haspin_Mmus VS--------------QGVDQRDYEESSACKDLRVPGEISRPKRTGPLRKRK-------- K08B4.5_Cele -----------------------IST----------------------------I-I--- H12I13.1_Cele -----------------------KMI----------------------------R-DN-- F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele -SIQQPQQDLEETAISENRLSHSTLKTT-PIE----------SRNESHQNSKIMTQQVSD aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele -----------------------RAS----------------------------E-R--- Y73B6A.1_Cele -----------------------QVH----------------------------R-E--- ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis -----------------------KND----------------------------N-Q--- ALK1_Scer -----QQQPLY---------------------------------------------N--- YBL009W_Scer -----KDFRSL--KFRSGSDFKCWGD----------------------------E-K--- Haspin_Spur RL-RTRQQD--NVSDIASRLSAIHLEQS-PIG----------DSHGSNEKSRTRECS--- aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin -----------------------AILVESDSDPDVARQPAQPKRTQRQKALVVVS-DVSD AqueK156_Aque --------------------------------------------QGSLENKE-------- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele SEDV-------------------------------------------------------- aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ------------------------------------------------------------ ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin SETENAPTAPSPAPPKTNRLSKLPTVEVVIPPAPYPIRPLARPSPPAGTQHRAATPTKPK AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap -----------------------------------HQEATETSLLHSHR--FKKG-QKLG Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus -----------------------------------QQEATGTPPRHYHQ--SKKK-RKAS K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ----------------------------EDVTFNRKAETSVTELLH------EEDEHERC aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ------------------------------------------------------------ ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------VRLSKISNESIEELGHGSMDLFEEGDQDLG aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin PAPPTARPGPAFQLPPSPIPRARPLTPIK------------------------------- AqueK156_Aque --------------------------------IY-KSKEKETLPKHRHV--KGNL-RKPA Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap KDSFPTQDLTPLQNVCFWTKTRASFS-FHKKKIVTDVSEVCS-------IYTTATSLS-- Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus V---SLWNLNTSQR-DSWTKTRASFG-FHKKKIITSVIEVCS-------S--VASSSS-- K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele SDLNLEE---SKYSK-KRQRTKSP-------------ETMCQGMSTVMTMQDDQDDLEAL aSWK213_Cele ----------------------------------------C------------------- T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ------------------------------------------------------------ ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur QDPEQDQ---GLDSK-SEVRLRSCLVSLERISL------SSG-------IWSDAADVS-- aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------------------------------------------------ AqueK156_Aque NN---------------------AFI-F-------------------------------- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap --GSLLSECSN---------------------------------------RP-------- Haspin_Dmel ----RLSNL-------------------------------------------NK-MVTAV Haspin_Mmus --RSLLSECST---------------------------------------PP-------- K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ----------------------------------KSSNK----VCRTSLS---------- F22H10.5_Cele ----------------------------------------------------KKKSPSSS C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele FEIEKENEIRKRTTLQ-----------------------------------PQQRQPSSR aSWK213_Cele ----MLAEL-------------------------------------------NKRAPSAR T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ----------------------------------------------------K------- Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ------------------------------------------------------------ ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur --AEQESMCRSRNNHRPFLRQRNDPILDEPNPI----------------KTP-------- aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin -------------------GMRRNGLFDPPSPPSPSLTDFDLSLDLSELN---------- AqueK156_Aque ------AGGAG---------------------------------------CP-------- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ----------------------VMNRT----------------------SGAPSSWHSS- Haspin_Dmel HPSISLNPGKWRKSLNNFIRSKITETNFTK------------------KVERRSS-ICQ- Haspin_Mmus ----------------------IKNRA----------------------HLTVSS-RCS- K08B4.5_Cele ----------------------------------------QRD-QIASQSFGSGSNED-- H12I13.1_Cele --------------------------------G----GAKK------------------- F22H10.5_Cele PR----------------------------------------------T--------PSL C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele HD-----------SI----NSAMEEMSLQQFLEDTMGEEFGKTQYSESR--------AE- aSWK213_Cele SA----------------------------------------------H--------PD- T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ----------------------------------------ARR----------------- Y73B6A.1_Cele ----------------------------------------G------------------- ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ----------------------------------------K------------------- ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ----------------------------------------T------------------- Haspin_Spur ----------------------LVNK-----------------------SISRLA-LDS- aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin --------------------------------IDA--ECVD------------------- AqueK156_Aque ----------------------II------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap SMYLLSPLNTLSISNKKA----------------SDAE---------------------- Haspin_Dmel DRKSLVLKGE--HKFENK-----------------YEE---------------------- Haspin_Mmus SVYLLSPLKTLHVTDQRP----------------SYAE---------------------- K08B4.5_Cele ---------SSAVLLMFL----------------QDYP---------------------- H12I13.1_Cele ---------KRKERNARS----------------EVGD---------------------- F22H10.5_Cele TSNNDH--GRNSIPQEEP-----------------AFQ---------------------- C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele -------------ADDSR-----------------CYG---------------------- C01H6.9_Cele SRNIPT--G-MTIHNEDPSILPFYLEDLTSEIDPSPMM---------------------- aSWK213_Cele SRNIPI--GSITFHNKDP-----------------SMA---------------------- T05E8.2_Cele ------------ATEDRR-----------------KYG---------------------- Y40A1A.1_Cele --------AR--EKNNEP-----------------ALE---------------------- Y48B6A.10_Cele ---------AKALEKD-F----------------EQFG---------------------- Y73B6A.1_Cele ---------ERAEANLRR----------------AHLN---------------------- ZK177.2_Cele -----------------H----------------KDVN---------------------- DDB0231182_Ddis ---------KNFKY-----------------------IEDNESDYLDDENDEENVDIDLS ALK1_Scer -----------ASLSSRR----------------SSIS---------------------- YBL009W_Scer ---------SSHVHSSSV----------------NSVN---------------------- Haspin_Spur FKVALTPTRN-RSTGKL----------------LSPKC---------------------- aSWK457_Cele -----------------H----------------VSIP---------------------- CC1G_01353_Ccin ---------AHDVEPNIP----------------AYLL---------------------- AqueK156_Aque ----QSPLIDYLSPDVRAS--------------LTVRE---------------------- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------KVYGECSQKG--PVPFSH------------------------------------ Haspin_Dmel ------DVLKYCHQCT--PLPFNT------------------------------------ Haspin_Mmus ------KVYGECNQEG--PIPFSD------------------------------------ K08B4.5_Cele ------ENIVNTKNIT--STCWKA------------------------------------ H12I13.1_Cele ------KILGITETKT--VTSWNE------------------------------------ F22H10.5_Cele ------QLLSKCGQYK--PEKWSS------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------NILDLVKRKK--VTNWTQ------------------------------------ C01H6.9_Cele ------QLLHVVGQKE--SKTWDS------------------------------------ aSWK213_Cele ------QLLRVVGQKE--AKPWGS------------------------------------ T05E8.2_Cele ------NILQIADKDH--IVLWSE------------------------------------ Y40A1A.1_Cele ------QLLNNCGQTK--PEKWSS------------------------------------ Y48B6A.10_Cele ------YLPEMTTKKK--VVQWPA------------------------------------ Y73B6A.1_Cele ------SLRKTTSSKR--IHSWES------------------------------------ ZK177.2_Cele ------AIVRETESKK--IVPWSD------------------------------------ DDB0231182_Ddis ILNVNFKIINENNSQN--NNNNKY------------------------------------ ALK1_Scer ------STVSSSSSSK--WRFWKRNKN------------QTPALLQPDHHSLKTFPAVNR YBL009W_Scer ------SFTSTTSSSK--WKFWKNDNLLSRSLSSRSVNDQDPNFVQ-------------- Haspin_Spur ------KVLAQCDQED--FITFSA------------------------------------ aSWK457_Cele ------AIIRKTEAKT--IVPWSD------------------------------------ CC1G_01353_Ccin ------PLLEECHQEECGPHDFSS------------------------------------ AqueK156_Aque ------KILALSNQND--IIPIED------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ------------------------------------------------------------ ALK1_Scer RDSMTPVEPRNMVKHKTSFSDFHKTIFSSNTYSES--------SDTISSMEITLKNKASS YBL009W_Scer ------PKPTNSLQKKSSISSFHNSIFGGGKHTEKKRNSGFIMPDHQSTKE--LNHKHSS Haspin_Spur ------------------------------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------------------------------------------------ AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ------------------------------------------------------------ ALK1_Scer SSLSLNVLKKRNSQSSLKHKSSHASLQKFKR-NKGKSSMIAPSTATNSSNDDSCSYSSKN YBL009W_Scer SNL---------SFRSLKHKTSHSSLNKLKVRRKGNTQELNH---------------PIK Haspin_Spur ------------------------------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------------------------------------------------ AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ----------CL---P-----------TEKLQR--------------------------- Haspin_Dmel ----------AY---E-----------QHKLLN--------------------------- Haspin_Mmus ----------CL---S-----------TEKLER--------------------------- K08B4.5_Cele ----------------------------LKIKV--------------------------- H12I13.1_Cele ----------------------------SGIEL--------------------------- F22H10.5_Cele ----------LS----------------LDSKN--------------------------- C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ----------------------------TRLVV--------------------------- C01H6.9_Cele ----------LP--KS-----------ALDGRR--------------------------- aSWK213_Cele ----------LP--TS-----------ALDARK--------------------------- T05E8.2_Cele ----------------------------LNIEA--------------------------- Y40A1A.1_Cele ----------LQ--KG-----------SFDYAN--------------------------- Y48B6A.10_Cele ----------------------------MKIEL--------------------------- Y73B6A.1_Cele ----------------------------LLTGK--------------------------- ZK177.2_Cele ----------------------------AKVQI--------------------------- DDB0231182_Ddis ----------------------------QINNN--------------------------- ALK1_Scer STLSHRISLPVPDQVS-----------RDKIQNKLRYSTSLLSLNSKSSLPMNKNDHDET YBL009W_Scer KTC--QISLPVPDQVS-----------KDKIQLKLKNSTSLASLSSEV-TPINTLDYNDS Haspin_Spur ----------CM---P-----------SAMMKK--------------------------- aSWK457_Cele ----------------------------AKVQI--------------------------- CC1G_01353_Ccin ----------FIDSFPFDPILRDGRSDAPSELE--------------------------- AqueK156_Aque ----------FF---T-----------PVMKRT--------------------------- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ----------CEKIGEGVFGEVFQTI-ADH-------TPVA------------------- Haspin_Dmel ----------TKKIGEGAYGEVFRCS-RNQEVLKDHISDIV------------------- Haspin_Mmus ----------CEKIGEGVFGEVFQII-NDQ-------APVA------------------- K08B4.5_Cele ----------LKLLGSGDSGDVYAVT-WMG-------TEYT------------------- H12I13.1_Cele ----------QRKIGFGAYGSAYSVK-YGG-------KTVV------------------- F22H10.5_Cele ----------IAKIGEGCYAEAFSTI-FNN-------QSVV------------------- C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ----------EGKLGEGLRGIAYKVK-HRN-------TMKC------------------- C01H6.9_Cele ----------VKKLGEGAYGEVFSTI-WDG-------KPVA------------------- aSWK213_Cele ----------VKKLGEGAYGEVFSTV-WNG-------RPVA------------------- T05E8.2_Cele ----------KSKLGFGQTGDVLQIE-RSG-------RSEA------------------- Y40A1A.1_Cele ----------VAKVGEGCFAEAFSTT-FKN-------VSVV------------------- Y48B6A.10_Cele ----------EQKLGGGIAGDAFNCT-WKG-------LERV------------------- Y73B6A.1_Cele ----------VEKLGQGNHGTIFKVR-WNG-------RRAA------------------- ZK177.2_Cele ----------KKFLGDGASGTAYLVV-WED-------KEVV------------------- DDB0231182_Ddis ----------MQKTG-GRNGSVFFVN-NNN-------NSNNNNNNNNNNNNNNNNNNNNN ALK1_Scer LLRQILLNCDIKRILNPAKGDVLPLI-NDV-------NHL-------------------- YBL009W_Scer ILQQILQLCDVKYIL--------HDL-REA-------QSLG------------------- Haspin_Spur ----------CVKIGEGVYGEVFRTFNNRK-------SSVA------------------- aSWK457_Cele ----------KKFLGYGASGTAYLVV-WED-------KEVV------------------- CC1G_01353_Ccin ----------FRKIGEASYSEVFGI------------ADVV------------------- AqueK156_Aque ----------LQKLGEGVFGEVFSCYTPEG-------DGLA------------------- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ---------------------------------------IK--IIAIEGPDLVN------ Haspin_Dmel ---------------------------------------LK--IIPLEGSTVIN------ Haspin_Mmus ---------------------------------------LK--IIAIEGLDLVN------ K08B4.5_Cele ---------------------------------------LK--LAKSNNSK--------- H12I13.1_Cele ---------------------------------------MK--LIGIRDN---------- F22H10.5_Cele ---------------------------------------MK--VLPCRDISN-----GEK C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ---------------------------------------LK--LLPLSWTS--------- C01H6.9_Cele ---------------------------------------IK--IVPFEKDGCNRQYFGEY aSWK213_Cele ---------------------------------------IK--VLPFENNGCFY---GN- T05E8.2_Cele ---------------------------------------LK--MCRLAGPD--------- Y40A1A.1_Cele ---------------------------------------VK--VLPLRDGPI-----GKD Y48B6A.10_Cele ---------------------------------------AK--IIPLHPSH--------- Y73B6A.1_Cele ---------------------------------------MK--VLHVPGEI--------- ZK177.2_Cele ---------------------------------------MK--VTGIHPQ---------- DDB0231182_Ddis NNNNNNNDNSNNKNNFKNNNTSYTHNSNKNNNENKNTFAIKQQLVSTPKN---------- ALK1_Scer -----------------------------------------------SSIQ--------- YBL009W_Scer ---------------------------------------LF--TLNTRSVQ--------- Haspin_Spur ---------------------------------------LK--IIPVEGDFPVN------ aSWK457_Cele ---------------------------------------MK--VTGIHPQ---------- CC1G_01353_Ccin ---------------------------------------LK--VIPLRDESAPGAI-STE AqueK156_Aque ---------------------------------------VK--IMPIEGKELIN------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ---GSHQKTFEEILPEIIISKELSLLSGE-VCN-R---TEGFIG---LNSVHCVQGSYP- Haspin_Dmel ---GEKQKTFSQILPEIIITKKMCSLRTS-KTN-S---TNGFVS---IQKVSLVKGRYP- Haspin_Mmus ---GSHQKTFEEILPEIIISKELSLLSSE-AYN-R---TEGFIG---LNSVHCVQGLYP- K08B4.5_Cele --------TKSEQLVEVQNMAKIQKV-----LP-D---APNFPE---CLEAYFI-NDIP- H12I13.1_Cele ---------EQLLFNELIITQQLGKLAK---NR-V---CPNFLE---YCGSHVM-TDVP- F22H10.5_Cele --CGEHTQGIDAVIAELAILKSLSALSTKNHAN-V---TENFVK---MVMAKVVIGKHP- C50H2.7_Cele ----------------------------------M---TPNVMR---LLKACFV-EQIP- C04G2.10_Cele --------RNKEALEDLVALRSLKTI-----KK-E---TPNYLT---FFDSFVLT-NLP- C01H6.9_Cele --HSEEMQTSDVVLPEVIVMKELSALRDEDAWN-S---TPNFIE---MISAEVVMGKYP- aSWK213_Cele --QSVEIPTTHAVLSEVIVMKELSALRDPNSWN-S---TPNFIE---MISAQIVMGEYP- T05E8.2_Cele --------TVQNAYKELKIWQSIKAI-----QM-A---TPNFPD---FYGSCVIK-EVQ- Y40A1A.1_Cele --CDEYVQRTEAVLAELIVLKLLSALSTKNRPN-V---TENFVK---LVMTKVVVGKYP- Y48B6A.10_Cele --------RNKKAFQEVAALNRLGDV-----AH-Q---TPNLVK---FEMAAVV-TGMP- Y73B6A.1_Cele --------SADTAKDEITVMKKVGSAVF---RK-K---NPSFLE---FLGAYLVE-GHS- ZK177.2_Cele --------SISVLHDELLITQKIGKL-----SK-S---CHNFLP---YHGSIVI-SDLP- DDB0231182_Ddis --------KLSQTYREKVILEHLNILIE---SN-KACNFPKLIN---WYKAAPTS-NLSN ALK1_Scer LTSNVWQ-------IGEVICKKVSLGTI---DDITW--DRKFLSLQELEKLKIMQ-QK-- YBL009W_Scer LSHNFWQ-TYHSDMQTSLICKKVCLGAL---SDLT---TSNLISLHELKSLRLIQ-GT-- Haspin_Spur ---EENQKPFEEILPEIVISWELSMLREG-EET-M---TTNFIG---VNHVSCVKGSYP- aSWK457_Cele --------SISVLHDELLITQKIGKL-----SK-S---CHNFLP---YHGSIVI-SDLP- CC1G_01353_Ccin LEEGPPPSDAQDVRKEIIVTRAMGEVY------------GGFVK---FLKTYIVRGKYP- AqueK156_Aque ---DEKQKTFEEILPEMVISK-----------------------------LGIGKGKYP- Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ---------------------------------------PL----L-LKAWDHYNSTK-- Haspin_Dmel ---------------------------------------PH----F-IKLWEKYDNEK-- Haspin_Mmus ---------------------------------------PL----L-LKAWDHYNTTK-- K08B4.5_Cele ---------------------------------------TEICQKL-------------- H12I13.1_Cele ---------------------------------------VG------------------- F22H10.5_Cele ---------------------------------------TS----L-LKAWDTYRVEE-- C50H2.7_Cele ---------------------------------------DEVCDEF-------------- C04G2.10_Cele ---------------------------------------ASTQDKL-NQ----------- C01H6.9_Cele ---------------------------------------KG----L-LSAWDSYDKLK-- aSWK213_Cele ---------------------------------------KG----L-LRAWDAYDKLN-- T05E8.2_Cele ---------------------------------------GNVEKLL-RH----------- Y40A1A.1_Cele ---------------------------------------TS----L-LKAWDKFRVEE-- Y48B6A.10_Cele ---------------------------------------QDVKNQL-------------- Y73B6A.1_Cele ---------------------------------------KTDPKLQ-FKN---------- ZK177.2_Cele ---------------------------------------AKMM----------------- DDB0231182_Ddis VNNNNSNNNNNNSNNNITNSRYGSNYEDIYDDNYYDEVDDYDSGKEEEES---------- ALK1_Scer ---------------------------------------FDGIPQL-LKS---------- YBL009W_Scer ----------------------------------------SGVANL-LQA---------- Haspin_Spur ---------------------------------------KK----L-LDEWDKYDRRKTS aSWK457_Cele ---------------------------------------AKMM----------------- CC1G_01353_Ccin ---------------------------------------EL----L-LNLWDEYNETK-- AqueK156_Aque ---------------------------------------EF----L-INAWDNWDEKE-- Haspin_Smoe ---------------------------------------KN----L-VRAWKKWDTQH-- Haspin_Hsap GSAN---------DRPDFFKD---DQLFIVLEFEFGGIDLE-----QMRTKL-----SSL Haspin_Dmel GSEN---------DHPELFGD---NQLFAVLELKFAGSDMA-----NFK--F-----LNS Haspin_Mmus RSAN---------DRPDFFQE---DQLFIILEFEFGGVDLE-----RMKTKL-----SSV K08B4.5_Cele ---------------QSSAK-VRVDNYCRIVE--YE------------------------ H12I13.1_Cele -------------MRRDPKA-----IRHLAILMARGGGVLD-----NWK--FK-----DY F22H10.5_Cele ESEN---------IRPSKFNK---NQLYLVLILSKGGTALE-----KFK--M-----ESI C50H2.7_Cele ---------------HLKK-----DTEHMILITKDGGMPIS-----KIK--P-----LSD C04G2.10_Cele -------------LDPQCPA-T--HYLGL--LVELGSNSLD-----NTM--LT-----TA C01H6.9_Cele ESEN---------TRPDVYSSI--DQNFILFVSANGGIALE-----DFV--L-----ESE aSWK213_Cele ESEH---------LRPDVYSSE--HQNFILFVSANGGISLA-----DFV--L-----ESE T05E8.2_Cele ------------------AG-K--VYCGI--FSEICKKRLD-----NIRRNSL-----TC Y40A1A.1_Cele QSGN---------IRPSKFKK---NQLYLLLIMSNGGTPLE-----KFE--M-----DNI Y48B6A.10_Cele ---------------RENWR----TNHMLVVILSRGGRPVA-----SQP--PDS---LTA Y73B6A.1_Cele --KN---------GHPLPEK-A--QFVAIFMELVEGGRSIG-----DFP--FK-----TD ZK177.2_Cele ---------------RNSE-----CVNHLAIFMGYGGTVLA-----DWR--T-----SDY DDB0231182_Ddis --TKTITKTITTTTASIKPN-I--QYMHLILEYANMGTLKEYGKDNNFE---F-----TI ALK1_Scer --FV--------VK----EA-N--GGLYLYLLFKDHGTPIS-----LIS--LK-----NW YBL009W_Scer --YV--------VPSNQCEN-D--QNLILYLFFKYQGTPLS-----RCS--NI-----DY Haspin_Spur GSEN---------DRPDIFPS---DQLFIIFEFADGGKDLE-----SFE--F-----ENI aSWK457_Cele ---------------RNSE-----CVNHLAIFMGYGGTVLA-----DWR--T-----SDY CC1G_01353_Ccin GSES---------MRPDTFK-L--SQVYAIIVLPNGGPDLE-----AYS--FNNPTKQGW AqueK156_Aque ESDN---------DRPDVFSP---KQLYVMFAFENSGCALE-----AFT--F-----HSK Haspin_Smoe NSEN---------DQPLAFPE---EQLYVVFVLADGGTDLE-----SFE--L-----LNY Haspin_Hsap ATAKSILHQL--TASLAVAEASLRFEHRDLHWGNVLLKKTS-L--KKLHY---TL--NG- Haspin_Dmel EQSYYALQQI--ILALAVGEEEYQFEHRDLHLGNILIEYTN-K--KHIVC---TF--KS- Haspin_Mmus ATAKSILHQI--TASLAVAEASLHFEHRDLHWGNVLLKKTN-L--KELRY---TL--NG- K08B4.5_Cele SKTLTPVRRRPNPPFTQSGKKENGFWHEDLHKGNILLAVTD-K--DFIKY---RV--DK- H12I13.1_Cele RQCVSVFCQL--VMSLKVVKDSINMVHRDIHLWNVLVSRTK-T--TCLDY---SM--DG- F22H10.5_Cele DQFHSIMQQL--VYSLAIAETELQFEHRDLHLGNVLIDKTG-A--EELEF---VL--NN- C50H2.7_Cele SQVLSVLSQI--LLSLYIGKRELQFSHNDLNPGNLLISETK-K--KSISY---KK--DG- C04G2.10_Cele VEGLSIVKQL--VLSLVIAKRRLDTNHNDVHPGNVLVKRSASP--KTLKY---TL--DG- C01H6.9_Cele NELFSIIHQL--VLSMNAAEAALEFEHRDLHLGNVLIDRNG-V--KELYY---TV--HG- aSWK213_Cele DELFSIIHQL--VLSMVAAEAALEFEHRDLNLSNVLIDRNG-V--EELSY---TV--HG- T05E8.2_Cele SESVAIMQQL--VLTLAIAKDRILLNHRDLFGGNVLIKVTG-K--TNLHY---TH--NG- Y40A1A.1_Cele GQFCSIIQQL--LFSLAIAEKEMQFEHRDLHLGNVLIKKQV-W--EST------------ Y48B6A.10_Cele QQSIGIMKQF--VMTMLIGETSLKLYHNDAHCRNVLLTDTD-D--EYLEY---KP--DG- Y73B6A.1_Cele NERKSFVCQL--VVGLMTAQKELGFSHGDLSVDNTIVTKTK-L--RTVAY---IL--EG- ZK177.2_Cele RRCITIMAQL--VLAMRIANDKMKFVHGDIYMMNILIAPTT-K--RWIEY---NI--DG- DDB0231182_Ddis SQMKSLLFQV--IYSLAISQKEFEFVHNDLHFGNVLLTSFP-VDKKYIVY---QDKLDN- ALK1_Scer KQILKIFWSC--AGIIHGLEKNLKFEHRNLTLDNILIDGNGN------------------ YBL009W_Scer SQALSIFWQC--SSILYVAESKFQLEHRNLTLDHILIDSKGN------------------ Haspin_Spur HQAVSVIRQV--TVALAVAERELEFEHRDLHWGNVLVGATD-D--DQVTF---ML--DG- aSWK457_Cele RRCITIMAQL--VLAMRIANDKMKFVHGDIYMMNILIAPTT-K--RWIEY---NI--DG- CC1G_01353_Ccin KQACSIFWQV--AKSLAHAEHLVSFEHRDLHWGQILVKNVP-S--QKPKLQPINV--NGV AqueK156_Aque REAMSVLAQI--AATLAVGEAALKFEHRDMHRGNILVRRTK-E--EKMVF---VI--DS- Haspin_Smoe EEVKSLLLQV--VLSLAVAEQAYGFEHRDLHWGNIVLSRDQ-H--EQLDF---RL--EN- . : * : : :: Haspin_Hsap ------KSST--IPSCGLQVSIIDYTLSRLER-------DGIVVFCD---VSMD-EDL-- Haspin_Dmel ------SNLT--LLSKGVNVTIIDYTLSRVTI-------NDCCYFND---LSRD-EEL-- Haspin_Mmus ------KTST--IPTHGLQVNIIDYTLSRLER-------DGIVVFCD---ISAE-EDL-- K08B4.5_Cele ------KLIK--LRTNGLMETSLTSCSYRIMK-------------------ELS-KKL-- H12I13.1_Cele -------KVK--LNSYGVVMHLIDFSKSL------------------------------- F22H10.5_Cele ------RPVR--IKLRGVRVTIIDFTWSRIQE-------GGKTIYVD---TEID-TAM-- C50H2.7_Cele ------KSIK--IKSHGRFLTLIDLQKSTF------------------------------ C04G2.10_Cele ------KVIR--IPSHGLVVGIIDFSEASFG----------------------------- C01H6.9_Cele ------QKVP--LSTHGIKVNIIDFTLSRISK-------GATTVYWD---LEND-PAI-- aSWK213_Cele ------QKIP--LRTHGIKVNIIDFTLSRISK-------DSTTIYWD---LEED-TTI-- T05E8.2_Cele ------VKIT--LMRKAMLCILLILDKVQLAVKVVKLPKNPKTD---YTL---------- Y40A1A.1_Cele -----------------------------------------QIIYED---MEKD-GAM-- Y48B6A.10_Cele ------GAVK--VKSYEKKLTIIDFGEATF------------------------------ Y73B6A.1_Cele ------KAVK--LKTSGVLLKIIDYGKSECSS-------DNKAS---TSF---------- ZK177.2_Cele ------KTIT--IQTFGIIPQLIDFSKSWC------------------------------ DDB0231182_Ddis ------GEFNNWIVGGDFIVKISDFGLSRIKL-------PSNEI---IYNQRNDR-SKEF ALK1_Scer -------------------ITIIDFKCSRLQT-------PQ-DD---VLYLRLDHPLF-F YBL009W_Scer -------------------VTLIDMKCCRFLN-------IDNNK---ASYTRLDHHYF-- Haspin_Spur ------QVIS--VESHGLHISIIDFTLSRLQK-------DDCTVFCD---LAED-PTL-- aSWK457_Cele ------KTIT--IQTFGIIPQLIDFSKSWC------------------------------ CC1G_01353_Ccin KSRKQRLMMD--DKSHGVQTTIIDLGLSRMDA-------GDGSGGYRVQWTPFD-EEV-- AqueK156_Aque ------HKYV--LPSEGVHVTVIDYTLSRLSQ-------GSCTSYND---LNNL-PWL-- Haspin_Smoe ------RHFL--VNTHGLSVALIDFTLSRIDT-------GKQVVFCD---LS-D-PSW-- Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis CFYSDLYSFSSLLNKIKIKESPSSSSTTSTSTSQVLIKSDSDSSSSASSSSSSSSSSSSS ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------------------------------------------------ AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis SSSSLPKSKNKSNRSKDNQSKLDPEKRLLTKLKKSMKDLPPYKLLDHPFFDSLKVCPNDC ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------------------------------------------------ AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis LPLNSIRISTNGIVPKEFPKPLSPIFEKNNIISIPSSPISTTTTTFPTTPTIKSTTKKIS ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------------------------------------------------ AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ----------------------FTG----------------------------------- Haspin_Dmel ----------------------FQA----------------------------------- Haspin_Mmus ----------------------FTG----------------------------------- K08B4.5_Cele ----------------------FEA----------------------------------- H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ----------------------FEG----------------------------------- C50H2.7_Cele -----------------------DE----------------------------------- C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ----------------------FEG----------------------------------- aSWK213_Cele ----------------------FEG----------------------------------- T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ----------------------FEG----------------------------------- Y48B6A.10_Cele -----------------------DV----------------------------------- Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele -----------------------GA----------------------------------- DDB0231182_Ddis KTIVIPSSPSLALPPNLSVKSPFAPPSKKQLQQYQQQQKQQTISMFKYDDEEEKEEEEKE ALK1_Scer ----------------------LNGKDKSKINEY-------------------------- YBL009W_Scer ----------------------FQG----------------------------------- Haspin_Spur ----------------------FTG----------------------------------- aSWK457_Cele -----------------------GA----------------------------------- CC1G_01353_Ccin ----------------------FMG----------------------------------- AqueK156_Aque ----------------------FKG----------------------------------- Haspin_Smoe ----------------------FEGP---------------------------------- Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis KEKEKEKEKEKEEEGEEGNIPKEKLILKMTPKPYIFIHHFSPNSLGPLSPPSSTSSTLLG ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------------------------------------------------ AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis ALSQEKFEKKQRQIQDSEKVNKNEEENQTKDDADNISPPLPHAIKKSIYNNKNNHQKIST ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------------------------------------------------ AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele ------------------------------------------------------------ Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis NTIIKTPIKAPIKTITQIPTETPNKIPNKTISQSNPVIIRDETPQKGIPFEKKVVSTPLI ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------------------------------------------------ AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap ------------------------------------------------------------ Haspin_Dmel ------------------------------------------------------------ Haspin_Mmus ------------------------------------------------------------ K08B4.5_Cele ------------------------------------------------------------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele ------------------------------------------------------------ aSWK213_Cele ------------------------------------------------------------ T05E8.2_Cele --------------------------EF-------------------------------- Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele ------------------------------------------------------------ DDB0231182_Ddis YKERPHFVFLKKAKLSSNSNNKENIINFHNNNNNNNNNNNNNNNNNNNNNNNNNNNKDSY ALK1_Scer ------------------------------------------------------------ YBL009W_Scer ------------------------------------------------------------ Haspin_Spur ------------------------------------------------------------ aSWK457_Cele ------------------------------------------------------------ CC1G_01353_Ccin ------------------------------------------------------------ AqueK156_Aque ------------------------------------------------------------ Haspin_Smoe ------------------------------------------------------------ Haspin_Hsap -----DGDY------QFDIY----------------------------------RLMKKE Haspin_Dmel -----TGDY------QYDVY----------------------------------RMMRNE Haspin_Mmus -----EGDY------QFEIY----------------------------------RLMRKE K08B4.5_Cele -----KTIE------EFWNY----------------------------------QDLLES H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele -----FSDS------QFDVY----------------------------------REMRRN C50H2.7_Cele -----KEDK------GLDCW----------------------------------KL---- C04G2.10_Cele ------------------------------------------------------------ C01H6.9_Cele -----QDDP------QFEVY----------------------------------REMRKN aSWK213_Cele -----PDAP------QFEVY----------------------------------REMREN T05E8.2_Cele FLWKTSIGIGFSIPKNRCT--------------------------YNFIL--IAQKLRAN Y40A1A.1_Cele -----FGDS------QFDVY----------------------------------REMRSN Y48B6A.10_Cele -----PNPR------KWPSH----------------------------------RF---- Y73B6A.1_Cele ---------------EDSDY---------------------------------------- ZK177.2_Cele -----DP-E------RHDIS----------------------------------RL---- DDB0231182_Ddis N-EKGNATSYCNGDDDDDDFKIDHKENVVSGFLIEKDHEFIGDKENSKEKQKVSKRVQDK ALK1_Scer -----QYQF------EFEIY----------------------------------QSMRIL YBL009W_Scer -----RGTL------QFEIY----------------------------------ELMRSM Haspin_Spur -----EGDK------QFDVY----------------------------------RSMKEH aSWK457_Cele -----DP-E------RHDIS----------------------------------RL---- CC1G_01353_Ccin -----EGEY------QFDVY----------------------------------RMMRDH AqueK156_Aque -----HGGI------QHDTY----------------------------------LRMRNA Haspin_Smoe -----KGDV------QADTY----------------------------------RRMKDI Haspin_Hsap N----------------------------------NNRWGE--YHPYSNV-LWLHYL--- Haspin_Dmel L----------------------------------RNNWSS--FSPKTNI-IWLSYV--- Haspin_Mmus N----------------------------------KNCWGE--YHPYNNV-LWLHYL--- K08B4.5_Cele ------------------------------------------------------VIVIDK H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ------------------------------------------------------------ C04G2.10_Cele ----------------------------------------R--ANGNSDV-GFLSFI--- C01H6.9_Cele C----------------------------------KSNWKK--FSRRTNL-MWIVYI--- aSWK213_Cele C----------------------------RYRYRYRGNWEK--FSRRTNL-MWIVYI--- T05E8.2_Cele E----------------RKVEKSTAQLLWD----TPRFWKF--FTKKDTATSDLSYG--- Y40A1A.1_Cele C----------------------------------KRNWQL--FSSKSNI-MWIKFI--- Y48B6A.10_Cele ------------------------------------------------------------ Y73B6A.1_Cele --------------------------------------------TKLRNHAMDVFKV--- ZK177.2_Cele ------------------------------------------------------HTV--- DDB0231182_Ddis AWQELNAFLRKNPTQGVSRIKSTDYPALSD----LFPKKK---RCSENNFVFEKEKK--- ALK1_Scer L----------------------------N------MDASA--FEPMTNL-YWLYYL--- YBL009W_Scer L----------------------------P----QPISWAT--FEPRTNL-LWLYHL--- Haspin_Spur N----------------------------------NNQWEG--FQPKTNV-FWIEYL--- aSWK457_Cele ------------------------------------------------------HTV--- CC1G_01353_Ccin T----------------------------G------DDWEG--YHPLTNV-MWLHYL--- AqueK156_Aque T----------------------------------KSDWSK--FAPRTNA-CWLYYI--- Haspin_Smoe T----------------------------------GGQWEGRQVFPKNNS-VWIHYV--- Haspin_Hsap -------------------------T---------------------------------- Haspin_Dmel -------------------------I---------------------------------- Haspin_Mmus -------------------------T---------------------------------- K08B4.5_Cele PNNINHIGI----------------L---------------------------------- H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele -------------------------N---------------------------------- C04G2.10_Cele -------------------------T---------------------------------- C01H6.9_Cele -------------------------A---------------------------------- aSWK213_Cele -------------------------A---------------------------------- T05E8.2_Cele -------------------------L---------------------------------- Y40A1A.1_Cele -------------------------A---------------------------------- Y48B6A.10_Cele -------------------------V---------------------------------- Y73B6A.1_Cele ------------------------------------------------------------ ZK177.2_Cele -------------------------A---------------------------------- DDB0231182_Ddis --------QEKENKEKENKEKEKKQLEKQKQLEREKLEKDRLEKDRLEKEQQEKDCLERE ALK1_Scer -------------------------S---------------------------------- YBL009W_Scer -------------------------S---------------------------------- Haspin_Spur -------------------------L---------------------------------- aSWK457_Cele -------------------------A---------------------------------- CC1G_01353_Ccin -------------------------A---------------------------------- AqueK156_Aque -------------------------V---------------------------------- Haspin_Smoe -------------------------A---------------------------------- Haspin_Hsap --------------DKMLKQMTF----------KTKCNTPAMK----QIK-RKIQ----- Haspin_Dmel --------------VKVLDSVKY----------K-SINTKVHR----MYI-DKIK----- Haspin_Mmus --------------DKILNKMKF----------KTKCQSAAMK----QIR-KNLQ----- K08B4.5_Cele --------------QDISNLR---------------IV-MTKK----KVFRFCL------ H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele --------------SRVRDQFLP-------------LVKEDTK----KILAKVA------ C04G2.10_Cele --------------EEISKTL----------------SKAENR----TFQ-TAI------ C01H6.9_Cele --------------NRLIDTKIC----------PKGLLTEKRR----M----ELK----- aSWK213_Cele --------------NRLIDTEIC----------PEGLFTDKRR----K----ELK----- T05E8.2_Cele --------------PRIGAELMT----------RT--VTAEKQ----ELK-KKF------ Y40A1A.1_Cele --------------TTIIRKNVS------------------------------------- Y48B6A.10_Cele --------------SRLADFLIR-------------RTTEDTR----YYVERAL------ Y73B6A.1_Cele ------------------------------------------P----GLK-ALA------ ZK177.2_Cele --------------KRVGH-SLN-------------GSKRDKK----KVR-QAV------ DDB0231182_Ddis KFLENERLEKEQEREKLEKEIKILVVSKKNRTNPL--QKDYDR----YIK-KVG------ ALK1_Scer --------------RVLLKFGDR----------KLGKNDANRD----KMA-RVIN----- YBL009W_Scer --------------SSLLKMAKK----------AV-VSGALNR----E-E-NILI----- Haspin_Spur --------------DKIIWEKKY----------PTD---RSQR----RVL-GQLK----- aSWK457_Cele --------------KRVGH-SLN-------------GSKRDKK----KVR-QAV------ CC1G_01353_Ccin --------------TKLLYGKGL----------KAPVVRKPKSGSEAPLA-TSSDAFSER AqueK156_Aque --------------NKMAIKSR--------------VKYVTRA----QIQ-AAFE----- Haspin_Smoe --------------EIIRKKKSF----------KSS---AKDK----RA----LS----- Haspin_Hsap -------EFHRTM------------------------------LNF------------S- Haspin_Dmel -------ELKNII------------------------------MTF------------E- Haspin_Mmus -------HFHRTV------------------------------LSF------------S- K08B4.5_Cele -----------LF------------------------------G--------------E- H12I13.1_Cele ------------------------------------------------------------ F22H10.5_Cele ------------------------------------------------------------ C50H2.7_Cele ----------EEI------------------------------EKT------------T- C04G2.10_Cele ----------DGL------------------------------TDA------------R- C01H6.9_Cele -------VLFDRF------------------------------AEF------------G- aSWK213_Cele -------HLFDRL------------------------------AEF------------G- T05E8.2_Cele ----------ELI------------------------------GKV------------D- Y40A1A.1_Cele ------------------------------------------------------------ Y48B6A.10_Cele ----------SQC------------------------------RDA------------T- Y73B6A.1_Cele ----------DAV------------------------------NNY------------DE ZK177.2_Cele ----------KMV------------------------------GAA------------K- DDB0231182_Ddis ----------SSL------------------------------TE--------------- ALK1_Scer -------HLEMNL-------A-VHKRG---GQLFKRLET----EDI------------K- YBL009W_Scer -------ELTHLL-------DPARKHS---KTIFKKEL------VI------------R- Haspin_Spur -------TLVREI------------------------------QQY------------L- aSWK457_Cele ----------KMV------------------------------GAA------------K- CC1G_01353_Ccin DCYESLLDIEQWLGSFLTGAFPAQSKAIAKTKGRRKTIALSSCLALRDGPSCAGEVVAYG AqueK156_Aque -------PLVNQF------------------------------LNY------------D- Haspin_Smoe -------AFSKRC------------------------------LSY------------E- Haspin_Hsap SATDLLC---------------QHSLFK Haspin_Dmel SASH-CA--------------NYLFNLN Haspin_Mmus SATDLLC---------------QHSLFR K08B4.5_Cele IKKF-ICP---------------DVLDS H12I13.1_Cele -------------------------YGG F22H10.5_Cele --------------------------CQ C50H2.7_Cele ILDWKLPG---------------MLPIQ C04G2.10_Cele SITAIYPNASI-------------FKKH C01H6.9_Cele SCGESLTNEEFFSDFYEGP-IGMSTTRQ aSWK213_Cele SCEESLTDAEFYRDFYGKSIEMSHTTSQ T05E8.2_Cele NDAQ-LLNSE---------------LMK Y40A1A.1_Cele -----------------------PSAEF Y48B6A.10_Cele GIDVHWPN-------------GLLFADA Y73B6A.1_Cele EHASWYPNSEL-----------FNGLIE ZK177.2_Cele NWKNLCLYRQLFK--------QVIVHDH DDB0231182_Ddis ----KRAS--K-----------PMNDNI ALK1_Scer NTGDL------------------LKLYK YBL009W_Scer TCGDLLS---L-----------KGEIMQ Haspin_Spur SAEDVFKNSDL-------------LSIG aSWK457_Cele NWKNLCLDRQLFK--------QVIVHEH CC1G_01353_Ccin VKKG-W----V-----------SATKLF AqueK156_Aque SAKDIFLE--YFSNPSPLSFESKKLKRN Haspin_Smoe SATAI-VDDEIFQKMWRK-EVTLNTPGN